Publications Photonic Nanosystems group


Selected Publications

 P. Acuna, F.M. Möller, P. Holzmeister, S. Beater, B. Lalkens and P. Tinnefeld, “Fluorescence Enhancement at Docking Sites of DNA-Directed Self-Assembled Nanoantennas”, Science, 338, pp. 506-510 (2012).

This work was highlighted in Nature Methods, “Dye shines bright”, Nature Chemistry, “Assembling nanoantennas” and Physik Journal, “Fokussieren mit Gold”. Selected for the Faculty of 1000.


P. Acuna, M. Bucher, I.H. Stein, C. Steinhauer, A. Kuzyk, P. Holzmeister, R. Schreiber, A. Moroz, F.D. Stefani, T. Liedl, F.C. Simmel, P. Tinnefeld, “Distance dependence of Single-Fluorophore Quenching by Gold Nanoparticles studied on DNA Origami”, ACS Nano, 6, pp. 3189-3195 (2012).

 Puchkova, C. Vietz, E. Pibiri, B. Wünsch, M. Sanz Paz, G. P. Acuna, P. Tinnefeld, “DNA Origami Nanoantennas with over 5000fold Fluorescence Enhancement and Single-Molecule Detection at 25 μM”, Nano Letters, 15 pp. 8354 (2015).


 Raab, C. Vietz, F. Stefani, G. P. Acuna, P Tinnefeld, “Single-Molecule Mirage: shifted molecular coupling in a single molecule-mirage”, Nat. Comm., 8 pp. 13966 (2017).

 Vietz, I. Kaminska, M. Sanz Paz, P. Tinnefeld, G. P. Acuna, “Broadband Fluorescence Enhancement with Self-Assembled Silver Nanoparticle Optical Antennas”, ACS Nano, 11 pp. 4969 (2017).

 For a full list of past publications please follow the following  link:
 

 

2023

  • Super‐Resolved FRET Imaging by Confocal Fluorescence‐Lifetime Single‐Molecule Localization Microscopy
    C Zaza, G Chiarelli, LP Zweifel, M Pilo‐Pais, E Sisamakis, F Barachati, ...
    Small Methods, 2201565 2023

 

  • Localización de molécula única mediante el escaneo de un mínimo de intensidad
    F Edorna, L Masullo, A Szalai, L Lopez, M Pilo-Pais, G Acuna, F Stefani
    Libro de Resúmenes XXIII CAFQI 2023

 

  • Fabrication of 3D Oriented MOF Micropatterns with Anisotropic Fluorescent Properties
    MJ Velásquez‐Hernández, M Linares‐Moreau, LA Brandner, B Marmiroli, ...
    Advanced Materials, 2211478 3 2023

 

  • Ultrasensitive and multiplexed miRNA detection system with DNA-PAINT
    S Kocabey, G Chiarelli, GP Acuna, C Ruegg
    Biosensors and Bioelectronics 224, 115053 2 2023

 

  • DNA origami assembled nanoantennas for manipulating single-molecule spectral emission
    M Sanz-Paz, F Zhu, N Bruder, K Kołątaj, AI Fernández-Domínguez, ...
    Nano Letters 2023

 

  • Gold nanorod DNA origami antennas for 3 orders of magnitude fluorescence enhancement in NIR
    K Trofymchuk, K Kołątaj, V Glembockyte, F Zhu, GP Acuna, T Liedl, ...
    ACS nano 17 (2), 1327-1334 5 2023

 

 

2022

  • Nanometer resolution imaging and tracking of single fluorophores by sequential structured illumination
    P Zdankowski, LF Lopez, GP Acuna, FD Stefani
    ACS Photonics 9 (12), 3777-3785 2 2022

 

  • Reconfigurable chirality with achiral excitonic materials in the strong-coupling regime
    PE Stamatopoulou, S Droulias, GP Acuna, NA Mortensen, C Tserkezis
    Nanoscale 14 (47), 17581-17588 5 2022

 

  • DNA origami book biosensor for multiplex detection of cancer-associated nucleic acids
    I Domljanovic, M Loretan, S Kempter, GP Acuna, S Kocabey, C Ruegg
    Nanoscale 14 (41), 15432-15441 3 2022

 

  • DNA-Templated Ultracompact Optical Antennas for Unidirectional Single-Molecule Emission
    F Zhu, M Sanz-Paz, AI Fernández-Domínguez, X Zhuo, LM Liz-Marzán, ...
    Nano Letters 2022

  • DNA self-assembly of single molecules with deterministic position and orientation
    AK Adamczyk, TAPM Huijben, M Sison, A di Luca, G Chiarelli, S Vanni, ...
    arXiv preprint arXiv:2207.06472 2022

