C. De Virgilio publications






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2024

Hofer SJ, Daskalaki I, Bergmann M, Zimmermann A, Müller MI, Abdellatif M, Nicastro R, Masser S, Durand S, Nartey A, Waltenstorfer M, Enzenhofer S, Faimann I, Gschiel V, Bajaj T, Niemeyer C, Gkikas I, Pein L, Cerrato G, Pan H, Liang YT, Tadic J, Jerkovi A, Aprahamian F, Robbins CE, Nirmalathasan N, Habisch H, Annerer E, Dethloff F, Stumpe M, Grundler F, Wilhelmi de Toledo F, Heinz DE, Koppold DA, Khokhar AR, Michalsen A, Tripolt NJ, Sourij H, Pieber TR, de Cabo R, McCormick MA, Magnes C, Kepp O, Dengjel J, Sigrist SJ, Gassen NC, Sedej S, Madl T, De Virgilio C, Stelzl U, Hoffmann MH, Eisenberg T, Tavernarakis N, Kroemer G & Madeo F (2024). Spermidine is essential for fasting-mediated autophagy and longevity. Nat. Cell Biol.,9:1571-158.

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Caligaris M & De Virgilio C (2024) Proxies introduce bias in decoding TORC1 activity. microPubl. Biol. 2024, 10.17912.

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Füllbrunn N, Nicastro R, Mari M, Griffith J, Herrmann E, Rasche R, Borchers AC, Auffarth K, Kümmel D, Reggiori F, De Virgilio C, Langemeyer L & Ungermann C. ()  (2024) The GTPase activating protein Gyp7 regulates Rab7/Ypt7 activity on late endosomes. J. Cell Biol. 223(6):e202305038.

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2023

Nicastro R, Brohée L, Alba J, Nüchel J, Figlia G, Kipschull S, Gollwitzer P, Romero-Pozuelo J, Fernandes SA, Lamprakis A, Vanni S (), Teleman AA (), De Virgilio C () & Demetriades C () (2023) Malonyl-CoA is a conserved endogenous ATP-competitive mTORC1 inhibitor. Nat. Cell Biol. 25, 1303-1318.
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Caligaris M, Sampaio-Marques B, Hatakeyama R, Pillet B, Ludovico P, De Virgilio C, Winderickx J & Nicastro R. () (2023) The yeast protein kinase Sch9 functions as a central nutrient-responsive hub that calibrates metabolic and stress-related responses. J. Fungi 9, 787.

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Grziwa S, Schäfer J-H, Nicastro R, Annabel A, De Virgilio C, Fröhlich F, Moeller A, Gao J, Langemeyer L () & Ungermann C () (2023) Yck3 casein kinase-mediated phosphorylation determines Ivy1 localization and function at endosomes and vacuole. J. Cell Sci. 136, jcs.260889.
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Sambri S, Ferniani M, Campostrini G, Testa M, Meraviglia V, de Araujo M, Dokládal L, Vilardo C, Monfregola J, Zampelli N, Del Vecchio Blanco F, Torella A, Ruosi C, Fecarotta S, Parenti G, Staiano L, Bellin M, Huber L, De Virgilio C, Trepiccione F, Nigro N & Ballabio A () (2023). RagD auto-activating mutations impair MiT/TFE activity in kidney tubulopathy and cardiomyopathy syndrome. Nat. Commun. 14, 2775.
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Deprez M-A, Caligaris M, Rosseels J, Hatakeyama R, Ghillebert R, Sampaio-Marques B, Mudholkar K, Eskes E, Meert E, Ungermann C, Ludovico P, Rospert S, De Virgilio C () & Winderickx J () (2023). The nutrient-responsive CDK Pho85 primes the Sch9 kinase for its activation by TORC1. PloS Genetics 19, e1010641.
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Caligaris M, Nicastro R (), Hu Z, Tripodi F, Hummel JE, Deprez M-A, Winderickx J, Rospert S, Coccetti P, Dengjel J & De Virgilio C () (2022). Snf1/AMPK fine-tunes TORC1 signaling in response to glucose starvation. eLife 12, e84319.
2022

Nicastro R, Gaillard H, Zarzuela L, Péli-Gulli MP, Fernández-García E, Tomé M, García-Rodríguez N, Durán RV & De Virgilio C () & Wellinger RE () (2022). Manganese is a physiologically relevant TORC1 activator in yeast and mammals. eLife 11, e80497.

