Yang Group


  • Yang Zhihong


    Liang X, Potenza DM, Brenna A, Ma Y, Ren Z, Cheng X, Ming X-F and Yang Z (2021) Hypoxia Induces Renal Epithelial Injury and Activates Fibrotic Signaling Through Up-Regulation of Arginase-II. Front. Physiol. 12:773719. doi: 10.3389/fphys.2021.773719

    Brenna A, Ripperger JA, Saro G, Glauser D, Yang Z, Albrecht U. PER2 mediates CREB-dependent light induction of Per1 via histone acetylation. Sci Reports (2021)

    Huang J, Liang X, Ladeiras D, Fellay B,  Ming X-F, Yang Z. Role of tubular epithelial arginase-II in renal inflammaging. npj Aging Mech Dis 7, 5 (2021). https://doi.org/10.1038/s41514-021-00057-8

    Huang J, Ladeiras D, Yu Y, Ming X-F, and Yang Z. Detrimental Effects of Chronic L-Arginine Rich Food on Aging Kidney. Front. Pharmacol. 2021, 11:1-13. DOI: 10.3389/fphar.2020.582155



    Yu Y, Ladeiras D, Boligan KD, Liang X, von Gunten S, Hunger RE, Ming X-F, Yang Z. Arginase-II promotes melanoma migration and adhesion through enhancing hydrogen peroxide production and STAT3 signaling. J Cell Physiol. 2020 Dec;235(12):9997-10011. DOI: 10.1002/jcp.29814. Epub 2020 May 29.

    Huang J., Liu C., Ming X.-F., Yang Z. Inhibition of p38mapk Reduces Adipose Tissue Inflammation in Aging Mediated by Arginase-II. Pharmacology. 2020;105:491-504. DOI: 10.1159/000507635. Published online: May 26, 2020.

    With Editorial: von Gunten S. Inflamm-Aging: Arginase-II as Stage Setter in Age-Related Adipose Tissue Inflammation. Pharmacology 2020;105:489–490. DOI: 10.1159/000510515



    Liang X, Arullampalam P, Ming X-F, Yang Z. Hypoxia enhances endothelial ICAM-1 expression through upregulation of arginase-II and mitochondrial oxidative stress. Front in Physiol 2019 August | Volume 10 | Article 1003. doi: 10.3389/fphys.2019.01003

    Yu Y, Xiong Y, Ladeiras D, Yang Z. Ming X-F. Myosin 1b regulates nuclear Akt activation through preventing localization of PTEN in the nucleus. iScience 2019;19:39-53. DOI: 10.1016/j.isci.2019.07.010

    University press news:

    https://www.unifr.ch/news/en/22848?utm_source=news&utm_medium=&utm_campaign=redirection_from_homehttp%3A%2F%2Fwww3.unifr.ch%2Fhome%2Fen%2F# and also by The German speaking news agency (SDA): Krebszellen: Universität Freiburg bestätigt möglichen Nutzen von Myosin-Blocker.



    Huang J, Montani JP, Verrey F, Feraille E, Ming XF, Yang Z. Arginase-II negatively regulates renal aquaporin-2 and water reabsorption. FASEB J. 2018 Oct;32(10):5520-5531. doi: 10.1096/fj.201701209R.

    Yu Y, Xiong Y, Montani J-P, Yang Z, Ming X-F. Arginase-II activates mTORC1 through myosin-1b in vascular cell senescence and apoptosis. Cell Death and Disease 2018;9:313. DOI 10.1038/s41419-018-0356-9

    Pillai SM, Seebeck P, Fingerhut R, Huang J, Ming X-F, Yang Z, Verrey F. Kidney mass reduction leads to L-arginine metabolism-dependent blood pressure increase in mice J Am Heart Assoc. 2018;7:e008025. DOI: 10.1161/JAHA.117.008025



    Xiong Y, Yepuri G, Montani J-P, Ming X-F, Yang Z. Arginase-II deficiency extends lifespan in mice. Front. Physiol. 2017;8:682. doi: 10.3389/fphys.2017.00682

    Xiong Y, Yepuri G, Necetin S, Montani J-P, Ming X-F, Yang Z. Arginase-II promotes tumor necrosis factor-α release from pancreatic acinar cells causing β-cell apoptosis in aging. Diabetes 2017;66:1636-1649 (ePub ahead: 2017, Mar 29. pii: db161190. doi: 10.2337/db16-1190.

    Zhu C, Yu Y, Montani J-P, Ming X-F, Yang Z. Arginase-I enhances vascular endothelial inflammation and senescence through eNOS-uncoupling. Zhu et al. BMC Res Notes 2017;10:82. DOI 10.1186/s13104-017-2399-x

    Yang Z and Ming X-F. Adventitia and perivascular adipose tissue – the integral unit in vascular disease (Chapter 20). In: ESC Textbook of Vascular Biology. Robert Krams and Magnus Bäck (eds.), OXFORD University Press, 2017, pp -320.

    Reiner MF, Akhmedov A, Stivala S, Keller S, Gaul DS, Bonetti NR, Savarese G, Glanzmann M, Zhu C, Ruf W, Yang Z, Matter CM, Lüscher TF, Camici GG, Beer JH. Ticagrelor, but not clopidogrel, reduces arterial thrombosis via endothelial tissue factor suppression. Cardiovasc Res. 2016 Nov 15. pii: cvw233. doi: 10.1093/cvr/cvw233. [Epub ahead of print] Cardiovascular Research 2017;113:61–69.

