Research and publications

• Publications
  150 publications

  The developing retina undergoes mitochondrial remodeling via PINK1/PRKN-dependent mitophagy
  Michael Stumpe, Juan Zapata-Munoz, Juan Ignacio Jimenez-Loygorri, Beatriz VILLAREJO ZORI, Patricia Boya, Sandra Alonso-Gil, Petra Teresak, Benan J Mathai, Ian G Ganley, Anne Simonsen, Joern Dengjel, (2025) | Preprint

  Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy
  Autophagy (2025) | Journal article

  Women in Autophagy: an initiative to promote gender parity in science
  Nature Cell Biology (2024) | Journal article

  Recycling the recyclers: lysophagy emerges as a new pharmacological target for retinal degeneration
  Autophagy (2024) | Journal article

  Aging STINGs: mitophagy at the crossroads of neuroinflammation
  Autophagy (2024) | Journal article

  Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy
  Alexandre Leytens, Rocio BENITEZ FERNANDEZ, Carlos JIMENEZ GARCIA, Carole ROUBATY, Michael Stumpe, Patricia BOYA, Joern Dengjel, Patricia Boya, Rocío Benítez-Fernández, Carlos Jiménez-García, Carole Roubaty, Jörn Dengjel, (2024) | Preprint

  Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
  Nature Communications (2024) | Journal article

  Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents
  Journal of Enzyme Inhibition and Medicinal Chemistry (2023) | Journal article

  Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens
  Progress in Retinal and Eye Research (2023) | Journal article

  Carbon Monoxide Stimulates Both Mitophagy And Mitochondrial Biogenesis to Mediate Protection Against Oxidative Stress in Astrocytes
  Molecular Neurobiology (2023) | Journal article

  The mechanism of macroautophagy: The movie
  Autophagy Reports (2022) | Journal article

  BNIP3L/NIX regulates both mitophagy and pexophagy
  The EMBO Journal (2022) | Journal article

  Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations
  International Journal of Molecular Sciences (2022) | Journal article

  Apoptosis-Inducing Factor Deficiency Induces Tissue-Specific Alterations in Autophagy: Insights from a Preclinical Model of Mitochondrial Disease and Exercise Training Effects
  Antioxidants (2022) | Journal article

  Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal
  Autophagy (2022) | Journal article

  Regulation of PRKN-independent mitophagy
  Autophagy (2022) | Journal article

  Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration
  Nature Communications (2022) | Journal article

  Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration
  Autophagy (2022) | Journal article

  Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration
  Ramírez-Pardo, I. and Villarejo-Zori, B. and Jiménez-Loygorri, J.I. and Sierra-Filardi, E. and Alonso-Gil, S. and Mariño, G. and de la Villa, P. and Fitze, P.S. and Fuentes, J.M. and García-Escudero, R. and Gomez-Sintes, R. and Boya, P. , bioRxiv (2022) | Other

  Discovery of mitophagy inhibitors with therapeutic potential in different familiar Amyotrophic Lateral Sclerosis mutations
  Maestro, I. and de la Ballina, L.R. and Porras, G. and Corrochano, S. and de Lago, E. and Simonsen, A. and Boya, P. and Martinez, A. , ResearchSquare (2022) | Other

  p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics
  Scientific Reports (2022) | Journal article

  Autophagy in major human diseases
  The EMBO Journal (2021) | Journal article

  Lipid dismantling of lens organelles for clear vision
  Nature (2021) | Journal article

  Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy
  International Journal of Molecular Sciences (2021) | Journal article

  HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice
  Cell Death and Differentiation (2021) | Journal article

  Autophagy and disease: new insights and challenges ahead
  Molecular Aspects of Medicine (2021) | Journal article

  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
  Autophagy (2021) | Journal article

  Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease
  ACS Chemical Neuroscience (2021) | Journal article

  New insights into the role of autophagy in retinal and eye diseases
  Molecular Aspects of Medicine (2021) | Journal article

  Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health
  Cell Stress (2021) | Journal article

  Microglial phagocytosis dysfunction during stroke is prevented by rapamycin
  Beccari, S. and Sierra-Torre, V. and Valero, J. and García-Zaballa, M. and Carretero-Guillen, A. and Capetillo-Zarate, E. and Domercq, M. and Huguet, P.R. and Ramonet, D. and Osman, A. and Han, W. and Dominguez, C. and Faust, T.E. and Touzani, O. and Boya, P. and Schafer, D. and Mariño, G. and Canet-Soulas, E. and Blomgren, K. and Plaza-Zabala, A. and Sierra, A. , bioRxiv (2021) | Other

