Multiple forms of balancing selection maintain inversion polymorphism
Paris, Margot, Mitchell, Esra Durmaz, Kerdaffrec, Envel, Rubin, Doriane, Spichtig, Cecile, Zurbriggen, Felicitas, Becker, Joel, Augustijnen, Hannah, Thyagarajan, Harshavardhan, Zinn, Eliane, Gagliardi, Fanny, Gobet, Elliot, Rey, Tristan, Rime, Yvan, Machado, Sofia Ribeiro, Bachmann, Jeremias, Sgammeglia, Noemi, Schmidt, Paul, Flatt, Thomas, Heredity (2026) | Journal article
A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context
Esra Durmaz Mitchell, Envel Kerdaffrec, Paul Schmidt, Thomas Flatt, Sebastian Kittelmann, John Parsch, Molecular Biology and Evolution (2025) | Journal article
Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of Drosophila melanogaster
Esra Durmaz Mitchell, Thomas Flatt
(2025) | Other
From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology
Hoedjes, Katja M., Grath, Sonja, Posnien, Nico, Ritchie, Michael G., Schloetterer, Christian, Abbott, Jessica K., Almudi, Isabel, Coronado-Zamora, Marta, Mitchell, Esra Durmaz, Flatt, Thomas, Fricke, Claudia, Glaser-Schmitt, Amanda, Gonzalez, Josefa, Holman, Luke, Kankare, Maaria, Lenhart, Benedict, Orengo, Dorcas J., Snook, Rhonda R., Yilmaz, Vera M., Yusuf, Leeban, Molecular Ecology (2025) | Journal article
Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource
Nunez, Joaquin C. B., Coronado-Zamora, Marta, Gautier, Mathieu, Kapun, Martin, Steindl, Sonja, Ometto, Lino, Hoedjes, Katja, Beets, Julia, Wiberg, R. Axel W., Mazzeo, Giovanni R., Bass, David J., Radionov, Denys, Kozeretska, Iryna, Zinchenko, Mariia, Protsenko, Oleksandra, Serga, Svitlana V., Amor-Jimenez, Cristina, Casillas, Sonia, Sanchez-Gracia, Alejandro, Patenkovic, Aleksandra, Glaser-Schmitt, Amanda, Barbadilla, Antonio, Buendia-Ruiz, Antonio J., Bertelli, Astra Clelia, Kiss, Balazs, Sebnem Oender, Banu, Roldan Matrin, Belen, Wertheim, Bregje, Deschamps, Candice, Arboleda-Bustos, Carlos E., Tinedo, Carlos, Feller, Christian, Schloetterer, Christian, Lawler, Clancy, Fricke, Claudia, Vieira, Cristina P., Vieira, Cristina, Obbard, Darren J., Juana Orengo, Dorcas, Vela, Doris, Amat, Eduardo, Loreto, Elgion, Kerdaffrec, Envel, Durmaz Mitchell, Esra, Puerma, Eva, Staubach, Fabian, Florencia Camus, M., Colinet, Herve, Hrcek, Jan, Givskov Sorensen, Jesper, Abbott, Jessica, Torro, Joan, Parsch, John, Vieira, Jorge, Luis Olmo, Jose, Khfif, Khalid, Wojciechowski, Krzysztof, Madi-Ravazzi, Lilian, Kankare, Maaria, Schou, Mads F., Ladoukakis, Emmanuel D., Gomez-Julian, M. Josefa, Espinosa-Jimenez, M. Luisa, Garcia Guerreiro, Maria Pilar, Parakatselaki, Maria-Eleni, Savic Veselinovic, Marija, Tanaskovic, Marija, Stamenkovic-Radak, Marina, Paris, Margot, Pascual, Marta, Ritchie, Michael G., Rera, Michel, Jelic, Mihailo, Hojat Ansari, Mina, Rakic, Mina, Merenciano, Miriam, Hernandes, Natalia, Gora, Nazar, Rode, Nicolas, Rota-Stabelli, Omar, Sepulveda, Paloma, Gibert, Patricia, Carazo, Pau, Kohlmeier, Pinar, Erickson, Priscilla A., Vitalis, Renaud, Roberto Torres, Jorge, Guirao-Rico, Sara, Ramos-Onsins, Sebastian E., Castillo, Silvana, Paulo, Tania F., Tyukmaeva, Venera, Alonso, Zahara, Alatortsev, Vladimir E., Pasyukova, Elena, Mukha, Dmitry V., Petrov, Dmitri A., Schmidt, Paul, Flatt, Thomas, Bergland, Alan O., Gonzalez, Josefa, Molecular Biology and Evolution (2025) | Journal article
The remoulding of dietary effects on the fecundity / longevity trade-off in a social insect
Rau, Veronika, Flatt, Thomas, Korb, Judith, BMC Genomics (2023) | Journal article
An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation
Kapun, Martin, Mitchell, Esra Durmaz, Kawecki, Tadeusz J, Schmidt, Paul, Flatt, Thomas, BioRxiv (2023) | Journal article
An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation
Kapun, Martin, Mitchell, Esra Durmaz, Kawecki, Tadeusz J., Schmidt, Paul, Flatt, Thomas, Molecular Biology and Evolution (2023) | Journal article
How chromosomal inversions reorient the evolutionary process
Berdan, Emma L., Barton, Nicholas H., Butlin, Roger, Charlesworth, Brian, Faria, Rui, Fragata, Ines, Gilbert, Kimberly J., Jay, Paul, Kapun, Martin, Lotterhos, Katie E., Merot, Claire, Mitchell, Esra Durmaz, Pascual, Marta, Peichel, Catherine L., Rafajlovic, Marina, Westram, Anja M., Schaeffer, Stephen W., Johannesson, Kerstin, Flatt, Thomas, Journal of Evolutionary Biology (2023) | Journal article
Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans
Santos, Josiane, Matos, Margarida, Flatt, Thomas, Chelo, Ivo M., Ecology and Evolution (2023) | Journal article
Germline proliferation trades off with lipid metabolism in Drosophila
Rodrigues, Marisa A., Dauphin-Villemant, Chantal, Paris, Margot, Kapun, Martin, Mitchell, Esra Durmaz, Kerdaffrec, Envel, Flatt, Thomas, Evolution Letters (2023) | Journal article
A Single Nucleotide Variant in the PPAR gamma-homolog Eip75B Affects Fecundity in Drosophila
Hoedjes, Katja M., Kostic, Hristina, Flatt, Thomas, Keller, Laurent, Molecular Biology and Evolution (2023) | Journal article
Genomic architecture of supergenes: connecting form and function
Berdan, Emma L., Flatt, Thomas, Kozak, Genevieve M., Lotterhos, Katie E., Wielstra, Ben, Philosophical Transactions of the Royal Society B: Biological Sciences (2022) | Journal article
The Biology of Aging in Insects: From Drosophila to Other Insects and Back
Promislow, Daniel E. L., Flatt, Thomas, Bonduriansky, Russell, Annual Review of Entomology (2022) | Journal article
Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals
Berdan, Emma L., Blanckaert, Alexandre, Butlin, Roger K., Flatt, Thomas, Slotte, Tanja, Wielstra, Ben, Philosophical Transactions of the Royal Society B: Biological Sciences (2022) | Journal article
Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity
Hoedjes, K. M., Kostic, H., Keller, L., Flatt, T., BioRxiv (2022) | Journal article
The rapid tempo of adaptation Selection in fruit flies leads to fast adaption to seasonal changes
Hoffmann, Ary H., Flatt, Thomas, Science (2022) | Journal article
Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans
Santos, J., Matos, M., Flatt, T., Chelo, I. M., BioRxiv (2022) | Journal article
Drosophila Evolution over Space and Time (DEST): a New Population Genomics Resource (vol 38, msab259, 2021)
Kapun, Martin, Nunez, Joaquin C. B., Bogaerts-Marquez, Maria, Murga-Moreno, Jesus, Paris, Margot, Outten, Joseph, Coronado-Zamora, Marta, Tern, Courtney, Rota-Stabelli, Omar, Guerreiro, Maria P. Garcia, Casillas, Sonia, Orengo, Dorcas J., Puerma, Eva, Kankare, Maaria, Ometto, Lino, Loeschcke, Volker, Onder, Banu S., Abbott, Jessica K., Schaeffer, Stephen W., Rajpurohit, Subhash, Behrman, Emily L., Schou, Mads F., Merritt, Thomas J. S., Lazzaro, Brian P., Glaser-Schmitt, Amanda, Argyridou, Eliza, Staubach, Fabian, Wang, Yun, Tauber, Eran, Serga, Svitlana V., Fabian, Daniel K., Dyer, Kelly A., Wheat, Christopher W., Parsch, John, Grath, Sonja, Veselinovic, Marija Savic, Stamenkovic-Radak, Marina, Jelic, Mihailo, Buendia-Ruiz, Antonio J., Gomez-Julian, Maria Josefa, Espinosa-Jimenez, Maria Luisa, Gallardo-Jimenez, Francisco D., Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horvath, Vivien, Obbard, Darren J., Pasyukova, Elena, Alatortsev, Vladimir E., Vieira, Cristina P., Vieira, Jorge, Torres, Jorge Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M., Montchamp-Moreau, Catherine, Mukha, Dmitry V., Machado, Heather E., Lamb, Keric, Paulo, Tania, Yusuf, Leeban, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O., Molecular Biology and Evolution (2022) | Journal article
Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity
Hoedjes, Katja M., Kostic, Hristina, Keller, Laurent, Flatt, Thomas, Proceedings of the Royal Society B: Biological Sciences (2022) | Journal article
Supergene degeneration opposes polymorphism: The curious case of balanced lethals
Emma Berdan and Alexandre Blanckaert and Roger K Butlin and Thomas Flatt and Tanja Slotte and Ben Wielstra
, Cold Spring Harbor Laboratory
(2021) | Other
Gene co-expression network reveals highly conserved, well-regulated anti-ageing mechanisms in old ant queens
Mark C Harrison and Luisa M Jaimes Niño and Marisa Almeida Rodrigues and Judith Ryll and Thomas Flatt and Jan Oettler and Erich Bornberg-Bauer, Genome Biology and Evolution (2021) | Journal article
Comparative transcriptomic analysis of the mechanisms underpinning ageing and fecundity in social insects
Judith Korb and Karen Meusemann and Denise Aumer and Abel Bernadou and Daniel Elsner and Barbara Feldmeyer and Susanne Foitzik and Jürgen Heinze and Romain Libbrecht and Silu Lin and Megha Majoe and José Manuel Monroy Kuhn and Volker Nehring and Matteo A. Negroni and Robert J. Paxton and Alice C. Séguret and Marah Stoldt and Thomas Flatt and, Philosophical Transactions of the Royal Society B: Biological Sciences (2021) | Journal article
The discovery, distribution and diversity of DNA viruses associated with Drosophila melanogaster in Europe
