NFP37 SOMATIC GENE THERAPY Teams

Phase B, 1999-2000

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RESEARCH TEAMS & PROJECTS
FORSCHUNGSGRUPPEN UND PROJEKTE
GROUPES DES RECHERCHE ET PROJETS
GRUPPI DI RICERCA E PROGETTI

PAGE IS STILL IN CONSTRUCTION!!!

Last Name

Site / City

Key words / Topics

AEBISCHER

LAUSANNE

Gene-assisted therapy of amyotrophic LS

BAUMGARTNER

BERN

Therapy of limb ischaemia

CECCHINI

BERN

Searching for vascular address zip codes

DREHER

GENEVA

Immunotherapy of tubercolosis

FILIPOWICZ

BASEL

Vectors for treatment of blood disorders

FONTANA

ZUERICH

Therapy of brain tumors

FREY

BERN

Ferry-boat system for genes

GAY

ZUERICH

Gene therapy strategies for Rheumatoid Arthritis

HERRERA

GENEVA

Inhibition of graft-versus-host disease

HOSSLE

ZUERICH

Therapy of chronic granulomatosis

IGGO

EPALINGES

Anticancer adenoviruses

KOLAKOFSKY

GENEVA

Paramyxoviruses as gene vectors

LUCHSINGER

BASEL

Legal and social aspects of gene therapy

MERLO

BASEL

Controlling proliferatory potential of glyoblastomas

MERMOD

LAUSANNE

Regulatory gene cassettes

OERTLI

BASEL

Imunotherapy of Melanomas

MOELLING

ZUERICH

Retroviral vectors

REHMANN-
SUTTER

BASEL

Perception of gene therapy by patients and doctors

RUEGG

EPALINGES

Anticancer strategies

RUSCONI

FRIBOURG

Direction

SCHNEIDER

FRIBOURG

Direct transfer of nucleic acids

SCHUEMPERLI

BERN

Bioactive digonucleotides

THALI

LAUSANNE

Vectors for treatment of blood disorders

TRONO

GENEVA

HIV based gene vehicles

VASSALLI

LAUSANNE

Cardiovascular gene therapy

VILLARD

GENEVA

Therapy of MSH II disorders

WALTER

ZUERICH

Nonviral delivery vectors for immunotherapy

YANG

ZUERICH

Inhibition of occlusion in grafted veins


AEBISCHER,
Patrick

CHUV, Division Recherche chirurgicale et centre de therapie genique, Pavillon 4, 1011 Lausanne
tel 021 314 2462; fax 021 314 2468
e-mail: patrick.aebischer@chuv.hospvd.ch

Title:

Development of a gene therapy approach for patients suffering from amyotrophic lateral sclerosis

Co-applicants:

Collaborators:

names

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BAUMGARTNER,
Iris

Inselspital Bern, Departement Innere Medizin, Abteilung Angiologie, Freiburgstrasse, 3010 Bern
tel 031 632 4237; fax 031 632 4793
e-mail: Iris.Baumgartner@insel.ch

Title:

Somatic phVEGF-C gene therapy in patients with chronic critical limb ischemia

Co-applicants:

Collaborators:

names

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CECCHINI,
Marco

Institut fuer Immunologie und Allergologie der Universitaet Bern, Inselspital, 3010 Bern
tel 031 632 3521; fax 031 381 5735
e-mail: email

Title:

Targeting genes to the vasculature of tumours using mimotopes and synthetic antibodies

Co-applicants:

Collaborators:

names

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DREHER,
Donatus

Hopital cantonal universitaire, Division de Pneumologie, 1211 Geneva 14
tel 022 372 9572; fax 022 372 9929
e-mail: dreher@dim.hcuge.ch

Title:

Gene transfer to human dendritic cells for immunotherapy of tuberculosis

Co-applicants:

Collaborators:

names

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FONTANA,
Adriano

Uni-Spital Zuerich, Dep.Innere Medizin, Abt.Klin.Immunologie, Haeldeliweg 4, CH-8044 Zuerich
tel 01 634 3813/14; fax 01 634 2902
e-mail: immfoa@usz.unizh.ch

Title:

FAS ligand gene transfer in brain tumor therapy

Co-applicants:

Collaborators:

names

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FILIPOWICZ,
Aleksandra

Kantonsspital Basel, Dept. Forschung, Experimentelle Hämatologie, Hebelstr. 20, CH- 4031 Basel,
tel 061 265 2332; fax 061 265 2350
e-mail: Aleksandra.Wodnar-Filipowicz@unibas.ch