    Yang Z. New discovery of an age-related diabetes mechanism 2017    http://www.unifr.ch/news/en/17377/new-discovery-of-an-age-related-diabetes-mechanism?&p=1 and http://www.freiburger-nachrichten.ch/kanton/bahnbrechende-erkenntnisse-zur-altersdiabetes



    Huang J, Rajapakse AG, Xiong Y, Montani J-P, Verrey F, Ming X-F, Yang Z. Genetic targeting of arginase-II in mouse prevents renal oxidative stress and inflammation in diet-induced obesity. Front. Physiol 2016, 7:560. doi: 10.3389/fphys.2016.00560

    Yu Y, Xiong YY, Montani JP, Yang Z, Ming-X-F. En face detection of nitric oxide and superoxide in endothelial layer of intact arteries. JoVE 2016 February 25, Issue 108; 53718 doi: 10.3791/53718

    Klionsky DJ, et al., Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition). Autophagy. 2016 Jan 2;12(1):1-222.

    Liu C, Rajapakse AG, Riedo E, Fellay B, Bernhard MC, Montani JP, Yang Z, Ming X-F. Targeting arginase-II protects mice from high-fat-diet-induced hepatic steatosis through suppression of macrophage inflammation. Sci Rep. 2016 Feb 5;6:20405. doi: 10.1038/srep20405.



    Wu Z, Yu Y, Liu C, Xiong Y, Montani JP, Yang Z, Ming X-F. Role of p38 mitogen-activated protein kinase in vascular endothelial aging: Interaction with Arginase-II and S6K1 signaling pathway. Aging (Albany NY) 2015;7(1):70-81

    Yang Z. Autophagie: Saubermachen in der Zelle. Universität Fribourg Communication 2015 http://www.unifr.ch/news/de/14187/

    Yang Z. Der Geist sitzt im Herzen. Interview by Zürich Heart House 2015.

    Yang Z. Vascular investigations – Age and Arginase. Interview by International Innovation 2015, issue 184: page 37-39 



    Xiong Y, Yepuri G, Forbiteh M, Yu Y, Montani J-P, Yang Z, Ming X-F. ARG2 impairs endothelial autophagy through regulation of MTOR and PRKAA/AMPK signaling in advanced atherosclerosis. Autophagy. 2014 Dec 2;10(12):2223-38. doi: 10.4161/15548627.2014.981789

    Yu Y, Rajapakse AG, Montani J-P, Yang Z, Ming X-F. p38 mitogen-activated protein kinase is involved in arginase-II-mediated eNOS-uncoupling in obesity. Cardiovasc Diabetol. 2014 Jul 18;13(1):113.

    Xiong Y; Forbiteh Fru M; Yu Y; Montani J-P; Ming X-F; Yang Z. Long term exposure to L-arginine accelerates endothelial cell senescence through arginase-II and S6K1 signaling. Aging. 2014;6:369-379

    Yang Z and Ming X-F. Functions of Arginase Isoforms in Macrophage Inflammatory Responses: Impact on Cardiovascular Diseases and Metabolic Disorders. Front. Immunol., October 27, 2014 | doi: 10.3389/fimmu.2014.00533



    Xiong Y, Yu Y, Montani JP, Yang Z, Ming XF. Arginase-II Induces Vascular Smooth Muscle Cell Senescence and Apoptosis Through p66Shc and p53 Independently of Its L-Arginine Ureahydrolase Activity: Implications for Atherosclerotic Plaque Vulnerability. J Am Heart Assoc. 2013 Jul 5;2(4):e000096. doi: 10.1161/JAHA.113.000096.

    This study was highlighted by an Editorial in JAHA written by Drs. Deepesh Pandey, Lewis Romer and Dan E. Berkowitz (http://jaha.ahajournals.org/content/2/4/e000392.full.html?etoc)

    Ming X-F, Yang Z. Functions and Mechanisms of arginase in age-associated cardiovascular diseases. Current Translational Geriatrics and Experimental Gerontology Reports 2013;2:268–274. DOI 10.1007/s13670-013-0060-7 (invited review article)

    Yang Z and Ming X-F. Arginase: the emerging therapeutic target for vascular oxidative stress and inflammation. Front. Immunol., 12 June 2013|doi: 10.3389/fimmu.2013.00149 (invited special topic review article)

    Yang Z. Endothelial NF-κB: the remote controller of the backyard fire in the vascular wall? Cardiovasc Res. 2013 Jan 1;97(1):8-9. doi: 10.1093/cvr/cvs331. Epub 2012 Nov 2. (Invited Editorial)



    Yepuri G, Velagapudi S, Xiong Y, Rajapakse AG, Montani JP, Ming XF, Yang Z. Positive crosstalk between arginase-II and S6K1 in vascular endothelial inflammation and aging. Aging Cell. 2012 Dec;11(6):1005-16. doi: 10.1111/acel.12001. Epub 2012 Sep 18.

