UNITÉ D'ANATOMIE
ABTEILUNG FÜR ANATOMIE
ANATOMY UNIT
MM

Research

Group Kretz

The visual system of the tree shrew
and the chick


Project description
Processing of visual information is crucial for creatures with a highly developped visual system. The goal of our research is to elucidate the morphological and physiological basis of vision. We study the developing and mature structures such as the retina, the optic nerve, chiasm and tract, the dorsal lateral geniculate nucleus, the optic tectum, and the primary visual cortex. Our laboratory animals are the tree shrew Tupaia belangeri, the closest relative to the primates, and the chick. We investigate the structural and physiological organization of the visual system using a broad range of methods such as light and electron microscopy, confocal laser scanning microscopy, localization of tracer substances, immunoreactivity of early genes, immunocytochemical visualization of neurotransmitter receptors (in collaboration), single cell electrophysiological studies in anaesthetized animals, morphometry and 3-D reconstructions of the whole brain and/or specific brain structures, biostatistics, and optical imaging of intrinsic signals (in collaboration).

Optical Imaging: Bilateral orientation difference signal (A) and bilateral response to a stimulus at the vertical meridian (B).


(T. Voigt)

The motor endplate



Project description
Synaptic transmission between axon and muscle fibres and the regulation of the muscle fibre type are controlled by the so called sole plate nuclei. Calcium plays a role at all these regulation procedures. Therefore we examine the motor endplate by means of the electron microscopy. Currently we follow the question whether pathological gene defects that concern the motor endplate lead to structural modifications of the T-system and the sarcoplasmic reticulum of the endplate.

Schematic drawing of the findings at the frog





Group members
Alberi Lavinia (assistant doctor), Brai Emanuel (PhD student), Guinnard Fanny (Animal care technician), Marathe Swananda (PhD Student), Marguerite Kaczorowski (lab technician), Robert Kretz (group leader, PA, PhD)



Funding
Novartis Foundation ; intramural budget (University of Fribourg)




Université de Fribourg   •   Faculté des sciences   •   Département de médecine   •   Unité d'Anatomie
1, Rte. Albert Gockel   •   CH-1700 Fribourg   •   Tél +41 26 300 85 40 / 84 90   •   Fax +41 26 300 97 32 / 97 33   •   Secrétariat   •   Webmaster