Megan A Wallace and Kelsey A Coffman and Clément Gilbert and Sanjana Ravindran and Gregory F Albery and Jessica Abbott and Eliza Argyridou and Paola Bellosta and Andrea J Betancourt and Hervé Colinet and Katarina Eric and Amanda Glaser-Schmitt and Sonja Grath and Mihailo Jelic and Maaria Kankare and Iryna Kozeretska and Volker Loeschcke and Catherine Montchamp-Moreau and Lino Ometto and Banu Sebnem Onder and Dorcas J Orengo and John Parsch and Marta Pascual and Aleksandra Patenkovic and Eva Puerma and Michael G Ritchie and Omar Rota-Stabelli and Mads Fristrup Schou and Svitlana V Serga and Marina Stamenkovic-Radak and Marija Tanaskovic and Marija Savic Veselinovic and Jorge Vieira and Cristina P Vieira and Martin Kapun and Thomas Flatt and Josefa González and Fabian Staubach and Darren J Obbard, Virus Evolution (2021) | Journal article
Note: Updating the metadata of four misidentified samples in the DrosRTEC dataset
Joaquin C. B. Nunez, Margot Paris, Heather Machado, Maria Bogaerts, Josefa Gonzalez, Thomas Flatt, Marta Coronado, Martin Kapun, Paul Schmidt, Dmitri Petrov, Alan Bergland, (2021) | Preprint
Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila
Machado, Heather E., Bergland, Alan O., Taylor, Ryan, Tilk, Susanne, Behrman, Emily, Dyer, Kelly, Fabian, Daniel K., Flatt, Thomas, Gonzalez, Josefa, Karasov, Talia L., Kim, Bernard, Kozeretska, Iryna, Lazzaro, Brian P., Merritt, Thomas J. S., Pool, John E., O'Brien, Katherine, Rajpurohit, Subhash, Roy, Paula R., Schaeffer, Stephen W., Serga, Svitlana, Schmidt, Paul, Petrov, Dmitri A., eLife (2021) | Journal article
A single nucleotide variant in the PPARgamma-homolog Eip75B affects fecundity in Drosophila
Hoedjes, K. M., Kostic, H., Flatt, T., Keller, L., BioRxiv (2021) | Journal article
Gene co-expression network reveals highly conserved, well-regulated anti-ageing mechanisms in old ant queens
Harrison, M. C., Jaimes Nino, L. M., Almeida Rodrigues, M., Ryll, J., Flatt, T., Oettler, J., Bornberg-Bauer, E., BioRxiv (2021) | Journal article
On the fixation or nonfixation of inversions under epistatic selection
Charlesworth, Brian, Flatt, Thomas, Molecular Ecology (2021) | Journal article
Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster
Betancourt, Nicolas J., Rajpurohit, Subhash, Durmaz, Esra, Fabian, Daniel K., Kapun, Martin, Flatt, Thomas, Schmidt, Paul, Molecular Ecology (2021) | Journal article
Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource
Kapun, Martin, Nunez, Joaquin C. B., Bogaerts-Marquez, Maria, Murga-Moreno, Jesus, Paris, Margot, Outten, Joseph, Coronado-Zamora, Marta, Tern, Courtney, Rota-Stabelli, Omar, Guerreiro, Maria P. Garcia, Casillas, Sonia, Orengo, Dorcas J., Puerma, Eva, Kankare, Maaria, Ometto, Lino, Loeschcke, Volker, Onder, Banu S., Abbott, Jessica K., Schaeffer, Stephen W., Rajpurohit, Subhash, Behrman, Emily L., Schou, Mads F., Merritt, Thomas J. S., Lazzaro, Brian P., Glaser-Schmitt, Amanda, Argyridou, Eliza, Staubach, Fabian, Wang, Yun, Tauber, Eran, Serga, Svitlana, V, Fabian, Daniel K., Dyer, Kelly A., Wheat, Christopher W., Parsch, John, Grath, Sonja, Veselinovic, Marija Savic, Stamenkovic-Radak, Marina, Jelic, Mihailo, Buendia-Ruiz, Antonio J., Gomez-Julian, Maria Josefa, Espinosa-Jimenez, Maria Luisa, Gallardo-Jimenez, Francisco D., Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horvath, Vivien, Obbard, Darren J., Pasyukova, Elena, Alatortsev, Vladimir E., Vieira, Cristina P., Vieira, Jorge, Torres, Jorge Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M., Montchamp-Moreau, Catherine, Mukha, Dmitry, V, Machado, Heather E., Lamb, Keric, Paulo, Tania, Yusuf, Leeban, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O., Molecular Biology and Evolution (2021) | Journal article
Asymmetry, division of labour and the evolution of ageing in multicellular organisms
Pen, Ido, Flatt, Thomas, Philosophical Transactions of the Royal Society B: Biological Sciences (2021) | Journal article
Transcriptomic evidence for a trade-off between germline proliferation and immunity in Drosophila
Rodrigues, Marisa A., Merckelbach, Antoine, Durmaz, Esra, Kerdaffrec, Envel, Flatt, Thomas, Evolution Letters (2021) | Journal article
Drosophila Evolution over Space and Time (DEST)- A New Population Genomics Resource