    Carvas JM, Vukolic A, Yepuri G, Xiong Y, Popp K, Schmutz I, Chappuis S, Albrecht U, Ming X-F, Montani J-P and Yang Z. Period2 gene mutant mice show compromised insulin-mediated endothelial nitric oxide release and altered glucose homeostasis. Front. Physio. 2012:3:337. doi: 10.3389/fphys.2012.00337

    Ming X-F, Rajapakse AG, Yepuri G, Xiong Y, Carvas JM, Ruffieux J, Scerri I, Wu Z, Popp K, Li J, Sartori C, Scherrer U, Kwak BR, Montani J-P, Yang Z. Arginase-II promotes macrophage inflammatory responses through mitochondrial reactive oxygen species, contributing to insulin resistance and atherogenesis. JAHA 2012;1:e000992doi:10.1161/JAHA.112.000992:

    This article was selected by ESC working group “Atherosclerosis and Vascular Biology” as the interview article of October 2012. https://www.escardio.org/Working-groups/Working-Group-on-Atherosclerosis-and-Vascular-biology/Publications/Arginase-II-Promotes-Macrophage-Inflammatory-Responses-Through-Mitochondrial-Rea and also has been recommended as being of special significance in its field by Amira Klip and Nicolas Pillon from the F1000 Faculty: http://f1000.com/prime/717967456

    Du JY, Chen MC, Hsu TC, Wang JH, Brackenbury L, Lin TH, Wu YY, Yang Z, Streuli CH, Lee YJ. The RhoA-Rok-myosin II pathway is involved in extracellular matrix-mediated regulation of prolactin signaling in mammary epithelial cells. J Cell Physiol. 2012 Apr;227(4):1553-60. doi: 10.1002/jcp.22886.

    Wu Z, Xiong Y, Gajanayake T, Ming XF, Yang Z. p38 Mitogen-Activated Protein Kinase Is Required for Glucosamine-Induced Endothelial Nitric Oxide Synthase Uncoupling and Plasminogen-Activator Inhibitor Expression. Circ J. 2012;76:2015-2022.

    Gebhard C, Holy EW, Camici GG, Akhmedov A, Stämpfli SF, Stähli BE, von Rickenbach B, Breitenstein A, Greutert H, Yang Z, Lüscher TF, Tanner FC. Caffeine induces endothelial tissue factor expression via phosphatidylinositol 3-kinase inhibition. Thromb Haemost. 2012;107:884-894.

    Yang Z, Ming X-F. mTOR signalling: the molecular interface connecting metabolic stress, aging and cardiovascular diseases. Obesity Review. 2012 Dec;13 Suppl 2:58-68. doi: 10.1111/j.1467-789X.2012.01038.x.

    Ming X-F, Montani J-P and Yang Z. Perspectives of targeting mTORC1–S6K1 in cardiovascular aging. Front Physiol. 2012;3:5. Epub 2012 Jan 25.

    Yang Z and Ming X-F. Arginase II Promotes Macrophage Inflammatory Responses Through Mitochondrial Reactive Oxygen Species Contributing to Insulin Resistance and Atherogenesis. Interview by Working Group on Atherosclerosis & Vascular Biology of the European Heart Society (01 Oct 2012). www.escardio.org/communities/Working-Groups/atherosclerosis-vascular-biology/publications/Pages/arginase-II.aspx



    Rajapakse AG, Yepuri G, Carvas JM, Stein S, Matter CM, Scerri I, Ruffieux J, Montani JP, Ming XF, Yang Z. Hyperactive S6K1 Mediates Oxidative Stress and Endothelial Dysfunction in Aging: Inhibition by Resveratrol. PLoS One. 2011 Apr 22;6(4):e19237.

    Yang Z, Ming X-F. CD36: the common soil for inflammation in obesity and atherosclerosis? Cardiovasc Res. 2011;89:485-486 (Invited Editorial).

    Yang Z. Rotwein hilft gegen die Alterung von Blutgefässen: Universität Fribourg Communication (11.05.2011): http://www.unifr.ch/news/de/7045/



    Vukolic A, Antic V, Van Vliet BN, Yang Z, Albrecht U, Montani JP. Role of mutation of the circadian clock gene Per2 in cardiovascular circadian rhythms. Am J Physiol Regul Integr Comp Physiol. 2010;298:R627-R634.

    Chadjichristos CE, Scheckenbach KE, van Veen TA, Richani Sarieddine MZ, de Wit C, Yang Z, Roth I, Bacchetta M, Viswambharan H, Foglia B, Dudez T, van Kempen MJ, Coenjaerts FE, Miquerol L, Deutsch U, Jongsma HJ, Chanson M, Kwak BR. Endothelial-Specific Deletion of Connexin40 Promotes Atherosclerosis by Increasing CD73-Dependent Leukocyte Adhesion. Circulation. 2010;121:123-131.

    Ming XF, Rajapakse AG, Carvas JM, Ruffieux J, Yang Z. Opposing and uncoupling effects of mTOR and S6K1 in the regulation of endothelial tissue factor expression. FEBS Lett. 2010;584:135-140.

    Yang Z, Ming XF. The Vascular SIRTainty. Aging, june 2010, Vol.2. No6 (Invited Editorial).



    Banz Y, Gajanayake T, Matozan K, Yang Z, Rieben R., Dextran sulfate modulates MAP kinase signaling and reduces endothelial injury in a rat aortic clamping model.  J Vasc Surg 2009;50:161-170.

    Rajapakse GA, Ming X-F, Carvas JM. Yang Z. O-linked β-N-acetylglucosamine during hyperglycemia exerts both anti-inflammatory and pro-oxidative properties in the endothelial system. Oxidative Medicine & Cellular Longevity 2009;(2):172-175.

    Lee YJ, Hsu TC, Du JY, Valentijn AJ, Wu TY, Cheng CF, Yang Z, Streuli CH. Extracellular matrix controls insulin signaling in mammary epithelial cells through the RhoA/Rok pathway. J Cell Physiol. 2009 Aug;220(2):476-84. doi: 10.1002/jcp.21793.

    Ming XF, Rajapakse AG, Carvas JM, Ruffieux J, Yang Z. Inhibition of S6K1 accounts partially for the anti-inflammatory effects of the arginase inhibitor L-norvaline. BMC Cardiovasc Disord. 2009 Mar 13;9(1):12.

