U. Albrecht publications

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Brenna, M. Borsa, G. Saro, J.A. Ripperger, D. Glauser, Z. Yang, A. Adamantidis, and U. Albrecht. Cyclin-dependent kinase 5 (Cdk5) activity is modulated by light and gates rapid phase shifts of the circadian clock. eLife, in press, 2024.

Mansingh, G. Maier, J. Delezie, P. Westermark, D. Ritz, W. Duchemin, G. Santos, B. Karrer-Cardel, S. A. Steurer, U. Albrecht, and C. Handschin. More than the clock: distinct regulation of muscle function and metabolism by PER2 and RORα. J. Physiol., in press, 2024. http://doi.org/10.1113/JP285585

J. A. Ripperger and U. Albrecht. Chronobiologie: Die zirkadiane Uhr und das Verhalten. BIOspektrum, 30: 1, 58-60, 2024.https://rdcu.be/dyFff



Z. Peng, P.G. Ziros, T. Martini, X.-H. Liao, R. Stoop, S. Refetoff, U. Albrecht, G.P. Sykiotis, and S Kellenberger. ASIC1a affects hypothalamic signaling and regulates the daily rhythm of body temperature in mice. Comm. Biol., 6: 857, 2023.pdf

K.S. Wendrich, H. Azimi, J.A. Ripperger, Y. Ravussin, G. Rainer, and U. Albrecht. Deletion of the circadian clock gene Per2 in the whole body, but not in neurons or astroglia, affects sleep in response to sleep deprivation. Clocks & Sleep, 5, 204-225, 2023.pdf

U. Albrecht. The circadian system and mood related behavior in mice. Adv. Prot. Chem. & Struct. Biol., in press, 2023.pdf



I. Olejniczak, B. Campbell, Y.-C. Tsai, S.K. Tayagaraian, U. Albrecht, J.A. Rippberger. Suprachiasmatic to paraventricular nuclei interaction generates normal food searching rhythms in mice. Front. Physiol., 13: 909795, 2022.pdf

J. A. Ripperger, R. Chavan, U. Albrecht, and A. Brenna. Physical interaction between cyclin-dependent kinase 5 (CDK5) and clock factors affects the circadain rhythmicity in peripheral oscillators. Clocks & Sleep, 4, 185-201, 2022.pdf

U. Albrecht. 'Mutational scanning of the CLOCKΔ19 domain identifies amino acids modulating circadian clock dynamics and co-regulator binding'. Acta Physiol., e13794, 2022.pdf



A. Brenna, J. A. Ripperger, G. Saro, D. Glauser, Z. Yang, and U. Albrecht. 'PER2 mediates CREB-dependent light induction of the clock gene Per1'. Scientific Rep.,11: 21766, 2021. pdf

T. Martini, J. A. Ripperger, J. Stalin, A. Kores, M. Stumpe, and U. Albrecht. 'Deletion of the clock gene Period2 (Per2) in glial cells alters mood-related behavior in mice'. Scientific Rep., 11: 12242, 2021.pdf

I. Olejniczak, J. A. Ripperger, F. Sandrelli, A. Schnell, L. Mansencal-Strittmatter, K. Wendrich, K.-Y. Hui, A. Brenna, N. Ben Fredj, and U. Albrecht. 'Light affects behavioral despair involving the clock gene Period1'. PLoS Genet., 17(7): e1009625.pdf

T. Martini, J.A. Ripperger, R. Chavan, M. Stumpe, C. Netzahualcoyotzi, L. Pellerin, U. Albrecht. 'The hepatic monocarboxylate transporter 1 (MCT1) contributes to the regulation of food anticipation in mice'. Front. Physiol., 12: 665476, 2021.pdf



A. Brenna and U. Albrecht. 'Phosphorylation and Circadian Molecular Timing'. Front. Physiol., 11: 612510, 2020.pdf

T. Amano, J.A. Ripperger, U. Albrecht. 'Changing the light schedule in late pregnancy alters birth timing in mice'. Theoriogenology, 154: 212-222, 2020.pdf

U. Albrecht. ‘Molecular Connections Between Circadian Clocks and Mood Related Behaviors’. J. Mol. Biol., 432, 3714-3721, 2020. pdf



Brenna, I. Olejniczak, R. Chavan, J.A. Ripperger, S. Langmesser, E. Cameroni, Z. Hu, C. De Virgilio, J. Dengjel, and U. Albrecht. “Cyclin dependent kinase 5 (CDK5) regulates the circadian clock”. eLife, 8: e50925, 2019. pdf