  Caty Casas (1967-2020)
  Autophagy (2020) | Journal article

  Age related retinal Ganglion cell susceptibility in context of autophagy deficiency
  Cell Death Discovery (2020) | Journal article

  The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models
  International Journal of Molecular Sciences (2020) | Journal article

  Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases
  Expert Opinion on Therapeutic Targets (2020) | Journal article

  HIF1α or mitophagy: Which drives cardiomyocyte differentiation?
  Cell Stress (2020) | Journal article

  A comparative map of macroautophagy and mitophagy in the vertebrate eye
  Autophagy (2019) | Journal article

  Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells
  The Journal of Immunology (2019) | Journal article

  Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy
  Autophagy (2019) | Journal article

  Lipotoxic Effects of Palmitic Acid on Astrocytes Are Associated with Autophagy Impairment
  Molecular Neurobiology (2019) | Journal article

  Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
  Cell Metabolism (2019) | Journal article

  Erratum: Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity (Cell Metabolism (2019) 30(4) (754–767.e9), (S1550413119303833), (10.1016/j.cmet.2019.07.010))
  Cell Metabolism (2019) | Journal article

  Lysosomal membrane permeabilization and cell death
  Traffic (2018) | Journal article

  BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming
  Autophagy (2018) | Journal article

  Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles
  Open Biology (2018) | Journal article

  Autophagy in stem cells: repair, remodelling and metabolic reprogramming
  Development (2018) | Journal article

  Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  Cell Death and Differentiation (2018) | Journal article

  Lysosomal membrane permeabilization as a cell death mechanism in cancer cells
  Biochemical Society Transactions (2018) | Journal article

  Mitophagy, metabolism, and cell fate
  Molecular & Cellular Oncology (2017) | Journal article

  Molecular definitions of autophagy and related processes
  The EMBO Journal (2017) | Journal article

  Why autophagy is good for retinal ganglion cells?
  Eye (2017) | Journal article

  Autophagy and vision
  Medecine Sciences: M/S (2017) | Journal article

  Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
  Cell Death and Disease (2017) | Journal article

  Programmed mitophagy is essential for the glycolytic switch during cell differentiation
  The EMBO Journal (2017) | Journal article

  Cytofluorometric Assessment of Mitophagic Flux in Mammalian Cells and Tissues
  Methods in Enzymology (2017) | Journal article

  Standard Assays for the Study of Autophagy in the Ex Vivo Retina
  Cells (2017) | Journal article

  The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss
  Experimental Eye Research (2017) | Journal article

  Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease
  Targeting the Lysosome (2016) | Journal article

  Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
  Autophagy (2016) | Journal article

  Lysosomal cell death mechanisms in aging
  Ageing Research Reviews (2016) | Journal article

  Autophagy in the eye: Development, degeneration, and aging
  Progress in Retinal and Eye Research (2016) | Journal article

  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  Autophagy (2016) | Journal article

  Altered Blood Gene Expression of Tumor-Related Genes (PRKCB, BECN1, and CDKN2A) in Alzheimer's Disease
  Molecular Neurobiology (2016) | Journal article

  Visual decline in aged mice is delayed by proinsulin
  Investigative Ophthalmology & Visual Science (2016) | Journal article

  Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids
  Oncotarget (2016) | Journal article

  VASCULAR BIOLOGY I. MITOPHAGY ACTS AS A SAFEGUARD MECHANISM AGAINST HUMAN VASCULAR SMOOTH MUSCLE CELL APOPTOSIS INDUCED BY ATHEROGENIC LIPIDS
  Atherosclerosis (2016) | Journal article

  Autophagy: The system of recycling and cellular defense which have all our cells,Autofagia: El sistema de reciclaje y defensa celular que tienen todas nuestras células
  Anales de la Real Academia Nacional de Farmacia (2016) | Journal article

  Erratum to: Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (Autophagy, 12, 1, 1-222, 10.1080/15548627.2015.1100356
  Autophagy (2016) | Journal article

  Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa
  Investigative Ophthalmology & Visual Science (2015) | Journal article

