Claims of human cloning?
update: 8.1.2003

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Collection of World's Press reactions (english)
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Mme Boisselier (CSO, Clonaid)

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Human reproductive cloning:
why now? why at all?

reflections of a biologist and gene therapist

Human cloning has little ot nothing to do with gene therapy. In strict sense it is not even a genetic manipulation, if at all it is just its contrary , its antihesis.
So, why should a molecular biologist with interests in gene therapy write a comment on the recent claims on human cloning?
To make the waters even more turbid?
To celebrate some obscure characters in search of fame or money?
No, just to make the point about how absurd and pathetic all this story is, both scientifically and morally, no matter the claim being true or a hoax....

continuation of this commentary.

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Sandro Rusconi, Director NFP37, December 31 2002
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Continuation of commentary by S. Rusconi:

It had to happen...
The technology of reproducing the genetically identical copy of a living organism starting with a nucleus of a somatic cell had attained the world's attention after the spectacular announcement of the cloned sheep Dolly. Since then, we have seen one reckless scientist after the other appearing on the international scene with claims of intending to clone human beings. Obviously, this had to happen, in spite of the technical hurdles that we painstakingly learned from animal experimentation (where cloning is still an erratic process with an extremely low success rate and lots of unpredictable misdevelopments.)
Therefore, the stubborness of some cloning fanatics has brought all of us very close from having to deal with the materialisation of this process. Be true or false what the Clonaid's officials have been claiming these weeks, one of the trials will sooner or later give birth to a human being generated with cloning techniques. We have been learning immense amounts of things from the cloning of mammals and now we are burning this precious knowledge into a socially futile application that will make some few people very rich and other very few people supposedly happy. Why? and with which consequences?

Not so impressive, after all...
Personally I am not much impressed by this achievement because I do not believe it will ever become a mass procedure; let's say until our society will maintain its solid heritage of ol' good common sense. If human cloning will become a serious issue, then we should not worry because of the cloning itself, but since we would have let slip away our judgement on the collective way we understand scientific and technological progress and the delicate balance between individual and societal needs. We should not fear misuses or abuses from human cloning if we are confident to be able to maintain our societal values. If we cannot guarantee that, then human cloning is just one of the many plagues that expect us, and probably not the major one.

No justifications for human reproductive cloning
Obviously I cannot buy any of the current justifications for human reproductive cloning (couple's sterility, making loved ones revive, serving the obsessions of some freaky sectarian movement etcetera...). Even with the best of my imagination I cannot figure out any solid objective argument in favour. Taken apart the obvious dangers of generating defective human beings, due to poorly controllable nucleus reprogramming, there is a major argument that speaks against this approach. Biologically it is a genuine nonsense because it goes straight counter-current with the principles of natural evolution. Only the ultimate arrogance of humans who believe to have achieved perfection could become a sort of grotesque justification for the perpetuation of their genetic setup. I am sure that my view is shared by essentially the entire scientific community. If not, I would not understand the scientific community any more.
We have heard many scandalised and counterarguments, certainly inspired by good will, but mostly rather awkward such as 'it is dangerous for the child' (which indirectly implies that if it would be not dangerous then it would be acceptable?); or 'it is morally unacceptable' (this very statement from world leading politicians who yet propose as morally acceptable the bombing of innocent people?); or 'it anyway does not work in their hands' (meager consolation generously given to us by other equally suspicious characters such as prospected cloner Antinori?).
What the heck! The only ever valid argument against human reproductive cloning remains the intrinsic anti-evolutionary nature of this procedure. Surprisingly, I found this reasoning only in one out of almost 100 commentaries (see the inspiring title from '24 heures' ( 75. Cloner l'homme est surtout biologiquement stupide ...(04.01.2003 ).

This is only one of the challenges for our democratic society, and perhaps not even the most important
Thus, I tend to consider this technological perversion just as one of the many recents tests for the stability of what we call a 'democratic societal system'. It will not have more impact that internet, mobile phones, prozac, organ transplants, low fare airplane traveling, viagra, market globalisation, pollution, global warming or any other recent gadgets and challenges that we have been and are currently facing.
I dont think we must particularly 'fear' the cloners or the clones, but rather those who want to make money with human suffering and stupidity. I see only three ways to fight againsts those people: a) make it impossible to make such easy money, (b) reduce human suffering. or (c) diminish human stupidity. Neither of the three is an easy job, but let's hope many of us keep trying.


MEDIA NEWS AND VIEWS
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http://www.dailytelegraph.news.com.au/common/story_page/0,5936,5811334%255E401,00.html

THE WORLD This story is from our news.com.au network Source: AFP

'Cloned baby' parents refuse tests From correspondents in Washington 08jan03

THE parents of a baby said to be the world's first human clone are refusing to allow genetic tests to verify the claim. US company Clonaid - which claims to have created the child, named Eve, and is linked to the Raelian sect - issued a statement on the issue today."Eve's parents have decided to postpone their decision to grant access to an independent expert," it said."They will allow the test to be performed only when they have the absolute guarantee that the baby will not be taken from them."

The human cloning company Clonaid, with offices in Las Vegas, Nevada, was founded by the Raelian sect, which believes humans were cloned from aliens who landed on Earth 25,000 years ago. Clonaid's president Brigitte Boisselier announced on December 26 the birth of what she claimed to be the world's first human baby clone.She later said a second cloned baby had been born to a lesbian couple in the Netherlands.Neither birth has been confirmed by independent scientists, and the Raelians have provided no proof to support their claims.US journalist Michael Guillen yesterday said he had suspended his effort to use DNA testing to verify the claims and said it could all be an "elaborate hoax".


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http://www.newscientist.com/hottopics/cloning/cloning.jsp?id=ns99993234

Cloning may be 'elaborate hoax' says monitor

The journalist charged with verifying the human cloning claims of the cult-linked company Clonaid has now reached the same conclusion Latest Articles: as many observers - the claims could well be "an elaborate hoax". Michael Guillen, former science editor of ABC News, said he has Cloning may be 'elaborate suspended the independent review process that would have hoax' says monitor genetically tested the first-born baby to prove that its DNA was 7 Jan 03 indeed identical to that of another person.

Dutch clone claimed - but "The team of scientists has had no access to the alleged family no proof and, therefore, cannot verify firsthand the claim that a human baby 6 Jan 03 has been cloned," Guillen said in a statement on Monday. "In other words, it's still entirely possible that Clonaid's announcement is Second cloned baby claim part of an elaborate hoax intended to bring publicity to the 3 Jan 03 Raelian movement."

Recent Articles: Clonaid says the first cloned baby was born on 26 December. The company claims a second was born in the Netherlands on Saturday, First cloned baby "born and that three more are due by the end of January. The company was on 26 December" set up by the Raelian religious cult, which believes that humans 27 Dec 02 were cloned from aliens who landed on the earth 25,000 years ago.

Australia OKs human embryo research Avoiding bias 5 Dec 02 Revelations on Sunday that Guillen had tried to sell exclusive First cloned baby 'due in coverage of the first child's birth several months ago had January' increased scepticism about his independence from the Raelians. 27 Nov 02 However, in the statement he added that he wanted to remove himself from the testing procedure in order to avoid possibility of bias. Cloned stem cells may give new lease of life Clonaid's spokesperson Nadine Gary said she was surprised by 8 Nov 02 Guillen's announcement and was "not aware" of any suspension.


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http://www.usatoday.com/life/columnist/mediamix/2003-01-07-media-mix_x.htm

Reporter caught in the wreckage of Clonaid story

Michael Guillen has been fascinated by cloning ever since 1997, when Dolly the sheep was cloned and he covered the story as a science editor for ABC's Good Morning America.

"He was extremely enthusiastic and did some very strong reporting," says GMA producer Shelly Ross. "He was determined to stay in the forefront of the story."

On Dec. 27, when the Montreal-based Clonaid claimed that a 7-pound cloned baby had been born, Guillen, now a freelance reporter, announced that he would oversee independent DNA tests on the baby to prove &emdash; or disprove &emdash; the group's claim.But Monday, after Clonaid continued to refuse to offer the baby for tests, Guillen withdrew from the project, saying it might be "an elaborate hoax." Tuesday, Clonaid said the parents wouldn't allow testing unless they are assured the baby wouldn't be taken from them &emdash; an issue since a Florida lawyer has filed such a lawsuit.

Now, Clonaid's questionable reputation may tarnish Guillen, a former Harvard professor who left ABC last fall after 14 years.After ducking reporters for two weeks, Guillen is trying to salvage his reputation. He talks to Charles Gibson on GMA this morning, and CNN's Connie Chung tonight.

Guillen, who refuses to give his age, says that Clonaid's refusal to agree to testing has rightly drawn criticism. "I'm tearing my hair out in frustration. I stuck my neck out and they knew it. "I'm like Joe Friday in Dragnet. 'Just the facts, ma'am.' All I want are some samples (from the baby) so we can find the truth."But Guillen, son of a Hispanic Pentacostal minister, wants to believe the group's claim: his initial skepticism of Clonaid officials in 1997 vanished after their science credentials checked out. "It would be unwise to dismiss these people offhand."

Clonaid was founded by a religious sect called Raelians. Founder Claude Vorilhon, 56, a former pop singer and French auto racing journalist, says extraterrestrials created humans and gave him the name Rael, meaning messenger.London's Daily Mail calls him "a master of media manipulation" and describes the movement's beliefs as "a mix of Sixties style free love and conviction that science holds the keys to humanity's problems."

Sunday, The New York Times reported that Guillen tried months ago to sell exclusive coverage of Clonaid's first baby to the major broadcast networks."That's what freelance reporters do every day of the week," says Guillen. "I have to earn a living. What's wrong with that?"

Guillen said that after Dolly was cloned, he knew it would be only a matter of time before someone cloned a human being. Shortly after the Dolly announcement, he did a quick Internet search on the subject and "out popped the Raelians. I said, 'This can't be real.' "On Dec. 27, Guillen says, "I watched the world have the same reaction to them (the Raelians) that I had six years earlier."The British Broadcasting Corporation reported the next day that the news was "greeted with a mixture of astonishment, revulsion and deep skepticism."


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http://www.abcnews.go.com/sections/scitech/DailyNews/cloning_guillen030107.html

One Week, No Proof Despite Earlier Promise, Raelians Have Not Offered Proof of Clone

By Malcolm Ritter The Associated Press

N E W Y O R K, Jan. 7 &emdash; A self-imposed deadline on a genetic testing decision has passed for a company that claims to have produced the first human clone. Still, there's been no DNA proof, and no baby is forthcoming.

The journalist who said he would oversee DNA testing to verify the company's claim said Monday he has abandoned the effort and could not rule out the possibility of "an elaborate hoax."Officials with Clonaid, the company that announced the birth of the world's first clone on Dec. 27, first promised DNA testing, then backed off. Clonaid said the parents of the 7-pound baby girl have refused to allow it."The team of scientists has had no access to the alleged family and, therefore, cannot verify firsthand the claim that a human baby has been cloned," said Michael Guillen, a former ABC science editor who had offered to arrange the testing.

Experts Not Surprised

Experts who had been demanding independent verification said Clonaid has never had credibility with the scientific community."We don't find it surprising that they are not in a position to offer any data," said Sean Tipton, spokesman for the American Society of Reproductive Medicine in Washington, D.C."We have been ignoring it because we don't view it as a scientifically valid statement," said Natalie Dewitt, an editor at Nature, the British science journal that published the milestone data in 1997 on Dolly the cloned sheep.

Clonaid was founded by the Raelian religious sect, which believes space aliens created life on Earth. Clonaid chief executive Brigitte Boisselier acknowledges outside DNA testing would be needed to make the claim credible.In a statement, Guillen said he had assembled experts to do the work but suspended the effort Monday. "It's still entirely possible Clonaid's announcement is part of an elaborate hoax intended to bring publicity to the Raelian movement," he said.Guillen indicated he was still willing to proceed. "When and if an opportunity to collect DNA samples as promised does arise, however, the team stands fully prepared to remobilize and conduct the necessary tests."

Journalist Wanted Exclusive

The freelance journalist has said previously he had no connection to Clonaid. But he said in his statement Monday he has been interested in doing a documentary on human cloning that would involve Clonaid's work. He said he has covered the "principal players" in human cloning since the cloning of Dolly the sheep was announced.The New York Times reported Sunday that Guillen tried months ago to sell exclusive coverage of Clonaid's first baby to the major broadcast networks.On Saturday, Boisselier said the baby's parents had promised to give her a final answer Monday about whether they would allow DNA tests. A spokesman for Guillen said his statement was not connected to that decision.

Clonaid did not immediately return phone calls requesting a response Monday.

Some scientists said Clonaid's two weeks of notoriety probably won't do lasting damage to legitimate reproductive research.Indeed, some believe it may have begun to educate the public on the differences between the cloning of stem cells and other therapeutic agents, and cloning to reproduce a baby.Others said it was a "big mistake" for policy-makers to have included Clonaid with legitimate scientists in congressional hearings and other science policy forums during the past year."By association, they have done some damage," Dewitt said. "But they are so far removed from legitimate science that I don't think it will cause a huge problem."


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http://www.boston.com/dailyglobe2/007/nation/Journalist_wary_of_hoax_drops_offer_to_verify_clone_+.shtml

Journalist, wary of hoax, drops offer to verify 'clone'

By Malcolm Ritter, Associated Press, 1/7/2003

NEW YORK - Michael Guillen, the journalist who had said he would oversee DNA testing of a supposed cloned baby, dropped out yesterday. He said he had given up because of a lack of cooperation from the religiously inspired company which claimed to have produced the clone, and the possibility of ''an elaborate hoax.''

Officials of Clonaid, the company that on Dec. 27 announced the birth of the world's first clone, first promised DNA testing and then backed off. Clonaid said the parents of the purported clone have refused to allow testing.''The team of scientists has had no access to the alleged family and, therefore, cannot verify firsthand the claim that a human baby has been cloned,'' said Guillen, a former ABC science editor who had offered to arrange the testing.

Clonaid was founded by the Raelian religious sect, which believes space aliens created life on Earth. Brigitte Boisselier, the group's chief executive, admits that outside DNA testing would be needed to make the claim credible.In a statement, Guillen said he had assembled specialists to do the work, but had suspended the effort yesterday morning. ''It's still entirely possible Clonaid's announcement is part of an elaborate hoax intended to bring publicity to the Raelian movement,'' he said.

Guillen indicated he was still willing to proceed. ''When and if an opportunity to collect DNA samples as promised does arise, however, the team stands fully prepared to re-mobilize and conduct the necessary tests,'' he said.The freelance journalist has said previously that he had no connection to Clonaid. But he said in his statement yesterday that he has been interested in doing a documentary on human cloning that would involve Clonaid's work. He said he has covered the ''principal players'' in human cloning since the cloning of Dolly the sheep was announced in 1997.

