Offene Stellen

  • Senior Scientist or Advanced Clinician Scientist (100%)

    The position is open at Division of Endocrinology of the Section of Medicine of the University of Fribourg, Switzerland, to study the molecular mechanisms of sex development in humans (https://www.unifr.ch/med/de/research/groups/lauber/)


    Beginning : April, 01, 2022
    Duration : 3-4 years
    Location: Université de Fribourg
    Working time: 100%

     

    Objective

    The main objective of our work is the elucidation of the molecular basis of human sex development to better define phenotypes and therapies of its complex defects.

    Goals

    1. Gain new insights in sex differentiation in humans.
    2. Create new models for understanding mechanism of disease.

    Technically, the focus of the work will be to

    a) create human male and female gonadal cells from inducible pluripotent stem cells directly from patients affected by differences of sex development to study the mechanisms that lead to disease.

    b) use the fruit fly drosophila melanogaster as an animal model to study the functional consequences of unknown variants found in patients with differences of sex development.

    We will also employ standard cell and molecular biology, genetics, biochemistry, exome and RNA-sequencing, CRISP-Cas9 gene editing and mass spectrometry techniques. Bioinformatic analysis of next generation sequencing data and 3D-modeling is also one of our expertise.

    Your profile

    • A PhD, MD or equivalent degree(s) are required.
    • Knowledge and experience in molecular and cell biology are mandatory. Knowledge and/or prior experience in stem cells, cell therapy and/or gene engineering are a plus.
    • Knowledge and/or prior experience in Drosophila melanogaster handling is desirable.
    • Knowledge of the German or the French language is of advantage
    • Successful candidates will be independent, creative and enthusiastic researchers, capable of working efficiently in an international team of other postdoctoral fellows and PhD students. Outstanding laboratory capabilities and strong organizational skills to support Bachelor, Master and PhD students as well as Post Docs are expected.
    • Candidates have to present a successful academic track record

    We look forward to receiving your application with the following documents

    • Cover letter with statement of interest
    • CV
    • If applicable: brief summary on the envisioned independent research
    • Diplomas and course transcripts
    • Contact details of three referees

    Contact

    Anna Lauber-Biason, M.D.
    Chair of Endocrinology
    University of Fribourg
    Section of Medicine, Faculty of Science and Medicine
    Chemin du Musée 5
    1700 Fribourg
    E-mail. anna.lauber@unifr.ch

     

    The University of Fribourg is Switzerland’s only bilingual university, offering a full academic curriculum both in French and German. A number of Master programmes are taught in English and the University offers a wide range of opportunities for PhD and doctoral studies as well as international Exchange and Summer School Programmes.

    The University of Fribourg places scientific research that is closely linked to academic teaching at the heart of its activities. With an array of centres of scientific excellence as well as research programmes across the entire disciplinary spectrum, we aim to extend the frontiers of scientific knowledge to help solve mankind’s current and future challenges. https://www.unifr.ch/home/en/

     
  • Höhere/r technische/r Sachbearbeiter/-in (90 /100%)

    Tätigkeitsgebiet:

    • Eigenständige Vorbereitung, Durchführung und Analyse von Verhaltenstests und elektrophysiologischen Experimenten im Tiermodell (Nager oder NHP) und am Menschen
    • Unterstützung von Postdoktoranden, Doktoranden und Studenten bei der Planung, Durchführung und Analyse von Experimenten
    • Vorbereitung der Beantragung von Tierversuchsvorhaben beim kantonalen Veterinäramt
    • Vorbereitung der Beantragung von Versuchsvorhaben am Menschen
    • Vorbereitung der Beantragung von Forschungsgeldern
    • Eigenständige Durchführung von praktischen Lehrveranstaltungen
    • Organisation und Supervision des Datenmanagements
    • Mitarbeit bei der Organisation und Durchführung von Lab-meetings, Journal Clubs, wissenschaftlicher Konferenzen, Öffentlichkeitsarbeit, Webpräsenz

    Anforderungen:

    • Diplom oder Eidg. Fachausweis oder HF-Diplom mit mehrjähriger Berufserfahrung
    • Mehrjährige Erfahrung im selbstständigen Umgang mit nicht-humanen Primaten (NHP) oder Nagern (Mäuse oder Ratten) oder Menschen in den Neurowissenschaften
    • Mehrjährige Erfahrung in der Durchführung oder Analyse elektrophysiologischer Experimente (Einzelzellableitungen, EEG)
    • Erfahrung im Umgang mit Computer-Software, die zum Verhaltenstraining von Labortieren oder Menschen eingesetzt wird (mworks oder ähnliches)
    • Solide Kenntnisse in Matlab
    • Erfahrung in der praktischen universitären Lehre
    • Bereitschaft im Team zu arbeiten und die Arbeit von Studenten, Doktoranden und Postdoktoranden praktisch zu unterstützen und zum Erfolg zu verhelfen.