C.R. Cederroth, U. Albrecht, J. Bass, S.A. Brown, J. Dyhrfjeld-Johnsen, F. Gachon, C.B. Green, M.H. Hastings, C. Helfrich-Förster, J. B. Hogenesch, F. Lévi, A. Loudon, G.B. Lundkvist, J. H. Meijer, M. Rosbash, J.S. Takahashi, M. Young, and B. Canlon. ‘Medicine in the fourth dimension’. Cell Metabol., 30: 238-250, 2019. pdf

A. de Juan, L. Ince, R. Pick, C. Chen, F. Molica, G. Zuchtriegel, C. Wang, D. Zhang, D. Druzd, M. Hessenauer, G. Pelli, I. Kolbe, H. Oster, C. Prophete, S. Hergenhan, U. Albrecht, J.A. Ripperger, E. Montanez, C. Reichel, O. Soehnlein, B. Kwak, P. Frenette, and C. Scheiermann. ‘Artery-associated sympathetic innervation drives rhythmic vascular inflammation of arteries and veins’. Circulation, 140: 1100-1114, 2019. pdf

H. Gerber, S. Mosser, B. Boury-Jamot, M. Stumpe, A. Piersigilli, C. Goepfert, J. Dengjel, U. Albrecht, F. Magara and P. C. Fraering. "The APMAP interactome reveals new modulators of APP processing and betaamyloid production that are altered in Alzheimer’s disease". Acta Neuropathologica Communications, 7:13, 2019. pdf



T. Martini, J. A. Ripperger and U. Albrecht. "Measuring Food Anticipation in Mice". Clocks & sleeppdf

U. Albrecht, J.A. Ripperger. "Circadian Clocks and Sleep: Impact of Rhythmic Metabolism and Waste Clearance on the Brain". Cell Press, 41: 677-688, 2018. pdf

K. Schmitt, A. Grimm, R. Dallmann, B. Oettinghaus, L.M. Restelli, M. Witzig, N. Ishihara, K. Mihara, J.A. Ripperger, U. Albrecht, S. Frank, S.A. Brown, A. Eckert. "Circadian control of DRP1 activity regulates mitochondrial dynamics and bioenergetics". Cell Metab., 27: 657-666, 2018.pdf

M.S. Stieglitz, S. Fenske, V. Hammelmann, E. Becirovic, V. Schöttle, J.E. Delorme, M. Schöll-Weidinger, R. Mader, J. Deussing, D.P. Wolfer, M.W. Seeliger, U. Albrecht, C.T. Wotjak, M. Biel, S. Michalakis, C. Wahl-Schott. "Disturbed processing of contextual information in HCN3 channel deficient mice". Front. Mol. Neurosci., 10: article 436, 2018. pdf

K. Richter, I. Schmutz, M. Darna, A. Piech, U. Albrecht, G. Ahnert-Hilger. "VGLUT isoform-specific binding to endocytic scaffolding proteins: The VGLUT1/endophilin interaction correlates with daily rhythms". Neuroscience, 371: 29-37, 2018. pdf



C. Xu, A. Messina, E. Somm, H. Miraoui, T. Kinnunen, J. Acierno, N. J. Niederländer, J. Bouilly, A. A. Dwyer, Y. Sidis, D. Cassatella, G. P. Sykiotis, R. Quinton, C. De Geyter, M. Dirlewanger, V. Schwitzgebel, T. R. Cole, A. A. Toogood, J. M. W. Kirk, L. Plummer, U. Albrecht, W. F. Crowley, M. Mohammadi, M. Tena-Sempere, V. Prevot, N. Pitteloud. "KLB, encoding β-Klotho, is mutated in patients with congenital hypogonadotropic hypogonadism". EMBO Molecular Medicine, 9: 1379-1397, 2017.  e201607376 (DOI: 10.15252/emmm.201607376). pdf

E. Somm, H. Henry, S.J. Bruce, S. Aeby, M. Rosikiewicz, G.P. Sykiotis, M. Asrih, F.R. Jornayvaz, P.D. Denechaud, U. Albrecht, M. Mohammadi, A. Dwyer, J.S. Acierno, K. Schoonjans, L. Fajas, G. Greub, N. Pitteloud. "Beta-Klotho deficiency protects against obesity through a crosstalk between liver, microbiota, and brown adipose tissue". JCI insight, 2 (8):e91809, 2017. pdf

R. Chavan, U. Albrecht and T Okabe. "Circadian clocks, metabolism and food-entrained rhythms" chap. 20 in "Biological Timekeeping: Clocks, Rhythms and Behaviour" ed. V. Kumar, pp 427-442, 2017, Springer (India). pdf

U. Albrecht. "The circadian clock, metabolism and obesity". Obesity Reviews, 18 (Suppl. 1), 25-33, 2017. pdf 

U. Albrecht. "Molecular mechanisms in mood regulation involving the circadian clock". Front. Neurol. 8: article 30, 2017. pdf