The New York Times reported Sunday that Guillen tried months ago to sell exclusive coverage of Clonaid's first baby to the major broadcast networks.He pitched to Fox Entertainment a proposal for a reality-based show, offering to produce and host the program that he proposed would begin before the births of the clones and continue into the future, the executive told the Times.

Joe Earley, a Fox spokesman, said, ''We were pitched the project, but we thought it was more appropriate for our news department and we referred it to them.'' Fox News also turned down the offer. A CNN executive said that the company listened to Guillen's proposal, but did not make an offer, saying that they were interested in ''the bigger story'' but would not pay for Guillen's program because they wanted to cover it themselves.

Guillen approched the Times unsuccessfully in May, offering an exclusive article about a couple trying to have a child through cloning. He said he was the only reporter allowed to follow the couple.In his proposal to the Times, Guillen wrote: ''During the better part of the past five years, I've cultivated close relationships with all the major human cloning scientists worldwide. In fact, I know more about what's going on than any of the individual players; that's because they all confide in me.''


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http://www.newsday.com/news/printedition/health/ny-dstop3077619jan07,0,4176047.story?coll=ny-discovery-print

The Mother Of All Questions On Cloning How far will people go to have a baby?

By Bryn Nelson STAFF WRITER January 7, 2003

Amid the flurry of news releases and quotes from dubious scientists, the unsubstantiated claims that a cloning group has produced the first human clones pose an important question in this era of rapidly expanding medical technology: How far are parents willing to go to have a baby?

The individual answers, shaped by religious beliefs, the strong desire to produce a genetic heir, and a varied understanding of what medical science can or cannot do, say as much about the range of human motivation as they do about the public's ambivalence and expectations toward the unprecedented power of science.

"There's really not quite a parallel to this in the past history of genetics, which is the ability to clone yourself," says Garland Allen, a professor of the history and philosophy of genetics at Washington University in St. Louis. "It's a new technology and has brought a whole new concept."

In-vitro fertilization provides some parallels, of course, both in terms of motivation and ethical concerns, and some advocates argue that reproductive cloning will be as widely accepted in a quarter-century as the fertilization technology that produced Louise Brown 24 years ago and the hundreds of thousands of babies since then.But cloning promises that an individual's DNA can yield a virtually identical genetic copy under the appropriate conditions, a latter-born twin of sorts. Hollywood has generated visions of clone armies, while religious objectors liken reproductive cloning to "playing God." The technology is additionally burdened with the so-called "yuck factor" - a visceral reaction often visited upon unfamiliar medical techniques - plus a host of misleading claims and unrealistic expectations.

"In America, I think that people have false expectations and hopes about what science can do and what science can bring," says Dr. Paul Kettl, a professor of psychiatry at Penn State Medical Center. "And while we discover amazing things daily, we still don't know enough."Clonaid, a company formed in 1997 under the auspices of a self-proclaimed prophet convinced that humans were created by extraterrestrial scientists, claims it has maximized existing knowledge by creating two human clones. The group, like its competitors, boasts a long list of couples desperate to take part in the risky venture. But Clonaid has yet to provide any evidence of its touted successes.

Besides considerable outreach to infertile or homosexual couples, some reproductive cloning advocates have advanced the claims that cloning technology could replace a lost child or eventually grant immortality. The latter claims, Allen says, are based on complete misunderstandings about genetics and the nature of human development.

"I hate to say it, but people are totally in the dark about this," Allen says. "You also get that idea with people wanting their pets back, that you're going to get Fido back. Obviously it doesn't happen."Researchers at Texas A&M University, armed with millions from a philanthropist hoping to obtain a clone of his beloved mixed-breed dog Missy, toiled for several years under a program dubbed "Missyplicity." Last year they announced an unexpected success: the creation, instead, of a kitten clone named CC, for CopyCat. Even then, the kitten differed significantly in its coat pattern from its cat DNA donor.

In August 2001 a Charleston lawyer and former West Virginia state legislator named Mark Hunt revealed he had invested nearly $500,000 in another venture, a secret cloning laboratory on the second floor of a converted high school in the small town of Nitro, W.Va. Hunt and his wife had hoped to replace the 10-month-old son they lost to a heart defect in 1999 and enlisted the help of Clonaid before parting ways."It's incredibly difficult to lose someone that you're close to and even more difficult to lose a child," Kettl says. The combination of intense grief and guilt over the perception that the parent somehow failed to protect the child can be "devastating."

Denial also plays a major role in the normal grieving process, he says, and through this potent mixture of emotions, it's not difficult to envision parents bent on reclaiming a lost child through any means, even if it requires a significant amount of self-deception."I can't help but think that the denial that folks feel would lead them to say, 'OK, Johnny's not gone, we just have a new version,'" Kettl says.

Difficulty in becoming pregnant also can place considerable stress upon a couple's relationship, Kettl says. Embracing cloning as a potential solution, may also reflect a desire to relieve the mounting stress.Another motivation can come as an outgrowth of the unrealistic expectations parents routinely place on their children, often with the hope that their children will carry on family traditions. "If you've ever been to a Little League baseball game, you know what I mean," Kettl says. "An exaggeration of that would be to have a child that is 'just like me' or 'just like my wife.'"Alternatively, parents may look to their children to succeed where they failed."Children, unfortunately, are saddled with the burden at times of doing things better than their parents ever did," Kettl says, "when the facts are, of course, that all people are different."

Identical twins are the current benchmark for genetic sameness, but researchers stress that even a perfect genetic match between a parent and a latter- born "twin" would not offer an identical match of personalities, abilities or disease susceptibilities.Apart from the unique environmental conditions encountered during embryonic development, genetic mutations accumulated in DNA from the donor's mature cells and even subtle changes induced by the cloning process itself could combine to create a child who is very different from the parent. An individual's accumulated life history further defines distinctions."It's very clear that experiences help to mold who we are," Kettl said.

Officially, the American Society for Reproductive Medicine is "opposed to any attempt at human reproductive cloning." But Dr. Sandra Carson, president of the society and a professor of obstetrics and gynecology at Baylor College of Medicine in Houston, admits that attitudes are more mixed among the society's 8,500 fertility experts. Rather than push for a complete ban or complete acceptance, Carson says, society should engage in an open-minded, tempered discussion of risks, benefits, and medical alternatives, so a conclusion can be reached that's best for everyone.

Even so, the desire for a genetic twin to replace a dead child is "probably the only motivation that we don't have a good alternative to right now," she says. But whatever caused the initial problem would likely be passed on to the clone offspring, "so I'm not sure that it's a very responsible thing to do."Adoption can also provide a solution, but the strong natural desire to produce a genetic heir often prevails."You want to be able to say your baby has your dad's gestures or your wife's eyes. I think it's a natural thing," Carson says. "I don't think it necessarily has to do with ego or a desire for immortality."Others aren't so sure.

Washington University biologist Ursula Goodenough says human cloning technology - if successful - would be available only to those with the means to pay for it. As a commodity, cloning may reflect ego, status or even the ultimate ego trip of immortality, or "faux immortality" as she calls it."That's faux in the sense that the person isn't really you at all," she says.

And while people may be reluctant to express such fantasies in public, Goodenough says she's heard plenty who privately whisper of their naive wish for immortality via cloning."They say, 'Well, gosh, you know, I'd still be here.' So it's tricky," she says.

Clonaid's scientific director, Brigitte Boisselier, has reinforced such notions by publicly reiterating the ultimate goal of the group's founder, former French journalist and racecar driver Claude Vorilhon, who calls himself Rael: the downloading of thoughts and emotions of an individual - the life history, if you will - into the body of his or her clone, a process by which the spiritual leader hopes to achieve immortality. The claim has done little to boost Clonaid's credibility.

"Of course, we have Ted Williams in an ice box," Goodenough says. "So people have been bilking people in the name of immortality for a long time, not to mention pharaohs and mummies."Dr. Jack Coulehan, a professor of preventive medicine and head of the medical ethics division at Stony Brook University Hospital, says the real issue in cloning, from an ethical perspective, comes down to motivation. As a technology, he believes, there is nothing intrinsically unethical or contradictory about pursuing therapeutic cloning (somatic cell nuclear transfer) and reproductive cloning.

In public, however, most scientists and the medical community have embraced therapeutic cloning technology for its promise in curing disease through the procurement of stem cells, while lambasting reproductive cloning. Coulehan says it's understandable that animosity would arise from scientists who perceive reproductive cloning as a lightning rod for controversy and thus a threat to their own work.Even then, however, a clearer look at the potential value of reproductive cloning may not be possible without "dissecting away the much more questionable areas," Coulehan says. In a culture where elective cosmetic surgery is increasingly looked upon as a means to improve a laundry list of physical features, for example, reproductive cloning may reflect the desire to perpetuate some physical feature or to create "designer children."

But while such reasons may invoke serious ethical concerns when they are applied to reproductive cloning, what about the subset of parents who have exhausted all other options in their attempts to produce biologically related children? "Getting rid of all that other stuff makes that small group clear," Coulehan says. "And even with that small group, you still need to ask the question, 'Should we really be putting our resources here?' But it at least focuses the question more."


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http://www.washingtonpost.com/wp-dyn/articles/A19718-2003Jan6.html

Crossing the Line on Cloning

Tuesday, January 7, 2003; Page A16

I was shocked by Bill McKibben's Jan. 6 op-ed article, "A Threat to Our Coherent Human Future." He wrote: "Robert Lanza . . . called the Raelian announcement 'appalling,' 'irresponsible' and 'a sad day for science.' Yet Lanza, two years ago, predicted that soon we would not just be cloning children but genetically souping them up: 'We're close to being able to add 20 or 30 IQ points, and an equivalent boost of their muscle mass,' to embryos, he said, adding, 'Who among us wouldn't say "yes"?' "

This misrepresents what I said at the State of the World Forum in 2000.

I did say that technology already existed to genetically increase muscle mass in animals by knocking out a gene known as myostatin and that someday scientists might figure out how to increase human intelligence. I also posed the question "What parent would not want to increase their child's IQ 20 or 30 points?" But I used this to illustrate the strong pressure that will develop to use cloning and genetic engineering to tamper with the human genome. I stated repeatedly that this "crossed the line" and was wrong.

Human evolution has taken millions of years, and it would be arrogant and foolhardy for us to think we can design a better person through science.

ROBERT P. LANZA

Vice President Medical and Scientific Development Advanced Cell Technology Inc. Worcester, Mass

 


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new scientists 6.1.03

Dutch clone claimed - but no proof

The cult-linked company Clonaid has made yet more claims about its human cloning programme and, once again, has failed to substantiate Latest Articles: them with any evidence.

Cloning may be 'elaborate The company, set up by the Raelian religious cult, says a second hoax' says monitor cloned baby was born on Friday night, to a Dutch lesbian couple. 7 Jan 03 But in the absence of any information about the babies and any scientific proof that they were cloned, the claims are increasingly Dutch clone claimed - but being dismissed as a lengthy publicity stunt. no proof 6 Jan 03 The affair is "totally ridiculous", says cloning expert Rudolph Jaenisch at the Massachusetts Institute of Technology. "In the Second cloned baby claim absence of any scientific evidence, I have to believe that it's not 3 Jan 03 true," he says. "They are extreme nuts."

Recent Articles: The birth of the second cloned baby took place in the Netherlands, according to Bart Overvliet, president of the Dutch chapter of the First cloned baby "born Raelians. The baby girl is allegedly a clone of her birth mother. on 26 December" 27 Dec 02 However, Brigitte Boisselier, the president of Clonaid, again refused to identify the location of the birth or the mother. Australia OKs human Planned genetic tests to verify that the first baby, born 26 embryo research December, is indeed a clone are still on hold. 5 Dec 02

First cloned baby 'due in Implantation experiments January' 27 Nov 02 Boisselier did reveal some details of Clonaid's cloning programme on Sunday. She told the BBC that her medical team had created Cloned stem cells may several hundred cloned embryos before conducting 10 implantation give new lease of life experiments. Two of these have lead to live births, she says, with 8 Nov 02 three more expected by the end of January.

Editorial: But Harry Griffin, head of the UK Roslin Institute and part of the team who cloned Dolly the sheep in 1997, told New Scientist that Brave new medicine such figures were "one of the more unbelievable aspects of the 1 Dec 01 story".

Not now, Dr Miracle "I believe Ms Boisselier has claimed five miscarriages, which [with 17 Mar 01 five successful implantations] gives a 100 per cent implantation rate," he says. "This is biologically possible, but IVF clinics Cloning FAQ only manage an implantation rate of about 20 per cent and that's with healthy embryos and implanting two embryos per woman." Do clones have shorter lifespans or greater He added that in animals only between one and two per cent of all susceptibility to cloned embryos make it to a live birth, although this can be higher disease? Your questions in some species. In cattle for example, if the cloned embryos can answered be persuaded to divide until they have 120 cells, then 20 per cent go on to produce live calves. Archived Cloning Articles "Clonaid have no track record but claim to have cloned hundreds of embryos - it just doesn't ring true," says Griffin.

Korean investigation

While Clonaid has yet to support its claims with any evidence, other agencies have begun investigations. The US Food and Drug Administration is reported to have visited the company's Las Vegas headquarters. Human cloning is not illegal in the US but any human experiments would have required FDA approval.

In South Korea, a police raid has taken place on the offices of BioFusion Tech Inc. - allegedly a subsidiary of Clonaid. BioFusion has been under investigation since July when it claimed that three Korean women were involved in a human cloning experiment and that one was pregnant.A Korean investigator told the Yonhap news agency that they could share information with the FDA, and that the FDA had said it would launch a full-fledged investigation if the Korean evidence provided any clues.

Exclusive coverage

It has also emerged that the journalist appointed by Clonaid to organise independent genetic tests attempted to sell exclusive coverage of the first child's cloning several months ago.According to the New York Times, the former ABC News science editor Michael Guillen approached CNN, ABC, NBC, CBS, HBO and Fox Entertainment. He offered a reality-based TV show, starting before the births, a Fox spokesman said.The revelations have increased scepticism about Guillen's independence from the Raelians. But Guillen has said that he is not being paid by Clonaid.


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http://www.washingtonpost.com/wp-dyn/articles/A15113-2003Jan5.html

Clonaid, Generating At Least One Kind of Copy

By Howard Kurtz Washington Post Staff Writer Monday, January 6, 2003; Page C01

Does the Clonaid crowd deserve any coverage?