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Gao J, Nicastro R, Péli-Gulli MP, Grziwa S, Chen Z, Kurre R, Piehler J, De Virgilio C, Fröhlich F & Ungermann C. () (2022). The HOPS tethering complex is required to maintain the identity of signaling endosomes and TORC1 activity. J. Cell Biol. 221, e202109084.
2021

Dokládal L, Stumpe M, Hu Z, Jaquenoud M, Dengjel J ()  & De Virgilio C () (2021). Phosphoproteomic responses of TORC1 target kinases reveal discrete and convergent mechanisms that orchestrate the quiescence program in yeast. Cell Rep. 37, 110149.

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Nicastro R, Raucci S, Michel AH, Stumpe M, Garcia Osuna GM, Jaquenoud M, Kornmann M & De Virgilio C () (2021). Indole-3-acetic acid is a physiological inhibitor of TORC1 in yeast. PLoS Genetics 17, e1009414.
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Dokládal L, Stumpe M, Pillet B, Hu Z, Garcia Osuna GM, Kressler D, Dengjel J & De Virgilio C () (2021). Global Phosphoproteomics pinpoints uncharted Gcn2-mediated mechanisms of translational control. Mol. Cell 81, 1879-1889.e6.
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Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition). (2021). Klionsky () et al. Autophagy 17, 1-382.
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Tate JJ, Rai R, De Virgilio C, & Cooper, TG () (2021). N- and C-terminal Gln3-Tor1 interaction sites: one acting negatively and the other positively to regulate nuclear Gln3 localization. Genetics 217, iyab017.
2020

Chen Z, Malia PC, Hatakeyama R, Nicastro R, Hu Z, Péli-Gulli MP, Gao J, Nishimura T, Eskes E, Stefan C, Winderickx J & De Virgilio C () & Ungermann C () (2021). TORC1 determines Fab1 lipid kinase function at signaling endosomes and vacuoles. Curr. Biol. 31, 1-13.

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2019
Brenna A, Olejniczak I, Chavan R, Ripperger JA, Langmesser S, Cameroni E, Hu Z, De Virgilio C, Dengjel J & and Albrecht U () (2019). Cyclin dependent kinase 5 (CDK5) regulates the circadian clock. eLife 8, e50925.
 

Zhang T, Péli-Gulli MP, Zhang Z, Tang X,, Ye J, De Virgilio C () & Ding J () (2019). Structural insights into the EGO-TC–mediated membrane tethering of the TORC1-regulatory Rag GTPases. Sci. Adv. 5, eaax8164.

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Hu Z, Raucci S, Jaquenoud M, Hatakeyama R, Stumpe M, Rohr R, Reggiori F, De Virgilio C ()  & Dengjel J. () (2019). Multilayered control of protein turnover by TORC1 and Atg1. Cell Rep. 28, 3486-3496.
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Kvainickas A, Nägele H, Qi W, Dokládal L, Jimenez-Orgaz A, Stehl L, Gangurde D, Zhao Q, Hu Z, Dengjel J, De Virgilio C, Baumeister R & Steinberg F () (2019). Retromer and TBC1D5 maintain late endosomal RAB7 domains to enable amino acid-induced mTORC1 signaling. J Cell Biol. 218, 3019-2038.

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Hatakeyama R & De Virgilio C () (2019). TORC1 specifically inhibits microautophagy through ESCRT-0. Curr. Genet. 65, 1243-1249.
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Hatakeyama R & De Virgilio C () (2019). A spatially and functionally distinct pool of TORC1 defines signaling endosomes in yeast. Autophagy 15, 915-916.

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Hatakeyama R, Péli-Gulli MP, Hu Z, Jaquenoud M, Garcia Osuna GM, Sardu A, Dengjel J & De Virgilio C () (2019). Spatially distinct pools of TORC1 balance protein homeostasis. Mol. Cell 73, 325-338.e8.

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2018

Fruhmann G, Marchal C, Vignaud H, Verduyckt M, Talarek N, De Virgilio C, Winderickx J () & Cullin, C () (2018). The impact of ESCRT on Aß1-42 induced membrane lesions in a yeast model for Alzheimer’s disease. Front. Mol. Neurosci. 11, 409.