    Rajapakse AG, Ming XF, Carvas JM, Yang Z. The hexosamine biosynthesis inhibitor azaserine prevents endothelial inflammation and dysfunction under hyperglycemic condition through antioxidant effects. Am J Physiol Heart Circ Physiol. 2009;296(3):H815-22.



    Largiadèr T, Eto M, Payeli SK, Greutert H, Viswambharan H, Lachat M, Zünd G, Yang Z, Tanner FC, Lüscher TF. Endothelial nitric oxide synthase gene transfer inhibits human smooth muscle cell migration via inhibition of Rho A. J Cardiovasc Pharmacol. 2008;52:369-74.

    Dulloo AG, Yang Z, Montani J-P. Dysfunctional foods in pathogenesis of obesity and metabolic syndrome. Int J Obes 2008;32:S1–S3.

    Interview by American Heart Association Journal "Circulation" 2008: A Change of Scene: Zhihong Yang, MD, Author of Almost 100 Peer-Reviewed Papers, Recipient of a String of Prizes, and Active in Many Advisory Roles. European Perspectives. Circulation 2008;118;f10-f12. DOI: 10.1161/CIRCULATIONAHA.108.189691



    Viswambharan H, Carvas JM, Antic V, Marecic A, Jud C, Zaugg CE, Ming XF, Montani JP, Albrecht U, Yang Z. Mutation of the circadian clock gene Per2 alters vascular endothelial function. Circulation. 2007;115:2188-2195.

    Yang Z, Montani J-P. Emerging roles of perivascular adipose tissue in regulation of vascular functions. Immunol Endocrine & Metab Agents 2007;7:137-141.



    Camici GG, Steffel J, Akhmedov A, Schafer N, Baldinger J, Schulz U, Shojaati K, Matter CM, Yang Z, Luscher TF, Tanner FC. Dimethyl sulfoxide inhibits tissue factor expression, thrombus formation, and vascular smooth muscle cell activation: a potential treatment strategy for drug-eluting stents. Circulation. 2006;114:1512-1521.

    Frischknecht K, Greutert H, Weisshaupt C, Kaspar M, Yang Z, Luscher TF, Carrel TP, Tanner FC. Different vascular smooth muscle cell apoptosis in the human internal mammary artery and the saphenous vein: implications for bypass graft disease. J Vasc Res. 2006;43:338-346.

    Dulloo AG Antic V, Yang Z. Montani J-P. Propellers of growth trajectories to obesity and the metabolic syndrome. Int J Obes 2006;30(Suppl. 4):S1-S3 (Editorial preface).

    Yang Z, Ming XF. Endothelial arginase: a new target in atherosclerosis. Curr Hypertens Rep. 2006;8:54-59.

    Yang Z. Ming X-F. Recent Advances in Understanding Endothelial dysfunction in atherosclerosis. Clin Med & Res 2006;4:53-65.

    Yang Z. Zu fette Ernährung lässt das Herz verhungern. UNIVERSITAS / MARS 2006, 22 - 23



    Kozai T, Eto M, Yang Z, Shimokawa H, Luscher TF. Statins prevent pulsatile stretch-induced proliferation of human saphenous vein smooth muscle cells via inhibition of Rho/Rho-kinase pathway. Cardiovasc Res. 2005;68:475-482.

    Barandier C, Montani JP, Yang Z. Mature adipocytes and perivascular adipose tissue stimulate vascular smooth muscle cell proliferation: effects of aging and obesity. Am J Physiol Heart Circ Physiol. 2005;289:H1807-H1813.

    This article was accompanied with an editorial by Engeli S. Is there a pathophysiological role for perivascular adipocytes? Am J Physiol Heart Circ Physiol. 2005 Nov;289(5):H1794-5.

     Zhu S, Viswambharan H, Gajanayake T, Ming XF, Yang Z. Sirolimus increases tissue factor expression but not activity in cultured human vascular smooth muscle cells. BMC Cardiovasc Disord. 2005;5:22. (http://www.biomedcentral.com/1471-2261/5/22)

     Mujynya-Ludunge K, Viswambharan H, Driscoll R, Ming XF, von Segesser LK, Kappenberger L, Yang Z, Vassalli G. Endothelial nitric oxide synthase gene transfer restores endothelium-dependent relaxations and attenuates lesion formation in carotid arteries in apolipoprotein E-deficient mice. Basic Res Cardiol. 2005;100:102-111

     Yang Z. Role of arginase in atherosclerotic endothelial dysfunction: another explanation for controversy of supplemental L-arginine therapy? Commentaries  published on-line for International Atherosclerosis Society (IAS).January 2005. (http://www.athero.org/commentaries/comm407.asp)

    Yang Z. Das gute (HDL)-Cholesterin: Warum es gut ist. Press Communication. Pfizer-Research Prize 2005 http://www.pfizerforschungspreis.ch/content/pfizerpreis/de/home/prizewinner/2005.html



    Ming X-F, Barandier C, Viswambharan H, Kwak BR, Mach F, Mazzolai L, Hayoz D, Ruffieux J, Rusconi S, Montani J-P, Yang Z. Thrombin stimulates human endothelial arginase enzymatic activity via RhoA/ROCK pathway: implications for atherosclerotic endothelial dysfunction. Circulation. 2004;110:3708-14. Epub 2004 Nov 29

    Viswambharan H, Ming XF, Zhu S, Hubsch A, Lerch P, Vergeres G, Rusconi S, Yang Z. Reconstituted high-density lipoprotein inhibits thrombin-induced endothelial tissue factor expression through inhibition of RhoA and stimulation of phosphatidylinositol 3-kinase but not Akt/endothelial nitric oxide synthase. Circ Res. 2004 Apr 16;94(7):918-925

    Tanner FC, Largiader T, Greutert H, Yang Z, Lüscher TF. Nitric oxide synthase gene transfer inhibits biological features of bypass graft disease in the human saphenous vein. J Thorac Cardiovasc Surg. 2004;127:20-26

    Montani JP, Carroll JF, Dwyer TM, Antic V, Yang Z, Dulloo AG. Ectopic fat storage in heart, blood vessels and kidneys in the pathogenesis of cardiovascular diseases. Int J Obes Relat Metab Disord. 2004;28 (Suppl. 4):S58-S65.

