Nuclear organization and chromatin dynamics - Nuclear organization and chromosome dynamics

  • Teaching

    Details

    Faculty Faculty of Science and Medicine
    Domain Biology
    Code UE-SBL.00130
    Languages English
    Type of lesson Lecture
    Level Master
    Semester SA-2022

    Title

    French Organisation nucléaire et dynamique chromosomale
    German Organisation im Zellkern und Chromosomen Dynamik
    English Nuclear organization and chromatin dynamics - Nuclear organization and chromosome dynamics

    Schedules and rooms

    Summary schedule Tuesday 09:15 - 11:00, Hebdomadaire (Autumn semester)
    Contact's hours 8

    Teaching

    Responsibles
    Teachers
    Description

    DNA associated processes, such transcription, replication, recombination, but also chromosome pairing during meiosis occur in the context of the highly organized cell nucleus. Several structural elements of the nucleus such as the nuclear lamina or special nuclear compartments are known to regulate these processes. Changes in the nuclear organization are accompanying development and differentiation processes and defects in the nuclear architecture are known to be responsible for several human diseases. This course will focus on the elements that are shaping the nuclear architecture and their role in the activity of the genome, such as transcription, replication and DNA recombination. Since meiotic nuclei are the home of a beautiful chromosome choreography and an intense nuclear reorganisation, this course will also include an overview of the mechanisms underlying these processes. Understanding the molecular mechanisms underlying nuclear organisation and chromosome dynamics is essential for human health and fertility.

    Key concepts of the lecture are nuclear architecture, chromatin domains, nuclear compartment, chromosome territories and pairing, recombination and genome stability.

    Training objectives

    At the end of this course, the student has an overview of the nuclear organization and its role in the regulation of processes associated with the DNA. He/she is able to use this knowledge to read and analyse the specialized literature on the topic and to appreciate the research of a lab working on nuclear architecture and chromosome dynamics.)

    Softskills
    No
    Off field
    No
    BeNeFri
    No
    Mobility
    No
    UniPop
    No
  • Dates and rooms
    Date Hour Type of lesson Place
    18.10.2022 09:15 - 11:00 Cours PER 04, Room 0.109
    25.10.2022 09:15 - 11:00 Cours PER 04, Room 0.109
    08.11.2022 09:15 - 11:00 Cours PER 04, Room 0.109
    15.11.2022 09:15 - 11:00 Cours PER 04, Room 0.109
    22.11.2022 09:15 - 11:00 Cours PER 04, Room 0.109
  • Assessments methods

    Written exam

    Assessments methods By rating
    Descriptions of Exams

    Written exam (30 min.) during the semester. One mark

  • Assignment
    Valid for the following curricula:
    Additional Courses in Sciences
    Version: ens_compl_sciences
    Paquet indépendant des branches > Specialized courses in Biology (Master level)

    Additional TDHSE programme in Biology
    Version: 2022_1/V_01
    Additional TDHSE Programme Requirements for BIOLOGIE E 60 or +30 > Programme 60 or +30 > Additional Programme Requirements to BIOLOGIE E+30 > Additional TDHSE programme for Biology +30 (from AS2020 on)

    Additional programme requirements for PhD studies [PRE-DOC]
    Version: 2020_1/v_01
    Additional programme requirements for PhD studies (Faculty of Science and Medicine) > Specialized courses in Biology (Master level)

    Biology +30 [MA] 30
    Version: 2022_1/V_01
    Minor in Biology +30 (BIOLOGY+30 for 90 ECTS) > BIOLOGY E +30, minor, Molecular life and health (from AS2021 on)

    Biology [3e cycle]
    Version: 2015_1/V_01
    Continuing education > Specialized courses in Biology (Master level)

    Biology [POST-DOC]
    Version: 2015_1/V_01
    Continuing education > Specialized courses in Biology (Master level)

    MSc in Molecular Life and Health Sciences, option Biochemistry and Cell Biology 120 [MA]
    Version: 2022_1/V_01
    MSc in Molecular Life and Health Sciences, option Biochemistry and Cell Biology, lectures and seminars (from AS2021 on) > MSc-ML, option Biochemistry and Cell Biology, elective courses (from AS2021 on) > Recommended courses

    MSc in Molecular Life and Health Sciences, option Developmental Biology and Regeneration 120 [MA]
    Version: 2022_1/V_01
    MSc in Molecular Life and Health Sciences, option Developmental Biology and Regeneration, lectures and seminars (from AS2021 on) > MSc-ML, option Developmental Biology and Regeneration, compulsory courses (from AS2021 on)

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    MSc in Molecular Life and Health Sciences, option Neurobiology 120 [MA]
    Version: 2022_1/V_01
    MSc in Molecular Life and Health Sciences, option Neurobiology, lectures and seminars (from AS2021 on) > MSc-ML, option Neurobiology, elective courses (from AS2021 on) > Recommended courses

    MSc in Molecular Life and Health Sciences, option Teaching 90 [MA]
    Version: 2022_1/V_01
    MSc in Molecular Life and Health Sciences, option Teaching, lectures and seminars (from AS2021 on) > MSc-ML, option Teaching, elective courses (from AS2021 on) > Recommended courses