Fink Group has recently published an article in the journal Frontiers in Bioengineering and Biotechnology, entitled; "The impact of cell density variations on nanoparticle uptake across bioprinted A549 gradients". 

For more information and to read the article: https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2025.1584635/full

Introduction: 

The safe-by-design of engineered nanoparticles (NPs) for any application requires a detailed understanding of how the particles interact with single cells. Most studies are based on two-dimensional, uniformly dense cell cultures, which do not represent the diverse and inhomogeneous cell environments found in situ. In-vitro models that accurately represent tissue complexity, including realistic cell densities, are essential to increase the predictive accuracy of studies on cell-NP interactions. This study uses a bioprinted cell gradient model to examine the relation between cell density and NP uptake in one dish.