Kapun, M., Nunez, J. C. B., Bogaerts-Marquez, M., Murga-Moreno, J., Paris, M., Outten, J., Coronado-Zamora, M., Tern, C., Rota-Stabelli, O., Guerreiro, M. P. Garcia, Casillas, S., Orengo, D. J., Puerma, E., Kankare, M., Ometto, L., Loeschcke, V. V., Onder, B. S., Abbott, J. K., Schaeffer, S. W., Rajpurohit, S., Behrman, E. L., Schou, M. F., Merritt, T. J. S., Lazzaro, B. P. B., Glaser-Schmitt, A., Argyridou, E., Staubach, F., Wang, Y., Tauber, E., Serga, S. V., Fabian, D. K., Dyer, K. A., Wheat, C. W., Parsch, J., Grath, S., Veselinovic, M.Savic, Stamenkovic-Radak, M., Jelic, M., Buendia-Ruiz, Antonio J., Gomez-Julian, M. Josefa, Espinosa-Jimenez, M. Luisa, Gallardo-Jimenez, Francisco D, Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horvath, Vivien, Obbard, Darren J, Pasyukova, Elena, Alatortsev, Vladimir E, Vieira, Cristina P., Vieira, Jorge, Torres, J. Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M, Montchamp-Moreau, Catherine, Mukha, Dmitry V., Machado, Heather E, Paulo, Tania F, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O., BioRxiv (2021) | Journal article
Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs
Ariane Ramaekers and Annelies Claeys and Martin Kapun and Emmanuèle Mouchel-Vielh and Delphine Potier and Simon Weinberger and Nicola Grillenzoni and Delphine Dardalhon-Cuménal and Jiekun Yan and Reinhard Wolf and Thomas Flatt and Erich Buchner and Bassem A. Hassan, Developmental Cell (2019) | Journal article
The diversity of population responses to environmental change
Fernando Colchero and Owen R. Jones and Dalia A. Conde and David Hodgson and Felix Zajitschek and Benedikt R. Schmidt and Aurelio F. Malo and Susan C. Alberts and Peter H. Becker and Sandra Bouwhuis and Anne M. Bronikowski and Kristel M. Vleeschouwer and Richard J. Delahay and Stefan Dummermuth and Eduardo Fernández-Duque and John Frisenvænge and Martin Hesselsøe and Sam Larson and Jean-Francois Lematre and Jennifer McDonald and David A.W. Miller and Colin ODonnell and Craig Packer and Becky E. Raboy and Chris J. Reading and Erik Wapstra and Henri Weimerskirch and Geoffrey M. While and Annette Baudisch and Thomas Flatt and Tim Coulson and Jean-Michel Gaillard, Ecology Letters (2019) | Journal article
A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila
Durmaz, E., Rajpurohit, S., Betancourt, N., Fabian, D. K., Kapun, M., Schmidt, P., Flatt, T., BioRxiv (2019) | Journal article
How flies turn food into progeny Sex-optimal diets have different effects on gene expression in female and male flies
Flatt, Thomas, eLife (2019) | Journal article
Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly
May, Christina M., van den Heuvel, Joost, Doroszuk, Agnieszka, Hoedjes, Katja M., Flatt, Thomas, Zwaan, Bas J., Journal of Evolutionary Biology (2019) | Journal article
The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster
Kapun, Martin, Flatt, Thomas, Molecular Ecology (2019) | Journal article
A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila*
Durmaz, Esra, Rajpurohit, Subhash, Betancourt, Nicolas, Fabian, Daniel K., Kapun, Martin, Schmidt, Paul, Flatt, Thomas, Evolution (2019) | Journal article
Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila
Hoedjes, Katja M., van den Heuvel, Joost, Kapun, Martin, Keller, Laurent, Flatt, Thomas, Zwaan, Bas J., Evolution Letters (2019) | Journal article
Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila
Heather Machado and Alan O. Bergland and Ryan Taylor and Susanne Tilk and Emily Behrman and Kelly Dyer and Daniel Fabian and Thomas Flatt and Josefa Gonzalez and Talia Karasov and Iryna Kozeretska and Brian P. Lazzaro and Thomas Merritt and John Pool and Katherine OBrien and Subhash Rajpurohit and Paula Roy and Stephen Schaeffer and Svitlana Serga and Paul Schmidt and Dmitri Petrov
, Cold Spring Harbor Laboratory
(2018) | Other
The interplay between immunity and aging in Drosophila [version 1; referees: 2 approved]
Kathrin Garschall, Thomas Flatt, (2018) | Journal article
Faculty of 1000 evaluation for Early-life inflammation, immune response and ageing.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Antimicrobial peptides extend lifespan in Drosophila.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Juvenile Hormone Suppresses Resistance to Infection in Mated Female Drosophila melanogaster.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Cellular immune defenses of Drosophila melanogaster.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Stochastic variation in the initial phase of bacterial infection predicts the probability of survival in D. melanogaster.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster.