That's the question reverberating in media circles in the wake of the group's spectacular -- and totally unproven -- claim of having cloned two baby girls.

Why, you might wonder, did the cable networks give live coverage to a wacky bunch who believe the human race was cloned by space aliens? Why did the nation's newspapers give substantial space to the followers of Rael, a former race car driver who says he was taken aboard a spaceship and entertained by voluptuous female robots?

The cloniacs and their space-cadet spokeswoman, Brigitte Boisselier, brought zero evidence to the table, even though they knew their claim would be greeted with fierce skepticism. No picture of the baby. No names for the parents. No DNA samples, no medical records, no nothing. Just the promise of some evidence down the road, to be validated by a former ABC newsman who once did a series that took seriously claims for astrology, ESP and moving objects through thought. And even as television shows have rushed to interview Rael -- who insisted that CNN's Connie Chung call him "Your Holiness" -- the group keeps making excuses for why the promised DNA tests haven't materialized.

Why not just ignore these characters?

The truth is it's not so easy.

Once the Raelians were on TV, lots of folks started buzzing about their claim. At that point, the media have some responsibility to shed light on the subject -- such as the fact that five successful pregnancies in 10 attempts (as the group claims) is the longest of long shots, based on past animal attempts.

Still, human cloning is hardly a scientific impossibility and, in the wake of Dolly the sheep and all the other animal clones, is probably inevitable.

And if the Raelians are just pulling off a spectacular hoax, well, that's a pretty interesting yarn, too. (What do they hope to get out of it? A movie deal?)

The initial coverage erred on the side of skepticism:

New York Times: "A sect that believes space travelers created the human race by cloning said today that it had produced the first human clone. . . . But the group's chief scientist gave few details and offered no proof of the claim, which some cloning experts greeted with skepticism."

The Washington Post: "The scientific director of a religious sect that believes humans are clones of extraterrestrials today claimed that the first human clone, a seven-pound baby girl nicknamed 'Eve,' has been born at a secret location outside the United States."

Los Angeles Times: "A member of a religious movement that claims space aliens created life on Earth announced Friday that her company had produced the first human clone, but provided no scientific proof."

None quite matched this New York Post headline: "CLONE KOOKS CLAIM SUCCESS." Subsequent critical pieces -- the New York Times has run several -- helped poke holes in the thin fabric of the Clonaid claims. But some media watchers are still upset.

"The newspapers of America owe an apology to anybody who has ever seen Big Foot tromp through the woods," wrote St. Paul Pioneer Press columnist Joe Soucheray. "We also owe apologies to people who claim to have seen images of the Blessed Virgin that show up on the sides of mailboxes and UFOs."

Los Angeles Times columnist Tim Rutten derided "a crackpot cult" -- consisting of "a bunch of kooks who operate a Canadian theme park called UFOland" -- producing "an international media frenzy. And while the majority of serious newspapers in the United States, including the Los Angeles Times and New York Times, kept the story off their front pages, dozens of others did not."


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http://www.washingtonpost.com/wp-dyn/articles/A18946-2003Jan6.html

Reporter Says Cloning Claim May Be Hoax

By Malcolm Ritter AP Science Writer Monday, January 6, 2003; 7:09 PM

NEW YORK &endash;&endash; The journalist who said he would oversee DNA testing to verify a company's claims it had produced a human clone said Monday he had dropped his efforts for lack of cooperation and could not rule out the possibility of "an elaborate hoax."

Officials with Clonaid, the company that announced Dec. 27 the birth of the world's first clone, initially promised DNA testing but later backed off. Clonaid said the parents of the 7-pound baby girl have refused to allow it."The team of scientists has had no access to the alleged family and, therefore, cannot verify firsthand the claim that a human baby has been cloned," said Michael Guillen, a former ABC science editor who had offered to arrange the testing.Experts who had been demanding independent verification said Clonaid has never had credibility with the scientific community.

"We don't find it surprising that they are not in a position to offer any data," said Sean Tipton, spokesman for the American Society of Reproductive Medicine in Washington, D.C.

"We have been ignoring it because we don't view it as a scientifically valid statement," said Natalie Dewitt, an editor at Nature, the British science journal which published the milestone data in 1997 on Dolly the cloned sheep.Clonaid was founded by the Raelian religious sect that believes space aliens created life on Earth, and chief executive Brigitte Boisselier acknowledges that outside DNA testing would be needed to make the claim credible.

In a statement, Guillen said he had assembled experts to do the work but suspended the effort Monday. "It's still entirely possible Clonaid's announcement is part of an elaborate hoax intended to bring publicity to the Raelian movement," he said.Guillen indicated he was still willing to proceed. "When and if an opportunity to collect DNA samples as promised does arise, however, the team stands fully prepared to re-mobilize and conduct the necessary tests."

The freelance journalist has said previously he had no connection to Clonaid. But he said in his statement Monday he has been interested in doing a documentary on human cloning that would involve Clonaid's work. He said he has covered the "principal players" in human cloning since the cloning of Dolly the sheep was announced.The New York Times reported Sunday that Guillen tried months ago to sell exclusive coverage of Clonaid's first baby to the major broadcast networks.

On Saturday, Boisselier said the baby's parents had promised to give her a final answer Monday about whether they would allow DNA tests. A spokesman for Guillen said his statement was not connected to that decision.Clonaid did not return phone calls requesting a response Monday.

Some scientists said Clonaid's two weeks of notoriety probably won't do lasting damage to legitimate reproductive research. Indeed, some believe it may have begun to educate the public on the differences between the cloning of stem cells and other therapeutic agents, and cloning to reproduce a baby.Others said it was a "big mistake" for policy-makers to have included Clonaid with legitimate scientists in congressional hearings and other science policy forums during the past year."By association, they have done some damage," Dewitt said. "But they are so far removed from legitimate science that I don't think it will cause a huge problem."

 


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http://www.daily-journal.com/content/?id=19355

Why can't we have cloning?

Mary Gooding, Daily Journal

January 06, 2003

It is the 30th anniversary month of the Supreme Court's 1973 Roe vs. Wade decision, which, along with subsequent rulings, allows abortion on demand at any time and for any reason. Having already decided, with the support of academics, clergy and journalists, that certain categories and stages of life are not entitled to the protection of law, why are so many appalled, outraged and surprised when cloning arrives at the door?

Cloning is the unnatural fruit -- there will be many more -- produced when the root of the tree of life has been pulled out of its nurturing soil and replanted into a soil of situational ethics that serve the temporal interests and feelings of humanity. What was it a few people said in 1973 about a slippery slope? We have slid a long way since then, and cloning is but a way station where the rest of humanity indulges itself in a slight gasp before resuming the downward spiral.

Whether or not "doctor" and cultist Brigitte Boisselier and her Clonaid operation have, in fact, cloned a girl named "Eve," the horror expressed in some quarters is a little late.

Ross Clark, a father of two, wrote a column in the London Times this week, asking why it's fine to "kill babies" in an abortion, but not to create them through cloning, "Our fear of clinicians in white coats is much greater when they are creating human life than when they are destroying it," he noted. Clark thinks the population growth fanatics don't mind when science kills, but they oppose anything that would add to our numbers. "We are more inclined to support science when it stops births than when it enables them," he said.

This is why pro-lifers favor returning to a uniform life ethic, covering the unborn, the handicapped, the elderly, racial and religious minorities, in short, all human life. Once one category of humanity is declared unfit to live -- regardless of the reason -- all others become at risk to the whims of society at a given moment. We still recoil at what Hitler did to the Jews, gypsies, homosexuals and the sick, but he was simply ahead of his time. Today, he might be invited to speak at Princeton about his unique form of eugenics. Why Princeton? It is the home of Dr. Peter Singer, the Australian philosopher who believes human life is not sacred and can and should be manipulated for whatever end the "healthy" and "fit" determine would serve their current interests. In fact, Hitler might be a candidate for cloning among those who believe his "work" should continue.

Cloning might produce large armies, such as those bred for war by the evil Saruman in "The Lord of the Rings." Clone wars might remove any sense of morality or immorality about war since those who are killing, or being killed, would be the fruits of soulless technology and of no greater value (but less expense) than an airplane or tank.

Some members of Congress, including many who have lost any moral standing on this issue because of their support of abortion through all nine months and even during delivery (known as "partial birth abortion"), now express shock and outrage over the latest cloning news. They are too late to be taken seriously. Having allowed the process to begin and failed to do anything to stop it, they may pass a law in hopes of slowing down the inevitable, but they will not succeed.

Western culture has told God that we don't need or want Him. It has told history that we will neither learn from it nor care. It worships at the shrine of The Self, and in so doing it has produced a type of "Rosemary's baby" that will be impossible to control absent a revival of the things that once mattered most about life.

After 40 million (and counting) aborted babies in the United States, who, or what, is going to stop cloning? And on what grounds?

Cal Thomas hosts "After Hours " on Fox News Channel Saturdays at 11 p.m. ET. Direct all mail for Cal Thomas to: Tribune Media Services, 435 N. Michigan Ave, Suite 1500, Chicago, Ill. 60611. Readers may also send e-mail to: www.calthomas.com.


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JN online

Is Cloning 'Kosher'?

Surprisingly diverse rabbinical views cut across movement lines.

Shelli Liebman Dorfman / Staff Writer

The claim by French bio-chemist Dr. Brigitte Boisselier that a human infant has been cloned stirred reaction from Detroit's rabbis that might be considered diverse &emdash; or even unexpected. At issue are two distinct aspects of the cloning controversy: • "medical cloning" &emdash; for medical research or repair of the body; "reproductive cloning" &emdash; to create a genetic-replica human being.

While many rabbis from divergent streams of Judaism are in agreement that cloning to benefit medical research would be acceptable, there is disagreement over the ethical and halachic (Jewish legal) fine points of reproductive cloning. "The use of cloning technology to help save diseased organs and repair cells should be considered permitted, and even obligatory, under the heading of saving a life," said Rabbi Daniel Nevins of the Conservative Adat Shalom Synagogue.

But to reproduce a human being from the genetic material of another human being, as opposed to a combination of two people's genetic material, goes against what Judaism believes about the creation of life." Orthodox Rabbi Herschel Finman, however, challenges this negative view of reproductive cloning. "The creation of life doesn't have to come from two people and still be halachically and ethically acceptable," said Rabbi Finman of Oak Park, who studied legal, medical and business ethics according to Halachah, at Yeshiva College in Melbourne, Australia. He responded to a statement by Israel's Chief Ashkenazic Rabbi Israel Meir Lau as reported by the Associated Press. Orthodox Rabbi Lau said Judaism favors technological developments and medical progress that can help save a life or solve infertility problems &emdash; but rejects the artificial creation of life.

Rabbi Finman disagrees. "The cloning of a human being is not artificial," he said. "It's just shuffling around what already exists. "The Talmud said, 'If all the scientists in the world got together, they could not create the wing of the mosquito and put life into it. That would be artificial.'" A statement from Chief Rabbi Lau's office said, "The moment medical science tries to take upon itself duties and areas which are not its responsibility &emdash; such as shortening life, cloning or creating life in an unnatural way &emdash; we must set down borders in order not to harm the Jewish basic belief that there is a creator of the universe in Community whose hands life and death are placed." Rabbi Finman said, "My fence is just moved a little While I agree we must not shorten life, the Torah says, 'HaShem will heal you,' and that healing comes through doctors. The tools or wisdom given to scientists to discover fertility techniques as solutions come from the Almighty."

Protecting Life One thing most rabbis agree on is the requirement that any procedure be protective of the life and well-being of those involved. "To me, cloning raises terrible fears of what illnesses could be introduced," Rabbi Nevins said. "It is not only very unwise but also an unethical policy to expose human beings to danger."

Rabbi Finman agrees that reproductive cloning may only be permissible if "no side effects" were presented. He also says the procedure must be performed only to help infertile couples and only when it does not involve a donor uterus or donor DNA. In acknowledging the varied interpretations of Halachah, Rabbi Finman says, "A very good thing about Judaism is that there is no absolute in determining Jewish law."

Reform Rabbi Paul Yedwab of Temple Israel is opposed to reproductive cloning. "Every morning a Jew prays, 'Oh God, the soul you have given me is a pure one,'" he said. "I interpret that to mean each soul is a unique one. "Creating a human being goes against that &emdash; as does the idea of reincarnation for the same reason &emdash; and both, in my opinion, go against Jewish law," Rabbi Yedwab says.


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http://news.bbc.co.uk/1/hi/health/2631395.stm

Clone' baby inquiry suspended

The Raelian sect believes humans were cloned by aliens An American journalist appointed to verify claims that a US-based company linked to the Raelian sect produced the first ever human clone has suspended his investigation. Michael Guillen said it was "entirely possible" that Clonaid's claims could be "an elaborate hoax". His announcement comes after reports that he tried unsuccessfully to sell TV programmes on the topic last year. Clonaid has refused offers from leading US scientists to perform tests on the mother and infant, who the group says was born on 26 December.

'Speculation'

"The team of scientists has had no access to the alleged family and, therefore, cannot verify firsthand the claim that a human baby has been cloned," said a statement from Mr Guillen. "It's still entirely possible Clonaid's announcement is part of an elaborate hoax intended to bring publicity to the Raelian movement," he added.

However, he said his team was prepared to conduct the tests if the opportunity to collect DNA from the alleged clones became available. Without independent tests, he said, "all we'll be left with is what we have now - opinion and speculation being passed off as fact". However, Clonaid says that the parents of baby Eve are reluctant to have the DNA tests as they could be obliged by law to reveal their identity.

Clonaid's claims have been met with widespread scepticism in the scientific community. Dr Brigitte Boisselier, Clonaid's chief executive, says she has implanted five cloned embryos, two of which have already been born.

'Sympathetic'Mr Guillen says that when he learned that Clonaid would be announcing cloned births, he proposed to put the claim of successful cloning to the test. The leader of the Raelian cult, which believes aliens created mankind, said they chose Mr Guillen to conduct the tests because he was "sympathetic".

Before Clonaid's announcement, Mr Guillen offered networks a reality-based show on the cloning process, which he would produce and present for around $100,000, the New York Times reported. The paper also said that it had been offered an article on the topic in May, which had been turned down.

Mr Guillen has a PhD from Cornell University and taught physics at Harvard before he moved into TV journalism. Correspondents say he has a history of TV reports examining scientifically questionable subjects like psychokinesis, astrology, auras, precognition and cold fusion. Several years ago he was given a spoof award by the sceptics' group the James Randi Foundation for what it called "promoting pseudoscience and quackery".

