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• Postdoctoral position in clinical neuroscience

  Postdoctoral position, 80-100 %

  
  University of Fribourg - Faculty of Science and Medicine
  Hospital of Fribourg – Department of Neurology

  The research of Prof. Dr. med. Selma Aybek and her team focusses on Functional Neurological Disorders (FND). The team is working interdisciplinary, involving neurologists, engineers, psychologists and neuroscientists in order to merge our expertise in conducting clinical research, aiming to better understand this disabling disorder and ultimately help the numerous patients suffering from FND. We design studies to investigate pathoethiological risk factors, pathophysiological mechanisms and study potential treatment options.
  We are looking for an enthusiastic candidate with excellent technical skills and track record (i.e., publications in high ranking journals) to join our research group.

  Your responsibilities
  • Independently plan and conduct scientific studies (e.g., ethical application, elaboration of study design, recruitment, collection and storage of data).
  • Work in direct contact with patients and healthy participants.
  • Autonomous data analysis and critical interpretation.
  • Presenting results in national and international conference and publish in peer-reviewed journals.
  • Supervision of junior team members.

  Your profile
  • You have a PhD in psychology, neuroscience, neurobiology, biomedical engineering or similar.
  • Expert knowledge in MRI/fMRI analysis is required.
  • Experience in EEG, TMS and/or augmented/virtual reality is an advantage.
  • You are experienced with Matlab and neuroimaging analysis tools (SPM, FSL, EEGLAB, Cartool, Ragu or similar) and statistical tools (R, Stata or similar).
  • You have a strong interest in neuroscientific methods as well as in elaborating potential treatment options for neuropsychiatric disorders.
  • You are fluent in English and have a good knowledge of German or French.
  • You demonstrate good communication, organizational and teamwork skills.

  What we offer

  We offer a postdoctoral position in a dynamic work environment starting July 2024 (or as agreed), which will be remunerated according to the guidelines of the University of Fribourg.

  Application

  Please send your application documents (including your CV, cover letter, list of publications, references) as a single PDF file to Francine Neuhaus and Janine Bühler (francine.neuhaus@h-fr.ch; janine.buehler@unifr.ch).

  In case of questions, please feel free to contact Janine Bühler (janine.buehler@unifr.ch). Applications will be reviewed until the position has been filled.

• PhD position in Sensorimotor Neuroscience

  THE LAB

  The group of Mario Prsa at the University of Fribourg (prsalab.org) is looking for PhD/Postdoc candidates to conduct research on neural mechanisms of forelimb sensorimotor adaptation and/or proprioceptive sensory processing.

  Our laboratory is part of the Department of Neuroscience and Movement Science within the Faculty of Medicine at the University of Fribourg comprised of a vibrant scientific community including more than 20 multi-disciplinary research groups.

  RESEARCH

  Movements are at the center of all our behavior and accurate movements allow us to properly interact with the world. Proprioception and sensorimotor adaptation are two physiological processes crucial for maintaining movement accuracy. The applicant will use state-of-the art behavioral, optogenetic, two-photon microscopy and neuroanatomical tracing techniques to dissect the underlying neuronal circuits in the mouse brain.  

  YOUR PROFILE

  • Master’s / PhD degree in Neuroscience, Engineering/Physics, Biology (or related discipline).
  • Highly motivated, excellent analytical, experimental and writing skills.
  • Experience in rodent behavior, optogenetics, in-vivo imaging and/or electrophysiology.
  • Proficiency in data analysis and experimental procedures
  • Knowledge of hardware programming and experimental control with Matlab is highly desirable.

  THE POSITION

  We offer a PhD and Postdoctoral positions planned to start in late 2023 or early 2024. Interested applicants should send a letter of motivation, complete CV and a list of referees to mario.prsa@unifr.ch.

• INTERSHIP POSITION : Minimum 6 month

  The IC Stoke Team is looking for a student to collaborate on their research projects in Switzerland.

  The student will have the opportunity to work in an international and highly motivating environment. The project involves the development of a new model of subcortical stroke in non-human primates and of cortico-spinal rehabilitation technologies for the recovery of arm and hand movements.

  The student will help with the management and setup of behavioral tasks, and participate to scientific discussions and data analysis.

  Prerequisites

  • Knowledge in English
  • Basic Knowledge in Matlab
  • Positive and pro-active attitude

  New Knowledge

  • Software: Vicon, Nexus, Matlab
  • Tasks: Kuka Robot, calibration, execution
  • Data analysis : Tracking, progam execution

  Interested persons lacking one or more of these requirements will be also considered according to the specific case.