  • An alternative to MINFLUX that enables nanometer resolution in a confocal microscope
    LA Masullo, AM Szalai, LF Lopez, M Pilo-Pais, GP Acuna, FD Stefani
    Light: Science & Applications 11 (1), 1-9 1 2022

  • Unidirectional ultracompact DNA-templated optical antennas
    F Zhu, M Sanz-Paz, A Fernandez-Dominguez, X Zhuo, LM Liz-Marzan, ...
    arXiv preprint arXiv:2204.03604 2022

  • Optical ultracompact directional antenna based on a dimer nanorod structure
    F Zhu, M Sanz-Paz, A Fernandez-Dominguez, M Pilo-Pais, GP Acuna
    arXiv preprint arXiv:2204.02347 1 2022

  • Correction: An alternative to MINFLUX that enables nanometer resolution in a confocal microscope
    LA Masullo, AM Szalai, LF Lopez, M Pilo-Pais, GP Acuna, FD Stefani
    Light, Science & Applications 11 2022

 

2021

  • Watching single unmodified enzymes at work
    C Ying, E Karakaci, E Bermudez-Urena, A Ianiro, C Foster, S Awasthi, ...
    arXiv preprint arXiv:2107.06407 2021

  • Determining the in-plane orientation and binding mode of single fluorescent dyes in DNA origami structures
    K Hübner, H Joshi, A Aksimentiev, FD Stefani, P Tinnefeld, GP Acuna
    ACS nano 15 (3), 5109-5117 2021

  • Addressable nanoantennas with cleared hotspots for single-molecule detection on a portable smartphone microscope
    K Trofymchuk, V Glembockyte, L Grabenhorst, F Steiner, C Vietz, C Close, ...
    Nature communications 12 (1), 1-8 2021

  • Nanoscale Advances
    GP Acuna, D Garoli
    2021

  • Three-dimensional total-internal reflection fluorescence nanoscopy with nanometric axial resolution by photometric localization of single molecules
    AM Szalai, B Siarry, J Lukin, DJ Williamson, N Unsain, A Cáceres, ...
    Nature communications 12 (1), 1-13 2021

  • Recent advances in plasmonic nanocavities for single-molecule spectroscopy
    N Maccaferri, G Barbillon, AN Koya, G Lu, GP Acuna, D Garoli
    Nanoscale Advances 3 (3), 633-642 2021

 

 

2020

  • In Situ Photothermal Response of Single Gold Nanoparticles through Hyperspectral Imaging Anti-Stokes Thermometry
    M Barella, IL Violi, J Gargiulo, LP Martinez, F Goschin, V Guglielmotti, ...
    ACS nano 15 (2), 2458-2467 2020

  • Self-Assembled Nanoparticle Optical Antennas
    K Trofymchuk, GP Acuna, V Glembockyte, P Tinnefeld
    21st Century Nanoscience–A Handbook, 8-1-8-14 2020

  • Self-Assembled Plasmonic DNA Origami Nanoantennas for Diagnostics Applications with Low-Tech Devices
    K Trofymchuk, V Glembockyte, L Grabenhorst, C Close, M Pfeiffer, ...
    2020

  • DNA origami as emerging technology for the engineering of fluorescent and plasmonic-based biosensors
    M Loretan, I Domljanovic, M Lakatos, C Rüegg, GP Acuna
    Materials 13 (9), 2185 2020

  • Three-dimensional total-internal reflection fluorescence nanoscopy with nanometric axial resolution by photometric localization of single molecules
    AM Szalai, B Siarry, J Lukin, DJ Williamson, N Unsain, D Refojo, ...
    bioRxiv, 693994

 

 
 
 

2019

  • Directing single-molecule emission with DNA origami-assembled optical antennas
    K Hübner, M Pilo-Pais, F Selbach, T Liedl, P Tinnefeld, FD Stefani, ...
    Nano Letters 19 (9), 6629-6634 2019

  • Distance dependence of single-molecule energy transfer to graphene measured with DNA origami nanopositioners
    I Kaminska, J Bohlen, S Rocchetti, F Selbach, GP Acuna, P Tinnefeld
    Nano Letters 19 (7), 4257-4262 2019

  • DNA‐Mediated Self‐Assembly of Plasmonic Antennas with a Single Quantum Dot in the Hot Spot
    F Nicoli, T Zhang, K Hübner, B Jin, F Selbach, G Acuna, C Argyropoulos, ...
    Small 15 (26), 1804418 2019

