DÉPARTEMENT DE MÉDECINE
DEPARTEMENT FÜR MEDIZIN
DEPARTMENT OF MEDICINE

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Principal Investigator

HOOGEWIJS David

Associate Professor of
Physiology

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  Research Topics • Oxygen physiology
• Cancer biology
 
       
  Subtopics • Regulation and function of globins in vitro and in vivo
• Globin gene family evolution
• Hypoxia-inducible factor (HIF)-dependent gene expression
• Erythropoietin regulation
 
       
 

Questions addressed

Our research is centered on studying novel oxygen-binding proteins as well as investigating the molecular mechanism of cellular response to reduced oxygen supply (hypoxia) using a broad variety of life science research methodologies, including biochemical, molecular, cell biological and bioinformatical techniques as well as genetically modified cells and animals.

We aim to elucidate the (patho)physiological role of androglobin and cytoglobin, two recently identified mammalian globins from the post-genomic era. Androglobin represents the latest addition to the globin family and consists of a calcium-dependent protease domain fused to a central circularly permuted globin domain. While androglobin expression is restricted to postmeiotic stages of spermatogenesis, cytoglobin is expressed mainly in fibroblasts from a broad range of organs. We particularly address the renal role of cytoglobin and the spermiogenesis-specific function of androglobin.

An additional research line aims to understand the differential regulation between the transcription factors hypoxia-inducible factor 1 (HIF-1) and HIF-2 in response to hypoxia with a strong focus on distal regulatory DNA regions and oxygen-dependent erythropoietin gene expression. Apart from numerous physiological and pathophysiological processes, including embryonic development, high-altitude adaptation and inflammation, the mechanisms of cellular adaptation to hypoxia are of crucial importance for clinically relevant diseases such as anemia, infarction and cancer.

 
       
  Keywords • Oxygen
• Globin
• Hypoxia
• Cellular oxygen sensing
• Erythropoietin
 
       
  Contact Email address david.hoogewijs [a] unifr.ch  
       
  Personal site http://www.unifr.ch/inph/groupehoogewijs/en/hoogewijs_en.php   
   

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