    Birkenhauer P, Yang Z, Gander B. Preventing restenosis in early drug-eluting stent era: recent developments and future perspectives. J Pharm Pharmacol. 2004;56:1339-1356.



    Viswambharan H, Seebeck T, Yang Z. Enhanced endothelial nitric oxide synthase activity in mice infected with Trypanosoma brucei. Int J Parasitol. 2003;33:1099-1104

    Barandier C, Ming X-F, Rusconi S, Yang Z. (2003) PKC is required for activation of ROCK by RhoA in human endothelial cells. Biochem Biophy Res Commun. 2003;304:714-719

    Barandier C, Ming X-F, Yang Z. The small G-proteins as therapeutic targets in cardiovascular medicine. News in Physiol. Sci. 2003;18:18-22



    Ming,X.-F., Viswambharan,H., Barandier,C., Ruffieux,J., Kaibuchi,K., Rusconi,S., and Yang Z. Rho GTPase/Rho Kinase Negatively Regulates Endothelial Nitric Oxide Synthase Phosphorilation trough the Inhibition of Protein Kinase B/Akt in Human Endothelial Cells. Mol. Cell. Biol. 2002;22: 8467-8477

    Yang Z., Madinova A., Kozai K., Joch H., Aebi U., Lüscher TF. Felodipine inhibits nuclear translocation of p42/44 mitogen-activated protein kinase and human smooth muscle cell growth. Cardiovasc Res 2002;53:227-231

    Montani JP., Antic V., Yang Z., Dulloo A. Pathways from obesity to hypertension: from the perspective of a vicious triangle. Int. J. Obes. Relat. Metab. Disord. 2002;26(Suppl. 2): S28-S38.

    Yang Z, Lüscher TF. Vascular Endothelium. In: PanVascular Medicine. Lanzer P, Topol EJ. (eds.), Springer Berlin - Heidelberg - New York, 2002, pp 190-204.

    Yang Z. Das Yin-Yang der Endothelfunktion bei gesunden und kranken Gefässen. Bull. Soc. Frib. Sc. Nat. 2002;91:45-48.



    Eto M., Barandier C., Rathgeb L., Kozai T., Joch H., Yang Z., Lüscher TF. Thrombin suppresses endothelial nitrix oxide synthase and up-regulates endothelin-converting enzyme-1 by distinct pathways: role of Rho/ROCK and MAP kinase. Circ Res. 2001;89:583-590.

    Yang Z., Huerlimann DA., Viswambharan H., Luescher TF. Phorbol ester downregulates PDGF b receptor via PKCb 1 in vascular smooth muscle cells. Biochem Biophys Res Commun. 2001;286:372-375. (doi:10.1006/bbrc.2001.5402)



    Yang Z., Kozai T., Van der Loo B., Viswambharan H., Lachat M., Turina MI., Malinski T., Lüscher TF. HMG-CoA reductase inhibition improves endothelial cell function and inhibits smooth muscle cell proliferation in human saphenous veins. J Am Coll Cardiol. 2000;36:1691-1697

    Ruschitzka F., Moehlen U., Quaschning T., Lachat M., Noll G., Shaw S., Yang Z., Teupser D., Subkowski T., Turina MI., Lüscher TF. Tissue endothelin-converting enzyme activity correlates with cardiovascular risk factors in coronary artery disease. Circulation. 2000;102:1086-1092

    Altwegg LA, d'Uscio LV, Barandier C, Cosentino F, Yang Z, Luscher TF. Nebivolol induces NO-mediated relaxations of rat small mesenteric but not of large elastic arteries. J. Cardiovasc. Pharmacol. 2000;36:316-320

    André D., Arnet U., Yang Z., Lüscher TF. Nebivolol inhibits human aortic smooth muscle cell growth: Effects on cell cycle regulatory proteins. J. Cardiovasc. Pharmacol. 2000;35:845-848



    Yang Z., Birkenhauer P., Julmy F., Chickering D., Ranieri JP., Merkle HP., Lüscher TF. Sustained release of heparin from polymeric particles for inhibition of human vascular smooth muscle cell proliferation. J Controlled Release 1999;60:269-277

    Yang Z., Krasnici N., Lüscher TF. Endothelin-1 potentiates human smooth muscle cell growth to PDGF: Effects of ETA and ETB receptor blockade. Circulation. 1999;100:5-8

    Tanner F.C., Largiadèr T., Yang Z., Lüscher T.F. Gentherapie bei Herzerkrankungen. Schweiz. Med. Wsch. 1999;129:1784-1791

    Arnet U., Yang Z., Lüscher TF. Pathophysiology of coronary artery disease: Endothelial function, platelets and coagulation factors. In: Cardiology, S. della Volta (ed.), 1999, pp. 323-330, McGraw-Hill: London, UK



    Yang Z., Oemar B.S., Carrel T., Kipfer B., Julmy F., Lüscher T.F. Different proliferative properties of smooth muscle cells of human arterial and venous bypass vessels: Role of PDGF Receptors, mitogen-activated protein kinase and cyclin-dependent kinase inhibitors. Circulation. 1998;97:181-187



    Hishikawa K., Oemar B.S., Yang Z., Lüscher T.F. Pulsatile stretsch stimulates superoxide production and activates nuclear factor-kB in human coronary smooth muscle. Circ. Res. 1997;81:797-803.

