Jürgen Ripperger



 +41 26 300 8674

Group leader; molecular biologist; co-responable person for the TPs; radiation safety officier

Research and publications

  • Publications for Jürgen A. Ripperger, PhD

    Hui KY, Ripperger JA (2018) The circadian clock and the aging process. In: Conn’s handbook of models for human aging, Editors: Ram JL, Conn PM; Elsevier, London UK: 1067-1102

    Schmitt K, Grimm A, Dallmann R, Oettinghaus B, Restelli LM, Witzig M, Ishihara N, Mihara K, Ripperger JA, Albrecht U, Frank S, Brown SA, Eckert A (2018) Circadian Control of DRP1 Activity Regulates Mitochondrial Dynamics and Bioenergetics. Cell Metabolism 27: 657-666.

    Fonseca Costa SS, Wegmann D, Ripperger JA (2017) Normalisation against circadian and age-related disturbances enables robust detection of gene expression in liver of aged mice. PLoS ONE 12: e0169615.

    Fonseca Costa SS, Ripperger JA (2016) Internal normalisation of nascent RNA sequencing experiments to identify age-related changes of the mouse liver transcriptome. Genomics and Computational Biology 3: e34.

    Klemz R, Reischl S, Wallach T, Witte N, Jürchott K, Klemz S, Lang V, Lorenzen S, Knauer M, Heidenreich S, Xu M, Ripperger JA, Schupp M, Stanewsky R, Kramer A (2017) Reciprocal regulation of carbon monoxide metabolism and the circadian clock. Nature Structural & Molecular Biology 24: 15-22.

    Okabe T, Chavan R, Fonseca Costa SS, Brenna A, Ripperger JA, Albrecht U (2016) REV-ERBalpha influences stability and nuclear localization of the glucocorticoid receptor. Journal of Cell Science, DOI: 10.1242/jcs.190959.

    Chavan R, Feillet C, Costa SS, Delorme JE, Okabe T, Ripperger JA, Albrecht U (2016) Liver-derived ketone bodies are necessary for food anticipation. Nature Communications 7: 10580.

    Mang GM, La Spada F, Emmenegger Y, Chappuis S, Ripperger JA, Albrecht U, Franken P (2016) Altered Sleep Homeostasis in Rev-erbalpha Knockout Mice. Sleep 39: 589-601.

    Fonseca Costa SS, Ripperger JA (2015) Impact of the circadian clock on the aging process. Front Neurol 6: 43.

    Hui KY, Ripperger JA (2015) Grab the wiggly tail: new insights into the dynamics of circadian clocks. Nature Structural & Molecular Biology 22: 435-436.

    Schnell A, Sandrelli F, Ranc V, Ripperger JA, Brai E, Alberi L, Rainer G, Albrecht U (2015) Mice lacking circadian clock components display different mood-related behaviors and do not respond uniformly to chronic lithium treatment. Chronobiology International 32: 1075-1089.

    Feillet CA, Bainier C, Mateo M, Blancas-Velazquez A, Salaberry NL, Ripperger JA, Albrecht U, Mendoza J (2015) Rev-erbalpha modulates the hypothalamic orexinergic system to influence pleasurable feeding behaviour in mice. Addiction Biology, doi:10.1111/adb.12339.

    Schnell A, Chappuis S, Schmutz I, Brai E, Ripperger JA, Schaad O, Welzl H, Descombes P, Alberi L, Albrecht U (2014) The nuclear receptor REV-ERBalpha regulates Fabp7 and modulates adult hippocampal neurogenesis. PLoS One 9: e99883.

    Schmutz I, Chavan R, Ripperger JA, Maywood ES, Langwieser N, Jurik A, Stauffer A, Delorme JE, Moosmang S, Hastings MH, Hofmann F, Albrecht U (2014) A specific role for the REV-ERBalpha-controlled L-Type Voltage-Gated Calcium Channel CaV1.2 in resetting the circadian clock in the late night. Journal of Biological Rhythms 29: 288-298.

    Kowalska E, Ripperger JA, Hoegger DC, Bruegger P, Buch T, Birchler T, Mueller A, Albrecht U, Contaldo C, Brown SA (2013) NONO couples the circadian clock to the cell cycle. Proc Natl Acad Sci U S A 110: 1592-1599.

    Chappuis S, Ripperger JA, Schnell A, Rando G, Jud C, Wahli W, Albrecht U (2013) Role of the circadian clock gene Per2 in adaptation to cold temperature. Mol Metab 2: 184-193.

    Zani F, Breasson L, Becattini B, Vukolic A, Montani JP, Albrecht U, Provenzani A, Ripperger JA, Solinas G (2013) PER2 promotes glucose storage to liver glycogen during feeding and acute fasting by inducing Gys2 PTG and G L expression. Mol Metab 2: 292-305.

    Schmutz I, Albrecht U, Ripperger JA (2012) The role of clock genes and rhythmicity in the liver. Mol Cell Endocrinol 349: 38-44.

    Ripperger JA, Albrecht U (2012) The circadian clock component PERIOD2: from molecular to cerebral functions. Prog Brain Res 199: 233-245.

    Ripperger JA, Albrecht U (2012) REV-ERB-erating nuclear receptor functions in circadian metabolism and physiology. Cell Res 22: 1319-1321.

    Jeyaraj D, Haldar SM, Wan X, McCauley MD, Ripperger JA, Hu K, Lu Y, Eapen BL, Sharma N, Ficker E, Cutler MJ, Gulick J, Sanbe A, Robbins J, Demolombe S, Kondratov RV, Shea SA, Albrecht U, Wehrens XH, Rosenbaum DS, Jain MK (2012) Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature 483: 96-99.

    Jeyaraj D, Scheer FA, Ripperger JA, Haldar SM, Lu Y, Prosdocimo DA, Eapen SJ, Eapen BL, Cui Y, Mahabeleshwar GH, Lee HG, Smith MA, Casadesus G, Mintz EM, Sun H, Wang Y, Ramsey KM, Bass J, Shea SA, Albrecht U, Jain MK. (2012) Klf15 orchestrates circadian nitrogen homeostasis. Cell Metabolism 15: 311-323.

    Kowalska E, Ripperger JA, Muheim C, Maier B, Kurihara Y, Fox AH, Kramer A, Brown SA (2012) Distinct roles of DBHS family members in the circadian transcriptional feedback loop. Mol Cell Biol 32: 4585-4594.

    Janich P, Pascual G, Merlos-Suarez A, Batlle E, Ripperger JA, Albrecht U, Cheng HY, Obrietan K, Di Croce L, Benitah SA (2011) The circadian molecular clock creates epidermal stem cell heterogeneity. Nature 480: 209-214.

    Ukai-Tadenuma M, Yamada RG, Xu H, Ripperger JA, Liu AC, Ueda HR (2011) Delay in feedback repression by cryptochrome 1 is required for circadian clock function. Cell 144: 268-281.

    Ripperger JA, Jud C, Albrecht U (2011) The daily rhythm of mice. FEBS Lett 585: 1384-1392.

    Ripperger JA, Merrow M (2011) Perfect timing: epigenetic regulation of the circadian clock. FEBS Lett 585: 1406-1411.