Thomas Flatt, (2018) | Data set
Faculty of 1000 evaluation for Mitochondrial peroxiredoxins are essential in regulating the relationship between Drosophila immunity and aging.
Thomas Flatt, (2018) | Data set
Evolution of longevity improves immunity in Drosophila
Fabian, Daniel K., Garschall, Kathrin, Klepsatel, Peter, Santos-Matos, Goncalo, Sucena, Elio, Kapun, Martin, Lemaitre, Bruno, Schloetterer, Christian, Arking, Robert, Flatt, Thomas, Evolution Letters (2018) | Journal article
Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly
May, T., van den Heuvel, J., Doroszuk, A., Hoedjes, K., Flatt, T., Zwaan, B., BioRxiv (2018) | Journal article
Genomic analysis of European Drosophila melanogaster populations on a dense spatial scale reveals longitudinal population structure and continent-wide selection
Kapun, M., Barron Aduriz, M. G., Staubach, F., Vieira, J., Obbard, D., Goubert, C., Rota Stabelli, O., Kankare, M., Haudry, A., Wiberg, R. A. W., Waidele, L., Kozeretska, I., Pasyukova, E., Loeschcke, V., Pascual, M., Vieira, C. P., Serga, S., Montchamp-Moreau, C., Abbott, J., Gibert, P., Porcelli, D., Posnien, N., Grath, S., Sucena, E., Bergland, A., Garcia Guerreiro, M. P., Onder, B. S., Argyridou, E., Guio, L., Schou, M. F., Deplancke, B., Vieira, C., Ritchie, M. G., Zwaan, B., Tauber, E., Orengo, D., Puerma, E., Aguade, M., Schmidt, P., Parsch, J., Betancourt, A., Flatt, T., Gonzalez, J., BioRxiv (2018) | Journal article
Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster
Betancourt, N., Rajpurohit, S., Durmaz, E., Fabian, D., Kapun, M., Flatt, T., Schmidt, P., BioRxiv (2018) | Journal article
An inversion supergene in Drosophila underpins latitudinal clines in survival traits
Durmaz, Esra, Benson, Clare, Kapun, Martin, Schmidt, Paul, Flatt, Thomas, Journal of Evolutionary Biology (2018) | Journal article
Horizons in the evolution of aging
Flatt, Thomas, Partridge, Linda, BMC Biology (2018) | Journal article
Aminergic Signaling Controls Ovarian Dormancy in Drosophila
Andreatta, Gabriele, Kyriacou, Charalambos P., Flatt, Thomas, Costa, Rodolfo, Scientific Reports (2018) | Journal article
Amino acid modulation of lifespan and reproduction in Drosophila
Hoedjes, Katja M., Rodrigues, Marisa A., Flatt, Thomas, Current Opinion in Insect Science (2017) | Journal article
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span (vol 3, 5, 2017)
Garschall, Kathrin, Dellago, Hanna, Glikov, Martina, Schosserer, Markus, Flatt, Thomas, Grillari, Johannes, Npj Aging and Mechanisms of Disease (2017) | Journal article
Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
Garschall, Kathrin, Dellago, Hanna, Galikov, Martina, Schosserer, Markus, Flatt, Thomas, Grillari, Johannes, Npj Aging and Mechanisms of Disease (2017) | Journal article
Adaptation to fluctuating environments in a selection experiment with Drosophila melanogaster
Kubrak, Olga I., Nylin, Soren, Flatt, Thomas, Nassel, Dick R., Leimar, Olof, Ecology and Evolution (2017) | Journal article
Faculty of 1000 evaluation for Can aging be programmed? A critical literature review.