    Yang Z., Ruschitzka F., Rabelink T.J., Noll G., Julmy F., Joch H., Gafner V., Aleksic I., Althaus U., Lüscher T.F. Different effects of thrombin receptor activation on endothelium and smooth muscle cells of human coronary bypass vessels: Implication for venous bypass graft failure. Circulation. 1997;95:1870-1876.

    Barton M., Wright E., Do D.D., Yang Z., Espinosa E., Arnet U., Lüscher T.F. Gefässprotektion durch Oestrogene: Wirkungen in vitro und in vivo - Mechanismen und klinische Implikationen. Praxis. 1997;86:129-137

    Oemar B.S., Hishikawa K., Yang Z., Lüscher T.F. Molekulare Kardiologie: Von der Pathophysiologie zur Gentherapie. In: Molekularbiologie in der Inneren Medizin. Blum H.E., Siegenthaler W. (eds.), 1997, pp. 172-187, Georg Thieme Verlag: Stuttgart, Germany



    Do D.D., Espinosa E., Liu G., Rabelink T.J., Julmy F., Yang Z., Mahler F., Lüscher T.F. 17b-Oestradiol inhibits proliferation and migration of human vascular smooth muscle cells: Similar effects in cells from postmenopausal females and males. Cardiovasc. Res. 1996;32:980-985.

    Yang Z., Do D.D., Espinosa E., Barton M., Arnet U., Lüscher T.F. 17b-Oestradiol inhibits growth of human vascular smooth muscle: Similar effects in cells from females and males. J. Cardiovasc. Pharmacol. 1996;28 (Suppl. 5): S34-S39.

    Lüscher T.F., Barton M., Wight E., Espinosa E., Yang Z. Wirkungen natürlicher Oestrogene auf die Gefässwand: molekulare Mechanismen und klinische Implikationen. Schweiz. Med. Wsch. 1996;126:1748-1755.

    Lüscher T.F., Oemar B.S., Yang Z., Noll G. Molekulare und zelluläre Mechanismen der Arteriosklerose und Restenose: Möglichkeit der Gentherapie. Z. Kardiol. 1996;85:495-508.

    Yang Z., Lüscher T.F. Biological and vasomotor properties of the internal thoracic artery: role of the endothelium. In: Arterial Conduits in Myocardial Revascularization. Angelini G.D., Bryan A.J., Dion R. (eds.), 1996, pp. 23-31, Arnold: London, UK



    Arnet U., Yang Z., Siebenmann R., Von Segesser L., Turina M., Stulz P., Lüscher T.F. Development of nitrate tolerance in human arteries and veins: Comparison of nitroglycerin and SPM 5185.  J. Cardiovasc. Pharmacol. 1995;26: 401-406

    Lüscher T.F., Oemar B.S., Yang Z., Noll G. Molekulare Medizin und Gentherapie am Beispiel von Arteriosklerose und Restenose. Schweiz. Med. Wsch. 1995;125: 2107-2121

    Oemar B.S., Yang Z., Lüscher T.F. Molecular and cellular mechanisms of atherosclerosis. Cur. Opin. Nephrol. Hypert. 1995;4:82-91

    Yang Z., Lüscher T.F. Atherosclerosis and Vasomotion: Endothelium-dependent regulation of vascular tone in coronary arteries and bypass vessels in health and atherosclerosis. In: Vasoreactivity of Human Vessels. Fabiani J.N., Yacoub M., Carpentiert A. (eds.), 1995, pp. 9-25, Arnette Blackwell S. A: Paris, France

    Yang Z., Noll G., Lüscher T.F. Mechanical forces as regulators of vascular cell function. In: Die Gefässwand als Pharmakologischer Angriffspunkt. Dengler H.J., Lüscher T.F., Markwardt F. (eds.), 1995, pp29-42, Gustav Fischer Verlag: Stuttgart, Germany

    Yang Z., Lüscher T.F. Functional changes in endothelial regulation of vascular tone and growth in atherosclerosis. In: Progression and Regression of Atherosclerosis. Koenig W., Hombach V., Bond M.G., Kramsch D.M. (eds.), 1995, pp. 55-60, Blackwell Wissenschaft: Wien. Austria



    Yang Z., Arnet U., Bauer E., Von Segesser L., Siebenmann R., Turina M., Lüscher T.F. Thrombin-induced endothelium-dependent inhibition and direct activation of platelet-vessel wall interaction: Role of prostacyclin, nitric oxide, and thromboxane A2. Circulation. 1994;89:2266-2272

    Lüscher T.F., Noll G., Yang Z. Vasculäre Mechanismen der koronaren Herzkrankheit und der Arteriosclerose in Bypassgefässen. In: Arterielle Hypertonie und Vaskuläre System. Bibliothek. Wambach G., Fritschka E., (eds.), 1994, pp. 35-59, Socio medico Verlag + Agentur für Medizinische Informationen: Gräfelfing, Germany

