Recherche et publications

• Publication list
  163 publications

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  Multiple forms of balancing selection maintain inversion polymorphism
  Paris, Margot, Mitchell, Esra Durmaz, Kerdaffrec, Envel, Rubin, Doriane, Spichtig, Cecile, Zurbriggen, Felicitas, Becker, Joel, Augustijnen, Hannah, Thyagarajan, Harshavardhan, Zinn, Eliane, Gagliardi, Fanny, Gobet, Elliot, Rey, Tristan, Rime, Yvan, Machado, Sofia Ribeiro, Bachmann, Jeremias, Sgammeglia, Noemi, Schmidt, Paul, Flatt, Thomas, Heredity (2026) | Article

  A Balanced Inversion Polymorphism Exhibits a Dominance Reversal at the Gene Expression Level that Depends on Developmental Context
  Esra Durmaz Mitchell, Envel Kerdaffrec, Paul Schmidt, Thomas Flatt, Sebastian Kittelmann, John Parsch, Molecular Biology and Evolution (2025) | Article

  Continent-wide differentiation of fitness traits and patterns of climate adaptation among European populations of Drosophila melanogaster
  Esra Durmaz Mitchell, Thomas Flatt (2025) | Autre

  From whole bodies to single cells: A guide to transcriptomic approaches for ecology and evolutionary biology
  Hoedjes, Katja M., Grath, Sonja, Posnien, Nico, Ritchie, Michael G., Schloetterer, Christian, Abbott, Jessica K., Almudi, Isabel, Coronado-Zamora, Marta, Mitchell, Esra Durmaz, Flatt, Thomas, Fricke, Claudia, Glaser-Schmitt, Amanda, Gonzalez, Josefa, Holman, Luke, Kankare, Maaria, Lenhart, Benedict, Orengo, Dorcas J., Snook, Rhonda R., Yilmaz, Vera M., Yusuf, Leeban, Molecular Ecology (2025) | Article

  Footprints of Worldwide Adaptation in Structured Populations of Drosophila melanogaster Through the Expanded DEST 2.0 Genomic Resource
  Nunez, Joaquin C. B., Coronado-Zamora, Marta, Gautier, Mathieu, Kapun, Martin, Steindl, Sonja, Ometto, Lino, Hoedjes, Katja, Beets, Julia, Wiberg, R. Axel W., Mazzeo, Giovanni R., Bass, David J., Radionov, Denys, Kozeretska, Iryna, Zinchenko, Mariia, Protsenko, Oleksandra, Serga, Svitlana V., Amor-Jimenez, Cristina, Casillas, Sonia, Sanchez-Gracia, Alejandro, Patenkovic, Aleksandra, Glaser-Schmitt, Amanda, Barbadilla, Antonio, Buendia-Ruiz, Antonio J., Bertelli, Astra Clelia, Kiss, Balazs, Sebnem Oender, Banu, Roldan Matrin, Belen, Wertheim, Bregje, Deschamps, Candice, Arboleda-Bustos, Carlos E., Tinedo, Carlos, Feller, Christian, Schloetterer, Christian, Lawler, Clancy, Fricke, Claudia, Vieira, Cristina P., Vieira, Cristina, Obbard, Darren J., Juana Orengo, Dorcas, Vela, Doris, Amat, Eduardo, Loreto, Elgion, Kerdaffrec, Envel, Durmaz Mitchell, Esra, Puerma, Eva, Staubach, Fabian, Florencia Camus, M., Colinet, Herve, Hrcek, Jan, Givskov Sorensen, Jesper, Abbott, Jessica, Torro, Joan, Parsch, John, Vieira, Jorge, Luis Olmo, Jose, Khfif, Khalid, Wojciechowski, Krzysztof, Madi-Ravazzi, Lilian, Kankare, Maaria, Schou, Mads F., Ladoukakis, Emmanuel D., Gomez-Julian, M. Josefa, Espinosa-Jimenez, M. Luisa, Garcia Guerreiro, Maria Pilar, Parakatselaki, Maria-Eleni, Savic Veselinovic, Marija, Tanaskovic, Marija, Stamenkovic-Radak, Marina, Paris, Margot, Pascual, Marta, Ritchie, Michael G., Rera, Michel, Jelic, Mihailo, Hojat Ansari, Mina, Rakic, Mina, Merenciano, Miriam, Hernandes, Natalia, Gora, Nazar, Rode, Nicolas, Rota-Stabelli, Omar, Sepulveda, Paloma, Gibert, Patricia, Carazo, Pau, Kohlmeier, Pinar, Erickson, Priscilla A., Vitalis, Renaud, Roberto Torres, Jorge, Guirao-Rico, Sara, Ramos-Onsins, Sebastian E., Castillo, Silvana, Paulo, Tania F., Tyukmaeva, Venera, Alonso, Zahara, Alatortsev, Vladimir E., Pasyukova, Elena, Mukha, Dmitry V., Petrov, Dmitri A., Schmidt, Paul, Flatt, Thomas, Bergland, Alan O., Gonzalez, Josefa, Molecular Biology and Evolution (2025) | Article

  The remoulding of dietary effects on the fecundity / longevity trade-off in a social insect
  Rau, Veronika, Flatt, Thomas, Korb, Judith, BMC Genomics (2023) | Article

  An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation
  Kapun, Martin, Mitchell, Esra Durmaz, Kawecki, Tadeusz J, Schmidt, Paul, Flatt, Thomas, BioRxiv (2023) | Article

  An Ancestral Balanced Inversion Polymorphism Confers Global Adaptation
  Kapun, Martin, Mitchell, Esra Durmaz, Kawecki, Tadeusz J., Schmidt, Paul, Flatt, Thomas, Molecular Biology and Evolution (2023) | Article

  How chromosomal inversions reorient the evolutionary process
  Berdan, Emma L., Barton, Nicholas H., Butlin, Roger, Charlesworth, Brian, Faria, Rui, Fragata, Ines, Gilbert, Kimberly J., Jay, Paul, Kapun, Martin, Lotterhos, Katie E., Merot, Claire, Mitchell, Esra Durmaz, Pascual, Marta, Peichel, Catherine L., Rafajlovic, Marina, Westram, Anja M., Schaeffer, Stephen W., Johannesson, Kerstin, Flatt, Thomas, Journal of Evolutionary Biology (2023) | Article

  Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans
  Santos, Josiane, Matos, Margarida, Flatt, Thomas, Chelo, Ivo M., Ecology and Evolution (2023) | Article

  Germline proliferation trades off with lipid metabolism in Drosophila
  Rodrigues, Marisa A., Dauphin-Villemant, Chantal, Paris, Margot, Kapun, Martin, Mitchell, Esra Durmaz, Kerdaffrec, Envel, Flatt, Thomas, Evolution Letters (2023) | Article

  A Single Nucleotide Variant in the PPAR gamma-homolog Eip75B Affects Fecundity in Drosophila
  Hoedjes, Katja M., Kostic, Hristina, Flatt, Thomas, Keller, Laurent, Molecular Biology and Evolution (2023) | Article

  Genomic architecture of supergenes: connecting form and function
  Berdan, Emma L., Flatt, Thomas, Kozak, Genevieve M., Lotterhos, Katie E., Wielstra, Ben, Philosophical Transactions of the Royal Society B: Biological Sciences (2022) | Article

  The Biology of Aging in Insects: From Drosophila to Other Insects and Back
  Promislow, Daniel E. L., Flatt, Thomas, Bonduriansky, Russell, Annual Review of Entomology (2022) | Article