Thomas Flatt, (2016) | Data set
Genomics of clinal variation in Drosophila: disentangling the interactions of selection and demography
Flatt, Thomas, Molecular Ecology (2016) | Journal article
BMC Zoology - a home for all zoological research in the BMC series
Kruger, Dirk, Packer, Laurence, Flatt, Thomas, Hoi, Herbert, Morand, Serge, Lieb, Bernhard, Malabarba, Luiz R., Fenton, M. Brock, BMC Zoology (2016) | Journal article
Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing
Fuellen, Georg, Schofield, Paul, Flatt, Thomas, Schulz, Ralf-Joachim, Boege, Fritz, Kraft, Karin, Rimbach, Gerald, Ibrahim, Saleh, Tietz, Alexander, Schmidt, Christian, Koehling, Ruediger, Simm, Andreas, Gerontology (2016) | Journal article
Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects
Rodrigues, Marisa A., Flatt, Thomas, Current Opinion in Insect Science (2016) | Journal article
Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster
Kapun, M., Schmidt, C., Durmaz, E., Schmidt, P. S., Flatt, T., Journal of Evolutionary Biology (2016) | Journal article
Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster
Kapun, Martin, Fabian, Daniel K., Goudet, Jerome, Flatt, Thomas, Molecular Biology and Evolution (2016) | Journal article
Faculty of 1000 evaluation for Early-late life trade-offs and the evolution of ageing in the wild.
Thomas Flatt, (2015) | Data set
Faculty of 1000 evaluation for Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.
Thomas Flatt, (2015) | Data set
Faculty of 1000 evaluation for Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.
Thomas Flatt, (2015) | Data set
Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa
Fabian, D. K., Lack, J. B., Mathur, V., Schloetterer, C., Schmidt, P. S., Pool, J. E., Flatt, T., Journal of Evolutionary Biology (2015) | Journal article
Overexpression of the DNA repair factor SNEVhPrp19/hPso4 extends cellular and organismal life span and increases resistance to genotoxic stress
Dellago, Hanna, Khan, Abdulhameed, Schosserer, Markus, Flatt, Thomas, Ammerer, Gustav, Jansen-Duerr, Pidder, Rudolph, Karl Lenhard, Grillari-Voglauer, Regina, Grillari, Johannes, Experimental Gerontology (2015) | Journal article
Paying the costs of reproduction When a female fly mates it produces a hormone that increases the size of its midgut and enhances fat metabolism in order to provide the energy needed for reproduction
Flatt, Thomas, eLife (2015) | Journal article
Faculty of 1000 evaluation for G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.
Thomas Flatt, (2014) | Data set
Faculty of 1000 evaluation for A quantitative genetic signature of senescence in a short-lived perennial plant.
Thomas Flatt, (2014) | Data set
Faculty of 1000 evaluation for Drosophila life span and physiology are modulated by sexual perception and reward.
Thomas Flatt, (2014) | Data set
Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster
Kapun, Martin, Van Schalkwyk, Hester, Mcallister, Bryant, Flatt, Thomas, Schloetterer, Christian, Molecular Ecology (2014) | Journal article
Reproduction, Fat Metabolism, and Life Span: What Is the Connection? (vol 17, pg 10, 2013)
Hansen, Malene, Flatt, Thomas, Aguilaniu, Hugo, Cell Metabolism (2014) | Journal article
SIMILARITIES AND DIFFERENCES IN ALTITUDINAL VERSUS LATITUDINAL VARIATION FOR MORPHOLOGICAL TRAITS IN DROSOPHILA MELANOGASTER
Klepsatel, Peter, Galikova, Martina, Huber, Christian D., Flatt, Thomas, Evolution (2014) | Journal article
Plasticity of lifespan: a reaction norm perspective
Flatt, Thomas, Proceedings of the Nutrition Society (2014) | Journal article
Faculty of 1000 evaluation for Heritability of life span is largely sex limited in Drosophila.
Thomas Flatt, (2013) | Data set
Faculty of 1000 evaluation for The size-life span trade-off decomposed: why large dogs die young.
Thomas Flatt, (2013) | Data set
Faculty of 1000 evaluation for Genomic response to selection for postponed senescence in Drosophila.
Thomas Flatt, (2013) | Data set
Faculty of 1000 evaluation for Longer life span evolves under high rates of condition-dependent mortality.
Thomas Flatt, (2013) | Data set
The role of the nervous system in aging and longevity.
Frontiers in genetics (2013) | Journal article
Neuronal inputs and outputs of aging and longevity.
