NFP37 SOMATIC GENE THERAPY ANNUAL MEETING October 3,4,5, 2001 «Gene Therapy's plausible future»

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Authors & Abstracts Invited Speakers Prg Wednesday 3.10 Prg Thursday 4.10 Prg Friday 5.10 Technical time schedule

last update 14.01.2002

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Invited speakers

coffee breaks sponsored...

...by Invitrogen

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Wednesday, October 3

coffee breaks sponsored...

...by Invitrogen

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TIME	EVENT	Place/Speaker
0830-0900	coffee / registration	Hall Chemistry Building
0900	enter	Lecture Hall
0900-0945	Ian Graham (Univ London, london, UK)	Oligonucleotide-based gene correction strategies: applications to neuromuscular and cardiovascular diseases apolipoproteins, dystrophin, gene targeting, hyperlipidemia, muscular dystrophies, point mutation, antisense, RNA splicing
0950 1030	poster ads /talks
1035	coffee break
1055 1130	poster ads/talks
1135	Michael Blaese (Valigen Inc., Newtown, PA, USA)	Therapy by Gene Repair Genoplasty, DNA repair, monogenic diseases, DNA sequence conversion, MutS, Chimeraplast
1210-1300	Poster session II, drinks, 1300 lunch	Hall , 'Salle de Lecture', Cafeteria EIF
1400 1525	short talks
1520	Coffee break	Hall
1600 1640	short talks
1700 -1745	Katherine High (Children's Hosp, Philadelphia, PA, USA)	Gene-Assisted Treatment of Hemophilia. Adeno-associated vectors, blood clotting factor, clinical trial
1800	Apero
1900	Official dinner

coffee breaks sponsored...

...by Invitrogen

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TIME	EVENT	Place/Speaker
0830-0900	coffee / registration	Hall Chemistry Building
0900	Welcome	Director
0910-0955	Roland Mertelsmann (Univ Klinikum, Freiburg i. Br, Germany)	Gene therapy and gene marking concepts in cancer treatment gene marking, stem cells, cancer therapy, gene therapy
1000 1030	Scientific presentations	Main Lecture Hall
1035	coffee break
1055 1230	Symposium 'Gene Therapy research in CH', where to go? R. Galeazzi H. Diggelmann F. Cavalli K. Dorsch
1135	Press / media corner /residual presentations	Small Lecture Hall /large lecture Hall
1210-1330	lunch break / (posters?)	Hall , 'Salle de Lecture', Cafeteria EIF
1400	Presentation of the steering committee for a Swiss Gene Therapy Network (SGTN)	Lecture Hall
1415	Holm Schneider (Children's Hosp, Erlangen)	In Utero Gene Therapy aims, candidate diseases, choice of vectors, routes of administratiuon, animal models, developmental windows, ethical considerations
1500	coffee break
1520	scientific presentations	main lecture hall
1640	Alan Colman (PPL therapeutics, Midlothian, UK)	Potential of Animal Cloning Technologies in Future Therapies nuclear transfer, reprogramming, imprinting, stem cells, cloning
1730	Meeting closure
hopefully:	see you at the next occasion proposed by SGTN