 


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http://politics.guardian.co.uk/homeaffairs/story/0,11026,868947,00.html

THE GUARDIAN

Court case could overturn controls on human cloning

Gaby Hinsliff, chief political correspondent Sunday January 5, 2003 The Observer

Controls on human cloning in Britain could be overturned by a new legal challenge from anti-abortion activists. The move comes amid worldwide controversy over claims from an American religious sect to have engineered the birth of the world's first cloned human babies.

The Raelian cult, who believe in extra-terrestrial life, announced yesterday that a second cloned baby has been born following the first birth on Boxing Day, the latest to a lesbian mother in the Netherlands. But the company has refused to provide proof of the supposed births, which have been greeted with widespread scepticism. The court case - which has led to calls to clarify the powers of the Human Fertilisation and Embryology Authority - centres on the creation of human embryos using cloning techniques which could provide cures for diseases or 'spare part' transplant organs.

Anti-abortion campaigners object because it involves the creation and then destruction of life. The Pro-Life Alliance will argue in the House of Lords next month that since techniques such as those used to create Dolly the sheep did not exist when the 1990 law was drawn up, embryos created in such ways are not covered by it and therefore not controlled by the HFEA. If the action succeeds, the case would not only halt therapeutic cloning but leave the HFEA powerless to regulate cloning for whatever purpose - although the law would still ban the implanting of clones into a woman in Britain. The threat highlights the HFEA's concerns that its powers are too loosely defined to resist sophisticated court challenges.

'The HFEA has too much power, and it is power they have not actually been given by Parliament,' said Josephine Quintavalle of Comment on Reproductive Ethics, which is linked to the case. Pro-lifers were encouraged by a surprise victory before Christmas, when the High Court ruled that the HFEA had overstepped its powers in giving the go-ahead for 'designer baby' techniques to be used to allow the parents of toddler Zain Hashmi, who has a rare blood disorder, to try for a second genetically matching baby who could supply stem cells to help treat Zain. The Hashmis must wait while the wrangle continues.

Yesterday, as the Department of Health said it was 'keeping under review' the need to tighten the 12-year-old Human Fertilisation and Embryology Act governing both developments, MPs called for action.

'The law has to be revisited, or it's going to happen anyway through the courts,' said Dr Ian Gibson, chairman of the Commons science and technology committee. 'The whole definition of life is up for grabs in a way it wasn't when the Act was written.' Although implanting a clone into a woman is illegal under British law, the fear is that a successful attack on the Act would destroy safeguards ensuring that cloned embryos created for genuine research cannot find their way into the hands of less scrupulous scientists.

Currently, anyone wanting to research 'therapeutic cloning' - duplicating human embryos for research or treatments - must be licensed and destroy the embryos at an early stage. The HFEA, under new chairwoman, Suzi Leather, is pushing privately for its powers to be clarified by Ministers to prevent more drawn-out court cases affecting families.

'There are aspects of the Act that are difficult because we are talking about an Act that was defined when infertility treatment was regarded as something that would be rare,' said an HFEA spokeswoman. The Pro-Life Alliance began its court battle last year with a victory in the High Court, which ruled that cloned embryos were not covered by the law. The Health Secretary, Alan Milburn, overturned that verdict on appeal. The Alliance is now taking its case to the House of Lords.

 


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http://www.voanews.com/article.cfm?objectID=4ED0519A-A153-47BE-A8CF7682D25A85B1

VOICE OF AMERICA

Scientists Dismiss Second Human Cloning Claim VOA News 05 Jan 2003, 14:29 UTC

Scientists are dismissing as a publicity stunt a second claim that a cloned baby has been born. Scientists say members of the Raelian movement, who claim a Dutch lesbian gave birth to a cloned baby on Friday, have given no evidence, pictures or details of the birth. Experts who are working on other human or animal cloning projects say they believe the claim is as fake as the first one. The Raelian-linked Clonaid company said last month a cloned girl nicknamed Eve had been born to an American mother. The controversial Italian embryologist Severino Antinori, who is working on his own human cloning projects, called the claims false and depressing for people doing serious research. He said announcements without scientific proof only create confusion.

Harry Griffin, the British scientist who lead the cloning of Dolly the sheep in 1996, says Clonaid is leading the media into a long drawn-out publicity stunt. The New York Times is reporting in its Sunday edition that the investigative journalist enlisted by Clonaid to verify the authenticity of its claims tried to sell the story for thousands of dollars to American media earlier this year. The report says the journalist Michael Guillen proposed a reality-based television program on the cloning effort to Fox Entertainment, but that the idea was rejected.

Clonaid says it has given little information on the births out of concern for the privacy of those involved. The company has also declined to say where the embryos were fertilized and implanted in the mothers and where the births took place, due to legal concerns. Raelians believe humans were cloned from aliens 25,000 years ago. The head of the Raelian movement, known as Rael, says he is striving for eternal life through cloning.Clonaid says three more cloned babies are due to be born before the end of the month. The first two claims brought worldwide media attention and condemnation by religious leaders.

 


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http://www.washingtonpost.com/wp-dyn/articles/A12928-2003Jan5.html

Report: Journalist Pitched Cloning Story

The Associated Press Sunday, January 5, 2003; 9:17 AM

NEW YORK &endash;&endash; The former ABC News science editor who said he would verify claims that the first human clone had been born tried months ago to sell exclusive coverage of the cloning to the major broadcast networks, according to a report published Sunday. CNN, ABC, NBC, CBS, HBO and Fox Entertainment all were approached by freelance television journalist Michael Guillen, The New York Times reported. At Fox, Guillen proposed a reality-based show on the cloning process, starting before the births, the Times said. He even offered to produce it and be the on-air host, but Fox rejected the proposal. "We thought it was more appropriate for our news department and we referred it to them," Joe Earley, a Fox spokesman, told the Times.

Another network executive, who the Times did not identify, said Guillen proposed an exclusive documentary on the cloning at a price of more than $100,000. The executive said the offer would have given the network too little editorial control. Guillen stepped into the cloning spotlight a week ago when he announced he would organize experts to independently test the claims of Clonaid, a company linked to a religious sect that believes life on Earth was created by extraterrestrials. The group claimed it had created the first cloned human, a girl it said was born to an American mother Dec. 26, but no DNA tests have yet verified the claim.

Brigitte Boisselier, Clonaid's chief executive, said Saturday that the DNA testing on the child had been delayed because the child's parents were concerned about legal ramifications if they came forward. She said they promised to tell her Monday whether they would allow the testing. Boisselier also announced Saturday that a second child cloned by the group had been born to Dutch parents, though no tests have verified that. Guillen, who said he was not being paid by Clonaid to arrange the testing, also pitched a story on the cloning process to the Times in May, saying he was the only reporter allowed to follow a couple trying to have a baby through cloning involving a Kentucky fertility specialist, the newspaper reported.

"During the better part of the past five years, I've cultivated close relationships with all the major human cloning scientists worldwide," Guillen wrote in his proposal, the Times said. "In fact, I know more about what's going on than any of the individual players; that's because they all confide in me." Editors of the Times refused Guillen's offer, the newspaper said. Guillen holds a Ph.D. from Cornell University and taught physics at Harvard before going into television journalism. He worked at ABC News from 1988 until last year. He has a written a few books, including "Five Equations That Changed the World: The Power and Poetry of Mathematics," which was named a book of the year by Publishers Weekly.

 


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http://abc.net.au/news/scitech/2003/01/item20030106074208_1.htm

Tue, Jan 7 2003 5:16 AM AEDT

Three more clones on the way: Clonaid

The controversial company Clonaid expects to unveil three more cloned babies over the coming weeks, after recently claiming a Dutch lesbian had given birth to the world's second cloned baby. But the company, funded by the Raelian movement which believes the human race was created by aliens, has so far refused to have their claims independently verified.

Clonaid chief executive Brigitte Boisselier claims the company's implantation program has produced a strong success rate."Before doing implantation we produced several hundreds of embyos just for testing, genetic tests and so on," Dr Boisselier told BBC television."But we did 10 implantations and of the ten implantations, five of them were successful."So two babies are born now and we're expecting the three other ones by the end of January, beginning of February."Dr Boisselier did not say where the three babies were due to be born.

The first baby, Eve, was born on December 26 to a US couple in an undisclosed location, followed by the second child, born to a Dutch lesbian couple.The claim comes as scepticism mounts among the scientific community.The credibility of the US journalist Clonaid has enlisted to authenticate its claims with DNA tests has been called into question. Reports have emerged that he tried to sell the story months before the first births.Michael Guillen, a former science editor at ABC television, had approached several broadcasters offering exclusive coverage for more than $US100,000.

Raelian sect founder Claude Vorilhon earlier called a halt to planned DNA tests after a Florida court summmoned him to a hearing to decide whether to place Eve - supposedly a clone of her American mother - under court protection."If there is any risk that this baby is taken away from the family, it is better to lose your credibility and not do the testing," Mr Vorilhon, who also also calls himself Rael, said."Cloning is the first step to achieving eternal life," he said.

The Canada-based Raelians believe humans were cloned from aliens who landed on Earth 25,000 years ago. Dr Boisselier says Eve's "parents" will authorise DNA tests to prove she was cloned only "when they are ready". Legal problems could also complicate the testing, she says."It's true that by having an independent expert going to their place, or even to a secret location, the expert would have the knowledge of who they are," she said. "And if the independent expert is asked by a judge to reveal who they are, he will have to do it."


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http://www.islam-online.net/english/news/2003-01/05/article12.shtm

Three More Cloned Babies Due In The Coming Weeks

LONDON, January 5 (IslamOnline & News Agencies) - Clonaid, the company that claims to have successfully cloned two human beings, said on Sunday, January 5, that three more cloned babies were due to be born in coming weeks, as skepticism mounted among the scientific community.

Clonaid head Brigitte Boisselier, whose firm has links with the Raelian sect, was speaking to BBC television after a second purportedly cloned child was born on Friday, January 3. "We produced several hundreds of embryos just for testing," said Boisselier, herself a member of the Raelians.

"Among them five were successful. Two babies are born now and we're expecting the three others by the end of January or beginning of February." Boisselier did not say where the three babies were due to be born. The first baby, Eve, was born on December 26 to a U.S. couple in an undisclosed location, followed by the second child, born to a Dutch lesbian couple. Meanwhile, the credibility of the U.S. journalist enlisted by Clonaid to authenticate its claims with DNA tests has been called into question, after reports emerged that he tried to sell the story months before the first births.

Michael Guillen, a former science editor at ABC television, had approached several broadcasters offering exclusive coverage for over 100,000 thousand dollars (euros). Raelian sect founder Claude Vorilhon had earlier called a halt to planned DNA tests after a Florida court summoned him to a hearing to decide whether to place Eve -- supposedly a clone of her American "mother" -- under court protection. "If there is any risk that this baby is taken away from the family, it is better to lose your credibility and not do the testing," said Vorilhon, who also calls himself "Rael". "Cloning is the first step to achieving eternal life," he said. The Canada-based Raelians believe humans were cloned from aliens who landed on Earth 25,000 years ago.

Boisselier said on Sunday that Eve's "parents" would authorize DNA tests to prove that Eve was cloned only "when they are ready". Legal problems could also complicate the testing, she said. "It's true that by having an independent expert going to their place, or even to a secret location, the expert would have the knowledge of who they are. And if the independent expert is asked by a judge to reveal who they are, he will have to do it."

On Saturday, January 4, the head of Russia's Molecular Genetics Institute, Vyacheslav Tarantul, responding to the announcement of the first birth of a human clone, warned that nearly all cloning efforts have led to horrific biological deformations. "It is theoretically possible to clone a human being, but who will take responsibility if a monster is born? This risk exists in 99 percent of the cases," ITAR-TASS reported him as saying. "During cloning experiments on animals, we have found anomalies in most cases - cancer, in particular," Tarantul added. Islam & Cloning The permissibility of the experiment in Islam sparked different viewpoints from prominent Muslim scholars.

Al-Azhar, the highest religious reference in the Sunni world, issued a fatwa ruling that human cloning is Haram (prohibited) and must be stopped. On the same line, prominent Muslim scholar Sheikh Yusuf Al-Qaradawi asserted that "viewed from the Islamic general objectives, rulings, and texts, human cloning is completely prohibited." However, Lebanon's top Shiite scholar Ayatollah Mohammad Hussein Fadlallah endorsed a different viewpoint, allowing human cloning if its positive aspects overweight negative ones. He stressed, however, that it is prohibited to use the organs of a cloned baby as "spare parts" in organs transplant operation.

In an interview with Tehran Radio on Tuesday, December 31, Fadlallah argued that cloning does not contradict with the question of creation or turns man into a creator. "Those who recently carried out the cloning operation were guided by the divine law in pollination and delivery," he said. "They did not get the elements of their experiment from nowhere and therefore cloning is not about a new law of creation but rather being guided by the divine law," added the Shiite scholar. "Cloning is a great scientific event which indicates man's genius in discovering the laws and systems created by Allah and his attempt to capitalize on them in his practical and scientific experiments," he said.


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http://www.canada.com/edmonton/edmontonjournal/story.asp?id=%7B7B786FBF-28FF-43A9-921F-02E241B91EC0%7D

What's scarier: Reality or Raelity?

JUST CLONING AROUND Jack Knox Victoria Times Colonist Sunday, January 05, 2003

Is it too late for Y2K?

I mean, three years ago the prospect got our knickers in a twist, but today it seems a nice, total systemic meltdown could be the best option for a planet suddenly sent spinning by technology that has not only run amok, but has sprinted into the wrong hands.

The ship of discovery, once piloted by those with the wisdom to match their newfound knowledge, has become the Exxon Valdez, six beer and one bad decision away from the rocks. Examples of misapplied science abound: North Korea has the bomb. Saddam may have one, too. Osama has a video camera. The Raelians claim to have cloned a human being. Diana Ross has a car. Your grandma has a DVD.

A few years ago, if someone suggested your granny had DVD, you would have popped him in the mouth. Then you would have given her de penicillin.No more. Now she's downloading pirated episodes of Murder She Wrote and burning them to disc, auctioning off grandpa's Viagra on eBay. It's unnerving. She's within three keystrokes and an unintentional password of disabling the power grid for southern Saskatchewan.

We're not terribly thrilled about North Korea having nukes, either. Kind of like looking in the rear-view mirror and seeing Ozzie Osbourne at the wheel of a school bus. It used to be that the nuclear club was exclusive. Now it's easier to join than Costco.But it's the Raelians who really grabbed our attention. According to their Web site, the Raelian Movement began after a French sportswriter was contacted by a being from another planet in 1973.

