Jihed Sehli (M.D.) is working on a multicentric combined MRS-PET-fMRI investigation of the involvement of glutamate signaling in bipolar disorder, early psychosis and nicotine addiction (GLUMULTI Study). The aim of GLUMULTI study is to explore how glutamate concentration and metabotropic glutamate receptors subtype 5 interact to alter resting-state brain activity in bipolar disorder and early/risk psychosis, with and without comorbid smoking.

This study is being conducted in three centers: Psychiatrie Nord St. Gallen, Freiburger Netzwerk für Psychische Gesundheit (FNPG), and Psychiatric Services Biel-Seeland-Bernese Jura (PDBBJ).

Jihed Sehli is the responsible of recruitment and clinical investigation of participants included form FNPG and PDBBJ.

Fields of research:

  • Molecular neuroimaging of the glutamate neurotransmitter system in early/risk psychosis and affective disorders
  • Glutamatergic brain abnormalities in early/risk psychosis and bipolar disorder
  • Ketamine effects in unipolar and bipolar depression.
  • Impact of COVID-19 outbreak on mental health and functioning in general population (COH-FIT international project)