Immunology and infectious diseases
In 2016, there were an estimated 216 million cases of malaria. Most cases of malaria remain clinically silent. However, some infected people develop severe symptoms, leading to the death of over 500’000 people a year. Why some patients die from malaria, while some are only mildly sick?
To gain insights into the pathogenesis of malaria, the Mantel lab investigates the regulation of host-parasite interactions. In particular, we are studying factors secreted by infected red blood cells and how those factors regulate the immune response.
Recently, our work has focused on extracellular vesicles (EVs), which are small vesicles secreted by Plasmodium falciparum infected red blood cells. Our lab has developed new tools to isolate EVs and we have described several cargoes including the RNA and protein contents. We have shown that EVs carry functional miRNAs that can regulate transcription in the recipient cells. Interestingly, we have demonstrated that miR451 transferred to endothelial cells via EVs can modulate the endothelial barrier permeability by directly regulation of gene expression.
The lab seeks to identify fundamental principles that explain the outcome of host-parasite interactions, with the goal of understanding how the parasite infections affects the immune response and pathogenesis. To achieve these goals, we use cell and molecular biology, immunology and the rodent malaria model.
Members
-
Group leader
- PhD student
- Technician
Publications
Validation of Effective Extracellular Vesicles Isolation Methods Adapted to Field Studies in Malaria Endemic Regions.
Zoia M, Yesodha Subramanian B, Eriksson KK, Ravi MS, Yaghmaei S, Fellay I, Scolari B, Michael Walch, Mantel PY, Frontiers in cell and developmental biology (2022) | Journal articleEpstein-Barr virus and malaria upregulate AID and APOBEC3 enzymes, but only AID seems to play a major mutagenic role in Burkitt lymphoma.
Summerauer AM, Jäggi V, Ogwang R, Traxel S, Colombo L, Amundsen E, Eyer T, Subramanian B, Jan Fehr, Mantel PY, Idro R, simone bürgler, European journal of immunology (2022) | Journal articleOxidative and Non-Oxidative Antimicrobial Activities of the Granzymes.
Marilyne LAVERGNE, Hernández-Castañeda MA, Mantel PY, Martinvalet D, Michael Walch, Frontiers in immunology (2021) | Journal articleA Profound Membrane Reorganization Defines Susceptibility of Plasmodium falciparum Infected Red Blood Cells to Lysis by Granulysin and Perforin.
Hernández-Castañeda MA, Marilyne LAVERGNE, Casanova P, Nydegger B, Merten C, Subramanian BY, Matthey P, Nils Lannes, Mantel PY, Michael Walch, Frontiers in immunology (2021) | Journal articleChemotaxis and swarming in differentiated HL-60 neutrophil-like cells.
Babatunde KA, Wang X, Hopke A, Nils Lannes, Mantel PY, Irimia D, Scientific reports (2021) | Journal articleErythroblasts provide a home for gametocytes
Pierre-Yves Mantel, Blood (2020) | Journal articleHuman Microglia Respond to Malaria-Induced Extracellular Vesicles
Smart Ikechukwu Mbagwu and Nils Lannes and Michael Walch and Luis Filgueira and Pierre-Yves Mantel, Pathogens (2019) | Journal articleChemotaxis and swarming in differentiated HL60 neutrophil-like cells
Kehinde Adebayo Babatunde and Xiao Wang and Alex Hopke and Pierre-Yves Mantel and Daniel Irimia, Cold Spring Harbor Laboratory (2019) | OtherEvaluation of Extracellular Vesicle Function During Malaria Infection
Hernandez-Castaneda, Maria Andrea and Mbagwu, Smart and Babatunde, Kehinde Adebayo and Walch, Michael and Filgueira, Luis and Mantel, Pierre-Yves, Jove-Journal of Visualized Experiments (2018) | Journal articleMalaria infected red blood cells release small regulatory RNAs through extracellular vesicles
Babatunde, Kehinde Adebayo and Mbagwu, Smart and Hernandez-Castaneda, Maria Andrea and Adapa, Swamy R. and Walch, Michael and Filgueira, Luis and Falquet, Laurent and Jiang, Rays H. Y. and Ghiran, Ionita and Mantel, Pierre-Yves, Scientific Reports (2018) | Journal articleSilver-nanoparticles increase bactericidal activity and radical oxygen responses against bacterial pathogens in human osteoclasts
Aurore, Valerie and Caldana, Fabienne and Blanchard, Marianne and Hess, Solange Kharoubi and Lannes, Nils and Mantel, Pierre-Yves and Filgueira, Luis and Walch, Michael, Nanomedicine-Nanotechnology Biology and Medicine (2018) | Journal articleKilling Bacteria with Cytotoxic Effector Proteins of Human Killer Immune Cells: Granzymes, Granulysin, and Perforin.