Rael, as the Frenchman is now known, describes the alien as being about four feet in height, with dark hair, almond-shaped eyes, olive skin and exuding harmony and humour. Apparently Rael was contacted by Tattoo from Fantasy Island.Anyway, Rael says he was told that human extraterrestrials, known as the Elohim, created man in their own image, using DNA and genetic engineering. The Raelians are now trying something similar, having founded Clonaid, a company which claims to have cloned a baby girl named Eve, born on Boxing Day.

The scientific community is skeptical about this claim, but hey, if we can celebrate a virgin birth on Dec. 25, we can suspend our doubts about a cloned baby on Dec. 26. Rael says the next step will be to clone an adult, without having to go through the growth process, and to transfer memory and personality into this person. (It would certainly save on the food bills, not to mention orthodontics, T-ball fees and Eminem recordings.)

Not sure about Rael being the one in charge of all this, though. It isn't the UFO stuff that's unsettling. Nor is it the fact that Rael dresses like Hugh Hefner on the Starship Enterprise. No, what's worrisome is Rael's past as a sportswriter. I've worked with a lot of sportswriters and, frankly, I don't think they should be allowed to breed, let alone be trusted with any form of reproductive technology.

Put conventional scientists in charge of cloning, and they'll build a new Einstein. But sportswriters? All you'll get is longer line-ups at the press box buffet. That, and 700,000 women who look just like Anna Kournikova. (Hmm, maybe this isn't such a bad idea ...)

Sorry. Sorry. No fair making fun of other people's beliefs, particularly when they may be more widely held than you think. The Raelians aren't the only ones looking to the stars: An Ipsos-Reid poll released last week found 22 per cent of Canadians believe life on other planets will be discovered in their lifetime. (A further 17 per cent believe life will be discovered in Toronto.)

Still, don't hold your breath. Raelian revelations aside, there's something to be said about the conceit of people who think that after all these millions of years, the great, once-in-an-eternity events -- Armageddon, an Earth-ending comet strike, contact with aliens, the Vancouver Canucks winning the Cup -- will occur during their own lifespan.

But I digress. We're supposed to be talking about applied science ending up in the hands of people without the brains to use it. Thank heavens most of the power still rests with rational leaders like George W. Bush. We used to worry about the president until Jean Chretien assured us that Bush is not -- repeat, not -- a moron, and certainly not a man just itching for an excuse, as opposed to a reason, to turn Baghdad into a parking lot.

Memo to Rael: Beam me up.

Jack Knox is a columnist with the Victoria Times Colonist


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http://enquirer.com/editions/2003/01/05/loc_pulfer05.html

Sunday, January 5, 2003

Necessary men , Too bad they can't be cloned

The sanctuary of the church was still decorated for Christmas. The whiff of pine in the air came from a tree, not from cleaning solution. The organist was the real thing, too. A pro. She never hit a sour note, and we'd have known. The hymns all were old family favorites.

As the music swelled and crested, the pastor stood with impeccable timing and a nice sense of drama. He looked toward the closed coffin in the aisle. And at us. At our red-rimmed eyes. At our obvious anguish.

He shook his head and smiled."He was ornery," he said of the deceased. It would not be one of "those" funerals, the kind where it appears that simply leading a good life is not good enough. The kind with so many embellishments that you finally wonder what saint they are talking about, surely not the real person you came to mourn. But this preacher never hit a sour note either. And we'd have known. Like the music, Uncle Dick was an old family favorite. A Dutch uncle

If you're lucky, your family has one of these guys. For one thing, he always showed up. At every holiday. At every birthday party. At every wedding and funeral. Not just for his kids, but for nieces and nephews. "My dad wasn't around much," one of my cousins said. But Uncle Dick danced at her wedding. Once he told me - a typical Uncle Dick kind of observation - that my brother's hair was too long and my skirt was too short. College students home for the holidays, Steve and I were reassured that we must look just the way we'd hoped. Mildly scandalous.

Most people edit themselves when they're around their pastor. "But Dick never did," the preacher said, miming perfectly our Aunt Peggy putting her hands over her face and saying through the lattice of fingers, "Oh, Diiiiiicckk." Making two syllables of his name. For 52 years. Uncle Dick would look a little shocked. "What? What? What'd I say?"

He was not conflicted about modern life. A man's job was to take care of his family. A man didn't "talk dirty" in front of women. A man disciplines his children and spoils his grandchildren. A man serves his country. A man goes to church on Sunday. Before the football game.

A carpenter, he sent his boys to college - making their lives easier, better than his had been. After retirement, he fixed everything that sagged or creaked in their houses. His sons are good men, a family trait owed not to genetics but to the power of observation.

One of the most offensive questions in the reliably offensive debate about human cloning is whether men now are unnecessary. As if all we expect of them is a dose of their DNA. We joke about cloning the good ones, as if we could find them in a petri dish. The ones who take the training wheels off your bike and help you balance the rest of your life. The ones who dance at your wedding. The men who build things and fix things.

Necessary men. No eloquent pretense. Just a lifetime of being real. And real good.

 


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http://www.reuters.com/newsArticle.jhtml?type=scienceNews&storyID=1992604

DNA Tests

Sun January 5, 2003 10:37 AM ET By Katherine Baldwin

LONDON (Reuters) - A cloning firm founded by a UFO sect defended Sunday its claim to have produced the world's first two cloned babies and said it would not pressure the parents to undergo DNA tests to silence skeptics.The Dutch branch of the Raelian movement, which believes the human race was created by aliens, said Saturday that a Dutch lesbian had given birth to a cloned baby.

That claim comes after the sect and cloning firm Clonaid said in December that a 31-year-old American had given birth to the first human clone, named Eve. No scientific evidence has been provided.Scientists have branded the claims as a baseless publicity stunt.In the Netherlands, where human cloning is banned, the government said it was investigating the second birth but pointed out there was no proof to support the sect's claim.Clonaid Chief Executive Brigitte Boisselier told BBC television Sunday she wanted DNA testing to happen as soon as possible but said she would not rush the parents. She acknowledged the public would remain incredulous even with DNA.

In the meantime, another three cloned babies should be born by late January or early February after five out of 10 embryo implantations proved successful, Boisselier said."Even if we have a legal contract saying they (the parents) should do it (DNA testing)...I have no heart to push them in that direction and I prefer to say let's wait until they are really ready to do it," Boisselier told the BBC's Breakfast with Frost from Canada.The parents are wary of undergoing DNA tests since experts could be obliged by law to reveal their identity, she said.A Florida attorney has asked a U.S. state court to appoint a legal guardian for baby Eve. Clonaid has refused to present the child publicly, say where it is or show medical evidence of the cloning.

CLOSE ENCOUNTER

Boisselier would not disclose where the second baby had been born. "The parents are a lesbian couple from Holland, and from what I heard from their voices, they are very happy," she said.The Raelian movement's profile has fed skepticism over their claims. The French founder of the movement, Claude Vorilhon, who calls himself Rael, defended his cult's theory Sunday that cloning was the first step toward attaining eternal life.Vorilhon told the BBC he had an encounter with extra-terrestrials in 1973 when he was a racecar magazine journalist.

"Through DNA and genetic engineering they created our life on Earth, they created synthetic life from scratch, from dust," he said.In an interview with Germany's Der Spiegel magazine, Vorilhon said he had discouraged Boisselier from presenting proof that baby Eve had been cloned because of the pending court case."I have advised Dr Boisselier to put her scientific reputation at stake rather than have the child taken from the mother. Now the child must be protected. That is more important than anything else," he told the magazine.

In cloning, the nucleus is removed from an egg cell and replaced with a nucleus from a cell of the animal to be cloned. It this is done at just the right time and in the right way, the egg cell starts to divide as if it had been fertilized by sperm. The resulting embryo is only an exact genetic duplicate of the mother if the mother's own egg cell was used


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http://www.washingtonpost.com/wp-dyn/articles/A11720-2003Jan4.html

Clonaid Claims Second Cloned Human Born

By Toby Sterling Associated Press Writer Saturday, January 4, 2003; 9:59 PM

AMSTERDAM, Netherlands &endash;&endash; Clonaid, the company that claims to have produced the first human clone, said Saturday it has produced a second one &endash; a girl born to a Dutch lesbian.

Neither baby has been confirmed to be a clone by genetic testing, and mainstream scientists are skeptical of the company's claims.

Clonaid spokeswoman Nadine Gary said in a telephone interview the child was born Friday night, but declined to say where. Clonaid vice president, Thomas Kaenzig, said the baby is a girl whose parents are two Dutch women. "It's a homosexual couple, a lesbian couple from Holland. The baby's doing fine. They're very happy and excited about it, and so are we," he told Associated Press Radio, speaking from an undisclosed location in the Dominican Republic.

Gary said she expects the second baby will undergo genetic testing to show it is a clone, with DNA identical to that of its mother. The group made a similar promise about Eve, a cloned girl purportedly born to U.S. parents on Dec. 26. But Clonaid now says the parents of that baby are balking at testing.

Brigitte Boisselier, Clonaid's chief executive and top scientist, told The Associated Press Television News on Saturday that the parents have promised to tell her Monday whether they will allow DNA testing to confirm the claim. The second baby's name had not been revealed. In television interviews, Boisselier has said the parents of the second baby want to remain anonymous.

Spokeswoman Gary said that, while the parents are Dutch, the birth did not take place in the Netherlands, where cloning is illegal. "The parents have Dutch nationality, but they are not in Holland," Gary said.

Clonaid was founded by the leader of the Raelians, a sect that believes aliens created life on Earth. Clonaid sells "cloning" services and products, and may benefit from the publicity around its claims, whether they are true or false. Scientists have successfully cloned mammals such as pigs and sheep, but the technology is not reliable and most scientists say it is difficult, unethical and risky to attempt to clone humans.

 


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http://europe.cnn.com/2003/HEALTH/01/04/human.cloning.chrono.reut/

CNN NEWS

Race to human cloning: Chronology

Saturday, January 4, 2003 Posted: 1649 GMT

LONDON, England (Reuters) - A religious cult that believes mankind was created by aliens has announced the world's second cloned baby has been born to a Dutch woman.

Clonaid, a cloning firm linked to the Raelian cult, claims to have engineered the birth. It announced last month that it had produced the first human clone, born to a 31-year-old American woman on December 26.

Cloning sidesteps the traditional process of reproduction, in which the male sperm fertilises the female egg. Instead, human cloning creates a person from an embryo by transplanting the DNA-containing nucleus of a person's cell into a woman's egg whose nucleus has been removed.

Here are key facts about the chronology of cloning:

February 24, 1997: Scientists at Scotland's Roslin Institute announce successful reproduction of a sheep named Dolly using DNA from a single adult sheep cell. The team took a normal embryo cell from an adult sheep and removed its nucleus. They then took a cell from another sheep's mammary gland and used an electric current to fuse it into the emptied cell.

March 4, 1997: U.S. President Bill Clinton issues an executive order prohibiting the use of federal funds for human cloning, citing "profound ethical issues."

July 1997: The British scientists who made Dolly clone Polly the lamb, who carries human genes. They hope to clone herds of identical sheep that can produce human proteins for medical use.

December 1997: Science magazine proclaims the cloning of Dolly the leading scientific advance of the year.

May 1999: The Roslin Institute is bought by U.S. biotechnology Company Geron Corporation. Shortly afterwards, Japan, India and most European countries ban cloning or impose laws supervising research.

February 2002: Japanese researchers who cloned a dozen mice report that virtually all the animals died early, casting doubts on the safety of cloning. The same month, scientists report that cloned mice have become obese.

February 2002: Scientists at Texas A&M University say they cloned a house cat and present a two-month-old kitten they call cc, short for carbon copy.

May 2002: A Lexington, Kentucky fertility expert, Panayiotis Zavos, tells a congressional panel "2002 will be the year of the clones" and says he is working to clone a human later in the year. He urges Congress to keep cloning legal so it can be regulated.

November 2002: Dr Severino Antinori, an Italian fertility expert, says he expects a patient to deliver a healthy cloned baby in January 2003 and that two other women are carrying cloned embryos.

December 27, 2002: Clonaid, a company associated with a group that believes mankind was created by aliens, announces first human clone, a baby girl weighing 7 pounds (3.1 kg) and delivered by Caesarean section, was born December 26.

January 4, 2003: The head of the Raelian movement in the Netherlands says a second cloned baby girl was born on January 3. Both child and mother are declared healthy.


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http://europe.cnn.com/2003/HEALTH/01/04/clone.dolly.reut/

Dolly institute head: Ban experiments

Sunday, January 5, 2003 Posted: 1027 GMT

LONDON, England (Reuters) -- Human clones are likely to be unhealthy and such experiments should be banned, the head of the institute that created Dolly the sheep said on Saturday, hours after a cult said it had produced the second cloned baby.

Harry Griffin of the Roslin Institute in Scotland, which made history by cloning Dolly from an adult sheep in 1996, told Reuters the claims by Clonaid, a group linked to the UFO-obsessed Raelian religious sect, were probably bogus. "Clonaid have made claims of two births, but of yet provided no evidence that either baby exists, no evidence from DNA tests, and as yet, therefore, there is no reason to believe this is anything other than a long, drawn out publicity stunt." But if cloned babies have been produced, the experiments should be stopped, Griffin said. "I think its entirely unacceptable for groups like Clonaid to be gambling with the health of children," he said.

Griffin said Clonaid's claim of a high success rate in its human cloning experiment flew in the face of years of research into cloning in other species. "There is a lot about this story that doesn't ring true. Success rates in every other species that have been cloned have been low, with lots of problems for the fetus and newborn clone," he said. "Attempts to clone monkeys have been entirely unsuccessful and the sort of successes claimed by Clonaid are totally at odds with all past history of cloning other species."

Dolly the sheep is still alive but suffers from severe arthritis. Griffin said scientists are unsure whether her health problems are a result of her being a clone, but countless other experiments have shown that clones are often unhealthy. "There is a whole raft of serious physiological deformities reported in clones, and even in entirely healthy animals its not entirely clear they are normal," he said.

The process of cloning involves taking the genes of an adult -- the instructions for life that make every organism unique -- and transferring them into an embryo, turning it into a genetic twin of the original. But Griffin said that although the clone has the same genes as the adult, there can be differences between the way genes behave, which often means the embryos of clones cannot grow to term, die shortly after birth or live crippled by disease. "You've got to persuade the 40,000 genes in that cell to stop beha ving as if they are in a mammary gland cell, or a skin cell or whatever, and start behaving as if they are in an embryo," he said. "We don't know how this reprogramming takes place. One, several or more of the genes can be inappropriately expressed."