  Mutation accumulation opposes polymorphism: supergenes and the curious case of balanced lethals
  Berdan, Emma L., Blanckaert, Alexandre, Butlin, Roger K., Flatt, Thomas, Slotte, Tanja, Wielstra, Ben, Philosophical Transactions of the Royal Society B: Biological Sciences (2022) | Article

  Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity
  Hoedjes, K. M., Kostic, H., Keller, L., Flatt, T., BioRxiv (2022) | Article

  The rapid tempo of adaptation Selection in fruit flies leads to fast adaption to seasonal changes
  Hoffmann, Ary H., Flatt, Thomas, Science (2022) | Article

  Microbes are potential key players in the evolution of life histories and aging in Caenorhabditis elegans
  Santos, J., Matos, M., Flatt, T., Chelo, I. M., BioRxiv (2022) | Article

  Drosophila Evolution over Space and Time (DEST): a New Population Genomics Resource (vol 38, msab259, 2021)
  Kapun, Martin, Nunez, Joaquin C. B., Bogaerts-Marquez, Maria, Murga-Moreno, Jesus, Paris, Margot, Outten, Joseph, Coronado-Zamora, Marta, Tern, Courtney, Rota-Stabelli, Omar, Guerreiro, Maria P. Garcia, Casillas, Sonia, Orengo, Dorcas J., Puerma, Eva, Kankare, Maaria, Ometto, Lino, Loeschcke, Volker, Onder, Banu S., Abbott, Jessica K., Schaeffer, Stephen W., Rajpurohit, Subhash, Behrman, Emily L., Schou, Mads F., Merritt, Thomas J. S., Lazzaro, Brian P., Glaser-Schmitt, Amanda, Argyridou, Eliza, Staubach, Fabian, Wang, Yun, Tauber, Eran, Serga, Svitlana V., Fabian, Daniel K., Dyer, Kelly A., Wheat, Christopher W., Parsch, John, Grath, Sonja, Veselinovic, Marija Savic, Stamenkovic-Radak, Marina, Jelic, Mihailo, Buendia-Ruiz, Antonio J., Gomez-Julian, Maria Josefa, Espinosa-Jimenez, Maria Luisa, Gallardo-Jimenez, Francisco D., Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horvath, Vivien, Obbard, Darren J., Pasyukova, Elena, Alatortsev, Vladimir E., Vieira, Cristina P., Vieira, Jorge, Torres, Jorge Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M., Montchamp-Moreau, Catherine, Mukha, Dmitry V., Machado, Heather E., Lamb, Keric, Paulo, Tania, Yusuf, Leeban, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O., Molecular Biology and Evolution (2022) | Article

  Natural alleles at the Doa locus underpin evolutionary changes in Drosophila lifespan and fecundity
  Hoedjes, Katja M., Kostic, Hristina, Keller, Laurent, Flatt, Thomas, Proceedings of the Royal Society B: Biological Sciences (2022) | Article

  Supergene degeneration opposes polymorphism: The curious case of balanced lethals
  Emma Berdan and Alexandre Blanckaert and Roger K Butlin and Thomas Flatt and Tanja Slotte and Ben Wielstra , Cold Spring Harbor Laboratory (2021) | Autre

  Gene co-expression network reveals highly conserved, well-regulated anti-ageing mechanisms in old ant queens
  Mark C Harrison and Luisa M Jaimes Niño and Marisa Almeida Rodrigues and Judith Ryll and Thomas Flatt and Jan Oettler and Erich Bornberg-Bauer, Genome Biology and Evolution (2021) | Article

  Comparative transcriptomic analysis of the mechanisms underpinning ageing and fecundity in social insects
  Judith Korb and Karen Meusemann and Denise Aumer and Abel Bernadou and Daniel Elsner and Barbara Feldmeyer and Susanne Foitzik and Jürgen Heinze and Romain Libbrecht and Silu Lin and Megha Majoe and José Manuel Monroy Kuhn and Volker Nehring and Matteo A. Negroni and Robert J. Paxton and Alice C. Séguret and Marah Stoldt and Thomas Flatt and, Philosophical Transactions of the Royal Society B: Biological Sciences (2021) | Article

  The discovery, distribution and diversity of DNA viruses associated with Drosophila melanogaster in Europe
  Megan A Wallace and Kelsey A Coffman and Clément Gilbert and Sanjana Ravindran and Gregory F Albery and Jessica Abbott and Eliza Argyridou and Paola Bellosta and Andrea J Betancourt and Hervé Colinet and Katarina Eric and Amanda Glaser-Schmitt and Sonja Grath and Mihailo Jelic and Maaria Kankare and Iryna Kozeretska and Volker Loeschcke and Catherine Montchamp-Moreau and Lino Ometto and Banu Sebnem Onder and Dorcas J Orengo and John Parsch and Marta Pascual and Aleksandra Patenkovic and Eva Puerma and Michael G Ritchie and Omar Rota-Stabelli and Mads Fristrup Schou and Svitlana V Serga and Marina Stamenkovic-Radak and Marija Tanaskovic and Marija Savic Veselinovic and Jorge Vieira and Cristina P Vieira and Martin Kapun and Thomas Flatt and Josefa González and Fabian Staubach and Darren J Obbard, Virus Evolution (2021) | Article

  Note: Updating the metadata of four misidentified samples in the DrosRTEC dataset
  Joaquin C. B. Nunez, Margot Paris, Heather Machado, Maria Bogaerts, Josefa Gonzalez, Thomas Flatt, Marta Coronado, Martin Kapun, Paul Schmidt, Dmitri Petrov, Alan Bergland, (2021) | Prépublication

  Broad geographic sampling reveals the shared basis and environmental correlates of seasonal adaptation in Drosophila
  Machado, Heather E., Bergland, Alan O., Taylor, Ryan, Tilk, Susanne, Behrman, Emily, Dyer, Kelly, Fabian, Daniel K., Flatt, Thomas, Gonzalez, Josefa, Karasov, Talia L., Kim, Bernard, Kozeretska, Iryna, Lazzaro, Brian P., Merritt, Thomas J. S., Pool, John E., O'Brien, Katherine, Rajpurohit, Subhash, Roy, Paula R., Schaeffer, Stephen W., Serga, Svitlana, Schmidt, Paul, Petrov, Dmitri A., eLife (2021) | Article

  A single nucleotide variant in the PPARgamma-homolog Eip75B affects fecundity in Drosophila
  Hoedjes, K. M., Kostic, H., Flatt, T., Keller, L., BioRxiv (2021) | Article

  Gene co-expression network reveals highly conserved, well-regulated anti-ageing mechanisms in old ant queens
  Harrison, M. C., Jaimes Nino, L. M., Almeida Rodrigues, M., Ryll, J., Flatt, T., Oettler, J., Bornberg-Bauer, E., BioRxiv (2021) | Article

  On the fixation or nonfixation of inversions under epistatic selection
  Charlesworth, Brian, Flatt, Thomas, Molecular Ecology (2021) | Article

  Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster
  Betancourt, Nicolas J., Rajpurohit, Subhash, Durmaz, Esra, Fabian, Daniel K., Kapun, Martin, Flatt, Thomas, Schmidt, Paul, Molecular Ecology (2021) | Article