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2017

Péli-Gulli MP, Raucci S, Hu Z, Dengjel J & De Virgilio C () (2017). Feedback inhibition of the Rag GTPase GAP complex Lst4-Lst7 safeguards TORC1 from hyperactivation by amino acid signals. Cell Reports 20, 281-288.

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Nicastro R, Sardu A, Panchaud N & De Virgilio C () (2017). The architecture of the Rag GTPase signaling network. Biomolecules 7(3), E48.

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Wilms T, Swinnen E, Eskes E, Dolz-Edo L, Uwineza A, Van Essche R, Rosseels J, Zabrocki P, Cameroni E, Franssens V, De Virgilio C, Smits GJ & Winderickx J. () (2017). The yeast protein kinase Sch9 adjusts V-ATPase assembly/disassembly to control pH homeostasis and longevity in response to glucose availability. PLoS Genet. 13(6), e1006835.

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Michel AH, Hatakeyama R, Kimmig P, Arter M, Peter M, Matos J, De Virgilio C & Kornmann B () (2017). Functional mapping of yeast genomes by saturated transposition. eLife 6, e23570.

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Moreno-Torres M, Jaquenoud M, Péli-Gulli MP, Nicastro R & De Virgilio C () (2017). TORC1 coordinates the conversion of Sic1 from a target to an inhibitor of cyclin-CDK-Cks1. Cell Discovery 3, 17012.

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2016

Hatakeyama R & De Virgilio C () (2016). Unsolved mysteries of Rag GTPase signaling in yeast. Small GTPases 7, 239-246.

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Powis K & De Virgilio C () (2016). Conserved regulators of Rag GTPases orchestrate amino acid-dependent TORC1 signaling. Cell Discovery 2, 15049.

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2015

Péli-Gulli M-P, Sardu A, Panchaud N, Raucci S & De Virgilio C () (2015). Amino acids stimulate TORC1 through Lst4-Lst7, a GTPase activating protein complex for the Rag family GTPase Gtr2. Cell Rep. 13, 1-7.

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Moreno-Torres M, Jaquenoud M & De Virgilio C () (2015). TORC1 controls G1–S cell cycle transition in yeast via Mpk1 and the greatwall kinase pathway. Nat. Commun. 6, 8256.

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Numrich J, Péli-Gulli M-P, Arlt H, Sardu A, Griffith J, Levine T, Engelbrecht-Vandré S, Reggiori F, De Virgilio C  & Ungermann C () (2015). The I-BAR protein Ivy1 is an effector of the Rab7 GTPase Ypt7 involved in vacuole membrane homeostasis. J. Cell Sci. 128, 2278-2292.

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Powis K, Zhang T, Panchaud N, Wang R, De Virgilio C () & Ding J () (2015). Crystal structure of the Ego1-Ego2-Ego3 complex and its role in promoting Rag GTPase-dependent TORC1 signaling. Cell Res. 25, 1043-1059.

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2014 

 

Dubots E, Cottier S, Péli-Gulli MP, Jaquenoud M, Bontron S, Schneiter R & De Virgilio C () (2014). TORC1 regulates Pah1 phosphatidate phosphatase activity via the Nem1/Spo7 protein phosphatase complex. PLoS ONE 9, e104194.

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2013

Panchaud N, Péli-Gulli MP & De Virgilio C () (2013). SEACing the GAP that nEGOCiates TORC1 activation: Evolutionary conservation of Rag GTPase regulation. Cell Cycle 12, 2948-2952.

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Talarek N, Bontron S & De Virgilio C () (2013). Quantification of mRNA stability of stress-responsive genes following conditional excision of open reading frames. RNA Biol. 10, 1299-1306.

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Panchaud N, Péli-Gulli MP & De Virgilio C () (2013). Amino acid deprivation inhibits TORC1 through a GTPase-activating protein complex for the Rag family GTPase Gtr1. Sci. Signal. 6, ra42.

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Bontron S, Jaquenoud M, Vaga S, Talarek N, Bodenmiller B, Aebersold R. & De Virgilio C. () (2013). Yeast endosulfines control entry into quiescence and chronological life span by inhibiting protein phosphatase 2A. Cell Rep. 3, 16-22.