Often cloned embryos do not survive to produce a live birth. Sometimes clones die shortly after birth, and other times they develop serious health problems later in life, he said. "All these things have been reported in the clones of cattle, sheep, pigs, goats, mice, rabbits. And there's no reason to believe that similar problems will not arise in the cloning of a child," he said

 


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http://www.usnews.com/usnews/issue/030113/health/13donor.b.htm

Health & Medicine 1/13/03

Donors at risk The high cost of eggs

It is illegal in the United States to buy or sell human body parts&endash;but an exception has slipped through some legal cracks: eggs. In ads placed in campus newspapers, so-called egg brokers dangle riches of tens of thousands of dollars before young women with the right pedigree of looks, talent, and SAT scores. Their eggs, carrying that pedigree, are wanted by infertile women. To the donor it might sound like a deal; in fact it's an ordeal.

For about a month, the donor actually turns her body over to the process. She must inject herself daily with hormones that stimulate her ovaries to produce up to several dozen ripened eggs rather than the usual one. These mature eggs are sucked out of her swollen ovaries with needles inserted through the vaginal wall. That is not especially pleasant. But the major risks relate to the heavy-duty drug treatments. In about 1 in every 100 women a "hyperstimulation" condition balloons the ovaries to the size of grapefruits and the belly fills with fluid, requiring hospitalization. There is a real but rare danger that an ovary will rupture or be irreversibly damaged, or even that a heart attack or stroke will occur. Brokers that solicit donors don't have to talk about this.

Safety warning. One Stanford student had a stroke while being treated for egg donation. Faced with student loans, she was one of many girls attracted by a broker's ad in the Stanford Daily offering $50,000 for the right eggs. A year ago, she told Stanford Magazine, "I wish I had been better warned." Warning patients of risks is a basic commandment in medicine. The American Society for Reproductive Medicine has developed guidelines that call for independent medical and psychological counseling about these risks. It also recommends a cap of $5,000 on donor compensation. The group is concerned that heftier payments might tempt donors to downplay risks. Jeffrey Goldberg, the head of Reproductive Endocrinology and Infertility at the Cleveland Clinic, believes the guidelines are on target, but "not all centers adhere to them." Unless the profession finds ways to enforce its standards, Goldberg believes, the government will step in. But even if standards are forced on the clinics, egg brokers and their anonymous clients are not subject to any of these professional constraints.

The use of egg donors is increasing at nearly 20 percent annually, as more women delay childbearing to the point where their own eggs are in trouble. (If human cloning, which relies on ripe eggs, becomes a reality, it will call for even more donors.) Though some years off, new technology might help. Scientists are finding ways to ripen eggs in test tubes rather than in women's bodies, eliminating the risk of ovary-stimulating drugs. And frozen egg technology will enable women to store their own eggs for later use&endash;rather than look to vulnerable students in search of tuition payments. &endash; Bernadine Healy, M.D.


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http://www.dailymail.com/news/Brad+McElhinny/2003010421/

It's all downhill from here Saturday January 04, 2003; 10:07 AM

My shoelaces tell me we've reached the pinnacle of human existence. Mine won't stay tied.

You know you're pretty far along in the evolutionary process when your inventions are designed to not actually function. I'll tell you one thing: You never see a squid walking around with his shoestrings undone. My laces slip apart moments after I tie them. It's embarrassing. This is a skill I learned in kindergarten, and now I can't do it successfully. Thankfully, all that investment in toilet training still is working out pretty well.

The laces are just rebellious. They like doing their own thing. They've tasted freedom, and it's for them. They enjoy flip-flip-flipping every time I take a step. They get a jolt out of dragging through puddles. Seriously: If YOU were a shoelace, how would you get your thrills?

It's our fault. We did it. We've engineered them this way. They're round. They're polyester. They aren't meant to lace. What is wrong with us?

The whole thing lends credence to the theory by that cloning group that we, as a species, were cultivated by aliens. Here's what they aren't telling us, though: Once we've rendered ourselves completely helpless, the aliens intend to eat us. If you think about it, all of our apparel is moving toward dysfunction. Pants. No longer meant to stay up. They're not even meant to cover your lower torso any more. Teenage boys, who represent our FUTURE, just put 'em on and let 'em drop to the ground.

Contact lenses. Not meant to make you see better. Again, it's the teenagers. They're buying contact lenses with wild tiger patterns or deep pools of blue. These lenses actually blind you. Teenagers don't bump into things, though. They can't walk around. They've already got the whole problem with the droopy pants.

What's next? Belts that don't buckle. Watches that don't tell time. Sweaters that make you shiver. One day, when evolution has run its course, we will be a species of 8-foot-tall beings with useless, spindly arms and rotund tummies. But our noses will be very tough after centuries of falling on them.

Writer Brad McElhinny can be reached at 348-4872.


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http://www.globetechnology.com/servlet/ArticleNews/gtnews/TGAM/20030104/COCLONE

I smell a cloned rat

Ottawa should not let the Raelians scare it into an inappropriate cloning law, says health policy researcher TIMOTHY CAULFIELD Saturday, January 4, 2003

If you believe the reports coming from the religious cult known as the Raelians, the first human clone was recently born.

Though I remain skeptical about the truth of this claim -- especially because the Raelians are balking on whether to allow genetic testing to confirm that the infant is, indeed, a clone -- such stories once again highlight the need to pass laws that govern the entire area of reproductive genetics. And, in fact, Canada is in the midst of just such a policymaking exercise. Parliament will be debating Bill C-13, the Assisted Human Reproduction Act, in the very near future.

Legislators, however, need to be careful not to let these spectacular (and grossly unethical) actions deflect from rational policy development. They need to be careful not to conflate the issues associated with reproductive cloning with those associated with the use of cloning technology in other contexts. Reproductive cloning, in general, is condemned by both ethicists and those in the scientific community. There is, however, much less social consensus about "therapeutic cloning" -- that is, the use of cloning technology for research purposes, such as the creation of cloned stem-cell lines or, perhaps, human tissue for transplantation.

Taken as a whole, few countries have specific cloning laws. Those that have regulated the area have chosen to ban reproductive cloning. There is, however, a great deal of variation in how countries deal with therapeutic cloning. For example, California, Britain, Singapore and Israel allow therapeutic cloning.

A number of countries, such as Ireland and Germany, have long banned all research involving human embryos; these prohibitive laws seem closely tied to a specific cultural or historic context, such as Ireland's strong Catholic tradition or the memory in Germany of the Nazis' eugenic policies. Other countries, such as Australia and France, have taken a middle-ground approach, allowing some forms of embryonic stem-cell research but banning therapeutic cloning; if Bill C-13 is passed as is, Canada will adopt such an approach.

Why the great diversity in approaches in such culturally similar countries? Do Canadians really feel so differently about therapeutic cloning as compared to Californians or Britons that a criminal sanction with a heavy prison sentence is required? Indeed, there are few other human activities that have met such different regulatory responses from such similar nations.

Available evidence indicates that most of the public supports the use of cloning technology for research purposes.

A 2002 Ipsos-Reid poll found that six in 10 Canadians approve of the creation of cloned human embryos for collecting stem cells. This seems a significant amount of support given that the controversial terms "embryo" and "cloning" are used and that the survey question makes no mention of potential therapeutic benefit. A study by PricewaterhouseCoopers did relate the technique to potential treatments, specifically to the cloning of human organs for transplant, and found that three-quarters of respondents said it was either very or somewhat acceptable. These findings are consistent with opinion research done in other countries, including the United States and Britain.

Despite such support, a sector of the public -- about 10 per cent to 20 per cent in Canada -- is steadfastly opposed to these activities. For this sector, no amount of scientific or potential therapeutic benefit can justify the research. As such, policymakers are left without a clear public mandate. In July, the U.S. President's Council on Bioethics explicitly noted this lack of consensus; it concluded that a ban on all forms of human cloning was not justified and that a moratorium should be imposed to give time "to seek moral consensus" -- a surprising result given the conservative position of the Bush administration.

I believe the international variation in cloning laws is a symptom of the deep moral ambiguity that surrounds reproductive genetics. With so much disagreement about the risks and benefits of cloning technologies, some countries have chosen to simply ban all forms of cloning involving human tissue. This is a mistake. Policymakers need to recognize that this is an area that will remain clouded by social uncertainty. All laws, especially criminal bans, need clear justifications. As noted in a 1982 federal report, The Criminal Law in Canadian Society, criminal law should be an instrument of "last resort" and should only be used to respond to "conduct which is culpable, seriously harmful, and generally conceived of as deserving of punishment." None of these elements are satisfied in the context of therapeutic cloning.

The Canadian government should not let the Raelians scare it into an inappropriate cloning law. Instead, it should amend Bill C-13 to make therapeutic cloning a carefully regulated, rather than banned, activity. Such an approach seems a much better way to recognize and respect the broad diversity of views relevant to this complex area. As recently argued by Australian scholars Brendan Gogerty and Dianne Nicol, "the public tends to demand prohibition of conduct that is universally opposed, but expects issues of moral ambiguity to be regulated." Timothy Caulfield holds the Canada research chair in health law and policy at the University of Alberta.zzz
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 http://www.thestar.com/NASApp/cs/ContentServer?pagename=thestar/Layout/Article_Type1&c=Article&cid=1035776143559&call_pageid=968867495754&col=969483191630

Fantasy of cloning more fearsome than its reality The truth is, we can't handle two of any of us

PHILIP MARCHAND BOOKS COLUMNIST, Jan. 4, 2003. 10:05 AM

It doesn't matter that the French journalist and cult leader who calls himself "Rael" is a charlatan on the order of L. Ron Hubbard, the late founder of Scientology. When he announced the other day that his "scientists" had brought to birth the world's first human clone, it jolted us. We know that if his announcement turns out to be a fraud &emdash; as it probably will &emdash; there are still lots of people in white lab coats who are dying to do something like this, and they will succeed, sooner or later.

I hate the idea of human cloning, but then I'm by temperament one of those peasants who march with torches and pitchforks on Dr. Frankenstein's Castle. Cease these unholy doings! Don't ask me to debate the issue.

It's an intuitive thing, partly. I like the human race as it is. I don't want it tampered with by Raelians, or by more respectable scientific minds, who dream of a post-human era in which we fiddle with genes all we want.

Perhaps, these people speculate, we'll create a super-race of human beings who can solve quadratic equations in a second. Perhaps we'll foster a much nicer species by removing our warlike and belligerent genes and replacing them with genes that encourage us to obey pedestrian signals even when there's not a car in sight. With luck, the entire human race will end up just like people who live in Ottawa.

Chalk up another triumph for the progress of science.

Actually, people who experiment with cloning are not so much scientists as the kind of scientific "projectors" satirized by Jonathan Swift in Gulliver's Travels. In that book, projectors conduct experiments to extract sunbeams out of cucumbers, breed naked sheep, and produce a race of mathematical geniuses via edible wafers on which mathematical propositions are written with a special tincture. "This the student was to swallow upon a fasting stomach, and for three days following eat nothing but bread and water. As the wafer digested, the tincture mounted to his brain, bearing the proposition along with it."

This kind of scientific project has a long history in the West, dating back to the alchemists of the Middle Ages and the Renaissance who thought they could transform things employing a species of scientific magic. It's the kind of thinking that Rael, whose cult is based on a worship of scientific technology, demonstrates when he proclaims, "Once we can clone exact replicas of ourselves, the next step will be to transfer our memory and personality into our newly cloned brains, which will allow us to live forever."

Or live long enough to see the Liberals lose a federal election, anyway. Reality has a way of thwarting scientific magic, unfortunately &emdash; or fortunately. In last Sunday's Star, a writer named Ronald Bailey pointed out a few such realities about cloning. He mentioned that a human clone "would be a complete human being who happens to share the same set of genes with another person. Today, we call such people identical twins."

He further observed that even identical twins are far from "exact replicas" of each other, and so nobody's going to produce an exact replica of himself or herself through cloning, or bring back dead children. Finally, he pointed out that animal cloning so far has produced dismal results, with only a tiny percentage of such clones surviving for any length of time.

Bailey's sobering words will probably have little effect on public consciousness, because "cloning" is much more a construct of the emotions and the imagination than an actual technical procedure. It's a dream or nightmare. Some people, for example, really would like exact replicas of themselves. You see it in fathers who bully their sons into choosing their occupations, cultivating their personal habits, and adopting their opinions. Ralph Waldo Emerson, when he saw this thing going on, protested eloquently: "You are trying to make that child another you. One's enough."

I love that "One's enough." One's enough of me, and one's enough of you, gentle reader. Nobody's yearning for the day when they can clone us.

The normal person shudders at the thought of an exact replica of himself or herself, anyway. I remember years ago when, in my circle of acquaintances, I was sometimes confused with another man with the same first name and a slightly similar appearance. He would sometimes be confused with me, likewise. Relations between us were distinctly cool.

Fraternal or identical twins may like each other or not &emdash; it depends on a lot of things &emdash; but for the rest of us, our natural response to a double is hostility. That's why we sometimes joke about our "evil twin," when referring to a person who is our double in some respect. It's like Edgar Allen Poe's story, "William Wilson," where the narrator is driven crazy by a man with an eerie similarity to him, a man who seems to be his alter ego.

"The feeling of vexation," the narrator recalls, "grew stronger with every circumstance tending to show resemblance, moral or physical, between my rival and myself." In a frenzy of rage, he carves up his double with a sword.

Can you imagine what would happen if Rael's vision came true?

Here you have your exact replica, with his newly cloned body and his newly cloned brain.

You're waiting for the moment, just before you die, when you can conveniently transfer your memory and personality into this waiting vessel and so gain a new lease on life. But he doesn't want your memory and personality. In fact, he'd willingly carve you up with a sword to prevent your dumping that memory and personality on his perfectly nice, unsullied brain.


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 http://www.washtimes.com/commentary/20030104-17858670.htm

January 4, 2003

Clones come marching in

Paul Greenberg

The news columns are semi-agog with the latest announcement that still another species has been cloned, this time the most dangerous of all: homo supposedly sapiens. It doesn't exactly add to the credibility of this latest, oh-so-scientific announcement &emdash; A Clone is born &emdash; that it should come from someone who (a) believes human life was brought to Earth by extraterrestrials and (b) is French. The quality of French science has been deteriorating steadily since Madame Curie, till now it begins to approach the level of French politics.

The trend is personified by Dr. Brigitte Boisselier, the head of something called Clonaid, which sounds like a corporation out of Woody Allen's "Sleeper." On the whole, I'd put more stock in Steven Spielberg's E.T., who at least wasn't trying to start up his own religion, clone farm or IPO. Dr. Boisselier is also Bishop Boisselier of the International Raelian Movement, which isn't easy to describe. Think of Amos 'n' Andy's Mystic Knights of the Sea conflated with a UFO fan club. The only surprising thing about Dr. Boisselier's announcement was that it wasn't made in Roswell, N.M. (The Raelians preferred Hollywood, Fla.)