    Lüscher T.F., Yang Z., Oemar B. Endothelium and vascular smooth muscle function of coronary bypass grafts. In: Coronary Artery Graft Disease: Mechanisms and Prevention. Lüscher T.F., Turina M., Braunwald E. (eds.), 1994, pp. 193-211, Springer-Verlag: Berlin, Germany



    Yang Z., Noll G., Lüscher T.F. Calcium antagonists differently inhibit proliferation of human coronary smooth muscle cells in response to pulsatile stretch and platelet-derived growth factor. Circulation. 1993;88:832-836

    Yang Z., Arnet U., Bauer E., Von Segesser L., Siebenmann R., Turina M., Lüscher T.F. Different effects of angiotensin-converting enzyme inhibition in human arteries and veins. J. Cardiovasc. Pharmacol. 1993;22 (Suppl. 5): S17-S22

    Lüscher T.F., Espinosa E., Dubey R.K., Yang Z. Vascular biology of human coronary artery and bypass graft disease. Cur. Opin. Cardiol. 1993;8:963-974

    Yang Z., Lüscher T.F. Heterogeneity of vascular biology of human blood vessels: Role of endothelium and smooth muscle. Coronary Artery Disease. Review in Depth: Endothelial Cell Mediators of Vascular Reactivity. Coronary Artery Disease. 1993;(suppl.): 88-101

    Lüscher T.F., Yang Z. Calcium antagonists and ACE-inhibitors: Effect on endothelium and vascular smooth muscle. Drugs 1993;46(Suppl.2):121-132

    Yang Z., Lüscher T.F. Basic cellular mechanisms of coronary bypass graft disease. Eur. Heart. J. 1993;14(Suppl. I):193-197

    Lüscher T.F., Boulanger C.M., Yang Z., Noll G., Dohi Y. Interactions between endothelium-derived relaxing and contracting factors in health and cardiovascular disease. Circulation. 1993;87(Suppl. V): V36-V44

    Yang Z., Oemar B., Lüscher T.F. Mechanismen der koronaren Bypass Graft Erkrankung. Schweiz Med Wsch 1993;123:422-427

    Lüscher T.F., Yang Z., Noll G., Pfisterer M. Thrombozytenhemmer in der kardiovaskulären Pharmakotherapie. In: Preventive Kardiologie in Klinik und Praxis. Lüscher T.F. (ed.), 1993, pp. 179-201, Hans Huber Verlag: Munich, Germany



    Predel H.G., Yang Z., Von Segesser L., Turina M., Bühler F.R., Lüscher T.F. Implication of pulsatile stretch on growth of saphenous vein and mammary artery smooth muscle. The Lancet. 1992;340: 878-879

    Li X.-N., Stulz P., Siebenmann R., Yang Z., Lüscher T.F. Different effects of activated platelets in the right gastroepiploic and internal mammary artery: Implications for coronary artery grafting. J. Thorac. Cardiovasc. Surg. 1992;104: 1294-1302

    Yang Z., Siebenmann R., Studer R., Egloff E., Lüscher T.F. Similar endothelium-dependent relaxation, but enhanced contractility of the right gastroepiploic artery as compared to internal mammary artery. J. Thorac. Cardiovasc. Surg. 1992;104: 459-464

    Diederich D., Yang Z., Lüscher T.F. Chronic cyclosporine therapy impairs endothelium-dependent relaxation in the renal artery of the rat. J. Am. Soc. Nephrol. 1992;2:1291-1297

    Lüscher T.F., Yang Z., Kiowski W., Linder L., Dohi Y. Endothelin-induced vasoconstriction and calcium antagonists. J. Human. Hypertension. 1992; 6(Suppl 2): S3-S8

    Lüscher T.F., Boulanger C.M., Dohi Y., Yang Z. Endothelium-derived contracting factors. Hypertension. 1992;19: 117-130

    Lüscher T.F., Dohi Y., Tanner F.C., Yang Z., Boulanger C.M. Clinical significance of endothelium-dependent vasomotor control in hypertension and coronary artery disease.. In: Applied Cardiovascular Biology 1990-1991, Int Soc Appl Cardiovasc Biol. Vol. 2. Zilla P., Fasol R., Callow A. (eds.), 1992, pp. 152-157



    Noll G., Bühler F.R., Yang Z., Lüscher T.F. Different potency of endothelium-derived relaxing factors against thromboxane, endothelin and potassium chloride in intramyocardial porcine coronary arteries. J. Cardiovasc. Pharmacol. 1991;18:120-126

    Yang Z., Stulz P., Von Segesser L., Bauer E., Turina M., Lüscher T.F. Different interactions of platelets with arterial and venous coronary bypass vessels. The Lancet. 1991;337:939-943

    Yang Z., Von Segesser L., Bauer E., Stulz P., Turina M., Lüscher T.F. Different activation of endothelial L-arginine and cyclooxygenase pathway in human internal mammary artery and saphenous vein. Circ. Res. 1991;68:52-60

    Noll G., Dohi Y., Kiowski W., Linder L., Yang Z., Tschudi M., Boulanger C.M., Bühler F.R., Lüscher T.F. Endothelial function of resistance arteries in aging and hypertension. J. Appl. Cardiol. 1991;6:185-189

    Lüscher T.F., Bock H.A., Yang Z., Diederich D. Endothelium-derived relaxing and contracting factors: perspectives in nephrology. Kidney Int. (Editorial review) 1991;39:575-590

    Yang Z., Lüscher T.F. Endothelium-dependent responses in human blood vessels in health and cardiovascular disease. Coronary Artery Disease 1991;2: 338-348

    Tanner F.C., Richard V., Tschudi M., Yang Z., Lüscher T.F. Serotonin, the endothelium and the coronary circulation. In: Serotonin: Molecular Biology , Receptors and Functional Effects. Fozard J.R., Saxena P.R. (eds.), 1991, pp. 406-413

    Lüscher T.F., Yang Z. Mechanisms of platelet-vessel wall interactions: Role of endothelium-derived nitric oxide. In: Thrombolysis and anti-thrombotics. Proceedings of the 4th SB Kurhaus Workshop on Cardiovascular Diseases 1991, pp.51-58.

