Biographie

SEFAGIA
WIA
LS2

Recherche et publications

• Publications
  176 publications

  Des chercheurs fribourgeois identifient une molécule contre la DMLA
  Patricia Boya (2026) | Autre

  Une solution bientôt trouvée pour combattre la perte de vision liée à l’âge?
  Patricia Boya (2026) | Autre

  The ‘mitochondrial guardian’ α-amyrin links colourful fruit consumption to cognitive resilience
  Autophagy (2026) | Article

  Autophagie reinigt die Zellen und lässt sich durch Fasten anregen , dans Apotheken Umschau
  Patricia Boya (21.7.2026) | Article de presse

  Chaperone-mediated autophagy protects against retinal photoreceptor degeneration by modulating proteostasis of glucose metabolism enzymes
  Proceedings of the National Academy of Sciences (2026) | Article

  The Mitochondrial Guardian α‐Amyrin Mitigates Alzheimer's Disease Pathology via Modulation of the DLK‐SARM1‐ULK1 Axis
  Advanced Science (2026) | Article

  Autophagy and mitophagy in age-related macular degeneration: Custodians of retinal longevity
  Geromedicine (2026) | Article

  Identification of ACBP as a potential target in ciliopathic obesity through multi-omics network analysis
  Nature Communications (2026) | Article

  Autophagy and mitophagy at the synapse and beyond: implications for learning, memory and neurological disorders
  Autophagy (2026) | Article

  Sirtuin 1 overexpression in mice preserves insulin and thermogenic responses in subcutaneous inguinal white adipose tissue under proinflammatory conditions
  Journal of Physiology and Biochemistry (2025) | Article

  Defective chaperone-mediated autophagy in the retinal pigment epithelium of age-related macular degeneration patients
  EMBO Molecular Medicine (2025) | Article

  Deferiprone protects against photoreceptor degeneration by inhibiting parthanatos
  Cell Death & Disease (2025) | Article

  Targeted proteomics addresses selectivity and complexity of protein degradation by autophagy
  Autophagy (2025) | Article

  How crosstalk between mitochondria, lysosomes, and other organelles can prevent or promote dry age-related macular degeneration
  Experimental Eye Research (2025) | Article

  The Developing Retina Undergoes Mitochondrial Remodeling via PINK1/PRKN-dependent Mitophagy
  Journal of Molecular Biology. (2025) | Article

  Women in Autophagy: an initiative to promote gender parity in science
  Nature Cell Biology (2024) | Article

  Recycling the recyclers: lysophagy emerges as a new pharmacological target for retinal degeneration
  Autophagy (2024) | Article

  Antiprotozoal Natural Products from Endophytic Fungi Associated with Cacao and Coffee.
  Metabolites (2024) | Article

  Fast and quantitative mitophagy assessment by flow cytometry using the mito-QC reporter
  Frontiers in Cell and Developmental Biology (2024) | Article

  Scientists at the University of Fribourg have revealed a mechanism that can reduce age-related neuroinflammation
  Patricia Boya (2024) | Autre

  Aging STINGs: mitophagy at the crossroads of neuroinflammation
  Autophagy (2024) | Article

  Urolithin A promotes p62-dependent lysophagy to prevent acute retinal neurodegeneration
  Molecular Neurodegeneration (2024) | Article

  Comprehensive Method Developed for More Accurate Disease Monitoring
  Unicom, Jörn Dengjel, Patricia Boya (2024) | Autre

  Nettoyer la cellule pour prolonger la santé , dans La Liberté
  Patricia Boya, Rémi Alt (7.3.2024) | Article de presse

  Faire le ménage dans nos cellules pour prolonger la santé physique , dans La Liberté 7 mars 2024
  Alt, Rémi (3.2024) | Article de presse

  A newly discovered natural compound protects against macular degeneration
  Patricia Boya (2024) | Autre

  Mitophagy curtails cytosolic mtDNA-dependent activation of cGAS/STING inflammation during aging
  Nature Communications (2024) | Article

