Details

Faculty	Faculty of Science and Medicine
Domain	Biology
Code	UE-SBL.00115
Languages	English
Type of lesson	Lecture
Level	Master
Semester	AS-2022

Schedules and rooms

Summary schedule	Tuesday 08:15 - 11:00, Hebdomadaire (Autumn semester)
Struct. of the schedule	3h par semaine durant 4 semaines à choix
Contact's hours	12

Teaching

Responsibles	Puoti Alessandro
Teachers	Puoti Alessandro
Description	The flow of genetic information goes from DNA to RNA, and from RNA to proteins. The question is how could the first proteins be made if they are needed for transcription and translation? The hypothesis of the RNA world suggests that catalytic RNAs (ribozymes) may have preceded proteins. This lecture will briefly describe the origins of life and emphasize the importance of ribozymes, their mode of action and their roles in today's world. Other themes include the discovery and mechanism of RNA interference, the importance of small and long non-coding RNAs, RNA-based technologies including RNA vaccines, the evolution of RNA-based adaptive CRISPR immunity.
Training objectives	DNA is best known to be transcribed into RNA which is then translated into protein. However, during the last decades, it has become clear that RNA also plays essential roles in the regulation of gene expression and catalysis. Students will discover the relevance of non-coding RNAs and their functions. From the catalytic role of RNAs in the "RNA World" when life has appeared on Earth, to the latest findings on RNA-mediated gene silencing, the lecture focuses on functions of RNAs that were totally unexpected.
Comments	Given in 4 x 3 hours
Softskills	No
Off field	No
BeNeFri	Yes
Mobility	Yes
UniPop	No

Oral exam - AS-2022, Session d'hiver 2023

Date	13.02.2023 08:25 - 14:30
Assessments methods	By rating
Descriptions of Exams	Oral exam, 15 min. One mark.

Oral exam - SS-2023, Autumn Session 2023

Date	13.09.2023 13:00 - 13:30
Assessments methods	By rating
Descriptions of Exams	Oral exam, 15 min. One mark.