Leon, Diego Lopez and Fellay, Isabelle and Mantel, Pierre-Yves and Walch, Michael, Methods in molecular biology (Clifton, N.J.) (2017) | Journal articleMalaria derived extracellular vesicles influence human neutrophils function
Babatunde, Kehinde Adebayo and Walch, Michael and Fellay, Isabelle and Kharoubi-Hess, Solange and Filgueira, Luis and Chiran, Lonita and Mantel, Pierre-Yves, Faseb Journal (2017) | Journal articlePLASMODIUM FALCIPARUM PHISTC PROTEINS ARE REQUIRED FOR ANTIGEN DELIVERY TO THE INFECTED ERYTHROCYTE SURFACE
Ravel, Deepali B. and Mantel, Pierre-Yves and Dantzler, Kathleen W. and Beyer, William C. and Brancucci, Nicolas M. and Duraisingh, Manoj T. and Marti, Matthias, American Journal of Tropical Medicine and Hygiene (2017) | Journal articleProduction and Characterization of Extracellular Vesicles in Malaria.
Mbagwu, Smart and Walch, Michael and Filgueira, Luis and Mantel, Pierre-Yves, Methods in molecular biology (Clifton, N.J.) (2017) | Journal articleAltered drug susceptibility during host adaptation of a Plasmodium falciparum strain in a non-human primate model
Obaldia, Nicanor, III and Dow, Geoffrey S. and Gerena, Lucia and Kyle, Dennis and Otero, William and Mantel, Pierre-Yves and Baro, Nicholas and Daniels, Rachel and Mukherjee, Angana and Childs, Lauren M. and Buckee, Caroline and Duraisingh, Manoj T. and Volkman, Sarah K. and Wirth, Dyann F. and Marti, Matthias, Scientific Reports (2016) | Journal articleDiurnal Variations of Circulating Extracellular Vesicles Measured by Nano Flow Cytometry
Danielson, Kirsty M. and Estanislau, Jessica and Tigges, John and Toxavidis, Vasilis and Camacho, Virginia and Felton, Edward J. and Khoory, Joseph and Kreimer, Simion and Ivanov, Alexander R. and Mantel, Pierre-Yves and Jones, Jennifer and Akuthota, Praveen and Das, Saumya and Ghiran, Ionita, Plos One (2016) | Journal articleInfected erythrocyte-derived extracellular vesicles alter vascular function via regulatory Ago2-miRNA complexes in malaria
Mantel, Pierre-Yves and Hjelmqvist, Daisy and Walch, Michael and Kharoubi-Hess, Solange and Nilsson, Sandra and Ravel, Deepali and Ribeiro, Marina and Gruring, Christof and Ma, Siyuan and Padmanabhan, Prasad and Trachtenberg, Alexander and Ankarklev, Johan and Brancucci, Nicolas M. and Huttenhower, Curtis and Duraisingh, Manoj T. and Ghiran, Ionita and Kuo, Winston P. and Filgueira, Luis and Martinelli, Roberta and Marti, Matthias, Nature Communications (2016) | Journal articleProfiling the Essential Nature of Lipid Metabolism in Asexual Blood and Gametocyte Stages of Plasmodium falciparum
Gulati, S. and Ekland, E. H. and Ruggles, K. V. and Chan, R. B. and Jayabalasingham, B. and Zhou, B. and Mantel, P. Y. and Lee, M. C. and Spottiswoode, N. and Coburn-Flynn, O. and Hjelmqvist, D. and Worgall, T. S. and Marti, M. and Di Paolo, G. and Fidock, D. A., Cell Host Microbe (2015) | Journal articleShared elements of host-targeting pathways among apicomplexan parasites of differing lifestyles
