Stéréochimie organique (cours avec exercices) / Organische Stereochemie (Vorlesung mit Übungen)
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Teaching
Details
Faculty Faculty of Science and Medicine Domain Chemistry Code UE-SCH.03212 Languages German , French Type of lesson Exercise
Lecture
Level Bachelor Semester SA-2022 Title
French Stéréochimie organique (cours avec exercices) German Organische Stereochemie (Vorlesung mit Übungen) English Organic stereochemistry (lecture with exercises) Schedules and rooms
Summary schedule Wednesday 10:15 - 12:00, Hebdomadaire (Autumn semester)
Struct. of the schedule 2h par semaine durant 14 semaines Contact's hours 28 Teaching
Responsibles - Bochet Christian
Teachers - Bochet Christian
Description Principes de base de la stéréochimie: Isomérie. Types de chiralité, nomenclature, règles. Complexes octaédriques. Chiralité des complexes métalliques. Méthodes de quantification des excès stéréomériques. Méthodes de détermination de la configuration absolue. Corrélation chimique. Analyse conformationelle. Prochiralité et réactions. Bases de la synthèse stéréosélective: Stratégies en synthèse asymétrique. Induction 1,2 et 1,3. Géométrie des énolates. Auxiliaires chiraux. Réactifs chiraux. Catalyse énantiosélective. Double stéréodifférentiation. Résolution cinétique. Effets non linéaires et amplification chirale
Basic principles in stereochemistry: Isomerism. Types of chirality, nomenclature, rules. Octahedral complexes. Chirality of metallic complexes. Quantification methods of stereomeric excesses. Determination of the absolute configuration. Chemical correlation. Conformational analysis. Prochirality and reactions. Bases of stereoselective synthesis: Strategies in asymmetric synthesis. 1,2- and 1,3-Induction. Geometry of enolates. Chiral auxiliairies. Chiral reagents. Enantioselective catalysis. Double stereodifférentiation. Kinetic resolution. Non-linear effects and chiral amplification
Grundlagen der Stereochemie: Isomerie. Typen von Chiralität, Nomenklatur, Regeln. Oktaedrische Komplexe. Chiralität von Metallkomplexen. Quantifizierungsmethoden von Stereoisomeren-Überschuss. Bestimmung von absoluten Konfigurationen. Chemische Korrelation. Konformationsanalyse. Prochiralität und Reaktionen. Grundlagen der Stereoselektiven Synthese: Strategie in asymmetrischer Synthese. 1,2- und 1,3-Induktion. Geometrie von Enolaten. Chirale Auxiliare. Chirale Reagenzien. Enantioselektive Katalyse. Doppel-Stereodifferenzierung. Kinetische Resolution. Nicht-lineare Effekte und chirale VerstärkungTraining objectives À l'issue de ce cours, vous devriez être capables de:
- Identifier la relation stéréochimique entre plusieurs molécules,
- quantifier les composants d'un mélange d'isomères,
- déterminer la configuration absolue d'une substance à l'aide des diverses techniques connues.
- concevoir un chemin synthétique afin d'obtenir sélectivement une substance énantio- et diastéréomériquement pure,
- rationaliser la stéréochimie d'une réaction quelconque.
Ziel dieser Vorlesung ist es, dass Sie fähig sein sollten :
- das stereochemische Verhältnis zwischen mehreren Molekülen zu bestimmen
- die Zusammensetzung eines Isomerengemisches zu quantifizieren
- die absolute Konfiguration einer Substanz mit verschiedenen bekannten Techniken zu ermitteln
- einen Syntheseweg zu konzipieren um selektiv eine Enantiomeren- und Diastereomeren-reine Verbindung zu erhalten
- die Stereochemie einer beliebigen Reaktion zu rationalisierenSoftskills No Off field No BeNeFri Yes Mobility Yes UniPop No -
Dates and rooms
Date Hour Type of lesson Place 21.09.2022 10:15 - 12:00 Cours PER 10, Room 433 28.09.2022 10:15 - 12:00 Cours PER 10, Room 433 05.10.2022 10:15 - 12:00 Cours PER 10, Room 433 12.10.2022 10:15 - 12:00 Cours PER 10, Room 433 19.10.2022 10:15 - 12:00 Cours PER 10, Room 433 26.10.2022 10:15 - 12:00 Cours PER 10, Room 433 02.11.2022 10:15 - 12:00 Cours PER 10, Room 433 09.11.2022 10:15 - 12:00 Cours PER 10, Room 433 16.11.2022 10:15 - 12:00 Cours PER 10, Room 433 23.11.2022 10:15 - 12:00 Cours PER 10, Room 433 30.11.2022 10:15 - 12:00 Cours PER 10, Room 433 07.12.2022 10:15 - 12:00 Cours PER 10, Room 433 14.12.2022 10:15 - 12:00 Cours PER 10, Room 433 21.12.2022 10:15 - 12:00 Cours PER 10, Room 433 -
Assessments methods
Oral exam - SA-2022, Session d'hiver 2023
Date 08.02.2023 08:00 - 16:15 Assessments methods By rating Descriptions of Exams épreuve orale de 30 min Comment Examen ORAL 30 min
Oral exam - SP-2023, Session d'été 2023
Assessments methods By rating Descriptions of Exams épreuve orale de 30 min Comment Examen ORAL 30 min
Oral exam - SP-2023, Autumn Session 2023
Date 01.09.2023 09:30 - 11:00 Assessments methods By rating Descriptions of Exams épreuve orale de 30 min Comment Examen ORAL 30 min
Oral exam - SA-2023, Session d'hiver 2024
Assessments methods By rating Descriptions of Exams épreuve orale de 30 min Comment Examen ORAL 30 min
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Assignment
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Chemistry, option Teaching 150
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