Research and publications

• Original publications
  24 publications

  2024 2023 2022 2020 2019 2018 2017 2013 2012 2011 2009 2007 2006 2005 2004

  Glucose and Oxygen Levels Modulate the Pore-Forming Effects of Cholesterol-Dependent Cytolysin Pneumolysin from Streptococcus pneumoniae
  Michelle Salomé Hoffet, Nikola S. Tomov, Sabrina Hupp, Timothy J. Mitchell, Asparouh I. Iliev, Toxins (2024) | Journal article

  Dendritic spine loss deep in the neocortex and dendrite distortion with diffusion disturbances occur early in experimental pneumococcal meningitis
  Baronti, D. and Tomov, N. and Hupp, S. and Mitchell, T.J. and Iliev, A.I., Frontiers in Neuroscience (2023) | Journal article

  Meningitis-associated pneumococcal serotype 8, ST 53, strain is hypervirulent in a rat model and has non-haemolytic pneumolysin which can be attenuated by liposomes
  Müller, A. and Lekhuleni, C. and Hupp, S. and du Plessis, M. and Holivololona, L. and Babiychuk, E. and Leib, S.L. and Grandgirard, D. and Iliev, A.I. and von Gottberg, A. and Hathaway, L.J., Frontiers in Cellular and Infection Microbiology (2023) | Journal article

  Easy to build cost-effective acute brain slice incubation system for parallel analysis of multiple treatment conditions
  Hupp, S. and Tomov, N.S. and Bischoff, C. and Baronti, D. and Iliev, A.I., Journal of Neuroscience Methods (2022) | Journal article

  Pneumolysin boosts the neuroinflammatory response to Streptococcus pneumoniae through enhanced endocytosis
  Hupp, S. and Förtsch, C. and Graber, F. and Mitchell, T.J. and Iliev, A.I., Nature Communications (2022) | Journal article

  CSF-1 receptor inhibition as a highly effective tool for depletion of microglia in mixed glial cultures
  Hupp, S. and Iliev, A.I., Journal of Neuroscience Methods (2020) | Journal article

  Pneumolysin and the bacterial capsule of Streptococcus pneumoniae cooperatively inhibit taxis and motility of microglia
  Hupp, S. and Grandgirard, D. and Mitchell, T.J. and Leib, S.L. and Hathaway, L.J. and Iliev, A.I., Journal of Neuroinflammation (2019) | Journal article

  The inflammatory response and neuronal injury in Streptococcus suis meningitis
  Seele, J. and Tauber, S.C. and Bunkowski, S. and Baums, C.G. and Valentin-Weigand, P. and de Buhr, N. and Beineke, A. and Iliev, A.I. and Brück, W. and Nau, R., BMC Infectious Diseases (2018) | Journal article

  Missing elimination via membrane vesicle shedding contributes to the diminished calcium sensitivity of listeriolysin O
  Maurer, J. and Hupp, S. and Pillich, H. and Mitchell, T.J. and Chakraborty, T. and Iliev, A.I., Scientific Reports (2018) | Journal article

  Distinct neurotoxicity profile of listeriolysin O from listeria monocytogenes
  Maurer, J. and Hupp, S. and Bischoff, C. and Foertsch, C. and Mitchell, T.J. and Chakraborty, T. and Iliev, A.I., Toxins (2017) | Journal article

  Magnesium therapy improves outcome in Streptococcus pneumoniae meningitis by altering pneumolysin pore formation
  Hupp, S. and Ribes, S. and Seele, J. and Bischoff, C. and Förtsch, C. and Maier, E. and Benz, R. and Mitchell, T.J. and Nau, R. and Iliev, A.I., British Journal of Pharmacology (2017) | Journal article

  Direct transmembrane interaction between actin and the pore-competent, cholesterol-dependent cytolysin pneumolysin
  Hupp, S. and Förtsch, C. and Wippel, C. and Ma, J. and Mitchell, T.J. and Iliev, A.I., Journal of Molecular Biology (2013) | Journal article