Frontiers in genetics (2013) | Journal article
Neuronal Inputs and Outputs of Aging and Longevity
Joy Alcedo, Thomas Flatt, Elena G. Pasyukova, ed. by Joy Alcedo and Thomas Flatt and Elena G. Pasyukova (Frontiers Media SA, 2013), ISBN: 9782889191604
| Book
Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster under laboratory conditions
Klepsatel, P., Galikova, M., De Maio, N., Ricci, S., Schloetterer, C., Flatt, T., Journal of Evolutionary Biology (2013) | Journal article
Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster
Kapun, Martin, Schalkwyk, Hester van, McAllister, Bryant, Flatt, Thomas, Schlötterer, Christian, ArXiv (2013) | Journal article
Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity
Rus, Florentina, Flatt, Thomas, Tong, Mei, Aggarwal, Kamna, Okuda, Kendi, Kleino, Anni, Yates, Elisabeth, Tatar, Marc, Silverman, Neal, The EMBO Journal (2013) | Journal article
VARIATION IN THERMAL PERFORMANCE AND REACTION NORMS AMONG POPULATIONS OF DROSOPHILA MELANOGASTER
Klepsatel, Peter, Galikova, Martina, De Maio, Nicola, Huber, Christian D., Schloetterer, Christian, Flatt, Thomas, Evolution (2013) | Journal article
LIFE-HISTORY EVOLUTION AND THE POLYPHENIC REGULATION OF SOMATIC MAINTENANCE AND SURVIVAL
Flatt, Thomas, Amdam, Gro V., Kirkwood, Thomas B. L., Omholt, Stig W., The Quarterly Review of Biology (2013) | Journal article
Reproduction, Fat Metabolism, and Life Span: What Is the Connection?
Hansen, Malene, Flatt, Thomas, Aguilaniu, Hugo, Cell Metabolism (2013) | Journal article
Faculty of 1000 evaluation for Genomic basis of aging and life-history evolution in Drosophila melanogaster.
Thomas Flatt, (2012) | Data set
Faculty of 1000 evaluation for A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
Thomas Flatt, (2012) | Data set
Faculty of 1000 evaluation for Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.
Thomas Flatt, (2012) | Data set
Faculty of 1000 evaluation for New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals.
Thomas Flatt, (2012) | Data set
A new definition of aging?
Frontiers in genetics (2012) | Journal article
What is Aging?
Frontiers in genetics (2012) | Journal article
Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles
Orozco-terWengel, Pablo, Kapun, Martin, Nolte, Viola, Kofler, Robert, Flatt, Thomas, Schloetterer, Christian, Molecular Ecology (2012) | Journal article
Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America
Fabian, Daniel K., Kapun, Martin, Nolte, Viola, Kofler, Robert, Schmidt, Paul S., Schloetterer, Christian, Flatt, Thomas, Molecular Ecology (2012) | Journal article
Faculty of 1000 evaluation for A metabolic signature of long life in Caenorhabditis elegans.
Thomas Flatt, (2011) | Data set
Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs
Thomas Flatt, Andreas Heyland, ed. by Thomas Flatt and Andreas Heyland (Oxford University Press, 2011), ISBN: 9780199568765
| Book
Integrating mechanistic and evolutionary analysis of life history variation
Braendle, Christian, Heyland, Andreas, Flatt, Thomas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Life history plasticity
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Reproduction
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Life history integration and trade-offs
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Lifespan, aging, and somatic maintenance
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Steroid hormone regulation of C. elegans and Drosophila aging and life history
Galikova, Martina, Klepsatel, Peter, Senti, Gabriele, Flatt, Thomas, Experimental Gerontology (2011) | Journal article
The genomic and physiological basis of life history variation in a butterfly metapopulation
Klepsatel, Peter, Flatt, Thomas, Molecular Ecology (2011) | Journal article
Growth, development, and maturation
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Integrating mechanisms into life history evolution
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
What mechanistic insights can or cannot contribute to life history evolution: An exchange between Stearns, Heyland, and Flatt
Flatt, Thomas, Heyland, Andreas, Stearns, Stephen C., Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Mechanisms of Life History Evolution The Genetics and Physiology of Life History Traits and Trade-Offs Preface
Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Journal article
Survival costs of reproduction in Drosophila
Flatt, Thomas, Experimental Gerontology (2011) | Journal article
Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.
Aging (2010) | Journal article
Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout
Galikova, Martina, Flatt, Thomas, Aging (2010) | Journal article
Host Range and Specificity of the Drosophila C Virus
Kapun, Martin, Nolte, Viola, Flatt, Thomas, Schloetterer, Christian, Plos One (2010) | Journal article
Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes
Vogl, Claus, Flatt, Thomas, Fuhrmann, Bernd, Hofmann, Elisabeth, Wallner, Barbara, Stiefvater, Rita, Kovarik, Pavel, Strobl, Birgit, Mueller, Mathias, BMC Genomics (2010) | Journal article
dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.