  • DNA origami nanotools for single-molecule biosensing and superresolution microscopy
    P Tinnefeld, GP Acuna, Q Wei, A Ozcan, C Vietz, B Lalkens, K Trofymchuk, ...
    Optical Manipulation and Its Applications, AW5E. 5 2019

  • Benchmarking smartphone fluorescence-based microscopy with DNA origami nanobeads: reducing the gap toward single-molecule sensitivity
    C Vietz, ML Schütte, Q Wei, L Richter, B Lalkens, A Ozcan, P Tinnefeld, ...
    ACS omega 4 (1), 637-642 2019

  • Plasmon-assisted Förster resonance energy transfer at the single-molecule level in the moderate quenching regime
    J Bohlen, Á Cuartero-González, E Pibiri, D Ruhlandt, ...
    Nanoscale 11 (16), 7674-7681

 

 

 

2015 
 DNA Origami Nanoantennas with over 5000fold Fluorescence Enhancement and Single-Molecule Detection at 25 µM 
      A. PuchkovaC.VietzE. PibiriB. WuenschM. Sanz PazG. P. AcunaP. Tinnefeld (2015): -
      -> see pdf    Nano.Letters   2015  15(12), pp8354-8359

   

      P. Holzmeister, E.Pibiri, J.J. Schmied, T. Sen, G.P. Acuna*, P. Tinnefeld(2014)

      -> see pdf    Nature Communications, 5:5356

 

  • Controlled reduction of photobleaching in DNA origami – gold nanoparticle hybrids

      J.V. Pellegrotti, G.P. Acuna*, A. Puchkova, P. Holzmeister, A. Gietl, B. Lalkens, F. Stefani, P. Tinnefeld (2014): 

      -> see pdf   Nano.Letters, 14(5), 2831-2836

 

  • Single-Molecule Positioning in Zeromode Waveguides by DNA Origami Nano-Adapters 

      E. Pibiri, P. Holzmeister, B. Lalkens, G.P. Acuna*, P. Tinnefled (2014):

      -> see pdf   Nano.Letters,14(6), 3499–3503

 

  • Breaking the Concentration Limit of Optical Single -Molecule Detection 

      Holzmeister, G. P. Acuna, D. Grohmann, P. Tinnefeld (2014): 

      -> see pdf   Chem.Soc.Rev., 43(4), 1014-1028 (issue back cover)

  

  • Placing Individual Molecules in the Center of Nanoapertures

      S. Heucke, F. Baumann, G.P. Acuna, P.M.D. Severin, S.W. Stahl, M. Strackharn, I.H. Stein, P. Altpeter, P. Tinnefeld,

      H.E. Gaub (2014):

     -> see pdf     Nano Lettres, 14(2), 391-395

 

2013

 Distance Control in-between Plasmonic Nanoparticles via Biological and Polymeric Spacers 

      X. Yu, D.Y. Lei, F. Amin, R. Hartmann, G.P. Acuna, A. Guerreo-Martinez, S.A. Maier, P. Tinnefeld,

      S. Carregal-Romero, W.J. Parak (2013): 

     -> see pdf    Nano Today, 8 (5), 480-493

 

  • Angular Modulation of Single-Molecule Fluorescence by Gold Nanoparticles on DNA Origami Templates

     F.M. Möller, P. Holzmeister, T. Sen, G.P. Acuna*, P. Tinnefeld (2013): -

    -> see pdf    Nanophotonics, 2(3), 167-172

 

  • DNA-Templated Nanoantennas for Single-Molecule Detection at Elevated Concentrations 

      G.P. Acuna*, P. Holzmeister, F.M. Möller, S. Beater, B. Lalkens, P. Tinnefeld (2013): 

      -> see pdf   Proc. SPIE 8595, online

 

 2012

  Fluorescence Enhancement at Docking Sites of DNA-Directed Self-Assembled Nanoantennas

       G.P. Acuna*, F.M. Möller, P. Holzmeister, S. Beater, B. Lalkens and P. Tinnefeld (2012):

       -> see pdf   Science, 338(6106): 506-510

  

  •  Distance Dependence of Single-Fluorophore Quenching by Gold Nanoparticles studied on DNA Origami

       G.P. Acuna*, M. Bucher, I.H. Stein, C. Steinhauer, A. Kuzyk, P. Holzmeister, R. Schreiber, A. Moroz, F.D. Stefani,

       T. Liedl, F.C. Simmel, P. Tinnefeld (2012):

        -> see pdf    CS Nano, 6, 4, 3189-3195

 

 

 

American Chemical Society, Chemistry for Life ®