  Identification of a new structural family of SGK1 inhibitors as potential neuroprotective agents
  Journal of Enzyme Inhibition and Medicinal Chemistry (2023) | Article

  Autophagy in the eye: from physiology to pathophysiology
  Autophagy Reports (2023) | Article

  Lysosomes in retinal health and disease
  Trends in Neurosciences (2023) | Article

  Mitophagy in the retina: Viewing mitochondrial homeostasis through a new lens
  Progress in Retinal and Eye Research (2023) | Article

  Transcriptomics and translatomics identify a robust inflammatory gene signature in brain endothelial cells after ischemic stroke.
  Journal of neuroinflammation (2023) | Article

  Bacteria‐instructed B cells cross‐prime naïve CD8+ T cells triggering effective cytotoxic responses
  EMBO reports (2023) | Article

  Apoptotic cell death in disease-Current understanding of the NCCD 2023.
  Cell death and differentiation (2023) | Article

  Carbon Monoxide Stimulates Both Mitophagy And Mitochondrial Biogenesis to Mediate Protection Against Oxidative Stress in Astrocytes
  Molecular Neurobiology (2023) | Article

  La saveur, toute une pizza , dans Universitas 02/2023
  Patricia, Boya (2.2023) | Article de presse

  El objetivo del Silver Film festival es dar visibilidad a las personas mayores. Es su primera edición y está teniendo una gran acogida.
  RTVEPaisVasco , Twitter (2023) | Autre

  Des goûts et des odeurs , dans Universitas 02/2023
  Patricia, Michaud (2023) | Article de presse

  Microglial phagocytosis dysfunction in stroke is driven by energy depletion and induction of autophagy.
  Autophagy (2023) | Article

  The mechanism of macroautophagy: The movie
  Autophagy Reports (2022) | Article

  BNIP3L/NIX regulates both mitophagy and pexophagy
  The EMBO Journal (2022) | Article

  Discovery of Mitophagy Inhibitors with Therapeutic Potential in Different Familial Amyotrophic Lateral Sclerosis Mutations
  International Journal of Molecular Sciences (2022) | Article

  Apoptosis-Inducing Factor Deficiency Induces Tissue-Specific Alterations in Autophagy: Insights from a Preclinical Model of Mitochondrial Disease and Exercise Training Effects
  Antioxidants (2022) | Article

  Autophagy induction during stem cell activation plays a key role in salivary gland self-renewal
  Autophagy (2022) | Article

  Investigación con ratones: por qué el sexo sí importa
  (2022) | Autre

  Regulation of PRKN-independent mitophagy
  Autophagy (2022) | Article

  Targeting retinoic acid receptor alpha-corepressor interaction activates chaperone-mediated autophagy and protects against retinal degeneration
  Nature Communications (2022) | Article

  Ambra1 haploinsufficiency in CD1 mice results in metabolic alterations and exacerbates age-associated retinal degeneration
  Autophagy (2022) | Article

  p38 MAPK priming boosts VSMC proliferation and arteriogenesis by promoting PGC1α-dependent mitochondrial dynamics
  Scientific Reports (2022) | Article

  Autophagy in major human diseases
  The EMBO Journal (2021) | Article

  Lipid dismantling of lens organelles for clear vision
  Nature (2021) | Article

  Molecular Alterations in Sporadic and SOD1-ALS Immortalized Lymphocytes: Towards a Personalized Therapy
  International Journal of Molecular Sciences (2021) | Article

  HDAC inhibition ameliorates cone survival in retinitis pigmentosa mice
  Cell Death and Differentiation (2021) | Article

  Autophagy and disease: new insights and challenges ahead
  Molecular Aspects of Medicine (2021) | Article

  Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)¹
  Autophagy (2021) | Article

  Phenotypic Assay Leads to Discovery of Mitophagy Inducers with Therapeutic Potential for Parkinson's Disease
  ACS Chemical Neuroscience (2021) | Article

  New insights into the role of autophagy in retinal and eye diseases
  Molecular Aspects of Medicine (2021) | Article

  Towards a better understanding of the neuro-developmental role of autophagy in sickness and in health
  Cell Stress (2021) | Article