  Drosophila Evolution over Space and Time (DEST): A New Population Genomics Resource
  Kapun, Martin, Nunez, Joaquin C. B., Bogaerts-Marquez, Maria, Murga-Moreno, Jesus, Paris, Margot, Outten, Joseph, Coronado-Zamora, Marta, Tern, Courtney, Rota-Stabelli, Omar, Guerreiro, Maria P. Garcia, Casillas, Sonia, Orengo, Dorcas J., Puerma, Eva, Kankare, Maaria, Ometto, Lino, Loeschcke, Volker, Onder, Banu S., Abbott, Jessica K., Schaeffer, Stephen W., Rajpurohit, Subhash, Behrman, Emily L., Schou, Mads F., Merritt, Thomas J. S., Lazzaro, Brian P., Glaser-Schmitt, Amanda, Argyridou, Eliza, Staubach, Fabian, Wang, Yun, Tauber, Eran, Serga, Svitlana, V, Fabian, Daniel K., Dyer, Kelly A., Wheat, Christopher W., Parsch, John, Grath, Sonja, Veselinovic, Marija Savic, Stamenkovic-Radak, Marina, Jelic, Mihailo, Buendia-Ruiz, Antonio J., Gomez-Julian, Maria Josefa, Espinosa-Jimenez, Maria Luisa, Gallardo-Jimenez, Francisco D., Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horvath, Vivien, Obbard, Darren J., Pasyukova, Elena, Alatortsev, Vladimir E., Vieira, Cristina P., Vieira, Jorge, Torres, Jorge Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M., Montchamp-Moreau, Catherine, Mukha, Dmitry, V, Machado, Heather E., Lamb, Keric, Paulo, Tania, Yusuf, Leeban, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O., Molecular Biology and Evolution (2021) | Article

  Asymmetry, division of labour and the evolution of ageing in multicellular organisms
  Pen, Ido, Flatt, Thomas, Philosophical Transactions of the Royal Society B: Biological Sciences (2021) | Article

  Transcriptomic evidence for a trade-off between germline proliferation and immunity in Drosophila
  Rodrigues, Marisa A., Merckelbach, Antoine, Durmaz, Esra, Kerdaffrec, Envel, Flatt, Thomas, Evolution Letters (2021) | Article

  Drosophila Evolution over Space and Time (DEST)- A New Population Genomics Resource
  Kapun, M., Nunez, J. C. B., Bogaerts-Marquez, M., Murga-Moreno, J., Paris, M., Outten, J., Coronado-Zamora, M., Tern, C., Rota-Stabelli, O., Guerreiro, M. P. Garcia, Casillas, S., Orengo, D. J., Puerma, E., Kankare, M., Ometto, L., Loeschcke, V. V., Onder, B. S., Abbott, J. K., Schaeffer, S. W., Rajpurohit, S., Behrman, E. L., Schou, M. F., Merritt, T. J. S., Lazzaro, B. P. B., Glaser-Schmitt, A., Argyridou, E., Staubach, F., Wang, Y., Tauber, E., Serga, S. V., Fabian, D. K., Dyer, K. A., Wheat, C. W., Parsch, J., Grath, S., Veselinovic, M.Savic, Stamenkovic-Radak, M., Jelic, M., Buendia-Ruiz, Antonio J., Gomez-Julian, M. Josefa, Espinosa-Jimenez, M. Luisa, Gallardo-Jimenez, Francisco D, Patenkovic, Aleksandra, Eric, Katarina, Tanaskovic, Marija, Ullastres, Anna, Guio, Lain, Merenciano, Miriam, Guirao-Rico, Sara, Horvath, Vivien, Obbard, Darren J, Pasyukova, Elena, Alatortsev, Vladimir E, Vieira, Cristina P., Vieira, Jorge, Torres, J. Roberto, Kozeretska, Iryna, Maistrenko, Oleksandr M, Montchamp-Moreau, Catherine, Mukha, Dmitry V., Machado, Heather E, Paulo, Tania F, Barbadilla, Antonio, Petrov, Dmitri, Schmidt, Paul, Gonzalez, Josefa, Flatt, Thomas, Bergland, Alan O., BioRxiv (2021) | Article

  How Selection Acts on Chromosomal Inversions
  Esra Durmaz and Envel Kerdaffrec and Georgios Katsianis and Martin Kapun and Thomas Flatt , Wiley (2020) | Autre

  Genomic Analysis of European Drosophila melanogaster Populations Reveals Longitudinal Structure, Continent-Wide Selection, and Previously Unknown DNA Viruses
  Martin Kapun and Maite G Barrón and Fabian Staubach and Darren J Obbard and R Axel W Wiberg and Jorge Vieira and Clément Goubert and Omar Rota-Stabelli and Maaria Kankare and María Bogaerts-Márquez and Annabelle Haudry and Lena Waidele and Iryna Kozeretska and Elena G Pasyukova and Volker Loeschcke and Marta Pascual and Cristina P Vieira and Svitlana Serga and Catherine Montchamp-Moreau and Jessica Abbott and Patricia Gibert and Damiano Porcelli and Nico Posnien and Alejandro Sánchez-Gracia and Sonja Grath and Élio Sucena and Alan O Bergland and Maria Pilar Garcia Guerreiro and Banu Sebnem Onder and Eliza Argyridou and Lain Guio and Mads Fristrup Schou and Bart Deplancke and Cristina Vieira and Michael G Ritchie and Bas J Zwaan and Eran Tauber and Dorcas J Orengo and Eva Puerma and Montserrat Aguadé and Paul Schmidt and John Parsch and Andrea J Betancourt and Thomas Flatt and Josefa González, Molecular Biology and Evolution (2020) | Article

  Evolutionary genomics can improve prediction of species’ responses to climate change
  Ann-Marie Waldvogel and Barbara Feldmeyer and Gregor Rolshausen and Moises Exposito-Alonso and Christian Rellstab and Robert Kofler and Thomas Mock and Karl Schmid and Imke Schmitt and Thomas Bataillon and Outi Savolainen and Alan Bergland and Thomas Flatt and Frederic Guillaume and Markus Pfenninger, Evolution Letters (2020) | Article

  Life-History Evolution and the Genetics of Fitness Components in Drosophila melanogaster
  Flatt, Thomas, Genetics (2020) | Article

  Altering the Temporal Regulation of One Transcription Factor Drives Evolutionary Trade-Offs between Head Sensory Organs
  Ariane Ramaekers and Annelies Claeys and Martin Kapun and Emmanuèle Mouchel-Vielh and Delphine Potier and Simon Weinberger and Nicola Grillenzoni and Delphine Dardalhon-Cuménal and Jiekun Yan and Reinhard Wolf and Thomas Flatt and Erich Buchner and Bassem A. Hassan, Developmental Cell (2019) | Article

  The diversity of population responses to environmental change
  Fernando Colchero and Owen R. Jones and Dalia A. Conde and David Hodgson and Felix Zajitschek and Benedikt R. Schmidt and Aurelio F. Malo and Susan C. Alberts and Peter H. Becker and Sandra Bouwhuis and Anne M. Bronikowski and Kristel M. Vleeschouwer and Richard J. Delahay and Stefan Dummermuth and Eduardo Fernández-Duque and John Frisenvænge and Martin Hesselsøe and Sam Larson and Jean-Francois Lematre and Jennifer McDonald and David A.W. Miller and Colin ODonnell and Craig Packer and Becky E. Raboy and Chris J. Reading and Erik Wapstra and Henri Weimerskirch and Geoffrey M. While and Annette Baudisch and Thomas Flatt and Tim Coulson and Jean-Michel Gaillard, Ecology Letters (2019) | Article

  A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila
  Durmaz, E., Rajpurohit, S., Betancourt, N., Fabian, D. K., Kapun, M., Schmidt, P., Flatt, T., BioRxiv (2019) | Article

