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GENE THERAPY Scientific Abstracts |
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Prof. Adriano Fontana; |
Innere Medizin; Klinische Immunologie; Uni-spital
Zürich; Häldeliweg 4; 8044 Zürich; CH; |
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Title: |
FAS ligand gene transfer in brain tumor therapy. |
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ABSTRACT | PUBLICATION | DIVULGATIONTEXT | BACK TO OUTLINE |
SCIENTIFIC ABSTRACT 1997:
Glioblastoma multiforme cells express Fas/Apo-1 which can be targeted by anti-Fas antibodies or by the Fas ligand, which results in apoptosis of the tumor cells. Both the expression of Fas/Apo-1 and the signal cascade involved in the intracellular killing pathway can be positively enhanced by cytokines, namely interferon g and tumor necrosis factor alpha. Interferon g also counteracts bcl-2, an oncogene expressed by selected glioma cells which inhibits Fas/Apo-1 mediated apoptosis. Interestingly, glioma cells which differ in their grade of malignancy show differences in expression of bcl-2: while the more malignant tumors are strongly positive for bcl-2, low grade tumors are negative or only borderline positive. These data will be substantiated and related to the expression of p53, bcl-2 and bax, all of which are known to influence apoptosis. The possibility of using the Fas/Apo-1 system as a target for immunotherapy will be evaluated in-vivo in mice with experimental murine glioma.
SCIENTIFIC ABSTRACT 1998:
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SCIENTIFIC ABSTRACT 1999:
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SCIENTIFIC ABSTRACT 2000:
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SCIENTIFIC ABSTRACT 2001:
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