Time	Name	Team	Abs Nr	min	Title
905	Johnson, L.	ONYX pharma., Richmond,USA	L01	45	Oncolytic Viruses
950	Hellwig, R.	HOSSLE	P02	5	Oligonucleotide-mediated Targeted Gene Repair Of X-linked Chronic Granulomatous ...
955	Bernasconi, L.	FONTANA	P03	5	Glioblastoma Multiforme Gene Therapy
1000	Dong, Z.	GUEST	P51	5	Overexpression Of Parkinson's Disease-associated Alpha-synuclein(a53t) In The ...
1005	Heister, T.	GUEST	P52	5	Hsv/aav Hybrid Vectors Mediate Long-term Gene Expression In Cultured Human Cells
1010	Hemmi, S.	GUEST	P53	5	Attenuated Replication-competent Adenoviruses As Tools For Melanoma Therapy
1015	Kostic, C.	GUEST	P54	5	Pattern Of Activity Of Viral And Housekeeping Gene Promoters Using Self-inactivating ...
1020	BREAK	COFFEE
1040	Pajusola, K.	GUEST	P55	5	Proteasome Activity And A Potentially Different Endosomal Routing Restrict Aav-2 ..
1045	Willers, J.	GUEST	P56	5	Interferon Resistance Of Cutaneous T-cell Lymphoma Derived Clonal T-helper 2 Cells ..
1050	Foletti, A.	RUEGG	M11	5	Disruption Of Integrin Function By Expressing Partial Regions Of The ...
1055	Iggo, R.	IGGO	M02	20	Adenoviruses With Tcf Binding Sites In Multiple Early Promoters Show Enhanced ...
1115	Villard, J.	VILLARD	M01	20	Diagnostic Test For Mhc Class Ii Deficiency Patients By Direct Genetic Correction
1135	Danos, O.	Genethon, Paris, France	L02	45	Biological And Clinical Features Of Aav Vectors
1220	BREAK	POSTERS & DRINKS
1230	Fuhrmann Benzakein, E.	HERRERA	P00	-	A Single-gene Approach To Devise Inducible Or Removable Therapeutic Genes: A General ...
1230	Genilloud, A.	RUSCONI	P01	-	Selection Of Spontaneously Translocating ...
1230	Matheux, F.	VILLARD	P04	-	Partial And Transient Restoration Of Mhc-ii Molecules In Rfx5-/- Mice By Lentiviral ...
1300	BREAK	POSTERS & LUNCH
1400	Aebischer, P.	AEBISCHER	M03	40	Lentiviral Vectors For The Treatment Of Neurodegenerative Disorders
1440	Wodnar-Filipowicz, A.	FILIPOWICZ/ Thali	M04	20	Lentivirus-mediated Gene Transfer Into Hematopoietic Precursor Cells From ...
1500	Rusconi, S.	FREY/Rusconi	M05	20	Selective Enhancement Of Gene Transfer By Steroid-mediated Gene Delivery (smgd).
1520	BREAK	REFRESHMENTS
1540	Greber, U.	GUEST	M51	20	Adenovirus-disassembly Reveals A Function Of Nuclear Histone-h1 In Viral Dna-import ..
1600	Hossle, J.	HOSSLE	M06	20	Progress In Somatic Gene Therapy Of X-linked Chronic Granulomatous Disease
1620	Baumgartner, I.	BAUMGARNTER	M07	20	Lessons Learned From Vegf Gene Therapy
1640	Losordo, D.	TUFTS, Boston, USA	L03	45	Early Results From Clinical Trials Of Gene Therapy For Myocardial Angiogenesis
1730	End-day1	REFRESHMENTS

Time	Name	Team	Abs Nr	min	Title
900	Graham, I.	Univ. London, Egham, UK	L04	45	Oligonucleotide-based Gene Correction Strategies: Applications To Neuromuscular And Cardiovascular Diseases
950	Arsenijevic, Y.	GUEST	P57	5	Lentiviral-mediated Transfer Of Ciliary ...
955	Lobianco, C.	AEBISCHER	P09	5	Dopaminergic Cell Loss Induced By Lentivir...
1000	Regulier, E.	AEBISCHER	P10	5	Lentiviral-mediated Delivery Of Mutant ...
1005	Odermatt, A.	FREY/Rusconi	P13	5	Selection Of Peptide Ligands Binding To The ..
1010	Ashrafuzzaman, M.	GUEST	P58	5	Harmonic Thermodynamical Behavior Of ...
1015	Esslinger, C.	GUEST	P59	5	Efficient Transduction Of Dendritic Cells And..
1020	Schafer, B.	GUEST	P60	5	Paired-box Containing Transcription Factor..
1025	Afanasieva, T.	KLEMENZ	P22	5	Single-chain Antibody And Its Derivatives ...
1030	BREAK	COFFEE
1050	Schultz, J.	MOELLING	P14	5	Ip-10 Encoding Plasmid Dna Immunization ...
1055	Schuemperli, D.	SCHUEMPERLI	M16	20	Stable Transduction And Expression Of ...
1115	Brun, C.	SCHUEMPERLI	P15	5	Exon Skipping Of Dystrophin Mrna By ...
1120	Jilek, S.	WALTER	P16	5?	Monitoring The Maturation Of Dendritic ...
1125	Kralisch, S.	WALTER	P17	5	Targeting Of Dendritc Cells By Specific...
1130	Li, J.	VASSALLI	P18	5	Adenoviral Gene Transfer Of A Soluble Il-1...
1135	Blaese, M.	VALIGEN Inc, Newtown, USA	L05	45	Therapy By Gene Repair
1220	BREAK	POSTERS & LUNCH
1230	Bensadoun, J.	AEBISCHER	P06	-	Neuroprotective Effect Of Interleukin-6 And..
1230	Guillot, S.	AEBISCHER	P07	-	Long-term Gene Transfer To The Mouse ...
1230	Hussain-khan, H.	AEBISCHER	P08	-	Bioartificial Pancreas: Matching Device And ..
1230	Ridet, J.	AEBISCHER	P11	-	In Vivo Characterization Of A Tetracycline...
1230	Schneider, A.	SCHNEIDER/ Rusconi	P05	-	Exploring The Limits Of Organellar ...
1230	Schwenter, F.	AEBISCHER	P12	-	Optimization Of Human Erythropoietin ...
1230	Stolarczyk, D.	GUEST	P107	-
1300	BREAK	POSTERS & LUNCH
1400	Jones, G.	MERLO	M08	20	The Focal Adhesion Kinase (fak) Is Highly ...
1420	Kolakofsky, D.	KOLAKOFSKY	M09	20	Prolonging The Life Span Of Mature Dendritic.
1440	Scully, J.	REHMANN-SUT.	M10	20	Perceptions Of Healing Needs: Somatic Gene ...
1500	Moelling, K.	MOELLING	M12	20	Cytokine-encoding Dna For Cancer Gene...
1520	BREAK	REFRESHMENTS
1540	Walter, E.	WALTER	M13	20	Microparticle-mediated Transfection Of ...
1600	Bisoffi, M.	STADLER/ Cecchini	M14	20	Scavenger Receptor Block As Improved ...
1620	Mermod, N.	MERMOD	M15	20	A Regulatory Network For The Efficient ...
1640	High, K.	Children's Hosp., Phila.	L06	45	Gene-Assisted Treatment of Hemophilia
1730	End-day2	REFRESHMENTS
1900	Dinner	Invitees