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2012

Zhang T, Péli-Gulli MP, Yang H, De Virgilio C () & Ding, J. () (2012). Ego3 functions as a homodimer to mediate the interaction between Gtr1-Gtr2 and Ego1 in the EGO complex to activate TORC1. Structure 20, 2151-2160.
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Bonfils G, Jaquenoud M, Bontron S, Ostrowicz C, Ungermann C & De Virgilio C () (2012). Leucyl-tRNA synthetase controls TORC1 via the EGO complex. Mol. Cell 46, 105-110.
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Chen J (), Young SM, Allen C, Seeber A, Péli-Gulli MP, Panchaud N, Waller A, Ursu O, Yao T, Golden J, Strouse JJ, Carter MB, Kang H, Foutz T, Bologa CG, Edwards B, Peterson BR, Aubé J, Werner-Washburne M, Loewith R, De Virgilio C & Sklar LA () (2012). Identification of a small molecule yeast TORC1 inhibitor with a flow cytometry based multiplex screen. ACS Chem. Biol. 7, 715-722.

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De Virgilio C () (2012). The essence of yeast quiescence. FEMS Microbiol. Rev. 36, 306-339.

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2011

Kawai S (), Urban J, Panchaud N, De Virgilio C & Loewith R () (2011). Mitochondrial genomic dysfunction causes dephosphorylation of Sch9 in the yeast Saccharomyces cerevisiae. Eukaryot. Cell 10, 1367-1369.

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Luo X, Talarek N & De Virgilio C () (2011). Initiation of the yeast G0 program requires Igo1 and Igo2, which antagonize activation of decapping of specific nutrient-regulated mRNAs. RNA Biol. 8, 14-17.

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2010

Talarek N, Cameron E, Jaquenoud M, Luo X, Bontron S, Lippman S, Devgan G, Snyder M, Broach JR & De Virgilio C () (2010). Initiation of the TORC1-regulated G0 program requires Igo1/2, which license specific mRNAs to evade degradation via the 5'-3' mRNA decay pathway. Mol. Cell 38, 345-355.

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Faculty Opinions

 

Mok J, Kim PM, LaM HY, Piccirillo S, Zhou X, Jeschke GR, Sheridan DL, Parker SA, Desai V, Jwa M, Cameroni E, Niu H, Good M, Remenyi A, Ma JL, Sheu YJ, Sassi HE, Sopko R, Chan CS, De Virgilio C, Hollingsworth NM, Lim WA, Stern DF, Stillman B, Andrews BJ, Gerstein MB, Snyder M () & Turk BE () (2010). Deciphering protein kinase specificity through large-scale analysis of yeast phosphorylation site motifs. Sci. Signal. 3, ra12.

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Binda M, Bonfils G, Panchaud N, Péli-Gulli MP & De Virgilio C () (2010). An EGOcentric view of TORC1 signaling. Cell Cycle 9, 221-222.

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Smets B, Ghillebert R, De Snijder P, Binda M, Swinnen E, De Virgilio C & Winderickx J () (2010). Life in the midst of scarcity: adaptations to nutrient availability in Saccharomyces cerevisiae. Curr. Genet. 56, 1-32.

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2009  

Binda M., Péli-Gulli MP, Bonfils G, Panchaud N, Urban J, Sturgill TW, Loewith R & De Virgilio C () (2009). The Vam6 GEF controls TORC1 by activating the EGO complex. Mol. Cell 35, 563-573.

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Faculty Opinions

2008 

Zabrocki P, Bastiaens I, Delay C, Bammens T, Ghillebert R, Pellens K, De Virgilio C, Van Leuven F & Winderickx J () (2008). Phosphorylation, lipid raft interaction and traffic of α-synuclein in a yeast model for Parkinson. Biochim. Biophys. Acta 1783, 1767-1780.

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Wanke V, Cameroni E, Uotila A, Piccolis M, Urban J, Loewith R () & De Virgilio C () (2008) Caffeine extends yeast life span by targeting TORC1. Mol. Microbiol. 69, 277-285.

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Fiechter V, Cameroni E, Cerutti L,  De Virgilio C, Barral Y & Fankhauser C () (2008). The evolutionary conserved BER1 gene is involved in microtubule stability in yeast. Curr. Genet. 53, 107-115.

