DÉPARTEMENT DE MÉDECINE
DEPARTEMENT FÜR MEDIZIN
DEPARTMENT OF MEDICINE

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Principal Investigator

NORDMANN Patrice

Full Professor of
Microbiology

Clinical Medicine

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  Research Topics • Emerging Antibiotic Resistance in Bacteria  
       
  Subtopics • Genetic and biochemistry of antibiotic resistance traits
• Epidemiology of emerging antibiotic resistance
• Rapid diagnostic tests
• Novel antibiotic strategy
 
       
 

Questions addressed

Emerging antibiotic resistance is dominated nowadays by difficult-to-treat infections due to multidrug and pandrug resistant gram negatives. Those gram negatives are mostly Enterobacteriacae, Pseudomonas aeruginosa and Acinetobacter baumannii. Multidrug resistance is observed not only among nosocomial but also among community-acquired pathogens. Focus is on ß-lactams since this class of antibiotics represents the most widely prescribed antibiotics and resistance to broad-spectrum ß-lactams is often associated to resistance to the other classes of antibiotics such as aminoglycosides, and fluoroquinolones and polymyxins.
Our research is mostly on emerging resistance in gram negatives which are the main cause of infections for humans and for which very few therapeutic options are left. Our research goals are the followings: (i) increase in the knowledge on the origin, the plasticity and diffusion of resistance genes, (ii) the prevention of their spread by implementing novel diagnostic tools, and (iii) the discovery of novel antibiotic molecules.
Our latest research focuses mostly on two emerging resistance determinants that are currently of utmost importance for humans, i.e. resistance to carbapenems and resistance to polymyxins (colistin).
Our current subjects of research are as follows:

  • Structure function analysis of carbapenemases of the GES and OXA-48 types. Which are the key amino acid residues as a source of carbapenemase activity? Which is the antibiotic selection pressure prone to select for a carbapenemase activity?
  • Studies on the transposon-mediated mobility of blaNDM carbapenemase gene in Acinetobacter baumannii.
  • Identification of novel antibiotic resistance traits as a source of multidrug resistance in gram negatives from human and veterinary medicine from worldwide origin.
  • Deciphering the molecular mechanisms leading to colistin resistance in Klebsiella pneumoniae.
  • Development of novel rapid diagnostic tests for identification of emerging antibiotic resistances.
  • Evaluation of novel antibiotic molecules using genetically well-defined bacterial strains and clinical isolates
 
       
  Keywords • Bacteria
• Antibiotic resistance
• Rapid detection
• Genetic
• Biochemistry, epidemiology antibiotic
 
       
  Contact Email address patrice.nordmann [at] unifr.ch  
       
  Personal site http://www.unifr.ch/microbiology/fr
http://www.unifr.ch/microbiology/fr/publications
 
   

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