But the good doctor and right reverend bishop promises that more clones are in utero and ready to pop, so there's still time for her to make it to Roswell and Area 51 for the next more or less blessed event. It would be the perfect locale. Everything in this scenario was perfectly predictable, right down to the nickname of the new baby &emdash; Eve. Or as I've often thought while relishing really bad sci-fi flicks, "Who writes this stuff?" It isn't the nutcases that scare me, any more than the B movies did. And for the same reason: All the special effects seem so phony. They don't seem to have changed basically since the days of "Flash Gordon" and "Ming the Merciless." The sheer commercialism of it all is as transparent as ever. Much like the special decoder ring that, after considerable effort on our young part, decoded only the name of a breakfast cereal. Talk about anticlimax. One suspects that all this hyperventilation over the First Human Clone will lead to a similar letdown. And that all these great scientists behind Cloning for Fun and Profit will turn out to be more Inspector Clouseau than Louis Pasteur.

What worries me are the quite respectable advocates of cloning. They come in an impressive number of models: The guys in suits and ties who appear before congressional committees and look, talk and act as if they were clones, all duly outfitted with the same techno-condescending vocabulary. The celebrity victims who seek only the good of mankind by duplicating it (mankind) for research purposes. The university administrators who explain why cloning isn't cloning when it's Therapeutic instead of Reproductive, lest we be confused on noticing that in both cases the technique is exactly the same. Then there are the politicians who think they are striking some sort of Solomonic compromise by proposing to create life with the assurance that it will soon be destroyed which is supposed to be comforting instead of doubly frightening.

Scary, too, are the entrepreneurs who have no doubt that, once this profitable little genie is out of the bottle, it'll be a cinch to get him/her/it/them back in once they've cashed in their stock options. On balance, I would prefer the old-fashioned Vincent Price of the drive-in movies &emdash; somebody chortling and frothing at the mouth as he tries to outfit a fly with a human head and vice-versa. Or a vampiric Bela Lugosi rubbing his hands with glee at the prospect of draining the fresh blood he desperately needs from some photogenic babe. The mad scientists in the movies didn't prepare us for the real ones, who appear so sane. They may think themselves in quite a different category from the Dr. Boisseliers and Raelian company, but they're up to the same thing.

They, too, are talking about moving beyond outdated ethical limits and becoming our own Creators, but their vocabulary is scientific and their euphemisms practiced as they calmly explain the benefits of putting these clusters of embryonic cells to good use at last. Hey, youth is wasted on the youngest of us, and they were going to be destroyed, anyway .

When Goethe said that nothing was so frightening as ignorance in action, he may not have considered the results of knowledge in action, especially when divorced from wisdom. Allow me to put in a word for the zanies. However dubious their claims, however full of hubris their aims, their objective is the most marvelous thing in the world: a human baby. And while they're trying to produce somebody's identical twin instead of child, at least they don't propose to sacrifice it in order to extend the lifespan of the rest of us. Their baby isn't just a means to our end. It is its own reason for being. Immanuel Kant, who had a thing about using persons as things, would be pleased.

But what is one to say of the eminent scientists, the sympathetic actors and the oh-so-moderate and reasonable political figures who explain that, while nobody in his right mind would be in favor of allowing a human clone be born, there's nothing wrong with creating one to serve our own purposes &emdash; so long as we kill it at a very early age. Maybe after just a few days in vitro, or a week, or a month, or three, or . There's the real horror.

Paul Greenberg is a nationally syndicated columnist.


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 http://story.news.yahoo.com/news?tmpl=story2&cid=679&ncid=742&e=2&u=/usatoday/20030103/cm_usatoday/4750582

USA TODAY

All human cloning is wrong Fri Jan 3, 5:51 AM ET

Sam Brownback

The announcement of the possible first live-born human clone came as a shock to many. And it should.

However, what the Raelians claim to have done is at its most basic level no different from what numerous biotech companies in this country, and elsewhere, are attempting to do. As observers of this issue know, there are several biotech companies and university research labs engaged -- or soon will be -- in the mass production of human embryos for research purposes. The human embryos will be harvested for their material, then destroyed.

This grisly prospect -- creating human life merely to conduct research on it -- must be outlawed.

Some proponents of human cloning would have society believe that there are two different types of cloning: so-called reproductive and so-called therapeutic. Science, however, tells us that there are not two types of cloning -- there is only one, and it always results in the creation of a new human embryo.

The essential point: Cloning is cloning is cloning, and all cloning is the same.

Whether the embryo created through the process of nuclear somatic-cell transfer (the technical name for cloning) is destined for implantation or for destructive research that ultimately kills him or her -- it is the same, and it should be banned.

Some Congress members who favor cloning in certain circumstances are offering a bill that bans the implantation of clonal human embryos while at the same time authorizing biotech companies to create thousands of human embryos.

Let us be clear: This proposal is not in any way a ban on human cloning. It is an endorsement of human cloning that attempts to restrict some of the ways the human clones may be used.If we do not ban the cloning of human embryos now, we will quickly find ourselves unable to put the genie back in the bottle.The only solution to the problem now facing humanity is to act quickly and to ban all human cloning now.

Along with Sen. Mary Landrieu, D-La., I have authored a bipartisan bill that bans all human cloning. The House has passed such a bill, and the president has indicated his strong support for this measure. Congress and the country can afford to wait no longer.

Sen. Sam Brownback is a Republican senator from Kansas.


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 http://www.washingtonpost.com/wp-dyn/articles/A7694-2003Jan3.html

Fla. Court Sets Date in Clone Baby Case

Reuters Friday, January 3, 2003; 7:11 PM Includes material from HEALTH-CLONE-DUTCH

By Frances Kerry

MIAMI (Reuters) - A Florida attorney who asked a state court this week to appoint a legal guardian for the baby girl purported to be the first human clone said on Friday that the court had set a hearing in the case for later this month.

Clonaid, set up by a cult that believes aliens created mankind, said in Florida a week ago that it had produced the first cloned baby. It refused to present the child publicly, say where it was or show medical evidence of the cloning. The company, whose claim drew widespread skepticism among scientific experts, said on Friday that a second cloned child was due to be born this weekend in Europe to a lesbian couple.

Attorney Bernard Siegel filed a petition with the state juvenile court in Fort Lauderdale on Tuesday aiming to protect the first purported human clone, saying the child was being exploited and may have suffered birth defects. He said on Friday that at the arraignment hearing in court on Jan. 22, the parties in the case would be expected to appear before the judge and the alleged parent or legal guardian would have to admit, deny or consent to the petition he filed.

"If they are served and fail to appear that could constitute consent to an adjudication of the child being a dependent child, and could ultimately result in loss of custody," Siegel told Reuters. He added however that his intention was not to get the child removed from the mother, but to have a court guardian appointed. Siegel has also acknowledged that the court would probably have no jurisdiction unless the child is in Florida.

'ALIENS STARTED HUMAN RACE'

Clonaid was set up by the Raelian Movement, a religious cult that claims 55,000 followers around the world and believes aliens landed on Earth 25,000 years ago and started the human race through cloning. The Belgian television channel, VTM, which interviewed Clonaid chief executive Brigitte Boisselier on Friday, said she confirmed to them that the birth of the baby girl would take place in the Netherlands.

Clonaid has yet to provide DNA samples or any other evidence to back up its assertions that it produced the first cloned human, a girl named Eve born to a still anonymous 31-year-old American woman. Since Siegel's court filing, which he undertook as a private citizen, Clonaid has suggested it might delay DNA testing that would prove its claim.

On Thursday, Boisselier said in interviews with France 2 television and BBC Two in Britain that DNA tests on the baby had been put off because the parents were anxious about keeping their identity secret. She said the baby's parents felt under pressure after the legal petition in Florida. "I can see why they might want to back off a DNA test," Siegel said on Friday of the delays. "Either the test will show this child is a clone and therefore has risk of a serious medical future and they inflicted it on her, or if the child is not a clone then they are part of an exploitative scheme."

Officials of Clonaid in the United States did not reply to a call seeking comment. Siegel asked in the dependency petition for a judge to appoint a legal guardian for the child and, if necessary, place her in state protective custody. Florida law allows anyone to file such a petition for court protection of a child if they have information that the child is in danger.

Siegel filed the petition in Florida because Clonaid chose Broward County to make its announcement a week ago, although there was no indication the child was in the state. "I am more and more skeptical that there is a child out there," Siegel said. "But the medical science exists for this to have happened, so if a child exists, and we ignore it we could be abandoning this child to this company."


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http://www.biomedcentral.com/news/20030103/05/

Identifying Eve

Alleged clone must pass rigorous tests, experts assert. By Emma Hitt, January 3, 2003

It's been one week since the Bahamas-based company Clonaid announced the birth of the alleged world's first human clone, a baby named Eve. The claim immediately met with widespread skepticism among scientists for several reasons: reproductive cloning has yet to be achieved in primates, the birth was announced at a press conference rather than in a peer-reviewed publication, and the company has yet to provide so much as photographic evidence of a baby.

Not strengthening its case, Clonaid is affiliated with the Raˆ´lian sect, whose founding tenet is that humans were cloned from extraterrestrials. In light of past fraudulent claims to have cloned humans, this latest ‚Äì if it's to be taken seriously ‚Äì will have to be verified independently and thoroughly.

In an attempt to do just that, Clonaid has agreed to allow freelance science reporter Michael Guillen to orchestrate independent genetic testing of the baby. A science correspondent for ABC News for 14 years, Guillen has a doctorate in physics, mathematics, and astronomy from Cornell University. At a press conference held December 27 with Clonaid's CEO, Brigitte Boisselier, Guillen outlined a proposed testing schedule. Blood samples were to be taken from mother and child this week, tested at two labs to verify a genetic match, and the results would be available sometime next week.

Guillen has not identified the labs performing the testing, nor precisely what kinds of tests will be performed. Since last week's press conference he has refused further public comment, and his agent's office told The Scientist that Guillen will continue a "no comment" policy until the test results become available.

Until that time, scientists can only speculate about the truth of the claim that the baby is a clone of her birth mother. While not probable at this stage, successful human reproductive cloning is certainly possible. "Many physicians have the skills to collect human ova and transfer human embryos, and many technicians could perform the nuclear transfer procedure," said Mark Westhusin associate professor with the College of Veterinary Medicine of Texas A&M University, College Station.

According to Westhusin, who heads a lab that last year produced the world's first cloned cat, analysis of DNA short tandem repeats (STRs) from the mother and baby's nuclear DNA could prove whether the child is indeed a clone. STRs are highly polymorphic among individuals, and if enough markers are analyzed, compared and found to be identical, then statistics can predict the probability of the mother and child being genetically identical, Westhusin told The Scientist.

Bruce Weir, professor of statistics and genetics at North Carolina State University and a DNA forensics expert who testified in OJ Simpson's trial, concurs that a standard 13-locus microsatellite (STR) forensic profile should be identical for the mother and child. He also pointed out that the mitochondrial DNA of the baby should be identical to that of the donor from which the oocyte was derived.

Perhaps the biggest issue in establishing the truth of the claim will be verifying the chain of custody of the samples. Tests must be conducted in duplicate by separate laboratories, noted Sir Alec Jeffreys, the inventor of DNA fingerprinting and professor of genetics at Leicester University, UK, in a written statement issued by the Royal Society on December 31.

According to Jeffreys, independent experts would also have to witness every step of the procedure for collecting the tissue samples of mother and baby so that they could vouch for the authenticity of the samples.

Beyond establishing the baby's identity, further testing would be needed to determine its health. Rudolf Jaenisch professor of biology at the Whitehead Institute claims that even if DNA evidence verifies that the infant is a clone, it's unlikely to be healthy or stay healthy. Animal experiments predict that the baby would have "all kinds of problems," he told The Scientist. The few clones that survive birth tend to have abnormal fetal development called large offspring syndrome. "So the ones that survive the perinatal period appear normal afterwards, but they are not."

Jaenisch and colleagues have studied gene expression in cloned mice, and have found hundreds of genes to be incorrectly expressed. "There's no reason to assume that what we see in mice would be different for humans," he said.

He also pointed out that brain function is a concern, and "of course, none of these brain effects have been tested in animals, because they are not suitable for that," he said. "One would predict that any clone that ages would have more and more of these problems."

Jaenisch, like many, is skeptical. "If these people supply any results, I wouldn't believe them," he said. "You need credible people doing this, not some charlatans."

Links for this article Clonaid http://www.clonaid.com

R. Weiss, "Cloning a previous hoax?" The Washington Post, December 31, 2002. http://www.washingtonpost.com/wp-dyn/articles/A56233-2002Dec30. html

J. Weitzman, "Copy cat," The Scientist, February 22, 2002. http://www.biomedcentral.com/news/20020222/01/

"Royal Society checklist to assess claims about human reproductive cloning," December 31, 2002. http://www.royalsoc.ac.uk/templates/press/showpresspage.cfm?fil e=425.txt

A. Legge, "Nuclear transfer results in inherently unstable offspring," The Scientist, July 12, 2001. http://www.biomedcentral.com/news/20010712/03/

N. Johnston, "Widespread dysregulation in clones," The Scientist, September 13, 2002. http://www.biomedcentral.com/news/20020913/07/


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 new scientist 03 jan 2003

Second cloned baby claim

The cult-linked company Clonaid, which claims to have cloned the world's first baby, now say a second cloned child will be born in Latest Articles: Europe by Sunday.

Cloning may be 'elaborate But scepticism is increasing as efforts to substantiate the claim hoax' says monitor of the first cloned birth on 26 December with DNA tests appear to 7 Jan 03 be unravelling.

Dutch clone claimed - but Clonaid was set up by the Raelian cult, which believes people are no proof clones of extraterrestrial aliens. It had promised to allow DNA 6 Jan 03 samples to be taken on 31 December from baby and mother for independent testing. Only if the baby's DNA can be proved to be Second cloned baby claim identical to that of another person will the baby be accepted as a 3 Jan 03 clone.

Recent Articles: But Clonaid president Brigitte Boisselier said on Thursday that the tests had been postponed in order to protect the parents' First cloned baby "born identities. This follows a Florida lawyer asking a state court to on 26 December" appoint a legal guardian for the baby girl, nicknamed Eve. 27 Dec 02 Boisselier claims the parents are concerned that the person appointed to carry out the DNA tests may have to reveal their Australia OKs human identity to the court. embryo research 5 Dec 02 48 hours First cloned baby 'due in January' "The parents told me they are giving themselves another 48 hours to 27 Nov 02 decide whether or not they will do the tests," she told the France 2 television station. She added that tests might instead be Cloned stem cells may performed on the second child: "Perhaps the second child will be give new lease of life more accessible because it is in Europe and the country in which he 8 Nov 02 or she will be born may be less sensitive."