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Froquet R, Cherix N, Birke R, Benghezal M, Cameroni E, Letourneur F, Mösch HU, De Virgilio C & Cosson P () (2008). Control of cellular physiology by TM9 proteins in yeast and Dictyostelium. J. Biol. Chem. 283, 6764-6772.

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2007

Mulder KW, Inagaki A, CameronI E, Mousson F, Winkler GS, De Virgilio C, Collart MA & Timmers HTM () (2007). Modulation of Ubc4p/Ubc5p-mediated stress responses by the RING-finger dependent ubiquitin-protein ligase Not4p in Saccharomyces cerevisiae. Genetics 176, 181-192.

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De Filippi L, Fournier M, Cameroni E, Linder P, De Virgilio C, Foti M & Deloche O () (2007). Membrane stress is coupled to a rapid translational control of gene expression in chlorpromazine-treated cells. Curr. Genetics 52, 171-185.

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Urban J, Soulard A, Huber A, Lippman S, Mukhopadhyay D, Deloche O, Wanke V, Anrather D, Ammerer G, Riezman H, Broach JR, De Virgilio C. Hall MN & Loewith R () (2007). Sch9 is a major target of TORC1 in Saccharomyces cerevisiaeMol. Cell. 26, 663-667.

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2006

Cameroni E, De Virgilio C & Deloche O () (2006). The phosphatidylinositol 4-phosphate is required for protein translation initiation in Saccharomyces cerevisiae. J. Biol. Chem. 281: 38139-38149.

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De Virgilio C () & Loewith R () (2006) Cell growth control: little eukaryotes make big contributions. Oncogene 25, 6392-6415.

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De Virgilio C () & Loewith R () (2006) The TOR signalling network from yeast to man. Int. J. Biochem. & Cell Biol. 38, 1476-1481.

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Swinnen E, Wanke V, Roosen J, Smets B, Pedruzzi I, Cameroni E, De Virgilio C & Winderickx J ()  (2006) Rim15 and the crossroads of nutrient signalling in Saccharomyces cerevisiae. Cell Div. 1, 3.

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2005

Wanke V, Pedruzzi I, Cameroni E, Dubouloz F & De Virgilio C () (2005). Regulation of G0 entry by the Pho80-Pho85 cyclin-CDK complex. EMBO J. 24, 4271-4278.

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Ptacek J, Devgan G, Michaud G, Zhu H., Zhu X, Fasolo J, Guo H, Jona G, Breitkreutz A, Sopko R, Lee SJ, McCartney RR, Schmidt MC, Rachidi N, Stark MJR, Stern DF, De Virgilio C, Tyers M, Andrews B, Gerstein M, Schweitzer B, Predki PF & Snyder M () (2005). Global analysis of protein phosphorylation in yeast. Nature 438, 679-684.

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Knaus M, Cameroni E, Pedruzzi I, Tatchell K, De Virgilio C() & Peter, M. () (2005). The Bud14p-Glc7p complex functions as a cortical regulator of dynein in budding yeast. EMBO J. 24, 3000-3011.

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Dubouloz F, Deloche O, Wanke V, Cameroni E & De Virgilio C () (2005). The TOR and EGO protein complexes orchestrate microautophagy in yeast. Mol. Cell 19, 15-26.

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Roosen J, Engelen K, Marchal K, Mathys J, Griffioen G, Cameroni E, Thevelein JM, De Virgilio C, De Moor B & Winderickx J () (2005). PKA and Sch9 control a molecular switch important for the proper adaptation to nutrient availability. Mol. Microbiol. 55, 862-880.

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Lenssen E, James N, Pedruzzi I, Dubouloz F, Cameroni E, Bisig R, Maillet L, Werner M, Roosen J, Petrovic K, Winderickx J, Collart MA () & De Virgilio C () (2005). The Ccr4-Not complex independently controls both Msn2-dependent transcriptional activation – via a newly identified Glc7/Bud14 type I protein phosphatase module – and TFIID promoter distribution. Mol. Cell. Biol. 25, 488-498.

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2004

Cameroni E., Hulo N, Roosen J, Winderickx J & De Virgilio C () (2004). The novel yeast PAS kinase Rim15 orchestrates G0-associated antioxidant defense mechanisms. Cell Cycle 3, 462-468.