  Caty Casas (1967-2020)
  Autophagy (2020) | Article

  Genome Mining, Microbial Interactions, and Molecular Networking Reveals New Dibromoalterochromides from Strains of Pseudoalteromonas of Coiba National Park-Panama.
  Marine drugs (2020) | Article

  Age related retinal Ganglion cell susceptibility in context of autophagy deficiency
  Cell Death Discovery (2020) | Article

  The mito-QC Reporter for Quantitative Mitophagy Assessment in Primary Retinal Ganglion Cells and Experimental Glaucoma Models
  International Journal of Molecular Sciences (2020) | Article

  Serum- and glucocorticoid-induced kinase 1, a new therapeutic target for autophagy modulation in chronic diseases
  Expert Opinion on Therapeutic Targets (2020) | Article

  HIF1α or mitophagy: Which drives cardiomyocyte differentiation?
  Cell Stress (2020) | Article

  A comparison of inducible, ontogenetic, and interspecific sources of variation in the foliar metabolome in tropical trees.
  PeerJ (2019) | Article

  A comparative map of macroautophagy and mitophagy in the vertebrate eye
  Autophagy (2019) | Article

  Immunological Synapse Formation Induces Mitochondrial Clustering and Mitophagy in Dendritic Cells
  The Journal of Immunology (2019) | Article

  Driving next-generation autophagy researchers towards translation (DRIVE), an international PhD training program on autophagy
  Autophagy (2019) | Article

  Viscosin-like lipopeptides from frog skin bacteria inhibit Aspergillus fumigatus and Batrachochytrium dendrobatidis detected by imaging mass spectrometry and molecular networking.
  Scientific reports (2019) | Article

  Lipotoxic Effects of Palmitic Acid on Astrocytes Are Associated with Autophagy Impairment
  Molecular Neurobiology (2019) | Article

  Acyl-CoA-Binding Protein Is a Lipogenic Factor that Triggers Food Intake and Obesity
  Cell Metabolism (2019) | Article

  Lysosomal membrane permeabilization and cell death
  Traffic (2018) | Article

  BNIP3L/NIX-dependent mitophagy regulates cell differentiation via metabolic reprogramming
  Autophagy (2018) | Article

  Lysosome-dependent cell death and deregulated autophagy induced by amine-modified polystyrene nanoparticles
  Open Biology (2018) | Article

  A protocol for high-throughput, untargeted forest community metabolomics using mass spectrometry molecular networks.
  Applications in plant sciences (2018) | Article

  Autophagy in stem cells: repair, remodelling and metabolic reprogramming
  Development (2018) | Article

  Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018
  Cell Death and Differentiation (2018) | Article

  Lysosomal membrane permeabilization as a cell death mechanism in cancer cells
  Biochemical Society Transactions (2018) | Article

  Mitophagy, metabolism, and cell fate
  Molecular & Cellular Oncology (2017) | Article

  Molecular definitions of autophagy and related processes
  The EMBO Journal (2017) | Article

  Imaging mass spectrometry and MS/MS molecular networking reveals chemical interactions among cuticular bacteria and pathogenic fungi associated with fungus-growing ants.
  Scientific reports (2017) | Article

  Why autophagy is good for retinal ganglion cells?
  Eye (2017) | Article

  Autophagy and vision
  Medecine Sciences: M/S (2017) | Article

  Autophagy couteracts weight gain, lipotoxicity and pancreatic β-cell death upon hypercaloric pro-diabetic regimens
  Cell Death and Disease (2017) | Article

  Programmed mitophagy is essential for the glycolytic switch during cell differentiation
  The EMBO Journal (2017) | Article

  Cytofluorometric Assessment of Mitophagic Flux in Mammalian Cells and Tissues
  Methods in Enzymology (2017) | Article

  Standard Assays for the Study of Autophagy in the Ex Vivo Retina
  Cells (2017) | Article

  The S1P1 receptor-selective agonist CYM-5442 protects retinal ganglion cells in endothelin-1 induced retinal ganglion cell loss
  Experimental Eye Research (2017) | Article

