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  • Post-doctoral position in Sensorimotor Neuroscience

    THE LAB
    The group of Mario Prsa at the University of Fribourg (prsalab.org) is looking for post-doctoral candidates to conduct research on neural mechanisms of forelimb sensorimotor adaptation and/or proprioceptive sensory processing.
    Our laboratory is part of the Department of Neuroscience and Movement Science within the Faculty of Medicine at the University of Fribourg comprised of a vibrant scientific community including more than 20 multi-disciplinary research groups.

    RESEARCH
    Movements are at the center of all our behavior and accurate movements allow us to properly interact with the world. Proprioception and sensorimotor adaptation are two physiological processes crucial for maintaining movement accuracy. The applicant will use state-of-the art behavioral, optogenetic, two-photon microscopy and neuroanatomical tracing techniques to dissect the underlying neuronal circuits in the mouse brain.

    YOUR PROFILE

    •  PhD degree in Systems Neuroscience (or related discipline)
    • Highly motivated, excellent analytical, experimental and writing skills.
    • Expertise in rodent behavior, optogenetics, in-vivo imaging and/or neuroanatomical tracing is highly
      desirable.
    • Proficiency in data analysis, hardware programming and experimental control with Matlab is
      preferred.

    THE POSITION
    We offer a fully funded post-doctoral position (1 year initial contract) planned to start in September 2022 (or earlier). Interested applicants should send a letter of motivation, complete CV and a list of referees to mario.prsa@unifr.ch.

  • Postdoctoral Position in Cancer Research 80-100%

     A 80-100% post doc position is available to study the effect of breast cancer progression and dormancy on the local and systemic immune/inflammatory responses using established in vivo models of dormancy, escape and metastasis, flow cytometry, immunohistology and transcriptmics analyses, and ex vivo co-culture models. Technical assistants will be available. Collaborations with bioinformatics, modeling and clinical transcriptomics groups. The position is available on an FNS funded project starting May 2022 for 2 years or longer.
    Lab description

    Requirements

    • PhD or MD/PhD with strong background in cancer biology and immunology
    • Experience with in vivo cancer models (mice)
    • Proficiency in FACS, RNASeq and bioinformatics analyses
    • Publications in the field
    • Motivation to independently thriving a project and establish collaborations
    • Command of written and spoken English

    We offer

    • Attractive and friendly working environment
    • Opportunity to actively lead and shape the development of the project
    • Possibility of teaching or coaching students

    Interested candidates should send the following documents in PDF format:

    • Motivation letter highlighting your background, interest in our research, and your career plan
    • Curriculum vitae, publication list and copies of certificates (MSC, MD, MD-PhD, PhD)
    • Contacts of two references

    Start: May 1st or upon agreement
    Send applications or queries to:
    Prof. Curzio Rüegg, curzio.ruegg@unifr.ch, copy to: Mrs Marie Tamm, marie.tamm@unifr.ch

  • INTERSHIP POSITION : Minimum 6 month

    The IC Stoke Team is looking for a student to collaborate on their research projects in Switzerland.

    The student will have the opportunity to work in an international and highly motivating environment. The project involves the development of a new model of subcortical stroke in non-human primates and of cortico-spinal rehabilitation technologies for the recovery of arm and hand movements.

    The student will help with the management and setup of behavioral tasks, and participate to scientific discussions and data analysis.

    Prerequisites

    • Knowledge in English
    • Basic Knowledge in Matlab
    • Positive and pro-active attitude

    New Knowledge

    • Software: Vicon, Nexus, Matlab
    • Tasks: Kuka Robot, calibration, execution
    • Data analysis : Tracking, progam execution

    Interested persons lacking one or more of these requirements will be also considered according to the specific case.

    Contact
    Dr. Charles Latchoumane, latchoumane.c@gmail.com

     

  • PhD position to investigate Selective Autophagy in Neurons 100%

    The research group
    Our lab uses cellular and animal models to understand the roles of autophagy in neurons in both physiological and pathological conditions. Autophagy is an essential intracellular degradation pathway that recycles cell components generating new building blocks and energy to maintain cellular homeostasis. Currently our main focus is on selective autophagy including the specific degradation of mitochondria via autophagy in the process called mitophagy.

    We are interested in the relationships between autophagy pathways and basic processes such as proliferation, differentiation and cell death to gain insight into development and physiological aging. Moreover, we want to understand the role of autophagy in pathologies such as neurodegenerative and other disease conditions. We also seek to identify new therapies that target autophagy to discovering new treatments for human diseases. We use modern cell biology techniques, primary neuronal cultures, ex vivo organotypic cultures and in vivo animal studies combined with biochemistry, state of the art light, time lapse, confocal and electron microscopy. We also use transgenic animal models deficient for autophagy as well as reporter animals to monitor autophagy pathways in vivo

    The candidate
    Ideal applicant should have a master’s degree in cell biology or neurobiology. Experience with primary cell culture, confocal microscopy and image analysis is a plus. Candidates are expected to be highly motivated, talented, hardworking and have the ability to work in a team and independently. Applicants should also have good communication skills and be proficient in spoken and written English.

    The PhD will enroll at Fribourg Graduate School of Life Sciences (FGLS) for doctoral education. The Boya Lab will move to the University of Fribourg, Switzerland, in August 2022, Department for Neuroscience and Movement Science.

    The project

    The position is available for 3-4 years to study some of these topics:
    1) The role selective autophagy during neurogenesis
    2) Why is selective autophagy altered in neurodegenerative diseases?
    3) Relationships between autophagy and cell death

    How to apply/Contact

    Please direct further questions and/or send your application (including a motivation letter, CV, academic records, references or reference contacts) in a single PDF file to Patricia Boya; patricia.boya@gmail.com.

    Deadline

    Apply as soon as possible, applications will be reviewed until the position is filled or by July 1, 2022.
    Postdoc positions will be also available soon.

    Selected recent papers from the Boya Lab

    • Ambra1 haploinsufficiency results in metabolic alterations and exacerbates age-associated retinal degeneration. Autophagy 2022, in press
    • Targeting NCoR-RARα interaction activates chaperone-mediated autophagy and protects against retinal degeneration. Nature Communications 2022, in press.
    • Programmed mitophagy is essential for the glycolytic switch during cell differentiation.
      EMBO Journal. 2017 Jun 14;36(12):1688-1706. full text.