DÉPARTEMENT DE MÉDECINE
DEPARTEMENT FÜR MEDIZIN
DEPARTMENT OF MEDICINE

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Principal Investigator

ROUILLER Eric

Full Professor of
Physiology

er

       
 
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  Research Topics • Motor control of voluntary movements
• Multisensory and sensorimotor integration
 
       
  Subtopics    
       
 

Questions addressed

The main research interest of the laboratory is the study of motor control of voluntary movements as well as mechanisms involved in multisensory and sensorimotor integration.
► Control of voluntary movements
How do non-human primates (monkeys) exert their sophisticated manual dexterity? Manual dexterity is assessed using a large palette of reach and grasping tasks, comprising manipulation of small objects with the fingers. What is the impact of a lesion of motor cortex on the manual dexterity? What are the extent and the mechanisms of spontaneous functional recovery after lesion of the motor cortex? Can such functional recovery be enhanced with various treatments, such as implantation of exogenous or endogenous progenitor cells, as well as neutralization of neurites growth inhibitors (such as Nogo-A)?
► Multisensory and sensorimotor integration
The facilitation of reaction time and performance provided by simultaneous presentation of auditory and visual stimuli, as compared to separate presentation for each modality, is studied in non-human primates. There is behavioral evidence in favor of very early multisensory integration. What are the brain regions where such early integration takes place? What are the pathways giving rapid access to the motor system for rapid sensorimotor response?

 
       
  Keywords • Anti-Nogo-A antibody treatment
• Auditory and visual stimuli
• Behavior
• Cell therapy
• Lesion of motor cortex
• Manual dexterity
• Non-human primates, monkeys
• Recovery from CNS lesion
• Tract tracing
 
       
  Contact Email address eric.rouiller [at] unifr.ch  
       
  Personal site Physiology ► Group Rouiller
Laboratory of Neurophysiology of Action and Hearing
 
   

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