  Autofagia: cómo nuestras células se reciclan
  Boya, Patricia (2017) | Article de presse

  Lysosomal membrane permeabilization in cell death: new evidence and implications for health and disease
  Targeting the Lysosome (2016) | Article

  Dihydroceramide accumulation mediates cytotoxic autophagy of cancer cells via autolysosome destabilization
  Autophagy (2016) | Article

  Lysosomal cell death mechanisms in aging
  Ageing Research Reviews (2016) | Article

  Autophagy in the eye: Development, degeneration, and aging
  Progress in Retinal and Eye Research (2016) | Article

  Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)
  Autophagy (2016) | Article

  Altered Blood Gene Expression of Tumor-Related Genes (PRKCB, BECN1, and CDKN2A) in Alzheimer's Disease
  Molecular Neurobiology (2016) | Article

  Visual decline in aged mice is delayed by proinsulin
  Investigative Ophthalmology & Visual Science (2016) | Article

  Mitophagy acts as a safeguard mechanism against human vascular smooth muscle cell apoptosis induced by atherogenic lipids
  Oncotarget (2016) | Article

  VASCULAR BIOLOGY I. MITOPHAGY ACTS AS A SAFEGUARD MECHANISM AGAINST HUMAN VASCULAR SMOOTH MUSCLE CELL APOPTOSIS INDUCED BY ATHEROGENIC LIPIDS
  Atherosclerosis (2016) | Article

  Autophagy: The system of recycling and cellular defense which have all our cells,Autofagia: El sistema de reciclaje y defensa celular que tienen todas nuestras células
  Anales de la Real Academia Nacional de Farmacia (2016) | Article

  Why is autophagy essential to keep our cells healthy? ¿Por qué la autofagia es esencial para mantener nuestras células sanas? , dans calameo.com
  (2016) | Article de presse

  Lysosomal membrane permeabilization and autophagy blockade contribute to photoreceptor cell death in a mouse model of retinitis pigmentosa
  Investigative Ophthalmology & Visual Science (2015) | Article

  New method to assess mitophagy flux by flow cytometry
  Autophagy (2015) | Article

  Autophagic flux determination in vivo and ex vivo
  Methods (2015) | Article

  Mitophagy in mitosis: More than a myth
  Autophagy (2015) | Article

  AMPK and PFKFB3 mediate glycolysis and survival in response to mitophagy during mitotic arrest
  Nature Cell Biology (2015) | Article

  Autophagy researchers.
  Autophagy (2014) | Article

  High sphingomyelin levels induce lysosomal damage and autophagy dysfunction in Niemann Pick disease type A
  Cell Death and Differentiation (2014) | Article

  Reduced autophagy in skin aging and positive regulation by a saponin-rich asparagus extract
  Journal of Investigative Dermatology (2014) | Article

  Autophagy in retina and axonal degeneration
  Acta Ophthalmologica (2014) | Article

  Balance between autophagic pathways preserves retinal homeostasis
  Aging Cell (2013) | Article

  Interactions between autophagic and endo-lysosomal markers in endothelial cells
  Histochemistry and Cell Biology (2013) | Article

  Time resolved study of cell death mechanisms induced by amine-modified polystyrene nanoparticles
  Nanoscale (2013) | Article

  Autophagy disregulation in the retina during aging and neurodegeneration
  Investigative Ophthalmology & Visual Science (2013) | Article

  Cell biology: Recycling in sight
  Nature (2013) | Article

  Emerging regulation and functions of autophagy
  Nature Cell Biology (2013) | Article

  Emerging regulation and functions of autophagy (vol 15, pg 713, 2013)
  Nature Cell Biology (2013) | Article

  Atg5 and Ambra1 differentially modulate neurogenesis in neural stem cells
  Autophagy (2012) | Article

  Autophagy disregulation in the retina: neurodegeneration and aging
  Febs Journal (2012) | Article

  Autophagy promotes survival of retinal ganglion cells after optic nerve axotomy in mice
  Cell Death and Differentiation (2012) | Article