Time	Name	Team	Abs Nr	min	Title
900	Mertelsmann, R.	Uni-Klinikum, Freiburg i.Br	L07	45	Gene Therapy And Gene Marking Concepts In Cancer Treatment
955	Kok, M.	DREHER	P20	5	Live Salmonella Vectors For Antigen Transfer Into Human Dendritic Cells.
1000	Obregon, C.	DREHER	P21	5	Salmonella Typhimurium Sipb Protein Modulates Activation And Release Of Il-18 ...
1005	Dreher, D.	DREHER	M17	20	From Genomics To Vaccination: Treatment Of Latent Tuberculosis By Recombinant ...
1025	BREAK	COFFEE	.	.
1045	Galeazzi, R.	INVITED PANELIST symp	none	30	NF and clinical research, report
1115	Diggelmann, H.	INVITED PANELIST symp	none	10	NF policy
1125	Cavalli, F.	INVITED PANELIST symp	none	10	The view of a Dr med/politician
1135	Dorsch, K.	INVITED PANELIST symp	none	10	Biosafety rules update
1145	All	EVENT/			panel and general discussion
1220	BREAK	POSTERS & LUNCH
1400	All	EVENT/			presentation of steering committee GT
1415	Schneider, H.	Children's Hosp. Erlangen, De	L08	45	In Utero Gene Therapy
1500	Seemayer, C.	GAY	M18	20	Gene Transfer For Treatment Of Rheumatoid Arthritis
1520	BREAK	REFRESHMENTS
1540	Wiznerowicz, M.	TRONO	M19	20	Hematopoietic Stem Cells-directed Gene Therapy: Chronic Granulomatous Disease
1600	Colman, A.	PPL Therapeutics Midlothian, UK	L09	45	Potential Of Animal Cloning Technologies In Future Therapies
1700	Closure	Safe return!

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BRIEF GEOGRAPHIC DESCRIPTION (see below for maps):

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The annual meeting NFP37 will be hold at the Chemistry building
(this is number 9 in the plan of Perolles site).
We will post some signs: 'NFP37 ANNUAL MEETING'.

BY CAR:

• Autobahn Zürich<->Geneva, Exit 'Fribourg SUD', Direction: 'Marly'
• The road is uphill for about 300 m, keep right lane.
• You enter a double circle, cross the intersecting road, maintain direction 'Marly'.
• The road is first flat then downhill, you are on Rte de Cormanon (500-700 m).
• You reach a junction and take left, the road (Rte de la Glane) is flat , then downhill (500 m).
• You reach a traffic light and take right (Rte de la fonderie),
• another 700 m then you are in Pérolles.
• The entrance is at the traffic circle, follow the sign 'Université' at your right
• and search a parking space. Congress visitors can use the 'A' area.