R. Chavan, N. Preitner, T. Okabe, L. Mansencal Strittmatter, C. Xu, J. A. Ripperger, N. Pitteloud and U. Albrecht. "REV-ERBα regulates Fgf21 expression in the liver via hepatic nuclear factor 6". Biol. Open, 6: 1-7 (online doi: 10.1242/bio.021519) 2017. pdf


T. Okabe, R. Chavan, S.S. Fonseca Costa, A. Brenna, J. A. Ripperger, and U. Albrecht. "REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor." J. Cell Sci., 129:4143-4154, 2016 (online doi: 10.1242/jcs.190959) pdf

R. Chavan, C.A. Feillet, S.S Fonseca Costa, J.E. Delorme, T. Okabe, J.A. Ripperger, and U. Albrecht. "Liver-derived ketone bodies are necessary for food anticipation". Nature Comm., 7: 10580, 2016. pdf

G.M. Mang, F. La Spada, Y. Emmenegger, S. Chappuis, J.A. Ripperger, U. Albrecht and P. Franken. "Altered sleep homeostasis in Rev-erba knockout mice". Sleep, 39: 589-601, 2016. pdf


C.A. Feillet, C. Bainier, M. Mateo, D. Clesse, J.A. Ripperger, E. Challet, U. Albrecht and J. Mendoza. "REV-ERB-alpha regulates the orexigenic system to influence pleasurable feeding behaviors in mice". Addiction Biol. (online doi:10.1111/adb.12339) 2015.

A. Schnell, F. Sandrelli, V. Ranc, E. Brai, L. Alberi, G. Rainer, and U. Albrecht. "Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment". Chronobiol. Int., 32: 1075-1089, 2015. pdf

L. Bee, S. Marini, G. Pontarin, P. Ferraro, R. Costa, U. Albrecht and L. Celotti. "Nucleotide excision repair efficiency in quiescent human fibroblasts is under control of the circadian clock". Nucl. Acids Res., 43: 2126-2137, 2015. pdf

M.C. Magnone, S. Langmesser, A. Bezdek, T. Tallone, S. Rusconi, and U. Albrecht. "The mammalian circadian clock gene Per2 modulates cell death in response to oxidative stress". Front. Neurol., 5: 289, 2015.  pdf


U. Albrecht. "Circadian clock, reward and addictive behavior". In: Circadian Medicine. Editor: C. Colwell, Whiley and Sons Inc., in press, 2014. 

I. Schmutz, R. Chavan, J.A. Ripperger, E.S. Maywood, N. Langwieser, A. Jurik, A. Stauffer, J.E. Delorme, S. Moosmang, M.H. Hastings, F. Hofmann and U. Albrecht. "A specific role for the REV-ERBa controlled L-type voltage gated calcium channel Cav1.2 in resetting the circadian clock in the late night". J. Biol. Rhythms, 29: 288-298, 2014. pdf

A. Schnell, S. Chappuis, I. Schmutz, E. Brai, J.A. Ripperger, O. Schaad, H. Welzl, P. Descombes, L. Alberi and U. Albrecht. "The nuclear receptor REV-ERBa regulates Fabp7 and modulates adult hippocampal neurogenesis". PLoS One, 9: 6, e99883, 2014. pdf

A. Schnell, U. Albrecht and F. Sandrelli. "Rhythm and Mood: Relationship between the circadian clock and mood-related behavior". Behav. Neurosci., 128: 326-343, 2014. pdf


M. Aramendy, S. Seibert, P. Treppmann, K. Richter, G. Ahnert-Hilger and U. Albrecht. "Synaptophysin is involved in resetting of the mammalian circadian clock". J. Circ. Rhythms, 11: 11 (doi:10.1186/1740-3391-11-11), 2013. pdf

F. Zani, L. Breasson, B. Becattini, A. Vukolic, J.P. Montani, U. Albrecht, A. Provenzani, J.A. Ripperger and G. Solinas. "PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and GL expression". Mol. Metab., 2, 292-305, 2013. pdf

S. Chappuis, J.A. Ripperger, A. Schnell, G. Rando, C. Jud, W. Wahli and U. Albrecht. "Role of the circadian clock gene Per2 in adaptation to cold temperature". Mol. Metab., 2, 184-193, 2013. pdf

A. Erzberger, G. Hampp, A. Granada, U. Albrecht and H. Herzel. "Genetic redundancy strengthens the circadian clock leading to a narrow entrainment range". J. R. Soc. Interface, 10: 20130221, 2013. pdf