  New method to assess mitophagy flux by flow cytometry
  Autophagy (2015) | Journal article

  Autophagic flux determination in vivo and ex vivo
  Methods (2015) | Journal article

  Mitophagy in mitosis: More than a myth
  Autophagy (2015) | Journal article

  AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
  Nature Cell Biology (2015) | Journal article

  Autophagy researchers.
  Autophagy (2014) | Journal article

  High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A
  Cell Death and Differentiation (2014) | Journal article

  Reduced autophagy in skin aging and positive regulation by a saponin-rich asparagus extract
  Journal of Investigative Dermatology (2014) | Journal article

  Autophagy in retina and axonal degeneration
  Acta Ophthalmologica (2014) | Journal article

  Balance between autophagic pathways preserves retinal homeostasis
  Aging Cell (2013) | Journal article

  CELL BIOLOGY Recycling in sight
  Nature (2013) | Journal article

  Emerging regulation and functions of autophagy
  Nature Cell Biology (2013) | Journal article

  Emerging regulation and functions of autophagy (vol 15, pg 713, 2013)
  Nature Cell Biology (2013) | Journal article

  Interactions between autophagic and endo-lysosomal markers in endothelial cells
  Histochemistry and Cell Biology (2013) | Journal article

  Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles
  Nanoscale (2013) | Journal article

  Autophagy disregulation in the retina during aging and neurodegeneration
  Investigative Ophthalmology & Visual Science (2013) | Journal article

  Cell biology: Recycling in sight
  Nature (2013) | Journal article

  Emerging regulation and functions of autophagy
  Nature Cell Biology (2013) | Journal article

  Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
  Autophagy (2012) | Journal article

  Autophagy disregulation in the retina: neurodegeneration and aging
  Febs Journal (2012) | Journal article

  Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice
  Cell Death and Differentiation (2012) | Journal article

  Axonal damage, autophagy and neuronal survival
  Autophagy (2012) | Journal article

  Guidelines for the use and interpretation of assays for monitoring autophagy
  Autophagy (2012) | Journal article

  Lysosomal Function and Dysfunction: Mechanism and Disease
  Antioxidants & Redox Signaling (2012) | Journal article

  Micronucleophagy: A new mechanism to protect against chromosomal instability?
  Cell Cycle (2012) | Journal article

  Role of autophagy during the development of the vertebrate nervous system
  Febs Journal (2012) | Journal article

  AUTOPHAGY IN THE RETINA: DEVELOPMENT, PHYSIOLOGY AND PATHOLOGY
  Autophagy of the Nervous System: Cellular Self-digestion in Neurons and Neurological Diseases (2012) | Journal article

  Lysosomal membrane permeabilization in Parkinson disease
  Autophagy (2011) | Journal article

  Impaired autophagy in Lafora disease
  Autophagy (2010) | Journal article

  Intracellular Silicon Chips in Living Cells
  Small (2010) | Journal article

  Laforin, the most common protein mutated in Lafora disease, regulates autophagy
  Human Molecular Genetics (2010) | Journal article

  Pathogenic Lysosomal Depletion in Parkinson's Disease
  Journal of Neuroscience (2010) | Journal article

  Structural Determinants Allowing Endolysosomal Sorting and Degradation of Endosomal GTPases
  Traffic (2010) | Journal article

  The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells
  Embo Reports (2010) | Journal article

  Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6
  Faseb Journal (2010) | Journal article

  Autophagy is not universally required for phosphatidyl-serine exposure and apoptotic cell engulfment during neural development
  Autophagy (2009) | Journal article

  Beclin 1: a BH3-only protein that fails to induce apoptosis
  Oncogene (2009) | Journal article

  Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
  Journal of Clinical Investigation (2009) | Journal article

  Early neural cell death: numbers and cues from the developing neuroretina
  International Journal of Developmental Biology (2009) | Journal article

  The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway
  Plos One (2009) | Journal article

  TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
  Autophagy (2009) | Journal article

  Single cell biomolecular recognition by silicon intracelullar chips
  Duch, M. and Vázquez, P. and Gómez-Martínez, R. and Boya, P. and Muriano, A. and Pinacho, D. and Sanvicens, N. and Sánchez-Baeza, F. and De La Rosa, E. and Esteve, J. and Suárez, T. and Plaza, J.A., Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences: (2009) | Conference