  How flies turn food into progeny Sex-optimal diets have different effects on gene expression in female and male flies
  Flatt, Thomas, eLife (2019) | Article

  Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly
  May, Christina M., van den Heuvel, Joost, Doroszuk, Agnieszka, Hoedjes, Katja M., Flatt, Thomas, Zwaan, Bas J., Journal of Evolutionary Biology (2019) | Article

  The adaptive significance of chromosomal inversion polymorphisms in Drosophila melanogaster
  Kapun, Martin, Flatt, Thomas, Molecular Ecology (2019) | Article

  A clinal polymorphism in the insulin signaling transcription factor foxo contributes to life-history adaptation in Drosophila*
  Durmaz, Esra, Rajpurohit, Subhash, Betancourt, Nicolas, Fabian, Daniel K., Kapun, Martin, Schmidt, Paul, Flatt, Thomas, Evolution (2019) | Article

  Distinct genomic signals of lifespan and life history evolution in response to postponed reproduction and larval diet in Drosophila
  Hoedjes, Katja M., van den Heuvel, Joost, Kapun, Martin, Keller, Laurent, Flatt, Thomas, Zwaan, Bas J., Evolution Letters (2019) | Article

  Broad geographic sampling reveals predictable, pervasive, and strong seasonal adaptation in Drosophila
  Heather Machado and Alan O. Bergland and Ryan Taylor and Susanne Tilk and Emily Behrman and Kelly Dyer and Daniel Fabian and Thomas Flatt and Josefa Gonzalez and Talia Karasov and Iryna Kozeretska and Brian P. Lazzaro and Thomas Merritt and John Pool and Katherine OBrien and Subhash Rajpurohit and Paula Roy and Stephen Schaeffer and Svitlana Serga and Paul Schmidt and Dmitri Petrov , Cold Spring Harbor Laboratory (2018) | Autre

  The interplay between immunity and aging in Drosophila [version 1; referees: 2 approved]
  Kathrin Garschall, Thomas Flatt, (2018) | Article

  Faculty of 1000 evaluation for Early-life inflammation, immune response and ageing.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Antimicrobial peptides extend lifespan in Drosophila.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Juvenile Hormone Suppresses Resistance to Infection in Mated Female Drosophila melanogaster.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Cellular immune defenses of Drosophila melanogaster.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for The Drosophila CD36 Homologue croquemort Is Required to Maintain Immune and Gut Homeostasis during Development and Aging.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Of flies, mice, and men: evolutionarily conserved tissue damage responses and aging.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Distinct Shifts in Microbiota Composition during Drosophila Aging Impair Intestinal Function and Drive Mortality.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Stochastic variation in the initial phase of bacterial infection predicts the probability of survival in D. melanogaster.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Preventing Age-Related Decline of Gut Compartmentalization Limits Microbiota Dysbiosis and Extends Lifespan.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Promoting Drp1-mediated mitochondrial fission in midlife prolongs healthy lifespan of Drosophila melanogaster.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for NF-κB Immunity in the Brain Determines Fly Lifespan in Healthy Aging and Age-Related Neurodegeneration.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Genome-Wide Gene Expression in relation to Age in Large Laboratory Cohorts of Drosophila melanogaster.
  Thomas Flatt, (2018) | Data set

  Faculty of 1000 evaluation for Mitochondrial peroxiredoxins are essential in regulating the relationship between Drosophila immunity and aging.
  Thomas Flatt, (2018) | Data set

  Evolution of longevity improves immunity in Drosophila
  Fabian, Daniel K., Garschall, Kathrin, Klepsatel, Peter, Santos-Matos, Goncalo, Sucena, Elio, Kapun, Martin, Lemaitre, Bruno, Schloetterer, Christian, Arking, Robert, Flatt, Thomas, Evolution Letters (2018) | Article

  Adaptation to developmental diet influences the response to selection on age at reproduction in the fruit fly
  May, T., van den Heuvel, J., Doroszuk, A., Hoedjes, K., Flatt, T., Zwaan, B., BioRxiv (2018) | Article

  Genomic analysis of European Drosophila melanogaster populations on a dense spatial scale reveals longitudinal population structure and continent-wide selection
  Kapun, M., Barron Aduriz, M. G., Staubach, F., Vieira, J., Obbard, D., Goubert, C., Rota Stabelli, O., Kankare, M., Haudry, A., Wiberg, R. A. W., Waidele, L., Kozeretska, I., Pasyukova, E., Loeschcke, V., Pascual, M., Vieira, C. P., Serga, S., Montchamp-Moreau, C., Abbott, J., Gibert, P., Porcelli, D., Posnien, N., Grath, S., Sucena, E., Bergland, A., Garcia Guerreiro, M. P., Onder, B. S., Argyridou, E., Guio, L., Schou, M. F., Deplancke, B., Vieira, C., Ritchie, M. G., Zwaan, B., Tauber, E., Orengo, D., Puerma, E., Aguade, M., Schmidt, P., Parsch, J., Betancourt, A., Flatt, T., Gonzalez, J., BioRxiv (2018) | Article

  Allelic polymorphism at foxo contributes to local adaptation in Drosophila melanogaster
  Betancourt, N., Rajpurohit, S., Durmaz, E., Fabian, D., Kapun, M., Flatt, T., Schmidt, P., BioRxiv (2018) | Article

  An inversion supergene in Drosophila underpins latitudinal clines in survival traits
  Durmaz, Esra, Benson, Clare, Kapun, Martin, Schmidt, Paul, Flatt, Thomas, Journal of Evolutionary Biology (2018) | Article

  Horizons in the evolution of aging
  Flatt, Thomas, Partridge, Linda, BMC Biology (2018) | Article

  Aminergic Signaling Controls Ovarian Dormancy in Drosophila
  Andreatta, Gabriele, Kyriacou, Charalambos P., Flatt, Thomas, Costa, Rodolfo, Scientific Reports (2018) | Article

  Amino acid modulation of lifespan and reproduction in Drosophila
  Hoedjes, Katja M., Rodrigues, Marisa A., Flatt, Thomas, Current Opinion in Insect Science (2017) | Article

  Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span (vol 3, 5, 2017)
  Garschall, Kathrin, Dellago, Hanna, Glikov, Martina, Schosserer, Markus, Flatt, Thomas, Grillari, Johannes, Npj Aging and Mechanisms of Disease (2017) | Article

  Ubiquitous overexpression of the DNA repair factor dPrp19 reduces DNA damage and extends Drosophila life span
  Garschall, Kathrin, Dellago, Hanna, Galikov, Martina, Schosserer, Markus, Flatt, Thomas, Grillari, Johannes, Npj Aging and Mechanisms of Disease (2017) | Article

  Adaptation to fluctuating environments in a selection experiment with Drosophila melanogaster
  Kubrak, Olga I., Nylin, Soren, Flatt, Thomas, Nassel, Dick R., Leimar, Olof, Ecology and Evolution (2017) | Article

  Faculty of 1000 evaluation for Can aging be programmed? A critical literature review.
  Thomas Flatt, (2016) | Data set

  Genomics of clinal variation in Drosophila: disentangling the interactions of selection and demography
  Flatt, Thomas, Molecular Ecology (2016) | Article

  BMC Zoology - a home for all zoological research in the BMC series
  Kruger, Dirk, Packer, Laurence, Flatt, Thomas, Hoi, Herbert, Morand, Serge, Lieb, Bernhard, Malabarba, Luiz R., Fenton, M. Brock, BMC Zoology (2016) | Article