Pellé, K. G. and Jiang, R. H. and Mantel, P. Y. and Xiao, Y. P. and Hjelmqvist, D. and Gallego-Lopez, G. M. and O T Lau, A. and Kang, B. H. and Allred, D. R. and Marti, M., Cell Microbiol (2015) | Journal articleSex: how malaria parasites get turned on
Ankarklev, J. and Brancucci, N. M. and Goldowitz, I. and Mantel, P. Y. and Marti, M., Curr Biol (2014) | Journal articleThe role of extracellular vesicles in Plasmodium and other protozoan parasites
Mantel, P. Y. and Marti, M., Cell Microbiol (2014) | Journal articleCurrent methods for the isolation of extracellular vesicles
Momen-Heravi, F. and Balaj, L. and Alian, S. and Mantel, P. Y. and Halleck, A. E. and Trachtenberg, A. J. and Soria, C. E. and Oquin, S. and Bonebreak, C. M. and Saracoglu, E. and Skog, J. and Kuo, W. P., Biol Chem (2013) | Journal articleMalaria-infected erythrocyte-derived microvesicles mediate cellular communication within the parasite population and with the host immune system
Mantel, P. Y. and Hoang, A. N. and Goldowitz, I. and Potashnikova, D. and Hamza, B. and Vorobjev, I. and Ghiran, I. and Toner, M. and Irimia, D. and Ivanov, A. R. and Barteneva, N. and Marti, M., Cell Host Microbe (2013) | Journal article[Role of microvesicles in malaria infections]
Pellé, K. G. and Ahouidi, A. D. and Mantel, P. Y., Med Sci (Paris) (2013) | Journal articleCD28 costimulation regulates FOXP3 in a RelA/NF-κB-dependent mechanism
Soligo, M. and Camperio, C. and Caristi, S. and Scottà, C. and Del Porto, P. and Costanzo, A. and Mantel, P. Y. and Schmidt-Weber, C. B. and Piccolella, E., Eur J Immunol (2011) | Journal articleFunctional analysis of the exported type IV HSP40 protein PfGECO in Plasmodium falciparum gametocytes
Morahan, B. J. and Strobel, C. and Hasan, U. and Czesny, B. and Mantel, P. Y. and Marti, M. and Eksi, S. and Williamson, K. C., Eukaryot Cell (2011) | Journal articleTransforming growth factor-beta: recent advances on its role in immune tolerance
Mantel, P. Y. and Schmidt-Weber, C. B., Methods Mol Biol (2011) | Journal articleRORC2 is involved in T cell polarization through interaction with the FOXP3 promoter
Burgler, S. and Mantel, P. Y. and Bassin, C. and Ouaked, N. and Akdis, C. A. and Schmidt-Weber, C. B., J Immunol (2010) | Journal articleDifferentiation and functional analysis of human T(H)17 cells
Burgler, S. and Ouaked, N. and Bassin, C. and Basinski, T. M. and Mantel, P. Y. and Siegmund, K. and Meyer, N. and Akdis, C. A. and Schmidt-Weber, C. B., J Allergy Clin Immunol (2009) | Journal articleRegulation of the foxp3 gene by the Th1 cytokines: the role of IL-27-induced STAT1
Ouaked, N. and Mantel, P. Y. and Bassin, C. and Burgler, S. and Siegmund, K. and Akdis, C. A. and Schmidt-Weber, C. B., J Immunol (2009) | Journal articleThe transcription factors RUNX1 and RUNX3 are essential for the induction of FOXP3 and the suppression capacity of T regulatory cells