  Autophagy is not universally required for phosphatidyl-serine exposure and apoptotic cell engulfment during neural development
  Autophagy (2009) | Journal article

  TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
  Autophagy (2009) | Journal article

  Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa
  Investigative Ophthalmology & Visual Science (2008) | Journal article

  How autophagy is related to programmed cell death during the development of the nervous system
  Biochemical Society Transactions (2008) | Journal article

  Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors
  Cell Death and Differentiation (2008) | Journal article

  Lysosomal membrane permeabilization in cell death
  Oncogene (2008) | Journal article

  The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium
  Cell Death and Differentiation (2008) | Journal article

  Early neural cell death: an overlooked process in neural development
  Anales De La Real Academia Nacional De Farmacia (2007) | Journal article

  Early neural cell death: An overlooked process in neural development
  Anales de la Real Academia Nacional de Farmacia (2007) | Journal article

  Cell death in early neural life.
  Birth defects research. Part C, Embryo today : reviews (2005) | Journal article

  Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
  Journal of Experimental Medicine (2005) | Journal article

  Inhibition of macroautophagy triggers apoptosis
  Molecular and Cellular Biology (2005) | Journal article

  The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
  Journal of Cell Science (2005) | Journal article

  An anti-apoptotic viral protein that recruits bax to mitochondria
  Journal of Biological Chemistry (2004) | Journal article

  An anti-apoptotic viral protein that recruits Bax to mitochondria
  Biochimica Et Biophysica Acta-Bioenergetics (2004) | Journal article

  Anti-apoptotic activity of the glutathione peroxidase homologue encoded by HIV-1
  Apoptosis (2004) | Journal article

  Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
  Apoptosis (2004) | Journal article

  NF-kappa B and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope
  Journal of Experimental Medicine (2004) | Journal article

  Viral proteins targeting mitochondria: controlling cell death
  Biochimica Et Biophysica Acta-Bioenergetics (2004) | Journal article

  A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine induced liver damage: A possible mechanism for viral persistence
  Journal of Hepatology (2003) | Journal article

  A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage
  Hepatology (2003) | Journal article

  Bcl-2 and CCND1/CDK4 as molecular markers of the cellular effects of mTOR inhibitors in human ovarian carcinoma cells
  Clinical Cancer Research (2003) | Journal article

  Cytofluorometric quantitation of apoptosis-driven inner mitochondrial membrane permeabilization
  Apoptosis (2003) | Journal article

  Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion
  Journal of Experimental Medicine (2003) | Journal article

  Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
  Oncogene (2003) | Journal article

  Mitochondrion-targeted apoptosis regulators of viral origin
  Biochemical and Biophysical Research Communications (2003) | Journal article

  The chemopreventive agent N-(4-hydroxyphenyl) retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family
  Oncogene (2003) | Journal article

  Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and BCI-X-L
  Oncogene (2002) | Journal article

  Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).
  Oncogene (2002) | Journal article

  Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization
  Cell Death and Differentiation (2002) | Journal article

  Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo
  Apoptosis (2002) | Journal article

  The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway
  Cell Death and Differentiation (2002) | Journal article

  Stat-1 and IRF-1: two factors in the signaling pathway of interferons related to viral load and liver damage in chronic hepatitis C (CH-C)
  Journal of Hepatology (2002) | Journal article

  Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha 5
  Journal of Viral Hepatitis (2001) | Journal article

  Nuclear factor-kappa B in the liver of patients with chronic hepatitis C: Decreased RelA expression is associated with enhanced fibrosis progression
  Hepatology (2001) | Journal article

  Viral and bacterial proteins regulating apoptosis at the mitochondrial level
  Embo Journal (2001) | Journal article

  Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C
  Journal of Hepatology (1999) | Journal article

  Interferon alfa subtypes and levels of type I interferons in the liver and peripheral mononuclear cells in patients with chronic hepatitis C and controls
  Hepatology (1999) | Journal article

  VIROIDS AND VIRUSES AT THE ORIGIN OF ORGANIZED LIFE
  CHEMICAL EVOLUTION: ORIGIN OF LIFE (1993) | Journal article

  A proteinaceus sequence for endo-lysosomal localization and degradation.
  Patricia Boya | Other

Teaching and courses

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