    Sprachen:
    Gute Kenntnisse in zumindest zwei der folgenden Sprachen: Französisch, Deutsch, Englisch

    Stellenantritt: 
    01.01.2022 (oder nach Vereinbarung)

    Bewerbungsfrist:
    27.08.2021

    Ihre vollständiges Bewerbungsdossier wird vorzugsweise per E-Mail erwartet: karine.schneuwly@unifr.ch
    oder per Post:
    Universität Freiburg
    Physiologie-Sekretariat PER09
    Frau Karine Schneuwly
    Ch. du Musée 5
    1700 Freiburg

    Weitere Informationen erhalten Sie bei:
    Professor Michael Schmid
    Tél. +41 26 300 86 09
    michael.schmid@unifr.ch
    www.unifr.ch/med 

  • Postdoc in Drosophila Behavioral Circuit Neuroscience (100%)

    The positions are open in the Philipsborn group: philipsborn-lab.org

    The lab will move to the University of Fribourg, Switzerland, in February 2022, (Department for Neuro- and Movement Science), where we will continue to work on Drosophila Circuit Neuroscience and Behavioral Genetics. We are interested in motor control and the neurobiology of reproduction, with a focus on chemical and acoustic communication during sexual interactions. We are employing behavioral assays, audio recordings, genetic manipulation and optogenetics, bioimaging and neuronal reconstructions to understand how circuit motifs shape behavior.

    Working area and tasks
    You are expected either to join a current project of the laboratory (addressing the communication of nervous system and reproductive organs and copulatory behavior) or to propose and develop your own project ideas (within the general interest and expertise of the lab). Involvement in academic teaching is possible, but no requirement. You are capable of training and fostering the scientific development of Bachelor and Master students. The position is fully funded, but efforts to acquire your own funding and work toward independence will be strongly supported.

    Your profile
    The ideal candidate has a PhD in Natural Sciences and a good academic track-record of original research, project management and problem-solving. Previous experience in any of the following areas is of advantage: neuroscience, Drosophila biology, connectomics or genetics, advanced microscopy or electrophysiology, mass spectrometry, behavioral experiments and their analysis and scientific programming.

    Beginning: February 2022, or later
    Duration: 3-4 years
    Location: University of Fribourg
    Working time: 100%
    How to apply/Contact
    Please direct further questions and/or send your application (including a cover letter, CV, key records, references or reference contacts) in a single PDF file to Anne von Philipsborn: avp@dandrite.au.dk.
    Deadline: October 10, 2021

  • PhD student in Drosophila Behavioral Circuit Neuroscience (100%)

    The positions are open in the Philipsborn group: philipsborn-lab.org

    The lab will move to the University of Fribourg, Switzerland, in February 2022, (Department for Neuro- and Movement Science), where we will continue to work on Drosophila Circuit Neuroscience and Behavioral Genetics. We are interested in motor control and the neurobiology of reproduction, with a focus on chemical and acoustic communication during sexual interactions. We are employing behavioral assays, audio recordings, genetic manipulation and optogenetics, bioimaging and neuronal reconstructions to understand how circuit motifs shape behavior.

    Working area and tasks
    You will enroll at Fribourg Graduate School of Life Sciences (FGLS) for doctoral education. Possible scientific projects address: 1) the role of seminal fluid in male and female reproductive behavior, 2) neuronal mechanisms of state- dependent action control during reproduction or 3) development and function of sexual dimorphisms in motor patterning circuits.

    Your profile
    The ideal candidate has a Master Degree in Natural Sciences, interest in animal behavior and neuroscience, proficiency in English and the ability to work independently, creatively and efficiently. Good computer literacy, programming experience and knowledge of methods in neuroscience, microscopy, genetics and molecular biology is of advantage.

    Beginning: February 2022, or later
    Duration: 3-4 years
    Location: University of Fribourg
    Working time: 100%
    How to apply/Contact
    Please direct further questions and/or send your application (including a cover letter, CV, key records, references or reference contacts) in a single PDF file to Anne von Philipsborn: avp@dandrite.au.dk.
    Deadline: October 10, 2021