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2003

Pedruzzi I, Dubouloz F, Cameroni E, Wanke V, Roosen J, Winderickx J & De Virgilio C () (2003). TOR and PKA signaling pathways converge on the protein kinase Rim15 to control entry into G0. Mol. Cell 12,1607-1613.

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Faculty Opinions

2002

Lee PR, Song S, Ro HS, Park CJ, Lippincott J, Li R, Pringle JR, De Virgilio C, Longtine MS & Lee KS () (2002). Bni5p, a septin-interacting protein, is required for normal septin functionand cytokinesis in S. cerevisiae. Mol. Cell. Biol. 22, 6906-6920.

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Zaragoza O, De Virgilio C, Ponton J & Gancedo C () (2002). Disruption in Candida albicans of the TPS2 gene encoding trehalose-6-phosphate phosphatase affects cell integrity and decreases infectivity. Microbiol. 148, 1281-1290.

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Lenssen E, Oberholzer U, Labarre J, De Virgilio C. & Collart MA () (2002). Saccharomyces cerevisiae Ccr4-Not complex contributes to the control of Msn2-dependent transcription by the Ras/cAMP pathway. Mol. Microbiol. 43, 1023-1037.

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2001

Harkins HA, Pagé N, Schenkman LR, De Virgilio C, Shaw S, Bussey H & Pringle JR () (2001). Bud8p and Bud9p, proteins that may mark the sites for bipolar budding in yeast. Mol. Biol. Cell 12, 2497-2518.

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2000

Pedruzzi I, Bürckert N, Egger P & De Virgilio C () (2000). Saccharomyces cerevisiae Ras/cAMP pathway controls post-diauxic shift element-dependent transcription through the zinc finger protein Gis1. EMBO J. 19, 2569-2597.

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1999

Reinders A, Romano I, Wiemken A. & De Virgilio C () (1999). The thermophilic yeast Hansenula polymorpha does not require trehalose synthesis for growth at high temperatures but does for normal acquisition of thermotolerance. J. Bacteriol. 181, 4665-4668.

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1998

Bell W, Sun W, Hohmann S, Wera S, Reinders A, De Virgilio C, Wiemken A & Thevelein J () (1998). Composition and functional analysis of the Saccharomyces cerevisiae trehalose synthase complex. J. Biol. Chem. 273, 33311-33319.

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Hochstrasser U, Lüscher M, De Virgilio C, Boller T & Wiemken A () (1998). Expression of a functional barley sucrose-fructan 6-fructosyltransferase in the methylotrophic yeast Pichia pastoris. FEBS Lett. 440, 356-360.

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Reinders A, Bürckert N, Boller T, Wiemken A & De Virgilio C () (1998). Saccharomyces cerevisiae cAMP-dependent protein kinase controls entry into stationary phase through the Rim15p protein kinase. Genes & Dev. 12, 2943-2955.

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1997

DeMarini DJ, Adams AEM, Fares H, De Virgilio C, Valle G, Chuang JS & Pringle JR () (1997). A septin-based hierachy of proteins required for localized deposition of chitin in the Saccharomyces cerevisiae cell wall. J. Cell Biol. 139, 75-93.

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Ribeiro MJS, Reinders A, Boller T. Wiemken A & De Virgilio C () (1997). Trehalose synthesis is important for the acquisition of thermotolerance in Schizosaccharomyces pombe. Mol. Microbiol. 25, 571-582.

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Reinders A, Bürckert N, Hohmann S, Thevelein JM, Boller, Wiemken A & De Virgilio C () (1997). Structural analysis of the subunits of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae and their function during heat shock. Mol. Microbiol. 24, 687-695.

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1996

De Virgilio C, DeMarini DJ & Pringle JR () (1996). SPR28, a sixth member of the septin gene family in Saccharomyces cerevisiae that is expressed specifically in sporulating cells. Microbiol. 142, 2897-2905.

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Longtine MS., DeMarini DJ, Valencik ML, Al-Awar OS, Fares H, De Virgilio C. & Pringle JR () (1996). The septins: roles in cytokinesis and other processes. Curr. Opin. Cell. Biol. 8, 106-119.