U. Albrecht. "Circadian clocks and mood-related behaviors". Handbook of Exp. Pharmacol., 217, 227-239, 2013. pdf

E. Kowalska, J.A. Ripperger, D.C. Hoegger, P. Bruegger, T. Buch, T. Birchler, A. Mueller, U. Albrecht, C. Contaldo, and S.A. Brown. "NONO couples the circadian clock to the cell cycle". Proc. Natl. Acad. Sci. USA, 110, 1592-1599, 2013. pdf


J.M. Carvas, A. Vukolic, G. Yepuri, Y. Xiong, K. Popp, I. Schmutz, S. Chappuis, U. Albrecht, X. Ming, J.P. Montani, Z. Yang. "Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis". Front. Physiol., 3, 337, 2012. pdf

J.A. Ripperger and U. Albrecht. "The circadian clock component PERIOD2: From molecular to cerebral functions" Eds. A. Kalsbeek, M. Merrow, T. Roenneberg and R.G. Foster. Prog. Brain Res., 199, 233-245, 2012. pdf

J.A. Ripperger and U. Albrecht. "REV-ERB-erating nuclear receptor function in circadian metabolism and physiology". Cell Research, 22: 1319-1321, 2012. pdf

U. Albrecht. "Timing to perfection: The biology of central and peripheral circadian clocks". Neuron, 74: 246-260, 2012. pdf

D. Jeyaraj, F.A.J.L. Scheer, J.A. Ripperger, S.M. Haldar, Y. Lu, D.A. Prosdocimo, S.J. Eapen, B.L. Eapen, Y. Cui, G.H. Mahabeleshwar, H. Lee, M.A. Smith, G. Casadesus, E.M. Mintz, H. Sun, Y. Wang, K.M. Ramsey, J. Bass, S.A. Shea, U. Albrecht, M.K. Jain. "Klf15 orchestrates circadian nitrogen homeostasis". Cell Metabol., 15: 311-323, 2012. pdf

D. Jeyaraj, S.M. Haldar, X. Wan, M.D. McCauley, J.A. Ripperger, K. Hu, Y. Lu, B.L. Eapen, N. Sharma, E. Ficker, M.J. Cutler, J. Gulick, A. Sanbe, J. Robbins, S. Demolombe, R. V. Kondratov, S.A. Shea, U. Albrecht, X.H.T. Wehrens, D.S. Rosenbaum, M.K. Jain. "Circadian rhythms govern cardiac repolarization and arrhythmogenesis". Nature, 483: 96-99, 2012. pdf

U. Albrecht. "Circadian Rhythms and Sleep - The Metabolic Connection". Pflug. Arch.- Eur. J. Physiol., 463, 23-30, 2012. pdf

I. Schmutz, U. Albrecht, and J.A. Ripperger. "The role of clock genes and rhythmicity in the liver". Mol. Cell. Endocrinol., 349, 38-44, 2012. pdf


P. Janich, G. Pascual, A. Merlos, E. Batlle, J. Ripperger, U. Albrecht, H.M. Cheng, K. Obrietan, L. Di Croce, and S. Aznar Benitah. "The circadian molecular clock creates epidermal stem cell heterogeneity". Nature, 480, 209-214, 2011. pdf

U. Albrecht. "The Circadian Clock, Reward and Memory". Front. Mol. Neurosci., 4, 41, 2011. pdf

I. Schmutz, S. Wendt, A. Schnell, A. Kramer, I. M. Mansuy, and U. Albrecht. "Protein phosphatase 1 (PP1) is a post-translational regulator of the mammalian circadian clock". PLoS One, 6: 6, e21325, 2011. pdf

L. Dong, A. Bilbao, M. Laucht, R. Henriksson, T. Yakovleva, M. Ridinger, S. Desrivieres, T. Clarke, A. Lourdusamy, M.N. Smolka, S, Cichon, D. Blomeyer, J. Treutlein, S. Perreau-Lenz, S. Witt, F. Leonardi-Essmann, N. Wodarz, P. Zill, M. Soyka, U. Albrecht, M. Rietschel, M. Lathrop, G. Bakalkin, R. Spanagel, G. Schumann. "The circadian rhythm gene Period1 is associated with psychosocial stress-induced alcohol drinking". Am. J. Psychiatry, 168, 1090-1098, 2011. pdf

J.A. Ripperger, C. Jud and U. Albrecht. The daily rhythm of mice. FEBS Lett., 585, 1384-1392, 2011. pdf

S. Daan, K. Spoelstra, U. Albrecht, I. Schmutz, M. Daan, B. Daan, F. Rienks, I. Poletaeva, G. dell'Omo, A. Vyssotski and H.P. Lipp. "Lab mice in the field: unorthodox daily activity and effects of a dysfunctional circadian clock allele". J. Biol. Rhythms, 26, 118-129, 2011. pdf