  Living Long and Well: Prospects for a Personalized Approach to the Medicine of Ageing
  Fuellen, Georg, Schofield, Paul, Flatt, Thomas, Schulz, Ralf-Joachim, Boege, Fritz, Kraft, Karin, Rimbach, Gerald, Ibrahim, Saleh, Tietz, Alexander, Schmidt, Christian, Koehling, Ruediger, Simm, Andreas, Gerontology (2016) | Article

  Endocrine uncoupling of the trade-off between reproduction and somatic maintenance in eusocial insects
  Rodrigues, Marisa A., Flatt, Thomas, Current Opinion in Insect Science (2016) | Article

  Parallel effects of the inversion In(3R)Payne on body size across the North American and Australian clines in Drosophila melanogaster
  Kapun, M., Schmidt, C., Durmaz, E., Schmidt, P. S., Flatt, T., Journal of Evolutionary Biology (2016) | Article

  Genomic Evidence for Adaptive Inversion Clines in Drosophila melanogaster
  Kapun, Martin, Fabian, Daniel K., Goudet, Jerome, Flatt, Thomas, Molecular Biology and Evolution (2016) | Article

  Faculty of 1000 evaluation for Early-late life trade-offs and the evolution of ageing in the wild.
  Thomas Flatt, (2015) | Data set

  Faculty of 1000 evaluation for Uncoupling lifespan and healthspan in Caenorhabditis elegans longevity mutants.
  Thomas Flatt, (2015) | Data set

  Faculty of 1000 evaluation for Genetic perturbation of key central metabolic genes extends lifespan in Drosophila and affects response to dietary restriction.
  Thomas Flatt, (2015) | Data set

  Spatially varying selection shapes life history clines among populations of Drosophila melanogaster from sub-Saharan Africa
  Fabian, D. K., Lack, J. B., Mathur, V., Schloetterer, C., Schmidt, P. S., Pool, J. E., Flatt, T., Journal of Evolutionary Biology (2015) | Article

  Overexpression of the DNA repair factor SNEVhPrp19/hPso4 extends cellular and organismal life span and increases resistance to genotoxic stress
  Dellago, Hanna, Khan, Abdulhameed, Schosserer, Markus, Flatt, Thomas, Ammerer, Gustav, Jansen-Duerr, Pidder, Rudolph, Karl Lenhard, Grillari-Voglauer, Regina, Grillari, Johannes, Experimental Gerontology (2015) | Article

  Paying the costs of reproduction When a female fly mates it produces a hormone that increases the size of its midgut and enhances fat metabolism in order to provide the energy needed for reproduction
  Flatt, Thomas, eLife (2015) | Article

  Faculty of 1000 evaluation for G×G×E for lifespan in Drosophila: mitochondrial, nuclear, and dietary interactions that modify longevity.
  Thomas Flatt, (2014) | Data set

  Faculty of 1000 evaluation for A quantitative genetic signature of senescence in a short-lived perennial plant.
  Thomas Flatt, (2014) | Data set

  Faculty of 1000 evaluation for Drosophila life span and physiology are modulated by sexual perception and reward.
  Thomas Flatt, (2014) | Data set

  Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster
  Kapun, Martin, Van Schalkwyk, Hester, Mcallister, Bryant, Flatt, Thomas, Schloetterer, Christian, Molecular Ecology (2014) | Article

  Reproduction, Fat Metabolism, and Life Span: What Is the Connection? (vol 17, pg 10, 2013)
  Hansen, Malene, Flatt, Thomas, Aguilaniu, Hugo, Cell Metabolism (2014) | Article

  SIMILARITIES AND DIFFERENCES IN ALTITUDINAL VERSUS LATITUDINAL VARIATION FOR MORPHOLOGICAL TRAITS IN DROSOPHILA MELANOGASTER
  Klepsatel, Peter, Galikova, Martina, Huber, Christian D., Flatt, Thomas, Evolution (2014) | Article

  Plasticity of lifespan: a reaction norm perspective
  Flatt, Thomas, Proceedings of the Nutrition Society (2014) | Article

  Faculty of 1000 evaluation for Heritability of life span is largely sex limited in Drosophila.
  Thomas Flatt, (2013) | Data set

  Faculty of 1000 evaluation for The size-life span trade-off decomposed: why large dogs die young.
  Thomas Flatt, (2013) | Data set

  Faculty of 1000 evaluation for Genomic response to selection for postponed senescence in Drosophila.
  Thomas Flatt, (2013) | Data set

  Faculty of 1000 evaluation for Longer life span evolves under high rates of condition-dependent mortality.
  Thomas Flatt, (2013) | Data set

  The role of the nervous system in aging and longevity.
  Frontiers in genetics (2013) | Article

  Neuronal inputs and outputs of aging and longevity.
  Frontiers in genetics (2013) | Article

  Neuronal Inputs and Outputs of Aging and Longevity
  Joy Alcedo, Thomas Flatt, Elena G. Pasyukova, éd. par Joy Alcedo and Thomas Flatt and Elena G. Pasyukova (Frontiers Media SA, 2013), ISBN: 9782889191604 | Livre

  Reproductive and post-reproductive life history of wild-caught Drosophila melanogaster under laboratory conditions
  Klepsatel, P., Galikova, M., De Maio, N., Ricci, S., Schloetterer, C., Flatt, T., Journal of Evolutionary Biology (2013) | Article

  Inference of chromosomal inversion dynamics from Pool-Seq data in natural and laboratory populations of Drosophila melanogaster
  Kapun, Martin, Schalkwyk, Hester van, McAllister, Bryant, Flatt, Thomas, Schlötterer, Christian, ArXiv (2013) | Article

  Ecdysone triggered PGRP-LC expression controls Drosophila innate immunity
  Rus, Florentina, Flatt, Thomas, Tong, Mei, Aggarwal, Kamna, Okuda, Kendi, Kleino, Anni, Yates, Elisabeth, Tatar, Marc, Silverman, Neal, The EMBO Journal (2013) | Article

  VARIATION IN THERMAL PERFORMANCE AND REACTION NORMS AMONG POPULATIONS OF DROSOPHILA MELANOGASTER
  Klepsatel, Peter, Galikova, Martina, De Maio, Nicola, Huber, Christian D., Schloetterer, Christian, Flatt, Thomas, Evolution (2013) | Article

  LIFE-HISTORY EVOLUTION AND THE POLYPHENIC REGULATION OF SOMATIC MAINTENANCE AND SURVIVAL
  Flatt, Thomas, Amdam, Gro V., Kirkwood, Thomas B. L., Omholt, Stig W., The Quarterly Review of Biology (2013) | Article

  Reproduction, Fat Metabolism, and Life Span: What Is the Connection?
  Hansen, Malene, Flatt, Thomas, Aguilaniu, Hugo, Cell Metabolism (2013) | Article

  Faculty of 1000 evaluation for Genomic basis of aging and life-history evolution in Drosophila melanogaster.
  Thomas Flatt, (2012) | Data set

  Faculty of 1000 evaluation for A novel 3-hydroxysteroid dehydrogenase that regulates reproductive development and longevity.
  Thomas Flatt, (2012) | Data set

  Faculty of 1000 evaluation for Lifespan extension by increased expression of the Drosophila homologue of the IGFBP7 tumour suppressor.
  Thomas Flatt, (2012) | Data set

  Faculty of 1000 evaluation for New genes that extend Caenorhabditis elegans' lifespan in response to reproductive signals.
  Thomas Flatt, (2012) | Data set