Title:

Lentivirus-mediated gene transfer into hematopoietic precursor cells from unbilical cord blood and fetal liver

Co-applicants:

Collaborators:

names

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FREY,
Felix Julius

Inselspital, Abt. für Nephrologie, Dep. für Innere Medizin, Freiburgstrasse 3, CH-3010 Bern
tel 031 632 3116; fax 031 632 9734
e-mail: Felix.Frey@insel.ch

Title:

Steroid-mediated gene delivery (SMGD) for therapy of 11beta-hydroxy-steroid dehydrogenase deficiency

Co-applicants:

Collaborators:

names

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GAY,
Steffen

Uni-Spital Zuerich, Zentrum für Experimentelle, Rheumatologie, Gloriastr. 25, CH-8091 Zuerich
tel. 01 255 5737; fax 01 255 4170
e-mail: ruzgay@ruz.unizh.ch

Title:

Inhibition of matrix metalloproteinases mediated joint destruction in rheumatoid arthritis by a three level gene transfer approach

Co-applicants:

Collaborators:

names

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HERRERA,
Pedro Luis

Dep.de Morphologie, CMU, Faculte de Medecine, 1 rue Michel-Servet, CH-1211 Geneva 4
tel 022 702 5225; fax 022 702 5260
e-mail: Pedro.Herrera@medecine.unige.ch

Title:

Devising an approach to modulate the graft versus host disease in protocols of adoptive immunotherapy

Co-applicants:

Collaborators:

names

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HOSSLE,
Johann

Kinderspital Zuerich, Abteilung Immunologie/Hämatologie, Steinwiesstr. 75, CH-8032 Zuerich
tel 01 266 7341; fax 01 266 7171
e-mail: hosslejp@kispi.unizh.ch

Title:

Development of clinically applicable protocols for transitory and permanent somatic gene therapy in chronic granulomatous disease

Co-applicants:

Collaborators:

names

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IGGO,
Richard

ISREC, Chemin des Bovéresses 155, CH-1066 Epalinges
tel 021 692 5889; 021 652 6933
e-mail: Richard.Iggo@isrec.unil.ch

Title:

Transcriptional targeting of replicating adenoviruses for cancer gene therapy: non-GMP costs

Co-applicants:

Collaborators:

names

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KOLAKOVSKY,
Daniel

Departement de Genetique et Microbiologie, CMU, 1 Rue Michel-Servet, CH-1211 Geneva 4
tel 022 702 5657; fax 022 702 5702
e-mail: kolakofs@cmu.unige.ch

Title:

Sendai paramyxovirus as a non-integrative RNA virus vector

Co-applicants:

Collaborators:

names

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LUCHSINGER
Thomas

Blumenrain 2, CH-4051 Basel
tel 061 261 9106; fax ---
e-mail: luchsinger@ubaclu.unibas.ch

Title:

Legal and ethical aspects of gene therapy

Co-applicants:

Collaborators:

names

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MERLO,
Adrian

Kantonsspital Basel, Labor für Molek. Neuro-Onkol., Spitalstrasse 21, CH-4031 Basel
tel 061 061 265 2525; fax 061 265 7138
e-mail: email

Title:

Inhibition of glioblastoma cell invasion by targeted inactivation of the focal adhesion kinase (FAK)

Co-applicants:

Collaborators:

names

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MERMOD,
Nicolas

Laboratoire de Biotechnologie moleculaire, Departement de chimie, EPFL, CH-1015 Lausanne
tel 021 693 6151; fax 021 693 6140
e-mail: nicolas.mermod@iba.unil.ch

Title:

Development of vectors for regulated expression in gene therapy

Co-applicants:

Collaborators:

names

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MOELLING,
Karin

Institut für Medizinische Virologie; Gloriastr. 30; CH-8028 Zürich;
Tel 01 634 2652; Fax 01 634 4967;
e-mail: moelling@immv.unizh.ch

Title:

Retroviral vectors for somatic gene therapy.