C. Jud, A. Hayoz and U. Albrecht. "High amplitude phase resetting in Rev-erba/Per1 double mutant mice". PLoS One, 5:9, e12540, 2010. pdf

E. Maronde, A. Schilling, S. Seitz, T. Schinke, I. Schmutz, G. van der Horst, M. Amling and U. Albrecht. "The clock genes Period 2 and Cryptochrome 2 differentially balance bone formation". PLoS One, 5:7, e11527, 2010. pdf

A. Dollet, U. Albrecht, H.M. Cooper, O. Dkhissi-Benyahya. "Cones are required for normal temporal responses to light of phase shifts and clock gene expression". Chronobiol. Int., 27: 768-781, 2010. pdf

J. Ripperger, I. Schmutz and U. Albrecht. "PERsuading nuclear receptors to dance the circadian rhythm". Cell Cycle, 9: 2515-2521, 2010. pdf

U. Albrecht. "Circadian clocks in mood related behaviors". Ann. Med., 42, 241-251, 2010. pdf

J. Mendoza, U. Albrecht, E. Challet. "Behavioral food-anticipation in clock gene deficient mice: confirming old phenotypes, describing new phenotypes". Genes Brain Behav., 9: 467-477, 2010. pdf

V. Vukolic, V. Antic, B. Van Vliet, Z. Yang, U. Albrecht and J.-P. Montani. "Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythm". Am. J. Physiol. RegulIntegr. Comp. Physiol., 298: R627-R634, 2010. pdf

I. Schmutz, J. A. Ripperger, S. Baeriswyl-Aebischer and U. Albrecht. "The mammalian clock component PERIOD2 coordinates circadian output by interaction with nuclear receptors". Genes Dev., 24: 345-357, 2010. pdf

C. Dibner, U. Schibler and U. Albrecht. "The mammalian circadian timing system: organization and coordination of central and peripheral clocks". Annu. Rev. Physiol., 72, 517-549, 2010. pdf

C. A. Feillet and U. Albrecht. "Clocks, Brain Function and Dysfunction" in The Circadian Clock, U. Albrecht (Ed.), Springer, Berlin, Heidelberg, New York, Protein Reviews Series, Volume 12, 229-282, 2010. pdf

F. Stadler, I. Schmutz, B. Schwaller, and U. Albrecht. "Lack of calbindin-D28K alters response of the murine circadian clock to light". Chronobiol. Int.., 27: 68-82, 2010. pdf


C. Jud, S. Chappuis, V. L. Revell, T. L. Sletten, D.-J. Saaltink, C. Cajochen, D. J. Skeene and U. Albrecht. "Age-dependent alterations in human PER2 levels after early morning blue light exposure". Chronobiol. Int., 26:1462-1469, 2009. pdf 

L. Borgs, P. Beukelaers, R. Vandenbosch, L. Nguyen, G. Moonen, P. Maquet, U. Albrecht, S. Belachew and B. Malgrange. "Period 2 regulates neural stem/progenitor cell proliferation in the adult hippocampus". BMC Neurosci. 10: 30, 2009. pdf

R. Feil, S. M. Hölter, K. Weindl, W. Wurst, S. Langmesser, A. Gerling, S. Feil and U. Albrecht. "cGMP-dependent protein kinase I, the circadian clock, sleep and learning". Commun. Integr. Biol. 2:4, 1-4, 2009. pdf

M. Darna, I. Schmutz, K. Richter, S. V. Yelamanchili, G. Pendyala, M. Höltje, U. Albrecht, and G. Ahnert-Hilger. "Time-of-day dependent sorting of vesicular glutamate transporter to the plasma membrane". J. Biol. Chem. 284, 4300-4307, 2009. pdf

S. Langmesser, P. Franken, S. Feil, Y. Emmenegger, U. Albrecht and R. Feil. "cGMP-dependent protein kinase type I is implicated in the regulation of the timing and quality of sleep and wakefulness". PLoS One 4: 1, e4238, 2009. pdf


J. Zhang, Z. Fang, C. Jud, M. J. Vansteensel, K. Kaasik, C. C. Lee, U. Albrecht, F. Tamanini, J. H. Meijer, B. A. Oostra, D. L. Nelson. Fragile X related proteins regulate mammalian circadian behavioral rhythms. Am. J. Hum. Genet., 83: 43-52, 2008. pdf

S. Langmesser, T. Tallone, A. Bordon, S. Rusconi, U. Albrecht. Interaction of circadian clock proteins PER2 and CRY with BMAL1 and CLOCK. BMC Mol. Biol., 9: 41, 2008. pdf