  A new definition of aging?
  Frontiers in genetics (2012) | Article

  What is Aging?
  Frontiers in genetics (2012) | Article

  Adaptation of Drosophila to a novel laboratory environment reveals temporally heterogeneous trajectories of selected alleles
  Orozco-terWengel, Pablo, Kapun, Martin, Nolte, Viola, Kofler, Robert, Flatt, Thomas, Schloetterer, Christian, Molecular Ecology (2012) | Article

  Genome-wide patterns of latitudinal differentiation among populations of Drosophila melanogaster from North America
  Fabian, Daniel K., Kapun, Martin, Nolte, Viola, Kofler, Robert, Schmidt, Paul S., Schloetterer, Christian, Flatt, Thomas, Molecular Ecology (2012) | Article

  Faculty of 1000 evaluation for A metabolic signature of long life in Caenorhabditis elegans.
  Thomas Flatt, (2011) | Data set

  Mechanisms of Life History Evolution: The Genetics and Physiology of Life History Traits and Trade-Offs
  Thomas Flatt, Andreas Heyland, éd. par Thomas Flatt and Andreas Heyland (Oxford University Press, 2011), ISBN: 9780199568765 | Livre

  Integrating mechanistic and evolutionary analysis of life history variation
  Braendle, Christian, Heyland, Andreas, Flatt, Thomas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Life history plasticity
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Reproduction
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Life history integration and trade-offs
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Lifespan, aging, and somatic maintenance
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Steroid hormone regulation of C. elegans and Drosophila aging and life history
  Galikova, Martina, Klepsatel, Peter, Senti, Gabriele, Flatt, Thomas, Experimental Gerontology (2011) | Article

  The genomic and physiological basis of life history variation in a butterfly metapopulation
  Klepsatel, Peter, Flatt, Thomas, Molecular Ecology (2011) | Article

  Growth, development, and maturation
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Integrating mechanisms into life history evolution
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  What mechanistic insights can or cannot contribute to life history evolution: An exchange between Stearns, Heyland, and Flatt
  Flatt, Thomas, Heyland, Andreas, Stearns, Stephen C., Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Mechanisms of Life History Evolution The Genetics and Physiology of Life History Traits and Trade-Offs Preface
  Flatt, Thomas, Heyland, Andreas, Mechanisms of Life History Evolution: the Genetics and Physiology of Life History Traits and Trade-offs (2011) | Article

  Survival costs of reproduction in Drosophila
  Flatt, Thomas, Experimental Gerontology (2011) | Article

  Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout.
  Aging (2010) | Article

  Dietary restriction and other lifespan extending pathways converge at the activation of the downstream effector takeout
  Galikova, Martina, Flatt, Thomas, Aging (2010) | Article

  Host Range and Specificity of the Drosophila C Virus
  Kapun, Martin, Nolte, Viola, Flatt, Thomas, Schloetterer, Christian, Plos One (2010) | Article

  Transcriptome analysis reveals a major impact of JAK protein tyrosine kinase 2 (Tyk2) on the expression of interferon-responsive and metabolic genes
  Vogl, Claus, Flatt, Thomas, Fuhrmann, Bernd, Hofmann, Elisabeth, Wallner, Barbara, Stiefvater, Rita, Kovarik, Pavel, Strobl, Birgit, Mueller, Mathias, BMC Genomics (2010) | Article

  dSir2 and Dmp53 interact to mediate aspects of CR-dependent lifespan extension in D. melanogaster.
  Aging (2009) | Article

  dSir2 and Dmp53 interact to mediate aspects of CR-dependent life span extension in D. melanogaster
  Bauer, Johannes H., Morris, Siti Nur Sarah, Chang, Chengyi, Flatt, Thomas, Wood, Jason G., Helfand, Stephen L., Aging (2009) | Article

  Integrating evolutionary and molecular genetics of aging
  Flatt, Thomas, Schmidt, Paul S., Biochimica et Biophysica Acta (BBA) - General Subjects (2009) | Article

  AGEING Diet and longevity in the balance
  Flatt, Thomas, Nature (2009) | Article

  Hormonal regulation of the humoral innate immune response in Drosophila melanogaster
  Flatt, Thomas, Heyland, Andreas, Rus, Florentina, Porpiglia, Ermelinda, Sherlock, Chris, Yamamoto, Rochele, Garbuzov, Alina, Palli, Subba R., Tatar, Marc, Silverman, Neal, Journal of Experimental Biology (2008) | Article

  Drosophila, germ-line modulation of insulin signaling and lifespan
  Flatt, Thomas, Min, Kyung-Jin, D'Alterio, Cecilia, Villa-Cuesta, Eugenia, Cumbers, John, Lehmann, Ruth, Jones, D. Leanne, Tatar, Marc, Proceedings of the National Academy of Sciences (2008) | Article

  Hormonal modulation of larval begging and growth in the burying beetle Nicrophorus vespilloides
  Crook, Tara C., Flatt, Thomas, Smiseth, Per T., Animal Behaviour (2008) | Article

  Counting calories in Drosophila diet restriction
  Min, Kyung-Jin, Flatt, Thomas, Kulaots, Indrek, Tatar, Marc, Experimental Gerontology (2007) | Article

  Still pondering an age-old question
  Flatt, Thomas, Promislow, Daniel E. L., Science (2007) | Article

  Juvenile hormone as a regulator of the trade-off between reproduction and life span in Drosophila melanogaster
  Flatt, Thomas, Kawecki, Tadeusz J., Evolution (2007) | Article

  Size and shape: the developmental regulation of static allometry in insects
  Shingleton, Alexander W., Frankino, W. Anthony, Flatt, Thomas, Nijhout, H. Frederik, Emlen, Douglas. J., BioEssays (2007) | Article

  Comparing thyroid and insect hormone signaling
  Flatt, Thomas, Moroz, Leonid L., Tatar, Marc, Heyland, Andreas, Integrative and Comparative Biology (2006) | Article

  Evolution in group-structured populations can resolve the tragedy of the commons
  Killingback, Timothy, Bieri, Jonas, Flatt, Thomas, Proceedings of the Royal Society B: Biological Sciences (2006) | Article

  A role for genetic accommodation in evolution?
  Braendle, Christian, Flatt, Thomas, BioEssays (2006) | Article

  What is metamorphosis?
  Bishop, C. D., Erezyilmaz, D. F., Flatt, T., Georgiou, C. D., Hadfield, M. G., Heyland, A., Hodin, J., Jacobs, M. W., Maslakova, S. A., Pires, A., Reitzel, A. M., Santagata, S., Tanaka, K., Youson, J. H., Integrative and Comparative Biology (2006) | Article

  Life history pleicitropy mediated by Methoprene-tolerant, a putative juvenile hormone receptor
  Flatt, T, Journal of Experimental Zoology. Part A, Comparative Experimental Biology (2006) | Article

  Winter weather affects asp viper Vipera aspis population dynamics through susceptible juveniles
  Res Altwegg and Stefan Dummermuth and Bradley R. Anholt and Thomas Flatt, Oikos (2005) | Article

  Juvenile and Steroid Hormones in Drosophila melanogaster Longevity
  Meng-Ping Tu and Thomas Flatt and Marc Tatar , Elsevier (2005) | Autre

  Winter weather affects asp viper Vipera aspis population dynamics through susceptible juveniles
  Altwegg, R, Dummermuth, S, Anholt, BR, Flatt, T, Oikos (2005) | Article

  The evolutionary genetics of canalization
  Flatt, T, The Quarterly Review of Biology (2005) | Article

  Juvenile hormone as an effector of metamorphosis and life history transitions
  Flatt, T, Integrative and Comparative Biology (2005) | Article