Co-applicants:

Dr. J. Pavlovic (Zürich)

Collaborators:

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OERTLI,
Daniel

Kantonsspital Basel, Departement Chirurgie, Universitaetskliniken, Spitalstr.21, CH-4031 Basel
tel 061 265 2374; fax 061 265 3990
e-mail: doertli@uhbs.ch

Title:

Active specific immunotherapy with recombinant vaccinia viruses expressing melanoma associated antigens and costimulatory molecules (non-GMP)

Co-applicants:

P.Zajac, W.R.Marti, G.Spagnoli, C.Noppen, E.Padovan, M.Zuber, U.Luescher, T.Kocher, F.Harder, M.Heberer

Collaborators:

R. Herrmann, P. Jantscheff, Ch. Rochlitz (Department of Medical Oncology), P. Schiller (Department of Dermatology)

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


REHMANN-SUTTER,
Christoph

Instit. f.Geschichte&Ethik der Medizin, Arbeitsstelle f. Bioethik, Schönbeinstr.20, CH-4056 Basel
tel 061 267 3067; fax 061 267 3190
e-mail: rehmannc@ubaclu.unibas.ch

Title:

Perceptions of healing needs: somatic gene therapy, disability and identity

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


RUEGG,
Curzio

ISREC, Centre Pluridisciplinaire d'Oncologie, 155 Chemin des Boveresses, CH-1066 Epalinges
tel 021 692 5853; fax 021 692 5872
e-mail: curzio.ruegg@isrec.unil.ch

Title:

Disruption of the tumor vasculature by inhibiting vascular integrin avB3 using a genetic approach

Co-applicants:

Collaborators:

names

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RUSCONI,
Sandro

Biochemisches Institut der Universitaet Freiburg, Rue du Musee 5, CH-1700 Fribourg
tel 026 300 8656, fax 026 300 9735
e-mail: sandro.rusconi@unifr.ch

Title:

Direction of the NRP37 "Somatische Gentherapie", tasks and budgets

Co-applicants:

Collaborators:

names

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SCHNEIDER,André

Institut für Zoologie, Universitaet Fribourg, Perolles, CH-1700 Fribourg
tel 026 300 88 93/94; fax 026 300 9741
e-mail: andre.schneider@unifr.ch

Title:

Translocation of ribonucleic acids across membranes - Novel approaches for gene therapy

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


SCHUEMPERLI,
Daniel

Zoologisches Institut, Abt. f. Zell- &Entw.biologie, Uni Bern, Baltzerstrasse 4, CH-3012 Bern
tel 031 631 4675; fax 031 631 4616
e-mail: daniel.schuemperli@zoi.unibe.ch

Title:

A small-RNA expression system for antisense gene therapy

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


THALI,
Markus
Filipowicz A.

Institut de Microbiologie de l'Universite de Lausanne, Rue du Bugnon 44, CH-1011 Lausanne
tel 021 314 4099; 021 314 4095
e-mail: Markus.Thali@inst.hospvd.ch

Title:

Lentivirus-mediated gene transfer into hematopoietic precursor cells from unbilical cord blood and fetal liver

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


TRONO,
Didier

Dept. de Genetique et Microbiologie, CMU,1 rue Michel-Servet, CH-1211 Geneva 4
tel 022 702 5720; fax 022 702 5721
e-mail: trono@cmu.unige.ch

Title:

A lentiviral vector allowing stable gene transfer in non dividing cells

Co-applicants:

Collaborators:

names

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VASSALLI,
Giuseppe

CHUV, Division de Cardiologie, Pavillon 4, CH-1011 Lausanne
tel 021 314 0006; fax 021 314 2468
e-mail: giuseppe.vassalli@chuv.hospvd.ch

Title:

Gene therapy of ischemic heart disease and dilated cardiomyopathy

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


VILLARD,
Jean

Departement de Genetique et Microbiologie, CMU, 1 Rue Michel-Servet, CH-1211 Geneva 4
tel 022 702 5672; fax 022 702 5702
e-mail: Jean.Villard@medecine.unige.ch

Title:

Towards gene therapy for MHC class II deficiency

Co-applicants:

Collaborators:

names

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WALTER,
Elke

Departement Pharmazie, ETH - Zuerich, Winterthurerstr. 190, CH-8057 Zuerich
tel 01 635 6013; fax 01 635 6881
e-mail: elke.walter@pharma.ethz

Title:

Targeting of dendritic cells for DNA vaccination

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP


YANG,
Zhihong

Physiologisches Institut, Universitaet Zuerich Irchel, Winterthurerstr. 190, CH-8057 Zuerich
tel 01 635 5097; fax 01 635 6827
e-mail: zihongy@physiol.unizh.ch

Title:

n vivo gene transfer of endothelial nitric oxide synthase in the saphenous vein: a pilot study for gene therapy of bypass graft disease

Co-applicants:

Collaborators:

names

SCIENTIFIC | PUBLICATION | DIVULGATION | BACK TO TOP



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