  Axonal damage, autophagy and neuronal survival
  Autophagy (2012) | Article

  Guidelines for the use and interpretation of assays for monitoring autophagy
  Autophagy (2012) | Article

  Lysosomal Function and Dysfunction: Mechanism and Disease
  Antioxidants & Redox Signaling (2012) | Article

  Micronucleophagy: A new mechanism to protect against chromosomal instability?
  Cell Cycle (2012) | Article

  Role of autophagy during the development of the vertebrate nervous system
  Febs Journal (2012) | Article

  AUTOPHAGY IN THE RETINA: DEVELOPMENT, PHYSIOLOGY AND PATHOLOGY
  Autophagy of the Nervous System: Cellular Self-digestion in Neurons and Neurological Diseases (2012) | Article

  Lysosomal membrane permeabilization in Parkinson disease
  Autophagy (2011) | Article

  Impaired autophagy in Lafora disease
  Autophagy (2010) | Article

  Intracellular Silicon Chips in Living Cells
  Small (2010) | Article

  Laforin, the most common protein mutated in Lafora disease, regulates autophagy
  Human Molecular Genetics (2010) | Article

  Pathogenic Lysosomal Depletion in Parkinson's Disease
  Journal of Neuroscience (2010) | Article

  Structural Determinants Allowing Endolysosomal Sorting and Degradation of Endosomal GTPases
  Traffic (2010) | Article

  The nuclear cofactor DOR regulates autophagy in mammalian and Drosophila cells
  Embo Reports (2010) | Article

  Tumor suppressor p27(Kip1) undergoes endolysosomal degradation through its interaction with sorting nexin 6
  Faseb Journal (2010) | Article

  Beclin 1: a BH3-only protein that fails to induce apoptosis
  Oncogene (2009) | Article

  Cannabinoid action induces autophagy-mediated cell death through stimulation of ER stress in human glioma cells
  Journal of Clinical Investigation (2009) | Article

  Early neural cell death: numbers and cues from the developing neuroretina
  International Journal of Developmental Biology (2009) | Article

  The C-Terminal Sequence of RhoB Directs Protein Degradation through an Endo-Lysosomal Pathway
  Plos One (2009) | Article

  Single cell biomolecular recognition by silicon intracelullar chips
  Duch, M. and Vázquez, P. and Gómez-Martínez, R. and Boya, P. and Muriano, A. and Pinacho, D. and Sanvicens, N. and Sánchez-Baeza, F. and De La Rosa, E. and Esteve, J. and Suárez, T. and Plaza, J.A., Proceedings of Conference, MicroTAS 2009 - The 13th International Conference on Miniaturized Systems for Chemistry and Life Sciences: (2009) | Conférence

  Autophagy is not universally required for phosphatidyl-serine exposure and apoptotic cell engulfment during neural development
  Autophagy (2009) | Article

  TRB3 links ER stress to autophagy in cannabinoid anti-tumoral action
  Autophagy (2009) | Article

  Attenuation of vision loss and delay in apoptosis of photoreceptors induced by proinsulin in a mouse model of retinitis pigmentosa
  Investigative Ophthalmology & Visual Science (2008) | Article

  How autophagy is related to programmed cell death during the development of the nervous system
  Biochemical Society Transactions (2008) | Article

  Intra-mitochondrial degradation of Tim23 curtails the survival of cells rescued from apoptosis by caspase inhibitors
  Cell Death and Differentiation (2008) | Article

  Lysosomal membrane permeabilization in cell death
  Oncogene (2008) | Article

  The autophagic machinery is necessary for removal of cell corpses from the developing retinal neuroepithelium
  Cell Death and Differentiation (2008) | Article

  Early neural cell death: An overlooked process in neural development
  Anales de la Real Academia Nacional de Farmacia (2007) | Article

  Youth and the future of science
  Boletín de la Sociedad Española de Bioquímica y Biología Molecular (2006) | Article

  ESOF, an initiative to bring science closer to society
  Boletín de la Sociedad Española de Bioquímica y Biología Molecular (2006) | Article