  Hormonal pleiotropy and the juvenile hormone regulation of Drosophila development and life history
  Flatt, T, Tu, MP, Tatar, M, BioEssays (2005) | Article

  Pleiotropic effects of methoprene-tolerant (Met), a gene involved in juvenile hormone metabolism, on life history traits in Drosophila melanogaster
  Flatt, T, Kawecki, TJ, Genetica (2004) | Article

  Assessing natural variation in genes affecting Drosophila lifespan
  Flatt, T, Mechanisms of Ageing and Development (2004) | Article

  Stabilizing factors interact in promoting host-parasite coexistence
  Flatt, T, Scheuring, I, Journal of Theoretical Biology (2004) | Article

  The influence of ant-attendance on aphid behaviour investigated with the electrical penetration graph technique.
  Entomologia experimentalis et applicata (2002) | Article

  The influence of ant-attendance on aphid behaviour investigated with the electrical penetration graph technique
  Rauch, G, Simon, JC, Chaubet, B, Haack, L, Flatt, T, Weisser, WW, Entomologia Experimentalis et Applicata (2002) | Article

  Phenotypic variation in an oviparous montane lizard (Bassiana duperreyi): the effects of thermal and hydric incubation environments
  Flatt, T, Shine, R, Borges-Landaez, PA, Downes, SJ, Biological Journal of the Linnean Society (2001) | Article

  A bit of sex stabilizes host-parasite dynamics
  Flatt, T, Maire, N, Doebeli, M, Journal of Theoretical Biology (2001) | Article

  The Effects of Mutualistic Ants on Aphid Life History Traits
  Thomas Flatt and Wolfgang W. Weisser, Ecology (2000) | Article

  The effects of mutualistic ants on aphid life history traits
  Flatt, T, Weisser, WW, Ecology (2000) | Article

  Mark-recapture estimates of survival in populations of the asp viper, Vipera aspis aspis
  Flatt, T, Dummermuth, S, Anholt, BR, Journal of Herpetology (1997) | Article

• Projets de recherche

  The Role of Adaptive Inversion Polymorphisms in their Ancestral Range
  Statut: En cours

  Début	01.03.2024
  Fin	29.02.2028
  Financement	FNS  Voir la fiche du projet
  Chromosome inversions have fascinated evolutionary biologists since the dawn of population genetics. Because they suppress single crossovers in heterozygous state, they can capture combinations of adaptive loci and protect them from recombination. Indeed, since their discovery in 1917, many adaptive, often stably polymorphic inversions have been found. Yet, despite a century of work, we do not conclusively understand their adaptive nature: What types of balancing selection act on inversions? What adaptive loci do they contain? What fitness traits do they affect? What selection pressures shape them? A classical model for studying inversions is Drosophila melanogaster. Most of this species’ inversions arose in Africa; after it migrated out of Africa and colonized the rest of the world, several became involved in climatic adaptation on other continents. However, little is known about these balanced cosmopolitan polymorphisms in their ancestral range, including whether they confer adaptation to wilderness habitats. Here, we seek to fill this major gap. By using a large panel of strains from southern-central Africa, we will study the role of these globally balanced polymorphisms in their ancestral range, thereby addressing fundamental questions about the nature of balancing selection. (1) Do cosmopolitan inversions represent long-term balanced polymorphisms? Did they capture adaptive loci before migrating out of Africa? What loci confer balancing selection upon inversions? Aim 1 will analyze phased sequencing data for four globally common inversions to identify footprints of balancing selection associated with these polymorphisms in ancestral populations. (2) Do inversions from ancestral habitats affect fitness traits? If yes, do such effects give us clues about selection pressures on inversions in ancestral habitats? Aim 2 will identify karyotype-phenotype associations by isolating karyotypes from a seasonally dry wilderness habitat in Zambia and measuring fitness-related stress response traits. (3) Are inversions from ancestral habitats subject to fluctuating balancing selection? We conjecture that inversions adaptively track wet-dry season fluctuations in temperature, precipitation, and food abundance in wilderness habitats. Aim 3 will survey seasonal fluctuations of inversion frequencies in samples from seasonally dry woodlands in Zambia and a tropical savannah climate in Nigeria. Secondly, we will use population cage assays to study the temporal dynamics of inversion frequencies in response to (i) seasonal changes in outdoor cages in a field facility subject to a humid subtropical climate that is similar to that of some ancestral habitats and (ii) controlled fluctuating conditions in laboratory population cages. Together, these approaches promise to yield novel insights into the adaptive nature of balanced polymorphisms and the mechanisms of fluctuating selection, a classical but largely unresolved question in evolutionary genetics.

  Entlastungsbeitrag
  Statut: Terminé

  Début	01.10.2022
  Fin	31.12.2023
  Financement	FNS  Voir la fiche du projet

  Spiel des Lebens / Le jeu de la vie
  Statut: Terminé

  Début	01.02.2022
  Fin	31.01.2023
  Financement	FNS  Voir la fiche du projet
  Questions about aging, longevity and immortality (the “fountain of youth”) have fascinated mankind since the dawn of time. Why do some people live much longer than others? Could we perhaps manage to stop aging and become immortal? These seemingly philosophical questions are firmly rooted in current research on aging and longevity. What is less well understood among non-biologists is why aging exists in the first place and how remarkably diverse patterns of lifespan and mortality are among organisms other than humans. The tremendous diversity of different patterns of aging and lifespan among bacteria, plants and animals holds great promise for answering deep questions such as: Are there organisms that truly do not age? If so, how do they manage to live so long and defeat aging? Is there a prize that organisms pay if they are exceptionally long-lived? To engage the public with these fundamental questions about life and death, the Natural History Museum of Fribourg will be organizing an exhibition that seeks to unite different perspectives (e.g., biological, philosophical, literary). The main exhibition is financed by the Museum itself. With this proposal we would like to add a subproject in collaboration with writers to dive into the topic in a new way. Regional authors will write fictional stories (based on biological facts) to be shown in the exhibition. Additionally, these authors will discuss their views on aging and life expectancy with scientists and offer writing courses for children and adults to write their own short stories about the exhibition’s topic. The best stories will make it into the exhibition. In this way, the subproject complements and extends the museum exhibition and will also reach audiences that are usually difficult to reach by traditional natural history museum exhibitions.

  The Role of Chromosomal Inversions in Clinal Adaptation
  Statut: Terminé

  Début	01.03.2019
  Fin	30.09.2023
  Financement	FNS  Voir la fiche du projet
  Chromosomal inversions are well known to suppress recombination. This fact, and the observation that many inversions form predictable clines, prompted Theodosius Dobzhansky in the 1940s to postulate that they represent „coadapted gene complexes“, epistatic combinations of linked adaptive loci. An alternative hypothesis posits that inversions evolve because they capture locally adapted alleles and protect them from maladaptive gene flow from other populations. However, although inversions are often considered to play a significant role in adaptation, the genic targets of selection carried by them or how they are selectively maintained is poorly understood. With very few exceptions, phased genomic data required to identify candidate targets of selection within inversions are not yet available, and how inversions affect fitness traits is largely unknown. Here we propose to address these fundamental issues using the fruit fly Drosophila melanogaster as a powerful experimental test bed, by applying population genomics, laboratory and field assays, and experimental genetics approaches to a cosmopolitan, clinally varying inversion polymorphism, In(3R)Payne. Although we have previously shown that this polymorphism is maintained by selection across latitudinal gradients, how selection does so remains unclear; yet, precisely because of its adaptive nature, this chromosomal rearrangement represents an ideal model system for studying the selective mechanisms that act on inversions. Aim 1 will identify candidate targets of selection inside this inversion by using phased whole-genome sequencing data from inverted and uninverted karyotypes, which are to be functionally tested in Aim 4. The data from Aim 1 will also be used to test a key requirement for the selective advantage of an adaptive inversion, namely the existence of linkage disequilibrium among the putative loci subject to selection, and to identify candidate haplotypes under selection. Aim 2 will determine the phenotypic effects of this inversion upon fitness components by systematic phenotyping of homo- and heterokaryons under different thermal conditions in the laboratory; these assays will also test whether the polymorphism might be maintained by fitness overdominance. Aim 3 will use laboratory and field experiments to examine whether the inversion is maintained by frequency-dependent selection. Aim 4 will map the genetic basis of variation in fitness-related traits associated with the inversion by employing CRISPR/Cas9 genome editing. Together, these synergistic approaches promise the most in-depth analysis of the adaptive role of any inversion system to date. By unraveling the mechanisms whereby an inversion polymorphism affects fitness, our research program will illuminate a longstanding but still unresolved problem in evolutionary biology.