Aging (2009) | Journal article
dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster
Bauer, Johannes H., Morris, Siti Nur Sarah, Chang, Chengyi, Flatt, Thomas, Wood, Jason G., Helfand, Stephen L., Aging (2009) | Journal article
Integrating evolutionary and molecular genetics of aging
Flatt, Thomas, Schmidt, Paul S., Biochimica et Biophysica Acta (BBA) - General Subjects (2009) | Journal article
AGEING Diet and longevity in the balance
Flatt, Thomas, Nature (2009) | Journal article
Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
Flatt, Thomas, Heyland, Andreas, Rus, Florentina, Porpiglia, Ermelinda, Sherlock, Chris, Yamamoto, Rochele, Garbuzov, Alina, Palli, Subba R., Tatar, Marc, Silverman, Neal, Journal of Experimental Biology (2008) | Journal article
Drosophila, germ-line modulation of insulin signaling and lifespan
Flatt, Thomas, Min, Kyung-Jin, D'Alterio, Cecilia, Villa-Cuesta, Eugenia, Cumbers, John, Lehmann, Ruth, Jones, D. Leanne, Tatar, Marc, Proceedings of the National Academy of Sciences (2008) | Journal article
Hormonal modulation of larval begging and growth in the burying beetle Nicrophorus vespilloides
Crook, Tara C., Flatt, Thomas, Smiseth, Per T., Animal Behaviour (2008) | Journal article
Counting calories in Drosophila diet restriction
Min, Kyung-Jin, Flatt, Thomas, Kulaots, Indrek, Tatar, Marc, Experimental Gerontology (2007) | Journal article
Still pondering an age-old question
Flatt, Thomas, Promislow, Daniel E. L., Science (2007) | Journal article
Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster
Flatt, Thomas, Kawecki, Tadeusz J., Evolution (2007) | Journal article
Size and shape: the developmental regulation of static allometry in insects
Shingleton, Alexander W., Frankino, W. Anthony, Flatt, Thomas, Nijhout, H. Frederik, Emlen, Douglas. J., BioEssays (2007) | Journal article
Comparing thyroid and insect hormone signaling
Flatt, Thomas, Moroz, Leonid L., Tatar, Marc, Heyland, Andreas, Integrative and Comparative Biology (2006) | Journal article
Evolution in group-structured populations can resolve the tragedy of the commons
Killingback, Timothy, Bieri, Jonas, Flatt, Thomas, Proceedings of the Royal Society B: Biological Sciences (2006) | Journal article
A role for genetic accommodation in evolution?
Braendle, Christian, Flatt, Thomas, BioEssays (2006) | Journal article
What is metamorphosis?
Bishop, C. D., Erezyilmaz, D. F., Flatt, T., Georgiou, C. D., Hadfield, M. G., Heyland, A., Hodin, J., Jacobs, M. W., Maslakova, S. A., Pires, A., Reitzel, A. M., Santagata, S., Tanaka, K., Youson, J. H., Integrative and Comparative Biology (2006) | Journal article
Life history pleicitropy mediated by Methoprene-tolerant, a putative juvenile hormone receptor
Flatt, T, Journal of Experimental Zoology. Part A, Comparative Experimental Biology (2006) | Journal article
Winter weather affects asp viper Vipera aspis population dynamics through susceptible juveniles
Res Altwegg and Stefan Dummermuth and Bradley R. Anholt and Thomas Flatt, Oikos (2005) | Journal article
Juvenile and Steroid Hormones in Drosophila melanogaster Longevity
Meng-Ping Tu and Thomas Flatt and Marc Tatar
, Elsevier
(2005) | Other
Winter weather affects asp viper Vipera aspis population dynamics through susceptible juveniles
Altwegg, R, Dummermuth, S, Anholt, BR, Flatt, T, Oikos (2005) | Journal article
The evolutionary genetics of canalization
Flatt, T, The Quarterly Review of Biology (2005) | Journal article
Juvenile hormone as an effector of metamorphosis and life history transitions
Flatt, T, Integrative and Comparative Biology (2005) | Journal article
Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
Flatt, T, Tu, MP, Tatar, M, BioEssays (2005) | Journal article
Pleiotropic effects of methoprene-tolerant (Met), a gene involved in juvenile hormone metabolism, on life history traits in Drosophila melanogaster
Flatt, T, Kawecki, TJ, Genetica (2004) | Journal article
Assessing natural variation in genes affecting Drosophila lifespan
Flatt, T, Mechanisms of Ageing and Development (2004) | Journal article
Stabilizing factors interact in promoting host-parasite coexistence
Flatt, T, Scheuring, I, Journal of Theoretical Biology (2004) | Journal article
The influence of ant-attendance on aphid behaviour investigated with the electrical penetration graph technique.
Entomologia experimentalis et applicata (2002) | Journal article
The influence of ant-attendance on aphid behaviour investigated with the electrical penetration graph technique
Rauch, G, Simon, JC, Chaubet, B, Haack, L, Flatt, T, Weisser, WW, Entomologia Experimentalis et Applicata (2002) | Journal article
Phenotypic variation in an oviparous montane lizard (Bassiana duperreyi): the effects of thermal and hydric incubation environments
Flatt, T, Shine, R, Borges-Landaez, PA, Downes, SJ, Biological Journal of the Linnean Society (2001) | Journal article
A bit of sex stabilizes host-parasite dynamics
Flatt, T, Maire, N, Doebeli, M, Journal of Theoretical Biology (2001) | Journal article