G. Hampp and U. Albrecht. The circadian clock and mood-related behavior. Commun. Integr. Biol., 1, 1-3, 2008. pdf

G. Hampp, J. A. Ripperger, T. Houben, I. Schmutz, C. Blex, S. Perrau-Lenz, I. Brunk, R. Spanagel, G. Ahnert-Hilger, J. Meijer, U. Albrecht. Regulation of the murine monoamine oxidase A gene by circadian clock components implies clock influence on mood. Curr. Biol., 18, 678-683, 2008. pdf

U. Albrecht and J. A. Ripperger.   Clock Genes. In: Binder, M.D, Hirokawa, N, Windhorst, U (eds). Encyclopedia of Neuroscience. Springer, Berlin Heidelberg New York (in press), 2008. pdf

J. A. Ripperger and U. Albrecht. Clock-Controlled   Genes. In: Binder, M.D, Hirokawa, N, Windhorst, U (eds). Encyclopedia of Neuroscience. Springer, Berlin Heidelberg New York (in press), 2008. pdf

C.A. Feillet, J. Mendoza, U. Albrecht, P. Pevet, E. Challet. Forebrain oscillators ticking with different clock hands. Mol. Cell. Neurosci., 37, 209-221, 2008. pdf


U. Albrecht, A. Bordon, I. Schmutz and J. Ripperger. "The multiple facets of Per2". Cold Spring Harbor Symposia on Quantitative Biology, Volume LXXII, 95-104, 2007. pdf

X. M. Li, B. Claustrat,   M. H. Hastings, U. Albrecht, F. Levi. "Interactions between clock gene mutation, circadian phenotype and tumor growth in mice". Pathol. Biol. (Paris), 55, 194-197, 2007. pdf

U. Albrecht "Per2 has time on its side", Nat. Chem. Biol., 3, 139-140, 2007. pdf

H. Viswambharan, J. M. Carvas, V. Antic, A. Marecic, C. Jud, C. Zaugg, X.-F.Ming, J.-P. Montani, U. Albrecht and Z. Yang. "Disruption of the circadian Per2 gene alters vascular endothelial function". Circulation, 115, 2188-2195, 2007. pdf

M.A. Farre-Castany, B. Schwaller, P. Gregory, J. Barski, C. Mariethoz, J. Erikson, I.V. Tetko, D. Wolfer, M.R. Celio, I. Schmutz, U. Albrecht, A.E.P. Villa. "Differences in locomotor behavior revealed in mice deficient for the calcium-binding proteins parvalbumin, calbindin-D28k or both", Behav. Brain Res., 178, 250-261, 2007. pdf

T. Zghoul, C. Abarca, C. Sanchis-Segura, U. Albrecht, G. Schumann and R. Spanagel. “Ethanol Self-Administration and Reinstatement of Ethanol-Seeking Behavior in Per1 Mutant Mice”. Psychopharmacology, 190, 13-19, 2007. pdf


U. Albrecht "Orchestration of Gene Expression and Physiology by the Circadian Clock". J. Physiol. (Paris), 100, 243-251, 2006. pdf

C.A. Feillet, U. Albrecht and E. Challet . "Feeding time   for the brain : a matter of clocks". J. Physiol. (Paris), 100, 252-260, 2006. pdf

C.A. Feillet, J. Ripperger, M.C. Magnone, A. Dulloo, U. Albrecht and E. Challet. “Lack of food anticipation in Per2 mutant mice”. Curr. Biol., 16, 2016-2022, 2006. pdf

U. Albrecht “Molecular orchestration of the hepatic circadian symphony”. Genome Biol., 7, 234, 2006. pdf

S.V. Yelamanchili, G. Pendyala, I. Brunk, M. Darna, U. Albrecht and G. Ahnert-Hilger. “Differential sorting of the vesicular glutamate transporter 1 into a defined vesicular pool is regulated by light signaling involving the clock gene Period 2”. J. Biol. Chem., 281: 15671-15679, 2006. pdf

D. Abraham, R. Dallmann, S. Steinlechner, U. Albrecht, G. Eichele and H. Oster. “Restoration of circadian rhythmicity in circadian clock deficient mice in constant light”. J. Biol. Rhythms, 21, 169-176, 2006. pdf

R. Dallmann, C. Touma, R. Palme, U. Albrecht, S. Steinlechner. “Impaired daily glucocorticoid rhythm in Per1Brd and Per2Brd mice”. J. Comp. Physiol. A, 192, 769-775, 2006. pdf

C. Jud and U. Albrecht. “Circadian rhythms in murine pups develop in absence of a functional maternal circadian clock”. J. Biol. Rhythms, 21, 149-154, 2006. pdf

C. Cajochen, C. Jud, M. Münch, S. Kobialka, A. Wirz-Justice and U. Albrecht. “Evening exposure to blue light stimulates the expression of the clock gene PER2 in humans”. Eur. J. Neurosci., 23: 1082-1086, 2006. pdf