    Lüscher T.F., Yang Z. Endothelium function in human coronary bypass grafts. In: Vascular endothelium: physiological basis of clinical problems. Catravas J. (ed.), 1991, pp.139-155, Planum Press: New York, USA

    Lüscher T.F., Boulanger C.M., Yang Z., Dohi Y. Interaction between endothelin and endothelium-derived relaxing factor(s). In: Endothelin. Rubanyi G.M. (ed.), 1991, pp. 125-136, Oxford University Press: Oxford, UK



    Yang Z., Von Segesser L., Bauer E., Stulz P., Turina M., Lüscher T.F. Different moblization of calcium in endothelin-1-induced contractions in human arteries and veins: Effects of calcium antagonist. J. Cardiovasc. Pharmacol. 1990;16: 654-660

    Yang Z., Richard V., Von Segesser L., Bauer E., Stulz P., Turina M., Lüscher T.F. Threshold concentrations of endothelin-1 potentiate contractions to norepinephrine and serotonin in human arteries: a new mechanism of vasospasm?. Circulation. 1990;82:188-195

    Lüscher T.F., Yang Z., Tschudi. M., Von Segesser L., Stulz P., Boulanger C., Siebenmann R., Turina M., Bühler F.R. Interaction between endothelin-1 and endothelium-derived relaxing factor in human arteries and veins. Circ. Res. 1990;66: 1088-1094

    Diederich D., Yang Z., Bühler F.R., Lüscher T.F. Impaired endothelium-dependent relaxations in hypertensive resistance arteries involve the cyclooxygenase pathway. Am. J. Physiol. 1990;258:H445-H451

    Lüscher T.F., Richard V., Tschudi M., Yang Z. Serotonin and the endothelium. Clin. Physiol. Biochem. 1990;8(suppl 3): 108-119

    Boulanger C.M., Resink T.J., Dohi Y., Yang Z., Bühler F.R., Lüscher T.F. Endothelin and hypertension.  J. Nephrol. 1990;1:29-34

    Lüscher T.F., Richard V., Tschudi M., Yang Z., Boulanger C.M. Endothelial control of vascular tone in large and small coronary arteries. J. Am. Coll. Cardiol. 1990;15: 519-527

    Richard V., Tschudi M., Yang Z., Lüscher T.F. NG-monomethyl-L-arginine differentially inhibits endothelium-dependent relaxations to bradykinin and 5-hydroxytryptamine in porcine coronary arteries. In: Nitric Oxide from L-arginine: a bioregulatory system, Moncada S. (ed.), 1990, pp. 439-445, Elsever Publisher: London, UK

    Yang Z., Richard V., Lüscher T.F. Endothelium-derived nitric oxide in human arteries and veins. In: Nitric Oxide from L-arginine: a bioregulatory system, Moncada S. (ed.), 1990, pp. 89-93, Elsever Publisher: London, UK



    Yang Z., Diederich D., Schneider K., Siebenmann R., Stulz P., Von Segesser L., Turina M., Bühler F.R., Lüscher T.F. Endothelium-derived relaxing factor and protection against contractions induced by histamine and serotonin in the human internal mammary artery and in the saphenous veins. Circulation. 1989;80: 1041-1048

    Yang Z., Bühler F.R., Diederich D., Lüscher T.F. Different effects of endothelium on cyclic AMP- and cyclic GMP-mediated vascular relaxation in human arteries and veins: Comparison with norepinephrine. J. Cardiovasc. Pharmacol 1989;(Suppl. 5)13:129-131

    Yang Z., Lüscher T.F. Endothelium-dependent regulatory mechanisms in human coronary bypass grafts: Possible clinical implications. Z. Kardiol. 1989;78(Suppl 6): 80-84

    Lüscher T.F. Yang Z., Diederich D., Bühler F.R. Endothelium-dependent vascular responses: Effect of hypertension and cyclosporine A.  Z. Kardiol. 1989;78(Suppl 6):132-136

    Lüscher T.F., Yang Z., Diederich D., Bühler F.R. Endothelium-derived vasoactive substances: Potential role in hypertension, atherosclerosis, and vascular occlusion. J. Cardiovasc. Pharmacol. 1989;14(Suppl 6): S63-S69

    Yang Z., Boulanger C., Lüscher T.F. Endothelium-derived relaxing factor: Ein endogenes Nitrat als Regulator im Kreislauf. Perfusion. 1989;89(3):78-82




    Lüscher T.F., Diederich D., Siebenmann R., Lehmann K., Stulz P., Von Segesser L., Yang Z., Turina M., Grädel E., Weber E., Bühler F.R. Difference between endothelium-dependent relaxations in arterial and in venous coronary bypass grafts. N. Engl. J. Med. 1988;319:462-467

    Lüscher T.F., Yang Z., Diederich D., Schneider K., Von Segesser L., Siebenmann R., Stulz P., Bühler F.R. Endothelium-derived relaxing factor (s): Endogene Nitrate im Kreislauf? Schweiz. Med. Wsch. 1988;118:1724-1729