Klunker, S. and Chong, M. and Mantel, P-Y and Rijckert, B. and Bassin, C. and Ziegler, M. and Meiler, F. and Akdis, M. and Littman, D. and Akdis, C., Swiss Medical Weekly (2009) | Journal articleTranscription factors RUNX1 and RUNX3 in the induction and suppressive function of Foxp3+ inducible regulatory T cells
Klunker, S. and Chong, M. M. and Mantel, P. Y. and Palomares, O. and Bassin, C. and Ziegler, M. and Rückert, B. and Meiler, F. and Akdis, M. and Littman, D. R. and Akdis, C. A., J Exp Med (2009) | Journal articleCharacterization of FOXP3+CD4+ regulatory T cells in Crohn's disease
Saruta, M. and Yu, Q. T. and Fleshner, P. R. and Mantel, P. Y. and Schmidt-Weber, C. B. and Banham, A. H. and Papadakis, K. A., Clin Immunol (2007) | Journal articleGATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells
Mantel, P. Y. and Kuipers, H. and Boyman, O. and Rhyner, C. and Ouaked, N. and Rückert, B. and Karagiannidis, C. and Lambrecht, B. N. and Hendriks, R. W. and Crameri, R. and Akdis, C. A. and Blaser, K. and Schmidt-Weber, C. B., PLoS Biol (2007) | Journal articleHighlights in cellular and molecular mechanisms of allergic diseases. XXVth Congress of the European Academy of Allergology and Clinical Immunology in Vienna
Basinski, T. and Ozdemir, C. and Sackesen, C. and Mantel, P. Y. and Barlan, I. and Akdis, M. and Jutel, M. and Akdis, C. A., Int Arch Allergy Immunol (2007) | Journal articleActivin A is an acute allergen-responsive cytokine and provides a link to TGF-beta-mediated airway remodeling in asthma
Karagiannidis, C. and Hense, G. and Martin, C. and Epstein, M. and Rückert, B. and Mantel, P. Y. and Menz, G. and Uhlig, S. and Blaser, K. and Schmidt-Weber, C. B., J Allergy Clin Immunol (2006) | Journal articleHigh-altitude climate therapy reduces local airway inflammation and modulates lymphocyte activation
Karagiannidis, C. and Hense, G. and Rueckert, B. and Mantel, P. Y. and Ichters, B. and Blaser, K. and Menz, G. and Schmidt-Weber, C. B., Scand J Immunol (2006) | Journal articleMolecular mechanisms underlying FOXP3 induction in human T cells
Mantel, P. Y. and Ouaked, N. and Rückert, B. and Karagiannidis, C. and Welz, R. and Blaser, K. and Schmidt-Weber, C. B., J Immunol (2006) | Journal articleGlucocorticoids upregulate FOXP3 expression and regulatory T cells in asthma
Karagiannidis, C. and Akdis, M. and Holopainen, P. and Woolley, N. J. and Hense, G. and Rückert, B. and Mantel, P. Y. and Menz, G. and Akdis, C. A. and Blaser, K. and Schmidt-Weber, C. B., J Allergy Clin Immunol (2004) | Journal articleHistamine enhances TGF-beta1-mediated suppression of Th2 responses
Kunzmann, S. and Mantel, P. Y. and Wohlfahrt, J. G. and Akdis, M. and Blaser, K. and Schmidt-Weber, C. B., FASEB J (2003) | Journal articleThe cellular protein level of parkin is regulated by its ubiquitin-like domain
Finney, N. and Walther, F. and Mantel, P. Y. and Stauffer, D. and Rovelli, G. and Dev, K. K., J Biol Chem (2003) | Journal article - PhD student