S. Langmesser and U. Albrecht “Life time – circadian clocks, mitochondria and metabolism” Chronobiol. Int., 23: 151-157, 2006. pdf


S.A. Brown, F. Fleury-Olela, E. Nagoshi, C. Hauser, C. Juge, C.A. Meier, R. Chicheportiche, J.-M. Dayer, U. Albrecht and  U. Schibler. "The period length of fibroblast circadian gene expression varies widely among human individuals". PLoS Biol. 3 (10), e338, 2005. pdf

M.J. Vansteensel, M.C. Magnone, F. van Oosterhout, S. Baeriswyl, U. Albrecht, H. Albus, A. Dahan and J.H. Meijer. "The opioid fentanyl affects light input, electrical activity and Per gene expression in the hamster suprachiasmatic nuclei". Eur. J. Neurosci., 21: 2958-2966, 2005. pdf

R. Spanagel, G. Pendyala, C. Abarca, T. Zghoul, C. Sanchis-Segura, M. C. Magnone, J. Lascorz, M. Depner, D. Holzberg, M. Soyka, S. Schreiber, F. Matsuda, M. Lathrop, G. Schumann and U. Albrecht. "The clock gene Period2 influences the glutamatergic system and thereby modulates alcohol consumption". Nat. Med., 11, 35-42, 2005. pdf

M.C. Magnone, B. Jacobmeier, C. Bertolucci, A. Foà and U. Albrecht. 'Circadian expression of the clock gene Per2 is altered in the ruin lizard (Podarcis sicula) when temperature changes'. Mol. Brain Res., 133, 281-285, 2005. pdf


U. Albrecht "Human molecular chronotyping in sight?". Genome Biol., 5, 246, 2004.  pdf

K.Spoelstra, U. Albrecht, G. T. J. van der Horst, V. Brauer and S.Daan. 'Phase responses to light pulses in mice lacking functional per or cry genes'. J. Biol. Rhythms, 19, 518-529, 2004. pdf

A. Avivi, H. Oster, A. Joel, A. Beiles, U. Albrecht and E. Nevo. "Circadian Genes in a Blind Subterranean Mammal III: Molecular Cloning and Circadian Regulation of Cryptochrome Genes in the Blind Subterranean Mole Rat, Spalax ehrenbergi Superspecies". J. Biol. Rhythms, 19, 22-34, 2004. pdf


U. Albrecht and G. Eichele. "The circadian clock". Curr. Opin. Gen. Dev., 13, 271-277, 2003. pdf

U. Abraham, U. Albrecht and R. Brandstätter. "Hypothalamic circadian organization in birds. II clock gene expression". Chronobiol. Int., 20, 657-669, 2003. pdf

H. Oster, G.T.J. van der Horst and U. Albrecht. "Daily variation of clock output gene activation in behaviorally arrhythmic mPer/mCry triple mutant mice". Chronobiol. Int., 20, 683-695, 2003. pdf

H. Oster, S. Baeriswyl, G.T.J. van der Horst and U. Albrecht. "Loss of circadian rhythmicity in aging mPer1-/-mCry2-/- mutant mice". Genes Dev., 17, 1366-1379, 2003. pdf

H. Oster, C. Werner, M.C. Magnone, H. Mayser, R. Feil, M.W. Seeliger, F. Hofmann and U. Albrecht. "cGMP-dependent protein kinase II alters mPer1 and mPer2 gene induction and influences phase shifts of the circadian clock". Curr. Biol., 13, 725-733, 2003. pdf


U. Albrecht and R.G. Foster. "Placing ocular mutants into a functional context: a chronobiological approach". Methods, 28, 465-477, 2002. pdf

H. Oster, A. Avivi, A. Joel, U. Albrecht and E. Nevo. "A switch from diurnal to nocturnal activity in the mole rat Spalax ehrenbergi superspecies is accompanied by an uncoupling of the ligth input and the circadian clock". Curr. Biol., 12, 1919-1922, 2002.  pdf

C. Kopp, U. Albrecht, B. Zheng and I. Tobler. "Homeostatic sleep regulation is preserved in mPer1 and mPer2 mutant mice". Eur. J. Neurosci., 16, 1099-1106, 2002.pdf

H. Oster, A. Yasui, G.T.J. van der Horst and U. Albrecht. "Disruption of mCry2 restores circadian rhythmicity in mPer2 mutant mice". Genes Dev. 16, 2633-2638, 2002. pdf

U. Abraham, U. Albrecht, E. Gwinner and R. Brandstätter. "Spatial and temporal variation of passerPer2 gene expression in the suprachiasmatic hypothalamus of the house sparrow (Passer domesticus)".Eur. J. Neurosci. 16, 429-436, 2002.pdf