  Contact
  Dr. Charles Latchoumane, latchoumane.c@gmail.com

   

• Ph.D. position in immune cell biology to study tissue-specific immune responses (Fall 2024)

  Ph.D. position in immune cell biology at the University of Fribourg, Switzerland to study tissue-specific immune responses (Fall 2024)

  The laboratory of Prof. Jens Stein at the Department of Oncology, Microbiology and Immunology (OMI) of the University of Fribourg (UNIFR)/Switzerland is looking for a motivated and skilled candidate to join our team working on distinct aspects of CD8+ T cell biology in mouse models of infection, including their interactions with lymphoid and non-lymphoid tissue microenvironments. Adaptive immune reponses are initated in lymphoid tissue such as lymph nodes, from where effector T cells spread out to infiltrate non-lymphoid tissue, where they eliminate infected target cells. After clearance of viral reservoirs, tissue-resident memory cells reside in these organs for prolonged periods of time as protective force. Our recent data have uncovered that tissue-specific properties cooperate with biochemical signals to influence the surveillance mechanisms of local immune cells, in a process involving nuclear mechanosensing. Here, we propose to further examine this phenomenon during tissue-immune cell crosstalk using novel genetic tools and innovative in vivo and ex vivo functional approaches, including spectral flow cytometry and RNA sequencing.

  Requirements

  • Master in Science with strong motivation to work in immunology, cell biology and imaging

  • Good work organization, curious, creative, goal-oriented

    Techniques applied during Ph.D.
    Cutting edge cellular and molecular immunology techniques including multiplex flow cytometry, single cell RNA sequencing, intravital imaging, transgenic mouse models, ex vivo functional assays.

  We offer

  • Collaborative international research environment in a dynamic and competitive field

  • Regular courses and seminars by UNIFR Graduate school and in neighboring Universities of Bern and Lausanne

  • High quality of life with numerous student activities and beautiful landscape
    
    Selected references (*, corresponding authorship)

  1. Exocrine gland-resident memory CD8+ T cells use mechanosensing for tissue surveillance. Ruef N, Martínez Magdaleno J, Ficht X, Purvanov V, Palayret M, Wissmann S, Pfenninger P, Stolp B, Thelen F, Barreto de Albuquerque J, Germann P, Sharpe J, Abe J, Legler DF, Stein JV*. Sci Immunol. 2023 Dec 22;8(90):eadd5724. doi: 10.1126/sciimmunol.add5724. Epub 2023 Dec 22

  2. Microbial uptake in oral mucosa-draining lymph nodes leads to rapid release of cytotoxic CD8+ T cells lacking a gut-homing phenotype. Barreto de Albuquerque J*, Altenburger LM, Abe J, von Werdt D, Wissmann S, Martínez Magdaleno J, Francisco D, van Geest G, Ficht X, Iannacone M, Bruggmann R, Mueller C*, Stein JV*. Sci Immunol. 2022 Jun 24;7(72):eabf1861. doi: 10.1126/sciimmunol.abf1861. Epub 2022 Jun 17.

  3. Salivary gland macrophages and tissue-resident CD8+ T cells cooperate for homeostatic organ surveillance. Stolp B, Thelen F, Ficht X, Altenburger LM, Ruef N, Inavalli VVGK, Germann P, Page N, Moalli F, Raimondi A, Keyser KA, Jafari SMS, Barone F, Dettmer MS, Merkler D, Iannacone M, Sharpe J, Schlapbach C, Fackler OT, Nägerl UV, Stein JV*. Sci Immunol. 2020 Apr 3;5(46). pii: eaaz4371. doi: 10.1126/sciimmunol.aaz4371.

  4. The Rho regulator Myosin IXb enables non-lymphoid tissue seeding of protective CD8+ T cells. Moalli F, Ficht X, Germann P, Vladymyrov M, Stolp B, de Vries I, Lyck R, Balmer J, Kreutzfeld M, Merkler D, Iannacone M, Ariga A, Stoffel M, Sharpe J, Bähler M, Sixt M, Diz-Muñoz A, Stein JV*. 2018. J Exp Med 2018. 215:1869–1890. doi:10.1084/jem.20170896.

  5. Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells. Hons M*, Kopf A, Hauschild R, Leithner A, Gärtner F, Abe J, Renkawitz J, Stein JV*, Sixt M*. Nat Immunol. 2018. Jun;19(6):606-616. doi: 10.1038/s41590-018-0109-z.

   

  Lab website: https://www3.unifr.ch/med/de/research/groups/ stein/
  We offer a PhD position planned to start fall 2024.
  Interested applicants should send a letter of motivation, complete CV and a list of referees to Prof. Jens Stein (jens.stein@unifr.ch)

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