  Bacterial Cytolysin during Meningitis Disrupts the Regulation of Glutamate in the Brain, Leading to Synaptic Damage
  Wippel, C. and Maurer, J. and Förtsch, C. and Hupp, S. and Bohl, A. and Ma, J. and Mitchell, T.J. and Bunkowski, S. and Brück, W. and Nau, R. and Iliev, A.I., PLoS Pathogens (2013) | Journal article

  Astrocytic tissue remodeling by the meningitis neurotoxin pneumolysin facilitates pathogen tissue penetration and produces interstitial brain edema
  Hupp, S. and Heimeroth, V. and Wippel, C. and Förtsch, C. and Ma, J. and Mitchell, T.J. and Iliev, A.I., GLIA (2012) | Journal article

  Extracellular calcium reduction strongly increases the lytic capacity of pneumolysin from Streptococcus pneumoniae in brain tissue
  Wippel, C. and Förtsch, C. and Hupp, S. and Maier, E. and Benz, R. and Ma, J. and Mitchell, T.J. and Iliev, A.I., Journal of Infectious Diseases (2011) | Journal article

  Changes in astrocyte shape induced by sublytic concentrations of the cholesterol-dependent cytolysin pneumolysin still require pore-forming capacity
  Förtsch, C. and Hupp, S. and Ma, J. and Mitchell, T.J. and Maier, E. and Benz, R. and Iliev, A.I., Toxins (2011) | Journal article

  Quantitative fluorescence microscopy techniques.
  Esposito, A. and Schlachter, S. and Schierle, G.S. and Elder, A.D. and Diaspro, A. and Wouters, F.S. and Kaminski, C.F. and Iliev, A.I., Methods in molecular biology (Clifton, N.J.) (2009) | Journal article

  Rapid microtubule bundling and stabilization by the Streptococcus pneumoniae neurotoxin pneumolysin in a cholesterol-dependent, non-lytic and Src-kinase dependent manner inhibits intracellular trafficking
  Iliev, A.I. and Djannatian, J.R. and Opazo, F. and Gerber, J. and Nau, R. and Mitchell, T.J. and Wouters, F.S., Molecular Microbiology (2009) | Journal article

  Application of simple photobleaching microscopy techniques for the determination of the balance between anterograde and retrograde axonal transport
  Iliev, A.I. and Wouters, F.S., Journal of Neuroscience Methods (2007) | Journal article

  Cholesterol-dependent actin remodeling via RhoA and Rac1 activation by the Streptococcus pneumoniae toxin pneumolysin
  Iliev, A.I. and Djannatian, J.R. and Nau, R. and Mitchell, T.J. and Wouters, F.S., Proceedings of the National Academy of Sciences of the United States of America (2007) | Journal article

  Removal of pattern-breaking sequences in microtubule binding repeats produces instantaneous tau aggregation and toxicity
  Iliev, A.I. and Ganesan, S. and Bunt, G. and Wouters, F.S., Journal of Biological Chemistry (2006) | Journal article

  Amyloid beta peptide 1-40 enhances the action of Toll-like receptor-2 and -4 agonists but antagonizes Toll-like receptor-9-induced inflammation in primary mouse microglial cell cultures
  Lotz, M. and Ebert, S. and Esselmann, H. and Iliev, A.I. and Prinz, M. and Wiazewicz, N. and Wiltfang, J. and Gerber, J. and Nau, R., Journal of Neurochemistry (2005) | Journal article

  Breakdown of axonal synaptic vesicle precursor transport by microglial nitric oxide
  Stagi, M. and Dittrich, P.S. and Frank, N. and Iliev, A.I. and Schwille, P. and Neumann, H., Journal of Neuroscience (2005) | Journal article

  Neuronal injury mediated via stimulation of microglial toll-like receptor-9 (TLR9).
  Iliev, A.I. and Stringaris, A.K. and Nau, R. and Neumann, H., The FASEB journal : official publication of the Federation of American Societies for Experimental Biology (2004) | Journal article