A. Avivi, H. Oster, A. Joel, A. Beiles, U. Albrecht and E. Nevo. "Circadian genes in a blind subterranean mammal II: Conservation and uniqueness of the three Period homologs in the blind subterranean mole rat, Spalax ehrenbergi". Proc. Natl. Acad. Sci., 99, 11718-11723, 2002. pdf

N. Preitner, F. Damiola, L. Lopez-Molina, J. Zakany, D. Duboule, U. Albrecht and U. Schibler. "The orphan nuclear receptor rev-erba controls circadian transcription within the positive limb of the mammalian circadian oscillator". Cell 110, 251-260, 2002. pdf

C. Abarca, U. Albrecht and R. Spanagel. "Cocaine sensitization and reward are under the influence of circadian genes and rhythm". Proc. Natl. Acad. Sci., 99, 9026-9030, 2002. pdf

U. Albrecht. "Regulation of mammalian circadian clock genes". J. Appl. Physiol., 92, 1348-1355, 2002. pdf

S. Steinlechner, B. Jacobmeier, F. Scherbarth, H. Dernbach, F. Kruse and U. Albrecht "Robust circadian rhythmicity of Per1 and Per2 mutant mice in constant light and dynamics of Per1 and Per2 gene expression under long and short photoperiods". J. Biol. Rhythms, 202-209, 2002. pdf

D. Motzkus, U. Albrecht and E. Maronde. "The human PER1 gene is inducible by interleukin-6". J. Mol. Neurosci., 18, 105-109, 2002. pdf


A. Avivi, U. Albrecht, H. Oster, A. Joel, A. Beiles and E. Nevo. Biological clock in total darkness: The Clock/Mop3 circadian system of the blind subterranean mole rat. Proc. Natl. Acad. Sci., 98, 13751-13756, 2001 pdf

U. Albrecht and H. Oster. The circadian clock and behavior.Behav. Brain Res., 125, 89-91, 2001 pdf

U. AlbrechtCircadian rhythms: A fine c(l)ocktail. Curr. Biol., 11, R517-R519, 2001 pdf

B. Zheng, U. Albrecht, K. Kaasik, M. Sage, W. Lu, S. Vaishnav, Q. Li, Z.S. Sun, G. Eichele, A. Bradley and C.C. Lee. Non-redundant roles of the mPer1 and mPer2 genes in the mammalian circadian clock. Cell, 105, 683-694, 2001. pdf

H. De Leersnyder, M.C. De Blois, B. Claustrat, S. Romana, U. Albrecht, J.C. von Kleist.REtzow, B. Delobel, G. Viot, S. Lyonnet, M. Vekemans and A. Munnich. Inversion of the cricadian rhythm of melatonin in the Smith-Magenis syndrome. J. Pediatr., 139, 111-116, 2001. pdf

R. Brandstätter, U. Abraham and U. AlbrechtInitial demonstration of rhythmic Per gene expression in the hypothalamus of a non-mammalian vertebrate, the house sparrow. NeuroReport, 12, 1167-1170, 2001. pdf

U. Albrecht, B. Zheng, D. Larkin, Z.S. Sun and C.C. Lee. mPer1 and mPer2 genes are essential components for normal resetting of the circadian clock. J. Biol. Rhythms, 16, 100-104, 2001. pdf

S. Daan, U. Albrecht, G.T.J. van der Horst, H. Illnerova, T. Roenneberg, T.A. Wehr and W.J. Schwartz. Assembling a clock for all seasons: are there M and E oscillators in the genes? J. Biol. Rhythms, 16, 105-116, 2001. pdf


D. Motzkus, E. Maronde, U. Grunenberg, C.C. Lee, W.-G. Forssmann and U. AlbrechtThe human PER1 gene is transcriptionally regulated by multiple signalling pathways. FEBS Lett., 486, 315-319, 2000. pdf


B. Zheng, D.W. Larkin, U. Albrecht, Z.S. Sun, M. Sage, G. Eichele, C.C. Lee and A. Bradley. The mPer2 gene encodes a functional component of the mammalian circadian clockNature, 400, 169-173, 1999. pdf



U. Albrecht, Z.S. Sun, G. Eichele and  C. C. Lee. A differential response of two putative mammalian circadian regulators, mper1 and mper2, to light. Cell 91, 1055-1064, 1997. pdf

Z. S. Sun, U. Albrecht, O. Zhuchenko, J. Bailey, G. Eichele and C. C. Lee. RIGUI, a putative mammalian ortholog of the Drosophila period gene. Cell 90, 1003-1011, 1997. pdf