  The Genomic Basis of Life History Adaptation
  Statut: Terminé

  Début	01.12.2016
  Fin	31.05.2019
  Financement	FNS  Voir la fiche du projet
  Life history traits are central to our understanding of adaptation because they represent direct targets of selection. However, while much progress has been made in uncovering the molecular mechanisms underlying fitness-related traits, mainly by studying large-effect mutants in model organisms, little is known about naturally occurring genetic variants that affect these traits. The central aim of my current SNSF Professorship grant is to identify naturally occurring polymorphisms that underlie evolutionary changes in life history, using Drosophila melanogaster as a model. Over the last 33 months, we have used two complementary approaches to tackle this problem: to generate "catalogs" of candidate variants we have applied whole-genome Pool-sequencing to (1) North American populations clinally differentiated for life history and (2) a >30-year-long artificial selection experiment for longevity. Both approaches are "designed" to maximize among-population life-history differentiation and thus to increase our ability to map life-history variants via sequencing. In a second step, we have begun to perform experiments to examine the life-history effects of some of these candidate mechanisms. Based on our genomic analyses, we have prioritized three candidate mechanisms for experiments: (1) for the cline, we have identified clinal SNP polymorphisms in several genes involved in insulin signaling, a pathway known from molecular studies to regulate life-history physiology, including a clinal 2-SNP polymorphism in the transcription factor gene foxo; (2) a clinal chromosomal inversion polymorphism, In(3R)Payne, to which 79% of the most strongly clinal SNPs in the genome map; and (3), in the selection experiment, we have found strong enrichment of immunity genes among our top candidates. To date, our experiments show that (1) the foxo polymorphism has major pleiotropic on egg-to-adult survival, body size and starvation resistance, in assays based on synthetic recombinant inbred lines; (2) the In(3R)Payne polymorphism is maintained by clinal selection, independent of neutrality and admixture, and affects body size, a strongly clinal trait; and (3) the long-lived selection lines survive pathogenic infections much better than the controls. In this application for a 2-year extension of my grant, we propose to follow up on these promising leads. First, to better understand how the foxo polymorphism affects life history, we will use homologous replacement of the 2 SNPs (and their allelic combinations) into a common background via CRISPR/Cas9, in collaboration with Alistair McGregor (Oxford); we will measure additive and epistatic effects of these constructs on life history and FOXO activity. Second, to identify targets of selection within In(3R)Payne, we will phase-sequence isochromosomal lines and apply ABC-based coalescent models to the data, in collaboration with Mark Kirkpatrick (Austin). In addition, we will perform RNA-seq of standard vs. inverted lines to uncover transcriptional differences between inversion karyotypes. Finally, to begin to uncover the regulatory details of the intriguing but poorly understood connection between lifespan and immunity in the longevity selection lines, we will assay transcriptional responses to infection in selection versus control lines, both in young and old flies, and – secondly – test whether silencing immune genes via transgenic RNAi affects lifespan, as hypothesized. Together, this integrative approach – spanning population genomics, functional genetics, and physiology – will significantly advance our understanding of the molecular basis of adaptive changes in life history and aging, a fundamental but largely unresolved problem in evolutionary biology.

  Physiological basis of the fecundity/longevity trade-off in Drosophila
  Statut: Terminé

  Début	01.01.2016
  Fin	30.06.2019
  Financement	FNS  Voir la fiche du projet
  In many organisms curtailed reproduction increases lifespan. Conversely, extended lifespan is often accompanied by reduced reproduction. The overarching aim of our Research Unit (RU) is to investigate the evolution and mechanisms of the fecundity/ longevity trade-off in insects by comparing experimental manipulations in social insects, where – remarkably – the fecundity/longevity trade-off is typically absent, with data from solitary insects (e.g., Drosophila), where this trade-off is common and well-established. As a model for understanding the mechanisms underlying the fecundity/ longevity trade-off, we are planning to perform experiments in the fruit fly (Drosophila melanogaster), which shall serve as “solitary insect” reference system or “control” for the work to be done in social insects in our RU. The fact that decreased food intake without malnourishment (dietary restriction) extends lifespan while concomitantly reducing reproduction suggests that the longevity-reproduction trade-off might represent an energetic resource allocation trade-off. If so, food limitation might divert resources away from reproduction and make them available for somatic maintenance and survival. However, the trade-off in energy allocation between fecundity and metabolic storage is not quantitatively exact, and dietary restriction can increase lifespan in gonadectomized worms (Caenorhabditis elegans) and sterile flies (D. melanogaster), findings which are at odds with the resource allocation model. In contrast to C. elegans that lack the entire gonad, worms that lack germ cells only are long-lived, and dietary restriction cannot further extend longevity in these individuals, suggesting that signals from the germline may oppose those of the somatic gonad to regulate ageing in the worm. Therefore, although current knowledge indicates that nutrient metabolism, reproduction and ageing represent interconnected regulatory axes, the actual mechanisms underlying the trade-off between reproduction and longevity remain largely unknown. The main goal of the research proposed here to use the genetically powerful fruit fly model Drosophila melanogaster to test whether the reproductive and nutritional regulatory axes converge onto the same mechanisms that affect ageing. Specifically, we will use a sterile mutant with oogenic arrest and a germline-less, long-lived transgenic strain as experimentals tool to discover how reproduction interacts with diet to affect lifespan and physiology. To systematically characterize the global physiology underlying the fecundity/longevity trade-off in Drosophila we will combine transcriptomics, metabolomics, endocrine assays, and RNAi silencing of candidate genes.

  The effects of germline stem cells on aging and reproduction in Drosophila melanogaster
  Statut: Terminé

  Début	01.04.2004
  Fin	31.03.2005
  Financement	FNS  Voir la fiche du projet
  The effects of germline stem cells on aging and reproduction in Drosophila melanogaster

  Pleiotropic effects of juvenile hormone metabolism on Drosophila life history
  Statut: Terminé

  Début	01.03.2003
  Fin	31.12.2003
  Financement	Autre  Voir la fiche du projet

  The effects of juvenile hormone on trait architecture in Drosophila melanogaster
  Statut: Terminé

  Début	01.10.2001
  Fin	28.01.2004
  Financement	Unifr

  Consequences of source-sink population dynamics for adaptive evolution in marginal habitats: theoretical and experimental approaches
  Statut: Terminé

  Début	01.03.1999
  Fin	31.12.2002
  Financement	FNS  Voir la fiche du projet

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