  Cell death in early neural life.
  Birth defects research. Part C, Embryo today : reviews (2005) | Article

  Essential role of p53 phosphorylation by p38 MAPK in apoptosis induction by the HIV-1 envelope
  Journal of Experimental Medicine (2005) | Article

  Inhibition of macroautophagy triggers apoptosis
  Molecular and Cellular Biology (2005) | Article

  The apoptosis/autophagy paradox: autophagic vacuolization before apoptotic death
  Journal of Cell Science (2005) | Article

  An anti-apoptotic viral protein that recruits bax to mitochondria
  Journal of Biological Chemistry (2004) | Article

  Anti-apoptotic activity of the glutathione peroxidase homologue encoded by HIV-1
  Apoptosis (2004) | Article

  Bcl-2 and CCND1/CDK4 expression levels predict the cellular effects of mTOR inhibitors in human ovarian carcinoma
  Apoptosis (2004) | Article

  NF-kappa B and p53 are the dominant apoptosis-inducing transcription factors elicited by the HIV-1 envelope
  Journal of Experimental Medicine (2004) | Article

  Viral proteins targeting mitochondria: controlling cell death
  Biochimica Et Biophysica Acta-Bioenergetics (2004) | Article

  A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine induced liver damage: A possible mechanism for viral persistence
  Journal of Hepatology (2003) | Article

  Cytofluorometric quantitation of apoptosis-driven inner mitochondrial membrane permeabilization
  Apoptosis (2003) | Article

  Lysosomal membrane permeabilization induces cell death in a mitochondrion-dependent fashion
  Journal of Experimental Medicine (2003) | Article

  Mitochondrial membrane permeabilization is a critical step of lysosome-initiated apoptosis induced by hydroxychloroquine
  Oncogene (2003) | Article

  Mitochondrion-targeted apoptosis regulators of viral origin
  Biochemical and Biophysical Research Communications (2003) | Article

  The chemopreventive agent N-(4-hydroxyphenyl) retinamide induces apoptosis through a mitochondrial pathway regulated by proteins from the Bcl-2 family
  Oncogene (2003) | Article

  A recombinant adenovirus encoding hepatitis C virus core and E1 proteins protects mice against cytokine-induced liver damage
  Hepatology (2003) | Article

  Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and BCI-X-L
  Oncogene (2002) | Article

  Endoplasmic reticulum stress-induced cell death requires mitochondrial membrane permeabilization
  Cell Death and Differentiation (2002) | Article

  Mitochondrial permeability transition as a novel principle of hepatorenal toxicity in vivo
  Apoptosis (2002) | Article

  The C-terminal moiety of HIV-1 Vpr induces cell death via a caspase-independent mitochondrial pathway
  Cell Death and Differentiation (2002) | Article

  STAT-1 and IRF-1: Two factors in the signaling pathway of interferons related to viral load and liver damage in chronic hepatitis C (CH-C)
  Journal of Hepatology (2002) | Article

  Cell permeable BH3-peptides overcome the cytoprotective effect of Bcl-2 and Bcl-X(L).
  Oncogene (2002) | Article

  Expression of interferon-alpha subtypes in peripheral mononuclear cells from patients with chronic hepatitis C: a role for interferon-alpha 5
  Journal of Viral Hepatitis (2001) | Article

  Nuclear factor-kappa B in the liver of patients with chronic hepatitis C: Decreased RelA expression is associated with enhanced fibrosis progression
  Hepatology (2001) | Article

  Viral and bacterial proteins regulating apoptosis at the mitochondrial level
  Embo Journal (2001) | Article

  Antioxidant status and glutathione metabolism in peripheral blood mononuclear cells from patients with chronic hepatitis C
  Journal of Hepatology (1999) | Article

  Interferon alfa subtypes and levels of type I interferons in the liver and peripheral mononuclear cells in patients with chronic hepatitis C and controls
  Hepatology (1999) | Article

  A proteinaceus sequence for endo-lysosomal localization and degradation.
  Patricia Boya | Autre

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