BY TRAIN: at the train station entrance you can take a bus ticket (1.50 Fr).
Bus Nr 1 will bring you to Perolles (it is the terminal after a five stops ride, about 5 min).
If you want to walk, you take Blvd. de Perolles until its end (about 15 min).

• Trains from Zürich (1h 40): every hour/04 or hour/34 ; (first train 0526)
• Trains from Basel (1h 40): every hour/04 or hour/10 ; (first train 0550)
• Trains from Geneva: (1h 35min): every hour/30 or hour/34 ; (first train 0434)
• Trains from Lausanne: (45min): every hour/06 or hour/26 ; (first train 0524)
• Trains To Zürich or Basel: every hour/16 or hour/51 ; (last train 2316)
• Trains To Geneva or Lausanne: every hour/09 or hour/44 ; (last train 2347)
• click here for more details on train schedules.

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FURTHER INDICATIONS AND MAPS:

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How to reach Fribourg (German): (http://www.unifr.ch/wwwunifr/body/planSuisseD.html)
How to reach Fribourg (French): (http://www.unifr.ch/wwwunifr/body/planSuisseF.html)

How to move around Fribourg (French): (http://www.unifr.ch/wwwunifr/body/planVilleF.html)
How to move around Perolles (French): (http://www.unifr.ch/wwwunifr/body/planPerollesF.html)

Railways Time table (english/french/german/italiano): (http://www.sbb.ch/)
Swissair Time Table (Zürich and Geneva) : (http://www.swissair.com/timetable/index.htm)

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PARKING IN PEROLLES, legend to figure

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Parking will be free of charge during the meeting, please use area A

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LODGING DURING THE MEETING

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Speakers and other invitees will lodge at the:

• HOTEL GOLDEN TULIP **** Grand Places 14
  (yellow dot marked 'A' in plan below)
  tel (026) 351 9191; fax (026) 351 9192
  directions to the hotel from the train station (5 min walk)

NFP37 attendees who wish to arrive to Fribourg
the evening before, are recommended to reserve at
one of the following hotels (temporary list).
Please mention the word "Meeting Gene therapy/Gentherapie"
when you reserve a room in one of these hotels,
so you profit by a special price:

• HOTEL ALPHA ***, Rue du Simplon 13;
  SFr. 88.-- single room, SFr. 116.-- double room
  (yellow dot marked 'C' on plan below); http://www.alpha-hotel.ch/
  tel (026) 322 7272 ; fax (026) 323 1000; e-mail: info@alpha-hotel.ch
• HOTEL DE LA ROSE ***, Rue de Morat 1,
  SFR 88.-- singel room, SFr. 128.-- double room
  (yellow dot marked 'D' on plan below); http://www.rose-fribourg.ch
  tel (026) 351 0102 ; fax (026) 351 0100, e-mail:
• HOTEL SAUVAGE ****, Planche-Superieure 12,
  (yellow dot marked 'E' on plan below); http://www.hotel-sauvage.ch/
  tel (026) 347 30 60; fax (026) 347 3061; e-mail: info@hotel-sauvage.ch
• HOTEL AU PARC ****, Rte de Villars 37 - CH-1700 Fribourg
  (yellow dot marked 'B' on plan below); http://www.auparc-hotel.ch/
  tel: 026 429 56 56; fax: 026 429 56 57; e-mail: parchotel-fribourg@bluewin.ch
• HOTEL ELITE, Rue du Criblet 7;
  SFr. 90- 105.-- single room, SFr. 140.- double room
  (yellow dot marked 'I' on plan below)
  tel: 026 322 3836; fax 026 322 4036; e-mail: elitefribourg@gmx.ch
• HOTEL CENTRAL, rue Nicolas-de-Praroman 2
  (yellow dot marked 'L' on plan below); e-mail: mauviba@mcnet.ch
  tel: 026 347 2288, fax 026 347 2289
• CITE ST-JUSTIN, Route du Jura 3;
  SFr. 36.-- (for students)
  (yellow dot market 'J' on plan below); http://www.justinfr.ch
  tel: 026 351 1616; fax: 026 323 4098, e-mail: justinfr@bluewin.ch
• AUBERGE DE JEUNESSE (YOUTH HOSTEL), rue de l'Hôpital 2; SFr. 26.65
  (yellow dot marked 'K' on plan below); http://www.youthhostel.ch/fribourg
  tel: 026 323 1916; fax 026 323 1940; e-mail: fribourg@youthhostel.ch
•  

Hotels in the region:

• HOTEL GRAND-PRE, Nouveau-Maché 1, 1723 Marly (3 km)
  tel 026 436 5060; fax 026 436 2150
• HOTEL ESCALE, rte Belfaux 3, 1762 Givisiez (3 km)
  tel 026 466 2767; fax 026 466 2827
•  

(We are currently negotiating special rates for NFP37 attendees in these
and other hotels,including some bed-and-breakfast, so this list will become
longer in the next weeks)

Color	Lettering	Meaning
light purple dots	1-20	UNIFR sites, Perolles (Faculty of sciences) bears Nr 2
yellow dots	A-E	Hotels: A, Golden Tulip // B, Au Parc // C, Alpha // D, de la Rose // E, Sauvage // I, Elite // J, Cité St-Justin // K, Youth Hostel // L, Central
Red dot	F	Position of Institutes of Biochemistry and Chemistry
Blue dot	G	Position of the Ecole Ingenieurs (EIF)
Green dot	H	Train station
Green Dot	S	Restaurant San Marco (Dinner 4.10)

• Poster sessions are held over the noon break.
• Poster space will be reserved with your poster number.
• Those who are scheduled for a 5 min advertisement should pay attention to the following rules:
• - the poster advertisement is meant to ATTRACT
  .. people to your poster, not to the opposite!
• - take a seat on the reserved yellow-marked places
• - make your presentation into 1 (max 2) transparent sheet
  . (no slides can be accepted for this kind of presentation)
• - be sure you maintain the 5 min limit
• - consider presenting in the order:
  - the hypothesis / rationale
  - the methods
  - the major result / conclusion
  - the perspectives
• - if you do it in a shorter time you are entitled to answer some questions
• You do not need to mention title and authors because they will be projected

• for the lectures you can use either transparencies, slides or your laptop
• a technical assistant will be ready to help you with the electronic setup
• the assigned times are including the discussion, so if you expect
  some questions, you should shorten your presentation accordingly.
• Extensions into overtime will only be accepted for the invited speakers

Directions Train-station->Hotel Golden Tulip
(for invited speakers)

• the hotel Golden Tulip is at 5 min walking distance
  from the Fribourg's train station.
• To reach the hotel you cross the main road
• Then you take your left, along the walkway.
• After about 200 m you can turn to the right
• (there is a provisory department store called 'EPA',
  which is pathetically painted black and white)
• In front of you there is the 150 m wide parking lot of the 'Grand places',
  and at its other side the Hotel Golden Tulip.
• You can't miss it, because it is the only building
  higher than 12 stores in the entire town.
• You will find your reservation under your name
  and a welcome message from my part, including some
  last-minute informations.
• Usually I organise a get-together faculty dinner
  every evening. Thurday evening there is the 'official'
  (but not too formal) dinner.
  
• 
  
• Exact address of the hotel:
  Hotel Golden Tulip
  Grand Places 14
  1700 Fribourg, Switzerland
  tel +41 26 351 9191 ; fax x9192
  WEB: http://www.goldentulip.com/static/welcome_24818.html
  
• 
  
• Transportation from/to meetg:
• We will organise transportation from the hotel
  to the meeting site (also not very far).
  A map of the essentials in Fribourg
  can be printed out from our picture
  
• In that map the train station is marked'H' (green dot),
  the golden Tulip is marked 'A' (yellow dot)
  and the meeting site is marked 'F' (red dot)
  the 4.10 dinner site is also marked (restaurant San Marco, green spot, 'S')
• the grid lines in that map are 500 m apart.
  
• 
  
• For any assistance
• If you have any problem during your trip,
  just to call my cell phone Nr: +41 79 375 6876
  which will be active 24-hr-a-day
  from monday Oct 1st til Saturdyay Oct 6th.

Geneva Airport - Fribourg

• Departure - arrival; <changes>
  .
• 6.21 - 7.50 <0>
• 7.21 - 8.50 <0>
• 8.21 - 9.50 <0>
• 9.21 - 10.50 <0>
• 10.21 - 11.50 <0>
• 11.21 - 12.50 <0>
• 12.21 - 13.50 <0>
• 13.21 - 14.50 <0>
• 14.21 - 15.50 <0>
• 15.21 - 16.50 <0>
• 16.21 - 17.50 <0>
• 17.21 - 18.50 <0>
• 18.21 - 19.50 <0>
• 19.21 - 20.50 <0>
• 20.21 - 21.50 <0>
• 21.21 - 22.50 <0>
• 22.09 - 0.15 <1 in Lausanne>