Editorial: Clonaid's attempts to prove their claim has also been undermined by criticism of the journalist they have asked to oversee the Brave new medicine verification process. Michael Guillen was formerly science editor 1 Dec 01 at US television station ABC.

Not now, Dr Miracle But Robert Park, a physicist at the University of Maryland and 17 Mar 01 prominent critic of pseudo-science, says Guillen has covered topics such as astrology and psychokinesis with a high degree of Cloning FAQ credulity. Of Guillen's doctorate, gained at Cornell University, Park says: "A PhD in physics is not an inoculation against Do clones have shorter foolishness." lifespans or greater susceptibility to disease? Your questions Abused child answered Lawyer Bernard Siegal says he filed his petition to the Fort Archived Cloning Articles Lauderdale court because, if true, the cloned baby was an "abused child that was being exploited by Clonaid" and needed court protection. The petition alleges that, if the child is cloned, it "is at risk of having permanent genetic defects, imperfections and mutations".

He says a hearing has been scheduled for 22 January should reveal the parent's identity. "Their failure to appear amounts to giving consent of an adjudication of the child to a guardian. They have to appear," says Siegel.

Clonaid's claims have provoked harsh criticism around the world and renewed calls for a global ban on reproductive cloning. But negotiations at the United Nations have been deadlocked over whether to include in the ban therapeutic cloning, in which early cloned embryos are used to provide stem cells for medical treatments.

Mainstream cloning scientists have consistently stated that attempting to clone a baby would be irresponsible and repugnant, given the high rates of deaths and defects seen in the seven mammalian species cloned so far. Many groups also oppose cloning babies as ethically unacceptable.


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new scientist 27.12.02

First cloned baby "born on 26 December"

The world's first cloned baby was born on 26 December, claims the Bahamas-based cloning company Clonaid. But there has been no Latest Articles: independent confirmation of the claim.

Cloning may be 'elaborate The girl, named Eve by the cloning team, was said to have been born hoax' says monitor by Caesarean section at 1155 EST. The birth at an undisclosed 7 Jan 03 location went "very well", said Brigitte Boisselier, president of Clonaid. The company was formed in 1997 by the Raelian cult, which Dutch clone claimed - but believes people are clones of aliens. no proof 6 Jan 03 "The baby is very healthy. She is doing fine," Roisselier told a press conference in Hollywood, Florida, on Friday. The seven-pound Second cloned baby claim baby is a clone of a 31-year-old American woman, whose partner is 3 Jan 03 infertile, she said.

Recent Articles: Proving that the baby is a clone of another person would be possible by showing that their DNA is identical. Genetic tests on First cloned baby "born the baby and "mother" will now be carried out and the results will on 26 December" be available "in eight or nine days", Boisselier said. 27 Dec 02 She told reporters: "You can still go back to your office and treat Australia OKs human me as a fraud. You have one week to do that." Boisselier added that embryo research Michael Guillen, science editor at ABC News and a former Harvard 5 Dec 02 University mathematician, will carry out the genetic tests.

First cloned baby 'due in January' Necessary expertise 27 Nov 02 Many scientists are sceptical of Boisselier's claim. Alan Trounson Cloned stem cells may of Monash University in Melbourne, Australia, says he does not give new lease of life believe the group has the necessary expertise to clone a person. 8 Nov 02 "And nearly everything they have said in the past has never been confirmed by scientific investigation," he told the Sydney Morning Editorial: Herald.

Brave new medicine Maverick fertility scientist Severino Antinori, who claimed earlier 1 Dec 01 in December that the first cloned baby would be born in January 2003, is also critical. "An announcement of this type has no Not now, Dr Miracle scientific corroboration and risks creating confusion," he said. 17 Mar 01 "We keep up our scientific work without making announcements. I don't take part in this ... race." Cloning FAQ Opponents of human cloning point to the high rate of miscarriages Do clones have shorter of cloned animal fetuses, and the high rate of defects in live lifespans or greater births. Boisselier has claimed that the large number of female cult susceptibility to members willing to act as surrogate mothers increased their chances disease? Your questions of success. answered

Archived Cloning Articles "Irresponsible and repugnant"

Attempting to clone humans is "irresponsible and repugnant and ignores the overwhelming scientific evidence from seven mammalian species cloned so far," Rudolph Jaenisch, a cloning expert at the Massachusetts Institute of Technology told New Scientist previously.

In May, US-based fertility scientist Panos Zavos told the US Congress that five groups of scientists were rushing to be the first to produce the first cloned human baby.

Reproductive cloning - creating a baby rather than a cloned early embryo - is illegal in many countries. But in November, talks on a global ban were suspended, following a series of deadlocked United Nations meetings.
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World's first human clone born'
A sect claims the world's first cloned human - a girl - has been born.
http://www.ananova.com/news/story/sm_733350.html

The child was born by caesarean section and the birth "went very well," said Brigitte Boisselier, a French chemist and member of the Raelian sect. Boisselier has called a news conference in Florida to make the announcement and a spokesman said she would have an "independent inspector" take DNA evidence from the baby and her 30-year-old-mother.

If the baby is a clone of the mother, the two will be genetically identical. The Raelians, who claim 55,000 followers worldwide, believe that life on Earth was established by extra-terrestrials who arrived in flying saucers 25,000 years ago, and that humans themselves were created by cloning. The movement's founder, Rael - the former French journalist Claude Vorilhon - lives in Canada. He describes himself as a prophet and claims that cloning will enable humanity to attain eternal life.

The sect formed the company Clonaid in 1997 to produce cloned humans but many scientists are sceptical about its ability to accomplish the feat. Cloning produces a new individual using only one person's DNA. The process is technically difficult but conceptually simple. Boisselier, who says she has two chemistry degrees and was previously marketing director for a chemical company in France, identifies herself as a Raelian "bishop" and said Clonaid retained philosophical but not economic links to the Raelians. She is not a specialist in reproductive medicine.


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THE ASSOCIATED PRESS, Newsday

Update on Baby Project December 27, 2002

http://www.newsday.com/news/health/ny-hsbaby27q3062685dec27,0,4594339.story?coll=ny-health-headlines

A chemist who said last week that her company would soon produce the world's first human clone - a baby girl genetically identical to her 30-year-old mother - has promised an announcement today.

Nadine Gary, a spokeswoman for Brigitte Boisselier and the company, Clonaid, declined to answer directly when asked if they will claim to have produced the world's first cloned baby. However, Gary said yesterday that Boisselier intends to have video equipment at a news briefing in Florida and would have an "independent inspector" take DNA evidence from baby and mother. If the baby was a clone of the mother, the two would be genetically identical.

Many scientists are skeptical about Clonaid's ability to accomplish the feat. The cloning process is technically difficult but conceptually simple. Scientists remove the genetic material from an unfertilized egg, then introduce new DNA from a cell of the animal to be cloned. Under the proper conditions, the egg begins dividing into new cells according to the instructions in the introduced DNA. So far scientists have succeeded in cloning sheep, mice, cows, pigs, goats and cats. Last year, scientists in Massachusetts produced cloned human embryos with the intention of using them as a source of stem cells, but the cloned embryos never grew bigger than six cells.

There is no specific law against human cloning for reproductive purposes in the United States, but the Food and Drug Administration contends it must approve any human experiments in this country. Boisselier has refused to say where Clonaid has been carrying out its experiments. Bush administration officials said yesterday they were aware of rumors of an announcement but had no plans to comment until after the details were known.

Boisselier, who has said she has two chemistry degrees and previously was marketing director for a chemical company in France, identifies herself as a "bishop" of a group called the Raelians and has said Clonaid retains philosophical but not economic links to the group. Clonaid was founded in the Bahamas in 1997 by Claude Vorilhon, a former French journalist and leader of the Raelians. Vorilhon and his followers claim aliens visiting him in the 1970s revealed they had created all life on Earth through genetic engineering.

Several weeks ago Italian fertility doctor Severino Antinori said he had engineered a cloned baby boy who would be born in January.


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Clonaid Plans Human Cloning Announcement Company Schedules Announcement on Controversial Human Cloning Effort

http://abcnews.go.com/wire/US/ap20021227_88.html

NEW YORK Dec. 27 &emdash; NEW YORK (AP) A chemist who said last week her company would soon produce the first human clone an infant girl genetically identical to her 30-year-old mother prepared an announcement on the effort even as scientists remain skeptical about the feat.

A spokeswoman for Brigitte Boisselier and the company, Clonaid, declined to answer directly when asked if they will claim at a briefing Friday to have produced the world's first cloned baby. But the spokeswoman, Nadine Gary, said Thursday that Boisselier intends to have video equipment at the news conference in Florida, and would have an "independent inspector" take DNA evidence from baby and mother. If the baby was a clone of the mother, the two would be genetically identical.

Many scientists are skeptical about Clonaid's ability to accomplish the cloning. The company was founded in the Bahamas in 1997 by Claude Vorilhon, a former French journalist and leader of a group called the Raelians. Vorilhon and his followers claim aliens visiting him in the 1970s revealed they had created all life on Earth through genetic engineering.

Cloning produces a new individual using only one person's DNA. The process is technically difficult but conceptually simple. Scientists remove the genetic material from an unfertilized egg, then introduce new DNA from a cell of the animal to be cloned. Under the proper conditions, the egg begins dividing into new cells according to the instructions in the introduced DNA.

Boisselier, who claims two chemistry degrees and previously was marketing director for a chemical company in France, identifies herself as a Raelian "bishop" and said Clonaid retains philosophical but not economic links to the Raelians. She is not a specialist in reproductive medicine.

Human cloning for reproductive purposes is banned in several countries. There is no specific law against it in the United States, but the Food and Drug Administration contends it must approve any human experiments in this country. Boisselier would not say where Clonaid has been carrying out its experiments. Bush administration officials said in Washington on Thursday they were aware of rumors of an announcement but had no plans to comment on the matter until after the details were known.

Boisselier's comments last week came several weeks after Italian fertility doctor Severino Antinori said a cloned baby boy would be born in January. So far scientists have succeeded in cloning sheep, mice, cows, pigs, goats and cats. Last year, scientists in Massachusetts produced cloned human embryos with the intention of using them as a source of stem cells, but the cloned embryos never grew bigger than six cells.

Many scientists oppose cloning to produce humans, saying it's too risky because of abnormalities seen in cloned animals.


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Cloning group to make 'major announcement'
From Miriam Falco CNN Friday, December 27, 2002 Posted: 3:37 PM HKT (0737 GMT)
http://asia.cnn.com/2002/HEALTH/12/27/human.cloning/

HOLLYWOOD, Florida (CNN) -- A controversial group that has claimed to be able and willing to clone a human has scheduled a news conference for Friday to make a "major announcement," according to the group's spokesperson.

Brigitte Boisselier, the scientific director of Clonaid, is scheduled to make the announcement Friday at 9 a.m. Last week, Boisselier told some news organizations that the birth of a cloned baby girl is imminent. Boisselier has told CNN in the past that she will not make an announcement until a healthy baby is born. She told a congressional committee last year that she believed she had the knowledge to produce a human clone in the near future.

Clonaid, which calls itself the "first human cloning company," was founded by a religious group called the Raelians in 1997. Boisselier is a bishop in the Raelian movement, which professes that life on Earth was created through genetic engineering by extraterrestrials.

The Raelians believe their spiritual leader Rael is a direct descendant of these aliens. Rael told CNN in July 2001 that the long-term goal for human cloning is to live forever. Rael says cloning a baby is only the first step: Eventually the group wants to learn how to clone an adult, then "transfer the brain to the clone." Boisselier says the immediate purpose for cloning is to help infertile couples. Last November, she told CNN she was "indeed doing human cloned embryos and we have many cell divisions," but she wouldn't confirm any pregnancies.

Group has not released any data on research

To make a clone, scientists first take an egg and remove all of its genetic material. Then the nucleus of a cell -- any cell in the body -- is taken from the individual to be cloned and inserted into the hollowed-out egg. The cell is then given a jolt of electricity or put in a chemical bath to activate cell division -- essentially tricking the cell into doing what a fertilized egg would normally do. Then the embryo is implanted into a woman's uterus to be carried to term. It is unknown which exact procedure Clonaid is using, because it has not published or released any data about its research. Boisselier has not revealed the location of her current lab, only to say it is no longer in the United States. She used to have a lab in West Virginia, but the U.S. Food and Drug Administration visited the lab and shut it down. Scientists so far have successfully cloned sheep, cows, goats, mice, pigs and a rare wild ox. But human cloning is controversial, because the experience with animal cloning has shown a lot of potential for things to go wrong.

'One shouldn't do this,' biologist says of human cloning

Many animal cloners -- including Ian Wilmut, the Scottish researcher who successfully cloned the first animal, Dolly the sheep, in 1997 -- disapprove of human cloning. Wilmut has said it took 276 failed attempts before Dolly was successfully cloned. "It is not responsible at this stage to even consider the cloning of humans, " said Rudolf Jaenisch, a biologist at MIT's Whitehead Institute for Biological Research, which clones mice. Janeisch said that even if a human clone appears healthy, it may not be once it gets older. Cloning a human at this point, he said, without knowing more about why things go wrong, is "essentially using humans as guinea pigs, and one shouldn't do this." According to Dr. Jon Hill, a veterinarian who successfully cloned cows at Texas A&M University, even clones who appear normal at birth often develop problems afterward. "Their livers, their lungs, their heart, their blood vessels are often abnormal after birth," Hill said.

Few legal prohibitions on human cloning

The Raelians are not the only group claiming to actively try to clone a human. Italian doctor Severino Antinori made several announcements in recent months, claiming that a woman was carrying a human clone that would be born in January 2003. And former University of Kentucky professor Panos Zavos has also announced plans to clone a human, but he told CNN earlier this year he had not successfully created an embryo yet.

Scientists and bioethicists have questioned whether any of these groups have the ability to clone a human. Art Caplan, director of the Center for Bioethics at the University of Pennsylvania, has said in the past that "we don't know how" to accomplish human cloning. Legally, there's very little to stop scientists from cloning. In January, the National Academy of Sciences recommended a ban on human cloning, but only four states -- California, Michigan, Louisiana and Rhode Island -- ban any type of cloning research. The FDA claims it has jurisdiction over human cloning based on the Public Health Service and Food, Drug and Cosmetic Act. It says it would regulate the cloning process like a drug.