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1995

Pringle JR (), Bi E, Harkins HA, Zahner J, De Virgilio C, Chant J, Corrado K & Fares H (1995). Establishment of cell polarity in yeast. Cold Spring Harbor Symp. Quant. Biol. 60, 729-744.

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Stevenson BJ, Ferguson B, De Virgilio C, Bi E, Pringl JR, Ammerer G & Sprague Jr. GF () (1995). Mutation of RGA1, which encodes a putative GTPase-activating protein for the polarity-establishment protein Cdc42p, activates the pheromone-response pathway in the yeast Saccharomyces cerevisiae. Genes & Dev. 9, 2949-2963.

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Simon MN, De Virgilio C, Souza B, Pringle JR, Abo A & Reed SI () (1995). Role for the Rho-family GTPase Cdc42p in yeast mating pheromone signal pathway. Nature 376, 702-705.

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Cvrcková F, De Virgilio C, Manser E, Pringle JR & Nasmyth K () (1995). Ste20-like protein kinases are required for localized cell growth and cytokinesis in budding yeast. Genes & Dev. 9, 1817-1830.

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1994

Hottiger T (), De Virgilio C, Hall MN, Boller T & Wiemken A (1994). The role of trehalose synthesis for the acquisition of thermotolerance in yeast. II. Physiological concentrations of trehalose increase the thermal stability of proteins in vitro. Eur. J. Biochem. 219, 187-193.

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De Virgilio C, Hottiger T, Dominguez J, Boller T. & Wiemken A () (1994). The role of trehalose synthesis for the acquisition of thermotolerance in yeast. I. Genetic evidence that trehalose is a thermoprotectant. Eur. J. Biochem. 219, 179-186.

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1993

Steensma HY, Barth G & De Virgilio C(1993). Genetic and physical localization of the acetyl-coenzyme A ynthetase gene ACS1, on chromosome I of Saccharomyces cerevisiae. Yeast 9, 419-421.

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De Virgilio C, Bürckert N, Bell W, Boller T & Wiemken A () (1993). Disruption of TPS2, the gene encoding the 100-kDa subunit of the trehalose-6-phosphate synthase/phosphatase complex in Saccharomyces cerevisiae, causes accumulation of trehalose-6-phosphate and loss of trehalose-6-phosphate phosphatase activity. Eur. J. Biochem. 212, 315-323.

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De Virgilio C, Bürckert N, Neuhaus, JM, Boller T & Wiemken A () (1993). CNE1, a Saccharomyces cerevisiae homologue of the genes encoding mammalian calnexin and calreticulin. Yeast 9, 185-188.

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1992

De Virgilio C, Bürckert N, Barth G, Neuhaus JM, Boller T  & Wiemken A () (1992). Cloning and disruption of a gene required for growth on acetate but not on ethanol: the acetyl-coenzyme A synthetase gene of Saccharomyces cerevisiae. Yeast 8, 1043-1051.

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Hottiger T, De Virgilio C, Bell W, Boller T & Wiemken A () (1992). The 70-kilodalton heat-shock proteins of the SSA subfamily negatively modulate heat-shock-induced accumulation of trehalose and promote recovery from heat stress in the yeast, Saccharomyces cerevisiae. Eur. J. Biochem. 210, 125-132.

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1991

De Virgilio C, Bürckert N, Boller T & Wiemken A () (1991). A method to study the rapid phosphorylation-related modulation of neutral trehalase activity by temperature shifts in yeast. FEBS Lett. 291, 355-358.

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De Virgilio C, Piper P, Boller T & Wiemken A () (1991). Acquisition of thermotolerance in Saccharomyces cerevisiae without heat shock protein hsp104 and in the absence of protein synthesis. FEBS Lett. 288, 86-90.

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De Virgilio C, Müller J, Boller T & Wiemken A () (1991). A constitutive, heat shock-activated neutral trehalase occurs in Schizosaccharomyces pombe in addition to the sporulation-specific acid trehalase. FEMS Microbiol. Lett. 84, 85-90.

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1990

De Virgilio C, Simmen U., Hottiger T, Boller T & Wiemken A () (1990). Heat shock induces enzymes of trehalose metabolism, trehalose accumulation, and thermotolerance in Schizosaccharomyces pombe, even in the presence of cycloheximide. FEBS Lett. 273, 107-110.

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