Geneva Airport - Lausanne: 45 min
Lausanne-Fribourg: 45 min

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Fribourg - Geneva Airport

• Departure- arrival <changes>
  .
• 4.48 - 6.35 <0>
• 6.04 - 7.39 <0>
• 7.09 - 8.39 <0>
• 8.09 - 9.39 <0>
• 9.09 - 10.39 <0>
• 10.09 - 11.39 <0>
• 11.09 - 12.39<0>
• 12.09 - 13.39 <0>
• 13.09 - 14.39 <0>
• 14.09 - 15.39 <0>
• 15.09 - 16.39 <0>
• 16.09 - 17.39 <0>
• 17.09 - 18.39 <0>
• 18.09 - 19.39 <0>
• 19.09 - 20.39 <0>
• 20.09 - 21.39 <0>
• 21.09 - 22.39 <0>
• 22.09 - 23.39 <0>

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Zurich Airport - Fribourg

• Departure - arrival <changes>
  .
• 5.37 - 7.43 <2 in Zurich Hauptbahnhof and Bern>
• 6.13 - 8.08 <0>
• 6.40 - 8.43 <1 in Bern>
• 7.13 - 9.08 <0>
• 7.43 - 9.43 <1 in Bern>
• 8.13 - 10.08 <0>
• 8.40 - 10.43 <1 in Bern>
• 9.13 - 11.08 <0>
• 9.40 - 11.43 <1 in Bern>
• 10.13 - 12.08 <0>
• 10.40- 12.43 <1 in Bern>
• 11.13- 13.08 <0>
• 11.40- 13.43 <1 in Bern>
• 12.13- 14.08 <0>
• 12.40- 14.43 <1 in Bern>
• 13.13 - 15.08 <0>
• 13.40 - 15.43 <1 in Bern>
• 14.13 - 16.08 <0>
• 14.40 - 16.43 <1 in Bern>
• 15.13 - 17.08 <0>
• 15.40 - 17.43 <1 in Bern>
• 16.13 - 18.08 <0>
• 16.40 - 18.43 <1 in Bern>
• 17.13 - 19.08 <0>
• 17.40 - 19.43 <1 in Bern>
• 18.13- 20.08 <0>
• 18.40 - 20.43 <1 in Bern>
• 19.13 - 21.08 <0>
• 19.40 - 22.04 <1 in Bern>
• 20.13 - 22.08 <0>
• 20.40 - 22.43 <1 in Bern>
• 21.40 - 23.45 <1 in Bern>
• 22.40 - 0.49 <1 in Bern>

Zurich Airport - ZH Hauptbahnhof: 10 min.
Zurich Airport - Bern: 90 min.
Zurich Hauptbahnhof - Bern: 70 min.
Bern-Fribourg 25 min
-------------------------------------------------------------------------

Fribourg - Zurich Airport

• departure - arrival <changes>
  .
• 5.50- 7.50 <1 in Bern>
• 6.16 - 8.16 <1 in Bern>
• 6.51 - 8.50 <0>
• 7.16 - 9.16 <1 in Bern>
• 7.51 - 9.50 <0>
• 8.16 - 10.16 <1 in Bern>
• 8.51 - 10.50 <0>
• 9.16 - 11.16 <1 in Bern>
• 9.51 - 11.50 <0>
• 10.16 - 12.16 <1 in Bern>
• 10.51 - 12.50 <0>
• 11.16 - 13.16 <1 in Bern>
• 11.51 - 13.50 <0>
• 12.16 - 14.16 <1 in Bern>
• 12.51 - 14.50 <0>
• 13.16 - 15.16 <1 in Bern>
• 13.51 - 15.50 <0>
• 14.16 - 16.16<1 in Bern>
• 14.51 - 16.50 <0>
• 15.16 - 17.16 <1 in Bern>
• 15.51 - 17.50 <0>
• 16.16 - 18.16 <1 in Bern>
• 16.51 - 18.50 <0>
• 17.16 - 19.16 <1 in Bern>
• 17.51 - 19.50 <0>
• 18.16 - 20.16 <1 in Bern>
• 18.51 - 20.50 <0>
• 19.16 - 21.16 <1 in Bern>
• 19.51 - 21.50 <0>
• 20.16 - 22.16 <1 in Bern>
• 20.51 - 22.50 <1 in Zurich Hauptbahnhof>
• 21.16 - 23.16 <1 in Bern>
• 21.51 - 0.27 <1 in Zurich Hauptbahnhof>

Fribourg - Bern: 20 min.
Fribourg - Zurich Hauptbahnhof: 95 min.

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